Home Blog Page 3

MNR has determined how many lakes and streams in Michigan have healthy fish

0

Surveys of Michigan’s lakes and streams are underway in parts of the state, as part of the state’s annual effort to collect data to better manage fisheries resources.

Michigan’s 10,000 lakes and 36,000 miles of rivers are teeming with data, Michigan Department of Natural Resources officials say, but the department only has enough staff to conduct about 250 to 300 surveys a year. .

Jay Wesley, DNR Fisheries Division Lake Michigan Basin Coordinator, said DNR crews completed more than 260 fisheries surveys in Michigan in 2021. DNR fisheries staff surveyed 152 lakes inland and 115 waterways.

Wesley said surveys have found about 80% of lakes and streams in the state have healthy, self-sustaining fish populations.

The surveys, which are underway in southern Michigan and begin in May in the Upper Peninsula, are useful for tracking inland fishery populations, assessing whether stocking is increasing angling opportunities or addressing angler concerns. throughout the year, Wesley said.

“Management units stepped up last year and conducted these surveys safely to assess whether management actions, such as stocking or habitat improvement projects, were having the desired effect,” said Wesley. “Surveys help us understand whether or not our management actions have resulted in better recreational fishing in certain areas or improved the overall health of a lake.”

Other annual surveys help managers track the status and trends of fish communities and important aquatic habitats on different lakes, Wesley said, providing a picture of the lakes environment over time.

Statewide streams are managed by two types of surveys called fixed sites and random sites.

“At fixed sites, we estimate fish population levels, typically trout in colder waters and smallmouth bass in warmer waters, on a three-year rotation, while random surveys at the sites provide insight into species and show relative abundance,” Wesley said. “The MNR collects habitat data at all surveyed sites.”

Fisheries managers use discretionary surveys to answer questions or respond to current concerns, such as an issue raised by a local biologist, angler group or lake association, Wesley said.

These surveys can be conducted to assess habitat suitability for a threatened or endangered fish species and typically represent 50% of the annual survey effort, state officials said.

Wesley said the information is used to strategize management actions, detect early indicators of invasive species, and recognize developing threats to fish health and habitat.

“Most of our funds come from fishing license fees, so we want to make sure these lakes have healthy fish populations,” Wesley said. “If not, we want to know what we can do to improve them.”

“In general, people are curious about what’s in their lake and how it’s doing,” he said.

jchambers@detroitnews.com

Skin cells look 30 years younger thanks to a new “rejuvenation” technique

0

British researchers have developed a way to reverse the aging process of skin cells, by turning the biological clock back by around 30 years.

Cell aging has become increasingly common over the past decade, with researchers reprogramming several mouse, rat and human cell types. But never before have cells been aged so many years and retained their specific type and function.

The method, developed by Diljeet Gill, a postdoctoral fellow at the Babraham Institute in Cambridge, and his colleagues, was published on April 8 in the journal eLifeand has been dubbed “transient reprogramming of the maturation phase”.

The researchers applied this technique to fibroblasts (a common type of the skin cell) from three middle-aged donors – with an average age of around 50 – and then compared them to younger cells from donors aged 20 to 22. The researchers found that the middle-aged cells were similar to younger cells, both chemically and genetically. . When explored further, the team even noticed that the technique affected genes linked to age-related diseases, like Alzheimer’s disease and cataracts.

Additionally, Gill and his colleagues examined the behavior of fibroblasts to determine if they could also act like younger skin cells. When they injured a layer of cells, they found that the rejuvenated cells moved quickly to fill the gap, similar to how younger cells behave when wounds heal.

This study is not the first to age skin cells. This title goes to the Nobel laureate Shinya Yamanakawho genetically reprogrammed mouse skin cells and transformed them into so-called induced pluripotent cells stem cellsor iPSCs, in 2006. These iPSCs resemble cells in early development and have the potential to form any type of cell in the body.

Related: What are stem cells?

The new research is based in part on Yamanaka’s method, but there are key differences. Yamanaka’s method takes about 50 days and completely reprograms cells to the biological age of an embryo. Gill’s method takes only 13 days and only partially reprograms the cells so that they retain their identity (in this case, the identity of skin cells.).

Although the transformation of mature cells into stem cells is ideal for research, the complete reprogramming process is not ideal for therapeutics. Completely reprogrammed cells lose their identity and specialized cellular functions. And when implanted in the body, these fully reprogrammed cells can become cancerous.

In contrast, partially reprogrammed cells, such as skin cells in Gill’s research, become biologically younger and retain specialized cellular functions, although they may still potentially pose a cancer risk. “Our results represent a major step forward in our understanding of cellular reprogramming,” Gill said in a statement. “We have proven that cells can be rejuvenated without losing their function and that rejuvenation seeks to restore certain functions to old cells.”

Although their work shows great promise, Gill and his colleagues acknowledge that their paper is a proof-of-concept study. The authors said they don’t know how fibroblasts from younger or older individuals would react to the new reprogramming method, or whether cells from people of vastly different ages would still age 30 years.

Another problem is that Gill’s technique is still based on Yamanaka’s method. It is still unclear how the reprogrammed cells might behave inside a living organism or what risks they pose.

Ben Van Handel, a stem cell biologist and co-founder of skincare company Heraux and biopharmaceutical company CarthroniX, said the technique “will never be used in a clinical setting because it’s currently a type of gene therapy that would be impossible to use in humans.” There is still a lot of concern about these cells becoming cancerous and controlling how far back the rejuvenation process goes.

But that does not detract from the impact of the study. “The way it was done will not be applicable in the real world, [but] the research is valuable,” Handel told Live Science. “We can discover practical ways to do this by studying the process…and that’s important!

The study’s lead author, Dr. Wolf Reik, director of the institute at biotech company Altos Labs and a former principal investigator at the Babraham Institute, said the long-term implications of the study are very interesting. “Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those that reduce the effects of aging,” he said in the release.

Originally posted on Live Science

Biology class learns about cancer from survivors

0

MEADOW HOMES — At the Vancouver Virtual Learning Academy, William Baur’s high school biology class is piloting the OpenSciEd high school science curriculum. The students recently started a cancer-focused unit. After spending the first part of the school year focusing on ecosystems, Baur wanted to focus on a subject that would build on students’ understanding of cells, DNA, proteins and body systems. human.

Cancer can be a difficult subject to talk about, but with 42% of cancer cases preventable, Baur hoped his students would become more aware of who is at risk of developing cancer and why.

At the beginning of each new scientific unit, students generate a list of questions on the subject. One of the first questions asked by Baur students was, “How is female breast cancer caused?”

Just then, Baur read a podcast, Rotten Melons, hosted by two Vancouver labor and delivery nurses and breast cancer survivors. He invited Deanna Berger and Meredith Pena to share their experiences and help answer one of the big questions from students: where should we focus our treatment and prevention efforts?

Much of the information available online and in various educational resources focuses on numbers and hard facts, rather than the emotional and other aspects of what it feels like to have breast cancer. Through their weekly podcast, nurses Berger and Pena tackle these lesser-known topics, such as hair loss, anxiety, chemotherapy, and toxic positivity. Baur reached out to them in hopes of broadening her students’ understanding of what it means and feels like to have breast cancer survivors, by providing their real-world stories to enhance the lessons.

Based on student feedback, Berger and Pena’s visit to the classroom made a lasting impression.

Review the life cycle of an important human parasite

0

The Cryptosporidium parasite, transmitted by water sources, is one of the most common causes of diarrheal disease worldwide. Credit: Muthgapatti Kandasamy and Boris Striepen

“We’ve had an interest in the romantic life of the Cryptosporidium parasite for some time,” says Boris Striepen, a scientist at Penn’s School of Veterinary Medicine.

Cryptosporidium is one of the leading causes of diarrheal disease in young children worldwide. The intestinal parasite contributes to infant mortality and causes malnutrition and stunted growth. How a parasite like this reproduces and completes its life cycle has a significant impact on the health of children.

“It’s the sex product of the parasite, which here is an infectious agent, a spore, that is transmitted through contaminated water,” Striepen explains. “So if you break his ability to have sex, you would break the cycle of transmission and infection.”

In a new article from PLOS Biology, Striepen and his colleagues in his lab are exploring new ways to understand how Cryptosporidium reproduces inside a host. Using an advanced imaging technique allowed scientists to observe the entire life cycle in the laboratory. They found that the parasite completed three cycles of asexual replication, then switched directly to male and female sexual forms. Their observations refute an intermediate stage introduced in the 1970s and fit well with the original description by physician and parasitologist Edward Tyzzer who discovered this pathogen more than a century ago.

“What we showed contradicts what you see in most textbooks today, including the description on the Centers for Disease Control and Prevention website,” Striepen says. “It’s really a super simple life cycle that is completed in a single host in three days and has only three characters: asexual cells, male cells and female cells.”

Other parasites, such as the malaria parasite Plasmodium, a “cousin” of Cryptosporidium, have more complicated and longer paths to follow a broadly similar life cycle. As Crypto completes its life cycle in a host, most malaria parasites move between two: a mosquito, where the parasite’s sexual reproduction occurs, and a human, where its asexual replication occurs.

“Cryptosporidium is an excellent model for studying parasite development; you can see steps analogous to what happens with the malaria parasite, but it’s much simpler because it all happens in just three days in a host, and we can observe it in simple cell cultures,” says Strepen.

In previous work on Cryptosporidium, Striepen and colleagues found that sexual reproduction seemed necessary for the parasite to move from one host to another to infect another, but also to maintain itself in a host during a chronic infection. Blocking the progression of development and sex of the parasite therefore presents itself as a strategy to cure or prevent infection.

Cryptosporidium is a tiny single-celled parasite that invades and reproduces inside the gut cells of its hosts. To get a closer look at what was going on, the researchers developed a live-cell microscopic imaging technique to follow the progression of the parasite over several days in cell cultures. Using genetic engineering, they added a fluorescent tag to the nucleus of each parasite, allowing them to observe the parasite’s replication in real time and distinguish the different stages of its life cycle.

What they saw was that the parasites “count to three,” says Striepen. Rather than responding to environmental cues, the parasites followed a rigid, built-in plan. After infecting a crop, the parasite underwent three cycles of asexual reproduction. Each cycle lasted about 12 hours, during which time the parasite established itself in the host cell and reproduced, resulting in eight new infectious parasites. These were then released to infect surrounding host cells.

After these three waves of amplification, their fate changes abruptly and they turn into male or female gametes, or sex cells, in a process that also lasted around 12 hours. By tracking individual parasites and their offspring, researchers have found no evidence of a specialized intermediate form assumed by many textbooks, demonstrating direct development.

Interestingly, the parasite seemed pre-committed to its future fate and carried that blueprint from host cell to host in ways not yet understood.

Researchers were intrigued to see that both males and females come from the infectious forms released by the same asexual parasites. “One of the really interesting things about gender identity here is that it’s not inherited and hard-wired into the genome, but much more fluid,” Striepen says. “There’s an asexual cell that divides into genetically identical clones, and then those clones somehow become male or female on the fly, resulting in radically different cell shape and behavior.”

Future research will focus on the molecular mechanism of commitment to understand how this life cycle is programmed into the biology of the parasite. Understanding Cryptosporidium’s life cycle is key to thinking about how to create a vaccine or therapy for the disease, Striepen says.

“How cells make decisions and carry out developmental plans is one of the most fundamental questions in biology. Cryptosporidium offers a tractable system to better understand this mechanism in parasites. Hopefully, we can gain insights that contribute to the understanding of cryptosporidiosis and malaria and pave the way for urgent new interventions for these important diseases.


Scientists identify key regulator of malaria parasite transmission


More information:
PLOS Biology (2022). journals.plos.org/plosbiology/ … journal.pbio.3001604

Provided by
University of Pennsylvania

Quote:
Reviewing the life cycle of an important human parasite (2022, April 15)
retrieved 15 April 2022
from https://phys.org/news/2022-04-lifecycle-important-human-parasite.html

This document is subject to copyright. Other than fair use for purposes of private study or research, no
any part may be reproduced without written permission. The content is provided for information only.

Orphan mountain lion cub spotted by hikers in San Mateo rescued after five days of search | News

0

First spotted last Tuesday by hikers, wildlife biologists and game wardens from the Midpeninsula Regional Open Space District and the California Department of Fish and Wildlife, they set up cameras and patrolled the area daily to find the emaciated female. Success was achieved yesterday when she was found by the team(s) and immediately brought to the Oakland Zoo for much needed medical treatment and rehabilitation.

OAKLAND, CA., April 15, 2022 /PRNewswire-PRWeb/ — Already named ‘Rose’ by her caregivers at the Oakland Zoo, the four- to five-month-old female was found in critical condition just in time upon arrival at the hospital zoo vet about 3 p.m. on Sunday, according to veterinarians at the Oakland Zoo. Extremely emaciated, Rose weighs only 8.8 pounds, and at her estimated age, a healthy mountain lioness should weigh around 30 pounds.

“Based on her initial examination, it appears she hasn’t eaten in weeks. She is excruciatingly thin. To survive, her body has resorted to consuming her own muscle mass. She also suffers from extreme dehydration and her temperature was so low she couldn’t even be read. But she survived her first night, which was critical. We can already tell that she has a fiery spirit and an obvious will to live, and we are grateful for that,” Oakland’s vice president of veterinary services told Zoo, Doctor. Alex Hermann.

Originally spotted by hikers last Tuesday at Thornewood Open Space Preserve in San Mateo, which is part of the Midpeninsula Regional Open Space District, wildlife biologists in Midpen contacted the California Department of Fish and Wildlife (CDFW) in a joint effort to find the elusive little orphan to save her. Cameras were installed in the area and daily patrols were carried out. The cub was spotted again on Friday using the cameras, but by the time wildlife biologists from both agencies arrived and searched, the cub was missing. Finally, yesterday a wildlife biologist and ranger from Midpen, along with two wildlife biologists from CDFW, Garrett Allen and Megan Senorlocated and retrieved the cub, bringing her to the Oakland Zoo where the veterinary team stood ready to receive her and administer immediate medical treatment.

Now receiving round-the-clock care at the Oakland Zoo, Rose, in addition to starvation and dehydration, was covered in fleas and ticks. Blood tests show a very low red blood cell count. dr. Ryan Sadler of the Oakland Zoo states that if her red blood cell count remains low, the plan is to give Rose a blood transfusion, using one of the zoo’s previously rescued mountain lions, now a permanent resident and healthy adult, as a donor. Daily blood tests are administered to monitor her, as well as her weight and other vital parameters.

For now, vets are cautiously optimistic about Rose’s recovery. Currently, she is receiving intravenous fluids and hydration, to avoid refeeding syndrome. For now, her healthcare team is bottle-feeding her small amounts of formula several times a day. Dr Sadler also reported that she had eaten meat this morning and was alert – signs of hope that she will continue to gain strength and recover in the weeks to come.

Although they searched, Midpen and CDFW could not locate the baby’s mother, confirming that she is indeed an orphan. The teams are also looking for possible siblings of Rose. None have been seen so far.

“We appreciate the hiker and the Midpeninsula Regional Open Space District team alerting us to the mountain lion cub and its condition. The Santa Cruz Mountains provide good habitat for mountain lions, but it is rare to see a mountain lion as they are elusive creatures. If you see a mountain lion, do not approach it. Adult animals, when hunting prey, may leave their offspring in a safe place for up to several days at a time. Seeing a young animal by itself does not indicate that it is an orphan and the intervention is appropriate,” said the CDFW biologist. Garrett Allen.

If all goes well with Rose’s recovery over the next few months, she will unfortunately not be able to be released into the wild. Cubs stay with their mother for up to two years, learning to hunt and survive on their own. The Oakland Zoo and CDFW will work together to find Rose a good home, likely at another zoo accredited by the Association of Zoos and Aquariums (AZA). This is the eighteenth orphan mountain lion cub the Oakland Zoo has received and rehabilitated from the CDFW since 2017. For three of the eighteen, ColomaToro and Silverado, there was space available at the Oakland Zoo for them to stay permanently. They can be seen daily by the public on the California Trail section of zoos, often sharing a large hammock together, showing their close bond.

Donate to support the Oakland Zoo Wildlife Rescue Program: http://www.oaklandzoo.org/savewildlife

Contact:

Isabelle Linares,

Marketing Manager

Oakland Zoo

ilinares@oaklandzoo.org

Office: 510-632-9525 ext. 239

Erin Harrison,

VP Marketing & Communications

Oakland Zoo

eharrison@oaklandzoo.org

Office: 510-46-7120

###

IN REGARDS TO OAKLAND ZOO AND THE CONSERVATION SOCIETY CALIFORNIA:

The Oakland Zoo, home to more than 850 native and exotic animals, is managed by the Conservation Society of California (CCS); a non-profit organization that leads an informed and inspired community to take action for wildlife locally and globally. With more than 25 conservation partners and projects around the world, SCC is committed to educating and saving species and their habitats in the wild. The Oakland Zoo is dedicated to the humane treatment of animals and is accredited by the Association of Zoos and Aquariums (AZA), the national organization that sets the highest standards of animal welfare for zoos and aquariums. .

Media Contact

Isabelle LinaresOakland Zoo, 5106329525, ilinares@oaklandzoo.org

SOURCE Oakland Zoo

Moving away from genetic continental ancestry

0

In a policy forum, Anna Lewis and her colleagues argue that for researchers and others wishing to invoke genetic ancestry, there is a scientific and ethical imperative to move away from continental ancestry categories and embrace rather a view of genetic ancestry that reflects continuous variation. and historical depth. Such a shift is a “prerequisite for any research that seeks links between genetics and health disparities,” the authors state. Continued reliance on continental ancestry categories risks exacerbating medical stereotypes about individuals and groups, contributing to rather than solving health disparities, and perpetuating (mis)understandings of race as biological, they add. Many research institutes are reconsidering their use of race as a biological variable and instead turning to concepts derived from genetics to capture the differences between groups of humans. Genetic ancestry – a dominant description of genetic ancestry associated with continents as meaningful groupings – is one of the main alternatives offered. However, the increasing prevalence of the use of categories of continental ancestry, such as “African ancestry” or “European ancestry”, has led to problematic ethical issues. Here Lewis et al. highlight the ethical concerns surrounding the continued use of continental ancestry to group individuals. Rather, they argue for the widespread adoption of a more complex approach to genetic ancestry—a multidimensional, continuous, and categoryless concept that reflects our historical depth and the full spectrum of human variation. lewis et al. provide a roadmap to achieve this goal, a journey that will require systems-level change, including new tools, methodologies and data structures, and a better understanding of how and why different fields use and apply the concept of ancestry. “Science is reductive, and a model that uses simple continental categories has been helpful in starting the process of understanding human genetic diversity,” Lewis writes. et al. “But all patterns have their legitimate areas of application and limitations, and a much more complex set of patterns should now be standard across a wide variety of use cases.”


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Should research on psychedelics be publicly funded?

0

Public funding for new mental health discoveries that can change the lives of millions of Americans for good? In a word: Absolutely.

Over the past three years, clinical trials of psilocybin-assisted therapy and MDMA psychedelics in particular have demonstrated their value in treating a variety of even difficult-to-treat mental conditions such as the so-called treatment-resistant depression. This new therapy is believed to offer real hope to the desperate.

The excitement of clinical trials is tempered by the fact that there are still many answers needed about how various psychedelics work inside the human brain. There is so much more work to do. But that is precisely why more public funding is needed.

Certainly, hundreds of millions of dollars of philanthropic investments are actively making a difference. An example: Stephen Jurvetson, co-founder of Future Ventures and member of the board of directors of SpaceX, is would have donating about half of his net worth to fund psychedelic science.

Non-profit research

The collaboration of funders of psychedelic science (PSFC), a non-profit organization founded in 2017 and created to support scientists and organizations working on psychedelic clinical trials, includes some of the leading funders of psychedelic medicine who support organizations at the forefront of research psychedelic. PSFC has funded several organizations at the forefront of the psychedelic field and in 2020 successfully completed a $30 million capital campaign in partnership with the Multidisciplinary Association for Psychedelic Studies (MAPS) to support the completion of trials Phase 3 clinics of MDMA-assisted psychotherapy. .

PSFC’s current areas of focus include supporting broad and equitable access to high-quality MDMA-assisted psychotherapy after FDA approval, and supporting the implementation of Oregon’s Measure 109.

It seems that almost every week another Entrepreneur or philanthropist escalates with a psychedelic fundraising target – SpaceX founder Elon Musk, Groupon co-founder Andrew Mason, and even an unnamed Bitcoin millionaire. But it’s not enough. Deeper pockets are needed for the more historic, life-changing results that psychedelic research has just begun to produce.

One of the main sources of federal funding for medical science comes from the National Institutes of Health (NIH). NIH-funded research contributed to a 60% reduction in mortality rates from coronary heart disease and stroke, a 40% drop in infant mortality over the past 20 years, and a 30% decrease in chronic disabilities in the elderly .

Psychedelic research is at a point where it is ripe for more government funding, as a growing number of US cities and states are taking legislative action to decriminalize or legalize psychedelic use and/or research; and a new one Harris Poll reporting that nearly two-thirds of Americans with anxiety/depression/PTSD believe that psychedelic medicine should be made available to patients with treatment-resistant anxiety, depression, or PTSD.

Government funding

And then: The DEA stepped up its authorized production quotas for Psychedelics in November citing “a significant increase in the use of Schedule I hallucinogenic controlled substances for research and clinical trials.”

There has been a silver lining for public funding of psychedelics. In October, Johns Hopkins Medicine received an NIH grant to explore the potential impacts of psilocybin on tobacco addiction. This is the first NIH grant in more than half a century to directly study the therapeutic effects of a classic psychedelic.

This announcement comes with a reference to the problem of stigma that began when studies of LSD and other psychedelics were raging over 50 years ago, in the 1960s and 1970s. LSD fell victim of a politicized youth culture at the time that turned the potential therapeutic good of LSD into just a party drug problem. It was made illegal by the DEA as a Schedule 1 drug. Recovering from over 50 years of public disparity has been somewhat achieved, but it’s still an ongoing problem not just with LSD but with all psychedelics.

It’s clear that today the NIH needs to get into the psychedelics game in an even bigger way than its recent grant to Johns Hopkins. the limited support from philanthropic sources has funded the research so far, but these are small trials with relatively small patient samples due to the cost of conducting larger studies.

On the other hand, The NIH is the largest public funder of biomedical research around the world. Every state and nearly every congressional district has earned a share of this investment. NIH investments in research focused on a particular area have been found to stimulate increased private investment in the same area. A $1.00 increase in public basic research stimulates an additional $8.38 investment in R&D from industry after 8 years. A $1.00 increase in public clinical research stimulates an additional $2.35 investment in R&D from industry after 3 years.


Post views:
80

How are fungal infections spread in humans

0

image: A chip-based infection model developed by researchers in Jena, Germany, enables live microscopic observation of lung tissue damage caused by aspergillosis, an invasive fungal infection. The team developed algorithms to track the spread of fungal hyphae as well as the response of immune cells.
to see After

Credit: Zoltán Cseresnyés/Leibniz-HKI

A chip-based infection model developed by researchers in Jena, Germany, allows live microscopic observation of lung tissue damage caused by invasive fungal aspergillosis. The team developed algorithms to track the spread of fungal hyphae as well as the response of immune cells. The development is based on a “lung on a chip” model also developed in Jena and can help reduce the number of animal experiments. The results were presented in the journal Biomaterials.

Aspergillosis is an infection caused by molds Aspergillus fumigatus, which often affects the lungs. The disease can be fatal, especially in immunocompromised people. In these cases, invasive aspergillosis usually occurs with fungal hyphae invading the blood vessels. So far, only a few active substances can fight against these fungal infections. “That’s why it was so important for us to be able to represent this invasive growth in a model,” says Marie von Lilienfeld-Toal, who co-led the study. The internist is a professor in the Department of Internal Medicine II at the University Hospital Jena and conducts research at the Leibniz Institute for Natural Products Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) in Jena , in Germany.

The new model of aspergillosis infection should make it possible to better observe both the growth of the fungus and the reaction of the immune system and to find new possible therapeutic approaches. In addition, new active substances can be tested. The expertise for this is available in Jena: organ chips have long been developed at the university hospital. The startup Dynamic42, which manufactures the lung chips used in the study, was founded there. First author Mai Hoang also joined the company after completing her doctorate.

From organ model to infection model

“With the help of the chip, we can observe and quantify aspergillosis in 3D live, under the microscope”, explains Marc Thilo Figge, head of the study. He is head of the applied systems biology research group at Leibniz-HKI and professor at the Friedrich Schiller University of Jena. The organ model consists of two layers of cells separated by an artificial membrane. One layer is exposed to the air and is made up of surface cells of the lung. The other layer is made up of blood vessel cells, with a blood-like nutrient solution flowing continuously past them.

To this model, the researchers then added the fungus. “In this way, we transformed the organ model into an infection model,” explains Susann Hartung, a member of the Infections in Hematology/Oncology group at Leibniz-HKI and one of the first three authors. The difficulty, she said, was establishing the right severity of infection. “If we add too much Aspergillus fumigatus in the model, the lung cells are dying. If there are too few, we don’t see anything,” adds the molecular biologist.

Human immune cells or various drugs, for example, can then be added to this system, as the research team shows in the present study.

Image evaluation algorithm

The evaluation of three-dimensional microscopic data presented a major challenge. “If we just look at the images, we get an idea of ​​the progression of the infection, but we cannot quantify it. For that, we need algorithms that can distinguish fungal hyphae or immune cells from tissue cells. as well as the environment,” explains Zoltán Cseresnyés, who is also one of the first authors of the article. He is part of the Figge team, which specializes in automated image analysis.

To help the computer tell them apart, the different cell types are color-coded using fluorescent dyes. “For example, fluorescence intensity can be used to determine how many fungi an immune cell has eaten,” Cseresnyés explains.

“Of course, this model is a simplification and cannot be compared one-to-one with a complete organ,” says Figge. “But we believe it is an important contribution to better research on fungal infections, because at the same time it can partially replace animal experiments.” The model will now be further optimized.

The research is supported by the German Research Foundation as part of the balance of the Microverse cluster of excellence and the collaborative research centers 124 FungiNet (Transregio) and 1278 PolyTarget. The Carl-Zeiss-Stiftung funded the project of the Excellence Graduate School Jena School for Microbial Communication. Additionally, the work is supported by the Center for Sepsis Control and Care funded by the German Federal Ministry of Education and Research and the Leibniz ScienceCampus InfectoOptics.


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

What is the difference between biology and bioengineering?

0

Bioengineering and biology are easy to confuse. If you don’t want to make this mistake, read on.

“Biologist” is an umbrella term encompassing many professions involving the study of life and living things. Biological engineers, conversely, use engineering principles for biological study and problem-solving applications.

Here, we dig deeper into the difference between bioengineering and biology. We look at the tasks, requirements and career prospects for each profession.

What do biological engineers do?

The goals of biological engineering are to solve biological problems and improve biological processes to better meet the needs of society.

Biological engineers design and create technologies that help us analyze, understand, improve and use biological systems. They can work with agricultural, animal, environmental and microbial systems.

Biological engineers specialize in many areas, including:

  • Medical technologies
  • Refueling
  • Physiological functions and processes
  • Energy-saving technologies
  • Energy systems

They may work with advanced models, machines, instruments, genetic manipulations, artificial organs, or molecular and nanomaterial technologies.

Their daily tasks may include research, programming, designing models, or performing statistical analysis.

Biological engineers can get hands-on by developing and testing equipment or devices, taking measurements or installing equipment, and providing support.

According to the Bureau of Labor Statistics (BLS), biological engineers typically work in manufacturing, healthcare, life sciences, and education industries.

What do biologists do?

Biologists study all types of plant and animal life.

They can specialize in sub-disciplines such as aquatic, marine, zoological, wildlife, botanical, and molecular biology. Biologists strive to better understand the living world so that society can preserve, benefit from, and live in harmony with other living things.

Biologists conduct extensive research on living organisms and their environments. Their work environment depends on their specialization and study focus, which can take them to the bottom of the ocean, zoos, farms, or laboratories.

They may study living samples, examine ecosystems, work with models and simulations, or conduct field experiments.

A typical day for a biologist might include modeling and analysis, investigation, research, or fieldwork.

According to ONet, biologists primarily work for government and the professional and technical services industry. Other industry opportunities include education and consulting services.

Compare biological engineers and biologists

Biological engineering and biology careers differ in their requirements and outlook. Below, we explore these differences in detail.

Training required

Biological engineers

According to the BLS, bioengineering generally requires applicants to have a minimum of a bachelor’s degree in engineering, usually in a field such as biomedical or biological engineering.

Specific employers and positions may require a college degree or extensive experience for the job.

Prior to graduation, students can gain experience through co-op programs or internships. Employers value hands-on experience in hospitals, laboratories, research, and field work.

Biologists

Biologists need a bachelor’s degree as a minimum for many jobs. Most professionals in this field have a master’s degree.

Master’s degrees generally qualify graduates for scientific research positions, while a Ph.D. qualifies them for academic positions.

Biologists may also need extensive fieldwork experience, which they can gain through internships, fieldwork and research teams, and volunteerism.



Salary comparison

Biological engineers

The median annual salary for bioengineers was $92,620 in May 2020. The top 10% in the field earned more than $149,440, while the lowest 10% earned less than $56,590.

Biological engineering salaries also vary by industry, with instrument manufacturing paying a median annual salary of $104,050, medical equipment manufacturing paying $94,960, and life science research and development paying $93,630. $.

Biologists

Salaries for biologists vary by role – and the roles of biologists vary widely. Microbiologists earned median salaries of $84,400 in May 2020, wildlife biologists earned $66,350, and environmental scientists earned $73,230.

Industry and job title also impact potential salaries. For example, in May 2020, microbiologists earned median annual salaries of:

  • $112,940 to the federal government
  • $108,300 in life sciences research and development
  • $73,830 in pharmaceutical manufacturing

Employment Growth and Job Demand

Biological engineers

Our growing technological capabilities are driving growth in the field of bioengineering. The BLS predicts 6% growth for professionals between 2020 and 2030, led by the biomedical field.

Other industries providing opportunities for these professionals include research and development, medical equipment, healthcare, instrument manufacturing, and education.

Biologists

The needs of society – including the preservation of our natural resources, wildlife and the environment – ​​drive the demand for biologists.

The BLS projects growth of 5% for wildlife biologists, 5% for microbiologists and 8% for environmental scientists. Fiscal restrictions limit growth in each of these areas.

Most jobs in these fields come from the government, scientific and technical consulting services, and education industries.

Next steps on the career ladder

Biological engineers

Biological engineers may pursue additional training, such as a master’s or doctoral degree, for roles in medical science or post-secondary education. Combining their engineering background with a business or medical background can help them land interdisciplinary positions.

Laboratory, research, and field experience can also go a long way in elevating a biological engineer to a leadership position.

Biologists

To progress into independent research and project management roles, biologists often need a master’s or doctoral degree. At this level, they can teach and conduct their own research projects.

With experience and additional training, biologists can manage organizations and oversee their own team of technicians, researchers, and scientists. They can also teach at the post-secondary level with a doctorate.

Which suits me best: bioengineering or biology?

When choosing between bioengineering and biology, prospective students should think about their career goals, strengths, and interests.

Although the fields may overlap in many ways, a degree in biology provides a foundation for future specialization. Biological engineering degree jobs lead to a more specific career path.

Budding engineers may be more drawn to problem-solving and innovation, while budding biologists may value research and discovery.

If you aspire to provide benefits to society, engineering might be a better choice. Want to preserve the living world? Biology may be more aligned with your values.

In conclusion

Biologists and biological engineers study and work with living things, but the fields have very different career goals and opportunities.

By understanding the differences between bioengineering and biology, you can better choose the most appropriate path for your future.

Unless otherwise noted, wage and employment growth data are from the United States Bureau of Labor Statistics to April 13, 2022.

Willoughby rainbow trout will jump

0

VTF&W Photo by Tom Rogers: A rainbow trout jumps upstream at Willoughby Falls, outside the village of Orleans, on its annual migration to the spawning grounds.

Vermont Business Magazine One of the state’s premier wildlife viewing opportunities takes place in Vermont. Rainbow trout began their migration upstream to jump waterfalls in a spectacular show of determination on their way to their spawning grounds.

Rainbow trout can be spotted ascending the falls on warmer days from mid-April to late April and occasionally into early May.

“A lot of people may not realize that we have the opportunity to see fish in Vermont, just like there are for birds and mammals,” said Pete Emerson, fisheries biologist at Vermont Fish and Wildlife Department.

“Witnessing the migration of these trout is a powerful reminder of the importance of maintaining healthy, connected waters to allow fish to thrive. We strive to conserve Vermont’s waterways and surrounding habitats so that future generations can continue to witness this incredible migration each spring. While the annual migration takes place over several weeks, the best opportunities to see jumping fish last only a few days when water flows and temperatures are just right.

Rainbow trout in the Willoughby River also provide an excellent fishing opportunity attracting anglers from across the northeast for the Vermont trout fishing season which opened April 9. closed to all fishing from April 9 to May 31.

ORLEANS, Vermont – Fish and Wildlife

Healing effects of sunlight help imperiled green sea turtles with tumors

0

A new study by researchers at Florida Atlantic University literally sheds “light” on a way to improve the health of endangered green sea turtles (Chelonia mydas) prone to a disease called fibropapillomatosis. Affecting around 60 percent of sea turtles in certain subpopulations, juveniles are most susceptible to this disease which causes the growth of large, debilitating tumors on the skin, eyes and shell.

Turtles with fibropapillomatosis are treated at rehabilitation centers where the tumors are surgically removed. Unfortunately, many of them do not survive or the tumors grow back.

One solution to help this population of sea turtles could be as simple as sunlight. Many turtle rehabilitation facilities have enclosures that limit sea turtle exposure to natural ultraviolet (UV) light. Sunlight is an important source of vitamin D, an essential nutrient in vertebrates that plays many physiological roles. It is important to note that sea turtles with fibropapillomatosis show reduced levels of vitamin D and variations in blood chemical parameters.

For the study, FAU researchers compared vitamin D levels in green sea turtles with and without obvious fibropapillomatosis to determine if sun exposure would influence vitamin D levels and other health parameters. They also looked at the differences between turtles brought to rehabilitation centers and healthy juvenile green turtles captured from the wild.

Additionally, researchers investigated whether higher levels of sun exposure increased vitamin D levels in sea turtles undergoing treatment for fibropapillomatosis compared to turtles receiving less ultraviolet light. As turtles with and without visible tumors entered the rehabilitation center, the researchers also checked whether there was a correlation between sun exposure, vitamin D and tumor regrowth.

Turtles receiving the treatment were housed in tanks exposed to varying levels of sunlight for up to six months. The researchers looked at hematology and blood chemistry parameters as well as vitamin D, parathyroid hormone (regulates blood calcium levels) and ionized calcium levels. Turtles that underwent tumor removal surgery were monitored for any regrowth.

The results of the study, published in the journal Animals, found that turtles exposed to greater sunlight had greater increases in plasma vitamin D and more successful recovery. Vitamin D levels increased over time in the rehabilitating turtles, with the greatest increases seen when the turtles were exposed to higher levels of UV light and for longer durations. Those turtles kept in the sunbeds experienced less tumor regrowth than those exposed to low UV light conditions. The results suggest that increasing sun exposure in rehabilitation facilities can improve the health and recovery of green sea turtles with fibropapillomatosis.

Upon ingestion, tumor turtles had lower plasma vitamin D and ionized calcium levels and higher parathyroid hormone levels compared to wild-caught and rehabilitation turtles without obvious tumors.

“The data from our study suggests that a potential method to improve the fate of sea turtles with this disease is to increase their exposure to UV light during rehabilitation,” said Sarah L. Milton, Ph.D., Senior Author, Chair and Professor, Department of Biological Sciences, FAU Charles E. Schmidt College of Science, and Fellow of the FAU Stiles-Nicholson Brain Institute and the FAU Institute for Human Health and Disease Intervention (I-Health). “Although a cure for this disease has not yet been discovered, we have shown that exposure to higher UV light increases vitamin D in turtles, as in other animals, including humans. Increased plasma levels of vitamin D are then correlated with lower rates of disease, so this potential for improved health could contribute to better recovery.For future studies, we would be interested to see if there are any links. direct links between vitamin D levels and immune function.

The study’s co-author is Victoria E. Garefino, an FAU graduate of Milton’s lab. This research was funded by the Friends of Gumbo Limbo and National Save the Sea Turtle Foundation Fellowships awarded to Milton.

Artificial bacteria could help protect the “good”

0

CAMBRIDGE, MA — Antibiotics are life-saving medicines, but they can also harm beneficial microbes that live in the human gut. Following antibiotic treatment, some patients are at risk of developing inflammation or opportunistic infections such as Clostridiodes difficult. The indiscriminate use of antibiotics on gut microbes can also contribute to the spread of drug resistance.

In an effort to reduce these risks, MIT engineers have developed a new way to help protect the natural flora of the human digestive tract. They took a strain of bacteria safe for human consumption and engineered it to safely produce an enzyme that breaks down a class of antibiotics called beta-lactams. These include ampicillin, amoxicillin, and other commonly used drugs.

When this “living biotherapeutic” is given with antibiotics, it protects the microbiota in the gut but allows circulating blood levels of antibiotics to remain high, researchers found in a mouse study.

“This work shows that synthetic biology can be harnessed to create a new class of therapies designed to reduce the adverse effects of antibiotics,” says James Collins, Termeer Professor of Medical Engineering and Science at the Institute of Engineering and Science. Medical Sciences (IMES) from MIT. and Department of Biological Engineering, and the lead author of the new study.

Andres Cubillos-Ruiz PhD ’15, a researcher at IMES and the Wyss Institute for Biologically Inspired Engineering at Harvard University, is the lead author of the paper, which appears today in Nature Biomedical Engineering. Other authors include MIT graduate students Miguel Alcantar and Pablo Cardenas, Wyss Institute staff scientist Nina Donghia, and Broad Institute research scientist Julian Avila-Pacheco.

Protect the gut

Over the past two decades, research has revealed that microbes in the human gut play an important role not only in metabolism, but also in immune function and nervous system function.

“Throughout your lifetime, these gut microbes come together into a very diverse community that performs important functions in your body,” says Cubillos-Ruiz. “The problem arises when interventions such as medications or particular diets affect the composition of the microbiota and create an altered state, called dysbiosis. Some microbial groups disappear and the metabolic activity of others increases. This imbalance can lead to various health problems.

A major complication that can occur is infection of It’s hard, a microbe that usually lives in the gut but does not usually cause harm. When antibiotics kill strains that compete with It’s hardhowever, these bacteria can take over and cause diarrhea and colitis. It’s hard infects about 500,000 people each year in the United States and causes about 15,000 deaths.

Doctors sometimes prescribe probiotics (mixtures of beneficial bacteria) for people taking antibiotics, but these probiotics are usually also sensitive to antibiotics and do not fully replicate the native microbiota present in the gut.

“Standard probiotics cannot be compared to the diversity of native microbes,” says Cubillos-Ruiz. “They can’t perform the same functions as the native microbes you’ve nurtured throughout your life.”

To protect the microbiota from antibiotics, the researchers decided to use modified bacteria. They engineered a strain of bacteria called Lactococcus lactis, which is normally used in cheese production, to deliver an enzyme that breaks down beta-lactam antibiotics. These drugs account for approximately 60% of the antibiotics prescribed in the United States.

When these bacteria are given orally, they transiently populate the intestines, where they secrete the enzyme called beta-lactamase. This enzyme then breaks down antibiotics that reach the intestinal tract. When antibiotics are taken orally, the drugs enter the bloodstream primarily from the stomach, so the drugs can still circulate through the body at high levels. This approach could also be used with injected antibiotics, which also eventually reach the gut. Once their work is done, the modified bacteria are excreted through the digestive tract.

The use of engineered bacteria that degrade antibiotics poses unique safety requirements: beta-lactamase enzymes confer antibiotic resistance to host cells and their genes can easily spread between different bacteria. To solve this problem, the researchers used a synthetic biology approach to recode how the bacterium synthesizes the enzyme. They split the beta-lactamase gene into two pieces, each coding for a fragment of the enzyme. These gene segments are located on different pieces of DNA, making it highly unlikely that both gene segments will be transferred to another bacterial cell.

These beta-lactamase fragments are exported out of the cell where they reassemble, restoring enzyme function. Since beta-lactamase is now free to diffuse into the surrounding environment, its activity becomes a “public good” for the intestinal bacterial communities. This prevents the modified cells from gaining an advantage over the native gut microbes.

“Our biocontainment strategy allows the delivery of antibiotic-degrading enzymes into the gut without the risk of horizontal gene transfer to other bacteria or gaining an additional competitive advantage through live biotherapy,” says Cubillos- Ruiz.

Maintain microbial diversity

To test their approach, the researchers gave the mice two oral doses of the modified bacteria for each injection of ampicillin. The modified bacteria traveled to the gut and started releasing beta-lactamase. In these mice, the researchers found that the amount of ampicillin circulating in the blood was as high as that of mice that had not received the modified bacteria.

In the gut, mice that received modified bacteria maintained a much higher level of microbial diversity than mice that received only antibiotics. In these mice, levels of microbial diversity dropped dramatically after receiving ampicillin. Moreover, none of the mice that received the modified bacteria developed opportunism. It’s hard infections, while all mice that received only antibiotics showed high levels of It’s hard in the intestine.

“It’s a strong demonstration that this approach can protect the gut microbiota, while preserving the effectiveness of the antibiotic, because you’re not changing the levels in the bloodstream,” says Cubillos-Ruiz.

The researchers also found that removing the evolutionary pressure of antibiotic treatment made it much less likely that gut microbes would develop antibiotic resistance after treatment. In contrast, they found many antibiotic resistance genes in the microbes that survived in the mice that received antibiotics, but not the modified bacteria. These genes can be passed on to harmful bacteria, compounding the problem of antibiotic resistance.

The researchers now plan to start developing a version of the treatment that could be tested in people at high risk of developing acute illnesses that stem from antibiotic-induced gut dysbiosis, and they hope that eventually it could be used. to protect anyone who needs to take antibiotics for infections outside of the gut.

“If antibiotic action is not needed in the gut, then you need to protect the microbiota. It’s like when you have an X-ray, you wear a lead apron to protect the rest of your body from ionizing radiation,” says Cubillos-Ruiz. “No previous intervention could offer this level of protection. With our new technology, we can make antibiotics safer by preserving beneficial gut microbes and reducing the chances of new antibiotic-resistant variants emerging.

###

The research was funded by the Defense Threat Reduction Agency, the Paul G. Allen Frontiers Group, the Wyss Institute, and a National Science Foundation postgraduate research grant.


Aviva Systems Biology Announces Launch of High Throughput Antibody Characterization Services

0

SAN DIEGO, April 11, 2022 /PRNewswire/ — Aviva Systems Biologya market leader in antibodies, immunoassay kits and recombinant proteins for life science research, today announced the launch of its new high-throughput service offering Antibody Characterization Services.

Aviva Systems Biology’s antibody characterization services offer drug discovery researchers in small to mid-sized biotechnology an affordable and easily accessible solution for rapid therapeutic antibody screening, kinetic analysis, mapping and clustering. epitopes. By leveraging the advanced Carterra® LSA™ platform, Aviva can provide high-throughput SPR analysis for biotherapeutic antibody development on a scale that other screening vendors cannot match.

“Adding our antibody characterization services to our current custom protein, ELISA and antibody development offering will allow our customers to reduce the cost and time it takes to bring a new biotherapeutic molecule at the clinic. We are thrilled to offer this unique solution to biotherapeutic antibody researchers,” said Kevin Harveypresident of Aviva Systems Biology.

Learn more about Aviva’s antibody characterization services at the 2022 AACR Annual Meeting at New Orleans at booth #1951, April 10-13, 2022or by visiting avivasysbio.com.

About Aviva Systems Biology
Aviva Systems Biology, founded in 2002, is a global leader in the proteomics research market offering a broad portfolio of polyclonal and monoclonal antibodies, immunoassay kits, recombinant proteins and custom protein expression and antibody characterization for academic and biopharmaceutical researchers. Based at San Diego, Californiathe Aviva offering supports multiple applications such as Western blotting, IHC, ELISA and immunoprecipitation, while providing researchers with one of the largest target and species catalogs to choose from.

Contact
Wendy Parenteau
Marketing Director
[email protected]

SOURCE Aviva Systems Biology

Georgia Wildlife Agency seeks to report invasive lizards

0

SOCIAL CIRCLE, Ga. – The Georgia Wildlife Agency is asking residents to report sightings of an invasive lizard that may pose a threat to native species.

The state Department of Natural Resources is trying to locate and eradicate South American tegus from Georgia before the lizards can thrive in larger numbers. So far, the only known wild population in the state has been found in Toombs and Tattnall counties in southeast Georgia.

Wildlife officials hope to prevent the black and white lizards from spreading further. They can be up to 1.2 meters long and weigh up to 4.5 kilograms. They have a varied appetite that favors the eggs of turtles, alligators, and ground-nesting birds.

“They can live almost anywhere and eat almost anything,” MNR wildlife biologist Daniel Sollenberger said in a news release.

“We are focusing our efforts on achieving two goals: documenting the extent of tegus presence in the southeast Georgia wilderness and removing these animals as soon as possible after they are detected,” Sollenberger said. “With locals, hunters and others helping us monitor and control tegus, we are cautiously optimistic about our ability to control this population.”

A d

Authorities aren’t sure exactly how tegus were introduced to the wild in Georgia, but they are commonly kept as pets.

Last year, the DNR removed a single tegu that was spotted on a game camera and later caught in a trap. Seven were recovered, dead and alive, in 2020.

Wildlife officials warn that if tegus become established in the wild, they will be nearly impossible to eradicate. Wild populations have also been found in South Carolina and Florida. Trapping at a site along Everglades National Park can produce hundreds of lizards each season.

Copyright 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission.

Life Science and Laboratory Equipment Market Size, Scope and Forecast

0

New Jersey, United States – This Life Sciences and Laboratory Equipment Market The report provides a comprehensive overview of significant aspects that will drive market growth such as market drivers, restraints, prospects, opportunities, restraints, current trends, and technical and industrial advancements. The detailed study of the industry, development and improvement of the industrial sector and new product launches described in this report on the Life Science and Laboratory Equipment market is an extraordinary help for new Commercial market key players are entering the market. This Life Science and Laboratory Equipment Market report performs careful assessment of the market and provides expert analysis of the market considering the trajectory of the market considering the current market situation and future projections. This Life Science and Laboratory Equipment Market report study highlights market driving factors, market overview, industry volume and market share. Since this Life Science and Laboratory Equipment Market report provides an effective market strategy, key players can earn huge profits by making the right investments in the market. As this Life Science and Laboratory Equipment market report depicts the ever-changing needs of consumers, sellers, and buyers across different regions, it becomes easy to target specific products and attain major revenue on the world market.

Get Sample Full PDF Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://www.verifiedmarketreports.com/download-sample/?rid=563126

This Life Science and Laboratory Equipment Market report throws light on few key sources which can be applied in the business to get the best results and revenue. It also covers some essential ways to manage global freedoms on the prowl and grow the business. With this well-founded market research, key players can easily earn a visible spot on the prowl. It also captures the global impact of COVID-19 on various industries and nations. This exploration report paints a fair picture of the future development drivers, restraints, fierce scene, section survey and insightful market size of Country and District Surveys for the definition period 2022- 2029. This market report also provides information on industry patterns, slices of the pie, development openings and difficulties. It further conducts the market review to indicate the progression patterns, strategies, and procedures followed by the major participants.

Key Players Mentioned in the Life Science and Laboratory Equipment Market Research Report:

Agilent Technologies, Becton, Dickinson and Company, Bio-Rad Laboratories, Danaher Corporation, F. Hoffmann-La Roche, PerkinElmer, Thermo Fisher Scientific, Waters Corporation, Bruker Corporation, Shimadzu Corporation

Life Sciences and Laboratory Equipment Market Segmentation:

By Product Type, the market is primarily split into:

• Spectroscopy
• Chromatography
• Laboratory automation
• Surface science
• DNA amplification and sequencing
• Immunoassay analyzer
• Flow cytometry
• Microgrid
• Electrophoresis

By application, this report covers the following segments:

• Medical
• Education
• Scientific Research
• Other

The strategic analysis performed in this Life Science and Laboratory Equipment market analysis includes aggregate information about the market environment, pricing structure, customer buying behavior, and micro and macro trends. Also, it aims to cover the geographical analysis of major regions such as Asia-Pacific, North America, Europe, Latin America, Middle East and Africa. Some of the major players are mentioned in this Life Science and Laboratory Equipment Market report along with their strengths, weaknesses and the strategies they are adopting. It further talks about major segments, market shares, market size, and secondary drivers. Detailed data about the current market developments and the overall market scenario are presented here.

Get a discount on the purchase of this report @ https://www.verifiedmarketreports.com/ask-for-discount/?rid=563126

Scope of the Life Science and Laboratory Equipment Market Report

ATTRIBUTES DETAILS
ESTIMATED YEAR 2022
YEAR OF REFERENCE 2021
FORECAST YEAR 2029
HISTORICAL YEAR 2020
UNITY Value (million USD/billion)
SECTORS COVERED Types, applications, end users, and more.
REPORT COVER Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends
BY REGION North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
CUSTOMIZATION SCOPE Free report customization (equivalent to up to 4 analyst business days) with purchase. Added or changed country, region and segment scope.

Geographic segment covered in the report:

The Life Science and Laboratory Equipment report provides information about the market, which is sub-categorized into sub-regions and countries/regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate of each region, country and sub-region over the estimated period.

• North America (USA and Canada)
• Europe (UK, Germany, France and rest of Europe)
• Asia-Pacific (China, Japan, India and the rest of the Asia-Pacific region)
• Latin America (Brazil, Mexico and rest of Latin America)
• Middle East and Africa (GCC and Rest of Middle East and Africa)

Answers to key questions in the report:

1. Who are the top five players in the Life Science and Laboratory Equipment Market?

2. How will the life science and laboratory equipment market evolve in the next five years?

3. Which product and application will occupy the lion’s share of the life science and laboratory equipment market?

4. What are the drivers and restraints of the Life Sciences and Laboratory Equipment Market?

5. Which regional market will show the strongest growth?

6. What will be the CAGR and size of the Life Sciences and Laboratory Equipment market throughout the forecast period?

For more information or query or customization before buying, visit @ https://www.verifiedmarketreports.com/product/life-sciences-and-laboratory-equipment-market-size-and-forecast/

Visualize the Life Science and Laboratory Equipment Market Using Verified Market Intelligence:-

Verified Market Intelligence is our BI platform for market narrative storytelling. VMI offers in-depth forecast trends and accurate insights on over 20,000 emerging and niche markets, helping you make critical revenue-impacting decisions for a bright future.

VMI provides a global overview and competitive landscape with respect to region, country and segment, as well as key players in your market. Present your market report and results with an integrated presentation function that saves you more than 70% of your time and resources for presentations to investors, sales and marketing, R&D and product development. products. VMI enables data delivery in Excel and interactive PDF formats with over 15+ key market indicators for your market.

Visualize the Life Science and Laboratory Equipment Market Using VMI@ https://www.verifiedmarketresearch.com/vmintelligence/

Most Popular Reports

Global Trolley Luggage Market Size and Forecast

Global Vacuum Cupping Market Size and Forecast

Global System Scaffolding Market Size and Forecast

Global Suction Cups Market Size and Forecast

Global Marine Rescue Equipment Market Size and Forecast

Global Centrifuge Market Size and Forecast

Global Railway Cable Market Size and Forecast

Global Pharmaceutical Storage and Handling Equipment Market Size and Forecast

Global Life Science and Laboratory Equipment Market Size and Forecast

Global IoT Medical Devices Market Size and Forecast

About Us: Verified Market Reports

Verified Market Reports is a leading global research and advisory company serving over 5000 global clients. We provide advanced analytical research solutions while delivering information-enriched research studies.

We also provide insight into the strategic and growth analytics and data needed to achieve business goals and critical revenue decisions.

Our 250 analysts and SMEs offer a high level of expertise in data collection and governance using industry techniques to collect and analyze data on over 25,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise and years of collective experience to produce informative and accurate research.

Our research spans a multitude of industries, including energy, technology, manufacturing and construction, chemicals and materials, food and beverage, and more. Having served many Fortune 2000 organizations, we bring a wealth of reliable experience that covers all kinds of research needs.

Contact us:

Mr. Edwyne Fernandes

USA: +1 (650)-781-4080
UK: +44 (753)-715-0008
APAC: +61 (488)-85-9400
US toll free: +1 (800)-782-1768

E-mail: sales@verifiedmarketreports.com

Website: – https://www.verifiedmarketreports.com/

LSU Vet School Presents Awards, Robert Gets Presidential Nomination | Economic news

0

Deidre Deculus Robert was appointed by President Joe Biden as State Director of Rural Development for Louisiana.

State directors of rural development serve as the general director of rural development and carry out the mission of the agency.

Robert has over two decades of experience in legal, administrative and executive management. She served as assistant city attorney in the East Baton Parish Attorney’s Office, assistant attorney general in the Louisiana Department of Justice, executive attorney in the Louisiana Department of Transportation and Development, and general counsel in the Southern University and the A&M College System.

The LSU School of Veterinary Medicine recently presented the following awards:

Alexandra Noel, Assistant Professor in the Department of Comparative Biomedical Sciences, received the Zoetis Award for Excellence in Research. Zoetis presents an honorarium and an engraved plaque to a faculty member who has excelled in veterinary medical research over the past two years. Noël’s research focuses on aerosol production and characterization, as well as inhalation and developmental toxicology. This includes studying engineered nanoparticles, second-hand smoke, e-cigarette vapour, hookah smoke, and a multi-pollutant approach to simulate real-world exposure scenarios.

Shisheng Li, professor in the Department of Comparative Biomedical Sciences, received the Distinguished Scholar Award from the Faculty of Veterinary Medicine. An honorarium and an engraved plaque are awarded to a faculty member who has made a significant contribution to the advancement of veterinary medicine through research and/or academic activities. Li’s research focuses on the mechanisms of DNA damage repair and mutagenesis.

Dr. Andrew Lewin, Assistant Professor of Veterinary Ophthalmology, received the Andrew Lackner Mentorship Award. This award honors the memory of Dr. Andrew Lackner, former director of the Tulane National Primate Research Center, and his dedication to training scientists. Lewin’s research focuses on ocular infectious diseases, next generation sequencing and clinical veterinary ophthalmology. He mentors veterinary students, interns, and residents at the LSU Vet Med Veterinary Teaching Hospital.

Purchases made through links on our site may earn us an affiliate commission

Scientists rejuvenated the skin of a 53-year-old woman to that of a 23-year-old woman

0

The dermis and epidermis of the scalp.

  • The Babraham Institute in Cambridge announced this week that researchers have succeeded in rejuvenating skin cells.
  • Scientists reprogrammed adult skin cells to look and behave 30 years younger than the original.
  • The technique cannot yet be used in a clinic because previous studies have shown it may increase the risk of cancer.
  • For more stories, go to www.BusinessInsider.co.za.

A team from the Babraham Institute in Cambridge has succeeded in rejuvenating the skin cells of a 53-year-old woman to look and behave like those of a 23-year-old woman, the research center announced on Thursday.

The team initially set out to create embryonic stem cells, which can divide into any type of cell in the body, using adult cells. Nobel laureate Shinya Yamanaka, a researcher at Kyoto University in Japan, first turned “normal” cells that have a specific function into stem cells in 2006.

The BBC reported that German molecular biologist Wolf Reik, postdoctoral student Diljeet Gill and a team from the Babraham Institute built on Yamanaka’s work. Yamanaka cultured stem cells by exposing adult cells to four molecules for about 50 days – a unique method he named iPS. Reik and Gill’s team exposed skin cells to the same molecules for just 13 days, then left them to grow under natural conditions.

By studying collagen production in cells, researchers found that age-related changes to skin cells were suppressed and they temporarily lost their identity. After growing under normal conditions for a while, the researchers found that the cells began to behave like skin cells again.

The team then measured age-related biological changes in the reprogrammed cells and found that the cells matched the profile of those 30 years younger than the reference data sets, Gill said in a statement.

“I remember the day I got the results and I didn’t really believe some of the cells were 30 years younger than they were supposed to be,” Gill told the BBC. “It was a very exciting day.”

The research was carried out in a laboratory and Reik told the BBC the team could not bring the technique to a clinic because the technique used to rejuvenate cells has the potential to increase cancer risk, possibly due of creating lasting genetic changes in cells.

But the biologist said the cell rejuvenation method could help speed healing time in burn victims and could potentially extend human life.

“Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those that reduce the effects of aging,” Reik said in a press release.

The researchers published their findings in the journal eLife on April 8.

Dr. Vanessa Northington Gamble discusses the intersection of race and infectious disease for the 2022 Sonenshine Endowed Lecture Series « News @ ODU














By Tiffany Whitfield



COVID-19 has brought the state of public health to the fore and highlighted disparities in health care access and outcomes. These disparities, however, are not new and have been revealed throughout history by other infectious diseases, according to Dr. Vanessa Northington Gamble, who was a 2022 speaker for the Daniel E. and Helen N. Sonenshine, organized by Old Dominion University College of Science and the Department of Biological Sciences.

Gamble, an internationally renowned physician, scholar, and activist, is a University Professor of Medical Humanities, Professor of Health Policy at the Milken Institute School of Public Health, and Professor of American Studies at George Washington University. She specializes in the history of American medicine, racial and ethnic disparities in health and health care, public health ethics, and bioethics.

Parallels in pandemics from 1918 to today

On March 31, Gamble delivered two in-depth lectures to students, faculty, and the public exploring health inequities during two epidemics and revealing the life and breakthroughs of an African-American female doctor and activist amid the 1900s.

His first lecture, “Exposing Pre-Existing Social Conditions: African Americans, the 1918 Influenza Epidemic, and COVID-19,” focused on exploring the impact of African Americans during the previous pandemic, provides historical context for understand the “racial dimensions of the contemporary epidemic”. The COVID-19 pandemic and its disproportionate impact on African Americans.”

Gamble gave examples of how the outbreaks “continue to lay bare racial and social inequalities in the United States.” During the 1918 flu epidemic, African Americans did not receive equal treatment in hospitals due to Jim Crow policies. Patients and victims of black flu received care and were buried in separate facilities. White scientists and physicians “believed the theories that African Americans were biologically, physiologically, and morally inferior to whites.”

“The hospital wasn’t the only black facility in Baltimore, Maryland overwhelmed by the flu pandemic,” Gamble said. “At Mount Auburn Cemetery, the largest black cemetery, the bodies arrived so quickly that the gravediggers could not keep up, and by the end of October the coffins of more than 150 dead African Americans had remained unburied, some for three weeks.”

The crisis was resolved after the US military tasked about 370 black soldiers to bury the dead in a mass grave. “These events in Baltimore underscore that the epidemic itself exposed the medical and political inequalities that African Americans faced, as seen in Baltimore but repeated across the country,” said Gamble. “The color line was so entrenched that African Americans took primary responsibility for providing care to members of the race affected by the influenza epidemic.”

Additionally, Gamble shared newspaper clippings and excerpts from books and articles from African-American leaders in Philadelphia and Richmond who pooled their resources to provide adequate care to their communities.

“African Americans lacked political and economic power and lived in the least desirable, most disease-ridden neighborhood,” Gamble said. “But despite their hardships, African Americans have established separate hospitals and care facilities to care for themselves.

“Just as the flu revealed racial inequities in our society in 1918, COVID-19 does today. Statistics show that a disproportionate number of African Americans are sick and dying from the coronavirus and very many black families are in mourning.”

She noted that a recent study by the Black Coalition Against COVID found that “COVID-19 severity among black Americans was a predicted outcome of structural and societal realities and not differences in genetic predispositions.”

“Systemic changes must address the separate and unequal health care system that has been exposed by COVID-19,” Gamble said.

Pioneer of racial justice in medicine

Gamble gave a second lecture on the life and career of Dr. Virginia M. Alexander, a pioneer in medicine, public health research, anti-racism activism and religion. Gamble writes a biography about her.

“I want to build this trailblazer to strip away the substance and character of racist theories and show her as a complex human being with strengths, triumphs and accomplishments,” Gamble said.

She took the Lê Planetarium audience inside the new Chemistry Building on a journey through the different phases of Alexander’s life and career, starting with her time as a student at the University of Pennsylvania and Woman’s Medical College of Pennsylvania.

Each phase of her professional career has encountered obstacles and barriers, but she has proven resilient.

“After graduating from the University of Pennsylvania in just three years, Virginia left for Kansas City in 1925 to complete her hospital internship because no Philadelphia hospital would accept her as an intern because of her race” , said Gamble.

After completing her internship in the Midwest, Alexander returned to the East Coast and converted part of her home in Brewerytown (north Philadelphia) into a six-bed clinic called Aspiranto Health Home.

Alexander struggled to find equal treatment for his patients in hospitals, but insisted on treating both African American and white patients in the late 1930s and 1940s.

Faith was essential for Alexander. When she was a freshman at the University of Pennsylvania in 1917, she attended her first Quaker meeting. Many of Alexander’s white patients were members of the Society of Friends (Quakers).

“She had close friends at the monthly Race and Arch Street (Quaker) meetings, and she joined the Fireside Club, an interracial group of white and African-American friends dedicated to interracial understanding,” Gamble said.

Alexander became the first African American named to the Race Relations Committee of the Philadelphia annual meeting. As part of her efforts with this committee, she worked to incorporate the Philadelphia Hospital. After some time, Alexander asked to become a member of the Germantown Friends monthly meeting.

“Despite his already respected status in the Quaker community, Friends were once again divided in their support for his membership,” Gamble said. “In 1931, more than a year after applying (and 14 years after her first Quaker meeting), she was finally approved for membership and became the only African-American (Quaker) member of the monthly Friends of Germantown.”

Over the years, Alexander has fought to break down systemic barriers in the medical profession and advocated on behalf of her black patients. She has conducted research on social, economic, and health issues in North Philadelphia, yielding startling results on health disparities affecting black patients, including high infant mortality rates and higher death rates for tuberculosis. In 1936 Alexander became the first black student to attend the Yale School of Public Health.

Alexander paved the way for other young doctors and his colleague, Dr. Helen Dickens, who mentors Gamble.

Gamble is the author of several acclaimed publications on the history of race and racism in American medicine and bioethics, is a Fellow of the National Academy of Medicine and the National Academy of Sciences, and is a Fellow of the Hastings Center. She chaired the committee that led a successful campaign to obtain an apology in 1997 from President Clinton for the United States Public Health Syphilis Study in Tuskegee.

The Daniel E. and Helen N. Sonenshine Infectious Disease Lecture Series was created so that ODU students could learn, listen to, and meet expert scientists in the hope that they would enter or contribute to the field of diseases infectious.






Related News

raymond kirby

He emphasized research and championed diversity among faculty and students. (After)

we2-2

ODU alumnus Sarah Golden spoke at the fifth annual Women Excelling in Engineering event at Batten College of Engineering and Technology. (After)

Pierre Bernat

Research findings from the 2020 Australian fires show a drop in the radiation-blocking stratospheric layer. (After)


Chris Beyrer named director of Duke Global Health Institute

Christopher C. Beyrer, MD, MPH, an internationally renowned epidemiologist who has worked on the front lines of HIV/AIDS and COVID-19 treatment and research, will be the next director of the Duke Global Health Institute (DGHI), University officials announced Friday.

Beyrer will join Duke on August 30 from the Johns Hopkins Bloomberg School of Public Health, where he is the first Desmond M. Tutu Professor of Public Health and Human Rights as well as a professor of epidemiology, nursing and medicine.

He succeeds Dennis Clements, MD, professor emeritus of pediatrics and professor-researcher of global health, who served as interim director since 2020.

“Chris Beyrer will be an outstanding and passionate leader of the Duke Global Health Institute,” said Provost Sally Kornbluth. “He is a researcher, scholar, teacher and advocate whose work has made a difference around the world. There has never been a more important time for global health, and under Chris’s leadership, DGHI and Duke will continue to be a leader in research, education and service to society.

Beyrer has extensive experience leading international collaborative research and training programs related to infectious disease epidemiology and disease prevention. At Johns Hopkins, he directs the HIV epidemiology and prevention science training program, is associate director of the Center for AIDS Research and the Center for Global Health, and is the founding director of the Center for Public Health and Human Rights.

“During this time of profound change, the Duke Global Health Institute has continued to shine a light on social and health inequities here and around the world,” said A. Eugene Washington, MD, chancellor of health affairs at Duke University. and Chairman and CEO. of the Duke University Health System. “At Chris, we have an exceptional leader, an exceptional administrator and an outstanding expert on human rights and inequality across various social gradients. His background, experiences and unrelenting passion for global health make him an ideal leader to help grow and amplify DGHI’s excellence and impact,” he added.

“The COVID-19 pandemic has taught us all how truly interconnected we are as a global human family and how critical advances in biomedical research have been,” Beyrer said, “but also how critical we have been challenged to answer fundamental questions of equity, access to health care, and compassion for the underserved. It is an honor and a privilege to join the extraordinary team at Duke Global Health Institute, who will continue to be part of the solution to these inequalities. I am confident that we can bring about real change where it matters most – in the lives of those we seek to serve.

Beyrer, who has worked on COVID-19 vaccine trials since 2020, is currently a senior scientific liaison with the COVID-19 Vaccine Prevention Network. He is past president of the International AIDS Society, the world’s largest group of HIV professionals and has served as an advisor to the President’s Emergency Plan for AIDS Relief (PEPFAR), the HIV Vaccine Trials Network , the National Institutes of Health’s Office of AIDS Research, the US Military HIV Research Program, the World Bank, the World Health Organization, and the Open Society Foundations, among many other organizations.

“Our mission at the School of Medicine is to advance patient care, research and education locally and globally,” said Mary E. Klotman, MD, dean of the School of Medicine at Duke University. “As an internationally recognized scientist and leader in the field of human rights and public health, Dr. Beyrer will be a visionary leader for our Institute of Global Health, expanding the work already underway and opening the door to new opportunities.

Born in Switzerland to American parents, Beyrer grew up in New York and has pursued research, studies and interests in more than 30 countries. Author of “War in the Blood: Sex, Politics and AIDS in Southeast Asia”, he conducted collaborative research in Thailand for 30 years.

He attended Hobart and William Smith colleges, where he majored in history and was elected a Phi Beta Kappa. He received his medical degree from SUNY Downstate Health Sciences University and holds a Masters in Public Health from Johns Hopkins Bloomberg School of Public Health. Beyrer was elected to the National Academy of Medicine in 2014.

Beyrer’s appointment follows a global search led by Gillian Sanders Schmidler, professor of population health sciences and medicine and deputy director of the Duke Margolis Center for Health Policy, and a committee of Duke and University faculty. global health experts.

“I am so grateful to Dennis Clements for leading DGHI through the most significant public health crisis of the last century, and to the Search Committee for their perseverance and dedication,” said Provost Kornbluth.

Beyrer is a widower. Her late husband, Michael Smit, was a nurse practitioner in his hometown of Baltimore.

Founded in 2006, the Duke Global Health Institute brings together professors of medicine and nursing, anthropology, psychology, public policy, engineering, environmental science, and other fields to conduct research and collaborative and interdisciplinary education on the most important global health issues of our time. DGHI hosts education programs for undergraduate, master’s, medical, and doctoral students in a wide range of disciplines. During the past academic year, DGHI researchers conducted 270 research projects that received funding totaling over $75 million.

CSIRO invests $50 million in four new research programs

0

Australia’s National Science Agency Invest $50 million over five years to develop technology to address important national challenges.

The four new research programs fall under CSIRO’s Future Science Platforms (FSPs), currently worth $200 million. FSPs will focus on breakthrough energy storage systems, permanent carbon locking, immune resilience, and advanced engineered biology.

Professor Bronwyn Fox, CSIRO Chief Scientist

CSIRO’s chief scientist, Professor Bronwyn Fox, said bringing industry and science together offers a great opportunity for innovation.

“CSIRO’s science platforms of the future are a big part of our strategy to stay at the forefront of discovery. They are an essential part of how we do science – they are our investment in cutting-edge, transformative research where we push the boundaries of science and lean towards the impossible,” said Professor Fox.

“The fundamental research that these four new science platforms of the future will undertake will pave the way for innovations and catalyze new industries that will help us better manage our health, food security, natural resources and environment in the decades to come.

FSP Director of Breakthrough Energy Storage Systems, Dr Adam Best, said research was needed to make charging electric vehicles as simple as filling gas tanks or keeping devices charged for several days. He also added that “on a larger scale, it could even mimic pumped hydropower through new technology and make it more responsive to grid needs.”

According to the director of the Permanent Carbon Locking FSP, Dr. Andrew Lenton, this project will focus on new solutions to remove carbon dioxide from the atmosphere and store it permanently. Dr Lenton said the technology has the potential to support new industries and reshape existing ones.

Due to the focus on immune technologies in recent years, Immune Resilience FSP Acting Director Dr Tim Doran said there are a number of biotechnology opportunities if Australian research builds on this dynamic. He said research should focus on improving immune resilience in humans and animals.

Regarding FSP Advanced Engineering Biology, Acting Director Dr. Colin Scott said that new tools for biological design and prototyping would be a boon for generating new goods and services.

“This research will help create the 50,000 jobs and $30 billion a year that have been identified in CSIRO’s synthetic biology roadmap,” said Dr Scott.

“This is a really exciting time for the bioeconomy in Australia. We are seeing significant growth in start-ups and the broader innovation ecosystem. Increased investment in this area of ​​research will help make from Australia a world leader in engineering biology.

The CSIRO FSP initiative was launched in 2016 to address Australian national challenges and now supports 20 unique research programs.

Earlier this year, CSIRO researchers published a paper on innovative vaccine storage and transport that extends their shelf life without the need for refrigeration.

Do you know more? Contact James Riley by email.

How to extend your longevity

0

It’s an age-old question: How can we extend our lives and make the years we have as disease-free and pain-free as possible? If you look on social media, there are a number of so-called experts providing quick tips for extending longevity. But what does the research say? What proven advice is backed by science? A hint, according to experts: if you want to prolong your life, you have to start today.

Nathan K. LeBrasseur is co-director of the Paul F. Glenn Center for Biology of Aging Research at Mayo Clinic. He says research shows beyond doubt that exercise is the most effective and robust way to prolong healthy aging. The goal, he says, is to compress morbidity until the very end of life and exercise is a great tool for this. “It’s a frontline defense against everything from Alzheimer’s disease to type 2 diabetes, cancer and even osteoarthritis,” he says.

According to LeBrasseur, exercise appears to be particularly effective in fighting aging because it thwarts mitochondrial dysfunction, a disorder that occurs when cellular structures that produce energy malfunction. It also helps detoxify the body of old and damaged cells, which can cause DNA damage over time. Ample evidence has shown that endurance exercises (done most days of the week) such as running, walking, swimming, and bicycling prolong neuromuscular, heart, and cognitive health. At the same time, resistance training, such as lifting weights several times a week, is important for maintaining muscle mass and functions important for mobility, he says.

But while structured exercise is crucial, everyday non-structural movement is also essential for living a long and healthy life. Online shopping, screen time and all things virtual have created the movement since our time, which is hurting healthy aging, says LeBrasseur. From picking up groceries to walking to the mailbox to parking farther from your destination, it’s best to expand the daily commute if you want to thrive in the years to come. “Physical inactivity is one of the biggest challenges to healthy aging,” he says.

Beyond movement, LeBrasseur says those who have more meaning and purpose in their day also tend to be happier and healthier. It’s hard to quantify in relation to exercise and we don’t know the mechanism, but it could be related to the fact that having structure and purpose opposes loneliness, which has been shown to cause an inflammatory response in the body. And chronic inflammation, a state where the body is producing inflammatory cellshas been shown to accelerate aging.

Eat for longevity

The third step to our healthy aging bowel movements is, unsurprisingly, diet. Three times a day, every day, your diet is your daily medicine if you choose the right foods. And according to a plenty of evidencethe Mediterranean diet – a way of eating inspired by those who live near the Mediterranean Sea – is the healthiest way to live a long life.

Marialaure Bonaccio is an epidemiologist at the Italian Ministry of Health who studies the impact of a Mediterranean diet on the inflammatory response. She says it’s not a particular superfood in the diet that promotes longevity, but rather a mix of foods including many fruits, vegetables, legumes, whole grains, fish, olive oil and red wine. “It’s the combination of staple foods typical of a Mediterranean diet that seems to stave off morbidity,” she says.

Research also showed that a Mediterranean diet appears to modulate the gut microbiota in a way that promotes longevity by increasing diversity in the gut as well as increasing the balance of good bacteria. Diet is also linked to fewer markers of inflammation in the stool.

Bonaccio notes that a very important difference in the Mediterranean diet, which seems to have an impact on lifespan, is related to the use of red wine. While in other parts of the world alcohol is consumed outside of meals, in a Mediterranean diet red wine is consumed exclusively with food. She says that’s a huge reason why it’s beneficial. When wine is accompanied by food, it is slowly absorbed into the bloodstream. This protects the liver by keeping it in the stomach longer and hence the body benefits from the antioxidants in wine without any negative impact on the liver.

Seasoning foods with olive oil instead of other forms of fat, which is typical of a Mediterranean diet, is another reason for the diet’s protective impact on aging. Olive oil is made up of monounsaturated fats which reduce the amount of bad cholesterol, also known as LDL cholesterol, which has an anti-inflammatory effect on the body.

Ultimately, longevity is a long game. Exercise, movement, a positive attitude, and a Mediterranean diet are pretty simple, but it takes commitment to make them happen. Yet being able to move, love, eat, and have fun later in life is now a worthwhile reward.

3D Printed Turtle Shells Could Help Save This Endangered Species

0

If you’re wandering around the Mojave Desert and come across a desert tortoise, don’t dig too close to the creature — you might find yourself covered in a surprise spray of artificial grape liquid. It would be because this turtle is a 3D printed impostor and thinks you are a crow.

Thanks to human activity, crows have invaded the deserts of the western United States, wreaking havoc on its ecosystems and threatening the desert tortoise in particular, preying on juveniles before their shells are fully formed. . In an effort to save people, a biologist has teamed up with engineers to forge a 3D-printed lookalike baby turtle that allows them to collect data on crow attacks and counterattack with non-toxic spray. He hopes that the “techno tort” partnership can serve as a model for other biologists to solve certain conservation crises.

[Image: Hardshell Labs/courtesy Autodesk]

Crows are considered an invasive native species. They have proliferated by 700% in the last 25 years due to the increased human presence in the desert, providing opportunities that did not previously exist in the harsh environment: road accidents and litter are now food, while billboards and transmission towers are nesting structures. . Tim Shields, a field biologist with more than 30 years of experience studying turtle behavior and populations, zoomed in on a call with Fast Company from his car outside Victorville, Calif., at the southwest end of the Mojave Desert. “I look at a landscape that has been transformed,” he says. “I don’t look at anything but opportunities for crows.”

[Photo: Hardshell Labs/courtesy Autodesk]

Crows eat well. They feast on burrowing owls; the colorfully named Coachella Valley Fringe-toed Lizard; and on young turtles, which crows eat by poking their beaks through soft shells when the turtles surface to escape scorching ground temperatures. They have no choice but to emerge: in the spring, juvenile turtles must come out and eat to help ossify their keratin shell, as the bone will make them more immune to long-term predation. But by doing this for 8-15 years of their childhood, then they risk attacks from crows. Desert tortoise populations have declined by at least 90% since the 1980s and are officially listed as threatened, although Shields says they should be in the endangered category.

[Photo: Hardshell Labs/courtesy Autodesk]

Enter “Techno Crime”, a counterfeit turtle made to trick crows. The concept has been in the works for more than a decade by Hardshell Labs, the Shields-based company that uses the technology to conserve native wildlife from avian damage. It was the ingenuity of a native Alaskan high school student from Shields that led the team to 3D print a shell, which was then enhanced by Autodesk, a software company that is one of the leaders in computer-aided design (CAD). Hardshell used the company’s CAD tool, Fusion 360, to 3D print a hard shell in plastic resin, painted to look like the baby creatures. They turned out to be realistic. “I fool professional biologists with these things all the time,” Shields says. “I am wrong.”

[Photo: Hardshell Labs/courtesy Autodesk]

It was crucial for them to be realistic in order to fool the crows. Knock-off turtles can track crows foraging on them with their internal sensors and cameras, and collect data on when, where and how the crows attack, and the severity of the threat. Previously, Shields’ research relied on random dead shells, which was a matter of forensics rather than “scientifically rigorous demonstration,” he says. They deployed these shells en masse in 2018 and 2019 and sold around 1,000 to the US Fish and Wildlife Service. Using data collected from their fake turtles, Shields’ team determined that a single crow per 2.5 square kilometers in the desert will ensure localized turtle extinction. “The odds of this little guy escaping detection by a crow, in the time period it takes to mature, are basically nil,” Shields says.

Now some of the fake wrongs are fighting back. Cornerstone Research Group, a defense manufacturing company, installed electronic accelerators and liquid canisters inside the hulls. If crows get aggressive, the shells will spray a non-toxic irritant called methyl anthranilate, an artificial grape flavor that repels birds. “Crows don’t like surprises,” Shields says, citing their high degree of neophobia, or fear of novelty. The idea is that they “shock the bejesus out of them, so that it gets burned into their brains”, and hopefully communicate the danger to their little ones. “We’re basically trying to insert a meme into crow society, and hopefully it will catch on,” he says.

[Photo: Hardshell Labs/courtesy Autodesk]

Hardshell is currently testing the performance of the armed prototypes in this “sting operation”, having tested 5 last year and 10 more this year. Shields is energized by collaboration and believes technology is the way to combat growing conservation disasters. On the other side are engineers who often work on dry issues, but are energized by turtles. “Autodesk went gaga over this,” he says. “They are so cute.”

[Photo: Hardshell Labs/courtesy Autodesk]

For years, Hardshell has targeted crows with other technological solutions, including using laser lights to deter them from their habitats, and a procedure they call “remote egg oiling.” Nozzles mounted on aerial drones apply a non-toxic oil to the crow’s eggs, which prevents oxygen exchange so they don’t hatch. But they remain intact, so the crows continue to incubate them and do not re-nest, which contributes to reduced breeding and reduced populations.

The next step will be to get ahead of the curious crows by making the mannequins even more deceptive. “When you’re dealing with an animal as intelligent as a crow, you don’t want to bet everything on the animal’s current behavior because it’s very flexible,” says Shields. He wants to make a robot turtle that can move, or whose head can stick out and wiggle. The team may also consider other aversive tools, including meat baits soaked in a chemical called carbachol, which would trigger nasty food poisoning, a gut reaction enough to keep us from tasting certain foods again.

He had fun making techno crimes a game. From a distance, players could control booby-trapped shells and potentially trigger the irritant. “Environmentalism based on the joy of games is a winner,” he says. “Environmentalism based on feelings of guilt is a loser.” Ultimately, he wants to find the best tools to get people off their screens and back into nature, and get them to care about conserving it. “Any game a human can build is a pale shadow of what ecosystems do all the time,” Shields says. “We should be madly in love with this planet.”

Measuring Immigrant PhDs Could Help National Security, U.S. Economy

In 2022, a country’s national security and economic vitality revolve around talent. Leaders in China, Russia and other countries have taken steps to ensure that their countries have the scientists and engineers needed for the 21st century. Analysts say the United States has natural advantages in the global competition for talent, but risks falling behind because it is too difficult for talented foreign-born people to stay or immigrate to America. Congress has the option to change that in legislation directed to a House-Senate conference committee.

Context: On March 30, 2022, “The House, by unanimous consent, rejected the Senate amendment to HR 4521—America COMPETES Act of 2022 and requested a conference with the Senate”, reported the House Press Gallery. “The President has stated that the appointment of speakers on HR 4521 will be made at a later date.”

On February 4, 2022, the United States House of Representatives passed the America COMPETES Act 222-210, but it received only one Republican vote. In June 2021, the Senate passed a similar bill focused on supporting the production of more semiconductors in the United States and grants for research and manufacturing in different parts of the country. The House bill is about 3,000 pages but contains unique provisions from the Senate bill, including some changes to immigration law to help the U.S. economy retain native-born scientists and engineers. ‘foreigner.

First, the bill creates an exemption from annual green card limits and arrears for foreign nationals with doctorates. in STEM fields (science, technology, engineering and mathematics). An additional exemption from green card limits includes those with a master’s degree “in a critical industry,” such as semiconductors.

Second, the bill creates a temporary visa for eligible foreign-born entrepreneurs — from Rep. Zoe Lofgren’s (D-CA) LIKE Act — and includes a way for entrepreneurs to obtain lawful permanent residency” whether the start-up entity meets certain additional criteria.” Innovations are often achieved through entrepreneurship, with examples from immigrants like Zoom (video conferencing), Moderna (biomedical research) and Tesla (electric vehicles).

Third, the bill’s measures fund scholarships for U.S. students in STEM fields by charging an additional $1,000 fee to those who receive a green card or status under the legislation. The bill also includes small measures that would make it easier to retain healthcare professionals and attract international students.

Russia: Following the invasion of Ukraine, the Russian government has tried to retain its talents in information technology (IT) and science, as they represent a source of wealth creation and national security. “Already, Russian talent is rushing out, in what could represent the seventh major wave of Russian emigration in the past century,” writes the washington post Catherine Rampel. “An estimated 50,000 to 70,000 IT specialists have left recently, according to a Russian technology group, which predicts another 100,000 could leave by the end of April. Others in the overseas rush include entrepreneurs, researchers and artists. . . The Russian government has yet to block emigration, but it is trying to slow the flow by interviewing those who leave or offering incentives to tech workers who stay. Rampell recommends using the provisions of the House bill to “drain Putin’s brain”.

A good example of the type of person who would represent America’s gain (but Russia’s loss) is Gleb Yushin. Yushin earned a bachelor’s degree in physics from the Polytechnic Institute in St. Petersburg, Russia, and came to America as an international student. He obtained a doctorate. in materials science from North Carolina State University. Yushin’s research has contributed to the development of battery materials now used to improve energy storage for many products. He became co-founder of Sila Nanotechnologies, a company valued today at more than 3 billion dollars. He teaches the next generation of American students as a professor of engineering and materials at Georgia Tech.

China: Like Russia, China recognizes the value of high-tech talent to a nation. “Chinese leaders understand how much the United States benefits from the influx of international talent,” Remco Zwetsloot writes in a report for the Center for Strategic and International Studies. “So they celebrate America’s flawed immigration system and fear reforms that would improve the attraction and retention of American talent. Commenting on the US retention of Chinese STEM students, the head of the CCP’s central talent work coordination group complained that “the number of top talent lost in China ranks first in the world.” China Daily United Statesa government-run newspaper said expanding the US employment-based immigration system “would pose a huge challenge for China, which has gone to great lengths to attract and retain talent.”

United States: In its final report, presented at a congressional hearing, the National Security Commission on Artificial Intelligence (AI) recommended changes to immigration law as one of the best ways for the United States to meet the challenges of China and other countries. In a summary of “Win ​​the Global Talent Competition,” the report states: “The United States risks losing global competition for scarce AI expertise if it does not cultivate more potential talent at home and recruit and retain more existing talent abroad.”

Recent years have shown that it is difficult to predict which innovations will become vital. Katalin Karikó produced the underlying research breakthrough that made messenger RNA possible for vaccines to combat Covid-19. She got her doctorate. in Hungary, but spent years in America on an uncertain career path, first as a postdoctoral researcher, before her work was recognized as groundbreaking. About 56% of postdoctoral researchers work on temporary visas, many of them in the biological sciences, medical sciences, engineering, and research and development.

Assimilation of the talents of immigrant scientists and engineers has paid great dividends for America for decades. “A number of America’s first Nobel laureates in physics were Jewish scientists who fled Europe after the rise of Hitler and Mussolini,” noted an analysis by the National Foundation for American Policy (NFAP). “These scientists were crucial in America becoming the first nation to develop the atomic bomb.

“In 1954, the Atomic Energy Act created an award to recognize scientific achievement in the field of atomic energy. The first winner of the prize was Enrico Fermi, of Italian origin. After his death, the prize became known as the Enrico Fermi Prize and five of the first 8 winners were immigrants. Felix Bloch (1952), born in Switzerland, Emilio Segre (1959), born in Italy, Maria Mayer (1963), born in Poland, and Eugene Wigner (1963), born in Hungary.

Today, the United States is losing top talent. According to a recent NFAP analysis. “Enrollment of Indian students in colleges and universities in Canada has increased by almost 300% between the 2015-2016 and 2019-2020 academic years. »

Although international students in Canada can obtain permanent residence in one or two years, the Congressional Research Service (CRS) estimates that it could take up to 195 years for Indian immigrants to obtain a green card in America in the employment-based second preference (EB-2). Canada does not have a per-country limit or low annual limits for employment-based immigrants like the United States.

Canada benefits from Indian talent diverted from American universities, notes Peter Rekai, a Toronto-based immigration lawyer. He cites the inability of Indian scientists and engineers to find a “reliable route to permanent residence in the United States” and the ease of doing so in Canada.

A House-Senate conference committee will determine whether America maintains the status quo or takes steps to strengthen national security and make American businesses more competitive.

Brain maps map the rapid growth and slow decline of the human brain over our lifetime

An international team of researchers has created a series of brain diagrams spanning our entire lives – from a 15-week-old fetus to a 100-year-old adult – that show how our brains grow rapidly in early life and slowly shrink as we go. as we age.

The graphs are the result of a research project spanning six continents and bringing together possibly the largest MRI datasets ever aggregated – nearly 125,000 brain scans from more than 100 different studies. Although not currently intended for clinical use, the team hopes the charts will become a routine clinical tool similar to how standardized pediatric growth charts are used.

Growth charts have been a cornerstone of pediatric health care for over 200 years and are ubiquitously used in clinics to help monitor the growth and development of children relative to their peers. A typical growth chart may plot age on the horizontal axis against height on the vertical axis, but rather than being a single line, it will show a range that reflects natural variability in height, height, weight or head circumference.

There are no analogous reference charts for measuring age-related changes in the human brain. The lack of standardized assessment tools for brain development and aging is particularly relevant to the study of psychiatric disorders, where the differences between conditions and their heterogeneity demand instruments that can tell something meaningful about a single individual from the same way clinical reference charts can, and to conditions such as Alzheimer’s disease that cause brain tissue degeneration and cognitive decline.

Today’s study, published in Nature, is a major step to fill this gap. Unlike pediatric growth charts, BrainChart – published on the open-access site brainchart.io – covers the whole of life, from development in the womb to old age, and aims to create a common language for describing the variability of brain development and maturation. .

The Incredible Growing and Shrinking Brain

The brain diagrams have allowed researchers to confirm – and in some cases show for the first time – developmental milestones that had previously only been hypothetical, such as at what age major classes of brain tissue reach maturity. peak volume and when specific regions of the brain mature.

Dr Richard Bethlehem from the University of Cambridge’s Department of Psychiatry, one of the study’s co-leads, said: “One of the things we were able to do, through a very concerted global effort, is to assemble data over the entire lifespan. This allowed us to measure the very early and rapid changes that occur in the brain, and the long, slow decline as we age.

Some of the key milestones observed by the team include:

  • The volume of gray matter (brain cells) increases rapidly from mid-gestation, reaching a peak just before the age of six. It then begins to slowly decrease.
  • The volume of white matter (brain connections) also increased rapidly from mid-gestation through infancy and peaked just before age 29.
  • The decrease in white matter volume begins to accelerate after age 50.
  • Gray matter volume in the subcortex (which controls basic bodily functions and behavior) peaks in adolescence at age 14½.

Towards a clinically useful tool

While the brain maps are already proving useful for research, in the long term, the team wants them to be used as a clinical tool. The datasets already contain around 165 different diagnostic labels, meaning researchers can see how the brain differs in conditions such as Alzheimer’s disease.

Alzheimer’s disease causes neurodegeneration and loss of brain tissue, so those affected by the disease are likely to have reduced brain volume compared to their peers. In the same way that some healthy adults are taller than others, there is variability in brain size – in other words, a slightly smaller brain does not necessarily indicate that something is wrong. . However, as brain diagrams show, while brain size naturally decreases with age, it does so much more rapidly in patients with Alzheimer’s disease.

Dr Bethlehem explained: “We are still at an extremely early stage with our Brain Charts, showing that it is possible to create these tools by bringing together huge sets of data. The charts are already starting to provide interesting insights into brain development, and our ambition is that in the future, as we integrate more datasets and refine the graphs, they could eventually become part of routine clinical practice.

“You can imagine them being used to help assess patients screened for conditions like Alzheimer’s disease, for example, allowing doctors to spot signs of neurodegeneration by comparing how quickly a patient’s brain volume has changed compared to its peers.”

Additionally, the team hopes to make brain maps more representative of the general population, highlighting the need for more brain MRI data on previously underrepresented socioeconomic and ethnic groups.

A huge technical feat

Dr Jakob Seidlitz of the Lifespan Brain Institute at Children’s Hospital of Philadelphia and the University of Pennsylvania, another of the study’s co-leads, said: “Creating these brain diagrams involved multiple feats techniques and a large team of collaborators. With data brain imaging, things are a little more complicated than simply pulling out a tape measure and measuring a person’s height or head circumference. There were significant challenges to overcome, including logistical and administrative hurdles as well as the enormous methodological variability we find between brain imaging datasets.”

The team used standardized neuroimaging software to extract data from MRI scans, starting with simple properties such as gray matter or white matter volume, then expanding their work to look at finer details, such as the thickness of the cortex or the volume of specific regions of the brain. They used a framework implemented by the World Health Organization for generating growth charts to construct their brain diagrams.

In total, they estimate that they used around 2 million hours of computing time, analyzing almost a petabyte of data (a petabyte equals 1,000,000,000,000,000 bytes).

“This really wouldn’t have been possible without access to Cambridge’s high-performance computing clusters,” Dr Seidlitz said. “But we still see this as a work in progress. It’s a first step towards establishing a standardized reference chart for neuroimaging. That’s why we built the website and created a large network of collaborators We plan to constantly update the tables and build on these models as new data becomes available.”

The team created the tool with a frame of reference to allow other researchers and clinicians to tune their own datasets, allowing them to be compared to the BrainChart population.

Dr Bethlehem explained: “The NHS performs millions of brain scans every year and in most of these cases they are assessed by radiologists or neurologists who draw on their vast expertise to judge whether there is something anything clinically relevant apparent on these scans. We hope clinicians in the future can compare their data to ours and produce a more comprehensive report that adds additional objective and quantitative observations to their assessment.”

“This should effectively allow the neurologist to answer the question ‘this area looks atypical but how atypical? “As the tool is standardized, it doesn’t matter where you have your brain scan – you should always be able to compare this.”

Working with Dr Bethlehem and Dr Seidlitz, the work was led by Cambridge researchers Dr Simon White and Professor Ed Bullmore, and Dr Aaron Alexander-Bloch of the University of Pennsylvania. It builds on a worldwide collective effort over the past decades to measure the structure of the human brain with MRI, in many groups of people at different ages. The team says this would not have been possible without open access to many high-quality MRI datasets, and hopes their results will contribute to greater openness and sharing of data and analysis for the science of brain imaging.

The research was supported by the British Academy, the Autism Center of Excellence, the Medical Research Council, the National Institute for Health Research (NIHR), the Wellcome Trust and the NIHR Cambridge Biomedical Research Centre.

Johns Hopkins researcher Elana Fertig named to the College of Fellows of the American Institute for Medical and Biological Engineering

0

Newswise – Cancer researcher Elana Fertig, Ph.D., has been elected by her peers as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), a Washington, DC-based nonprofit organization representing the most accomplished individuals in the fields of medical and biological engineering. The College of Fellows comprises the top 2% of medical and biological engineers in the United States.

Fertig is one of 152 new fellows making up the Class of 2022. She is recognized for her outstanding contributions to cancer systems biology and multi-omics.

At Johns Hopkins Kimmel Cancer Center, Fertig has held several leadership positions, including as director of the Quantitative Sciences Division, co-director of the Convergence Institute at the Kimmel Cancer Center, co-director of the Single-Cell Consortium, and associate director of quantitative sciences at the cancer center. She is a Daniel Nathans Science Innovator and Associate Professor of Oncology, Biomedical Engineering, and Applied Mathematics and Statistics.

AIMBE Scholars are regularly recognized for their contributions to teaching, research and innovation. AIMBE Fellows have been awarded the Nobel Prize, Presidential Medal of Science, and Presidential Medal of Technology and Innovation, and many are also members of the National Academy of Engineering, National Academy of Medicine, and the National Academy of Sciences. An official induction ceremony was held at AIMBE’s 2022 annual event on March 25.

Since 1991, the AIMBE College of Fellows has paved the way for technological growth and advancement in the fields of medical and biological engineering. AIMBE Fellows have helped revolutionize medicine and related fields to improve and extend the lives of people all over the world. They have successfully advocated for public policies that have enabled researchers and entrepreneurs to advance the interests of engineers, teachers, scientists, clinicians and, ultimately, patients.

The names of all winners are published here.

Federal Court Rejects Fort Huachuca Groundwater Pumping Plan For Fourth Time

0

TUCSON, Arizona– A federal judge has thrown out the latest plan by the U.S. military and U.S. Fish and Wildlife Service to prevent harm to the San Pedro River and its endangered species from pumping groundwater to serve Fort Huachuca and the population of the fort in the surrounding areas.

Friday’s ruling, by U.S. District Judge Raner C. Collins, means the Army and Fish and Wildlife Service will have to produce a new environmental plan to protect the river from groundwater pumping from the Fort. The judge also ruled that officials relied on accounting that overstated the water credits claimed by the military base and failed to adequately account for the effects of climate change on the river and on endangered plants and animals. disappearance that depend on it.

“Generally, the court gives deference to an agency’s predictions about the possible effects of climate change,” Judge Collins wrote. “However, an agency cannot simply summarize the effects of climate change and then analyze the proposed action assuming that climate change will have no effect.”

This is the fourth time in 20 years that the courts have rejected Fort Huachuca’s environmental plan, including its groundwater pumping, which had been approved by the Fish and Wildlife Service.

“Pumping groundwater from the Fort’s off-post population is killing the San Pedro River and the endangered species that depend on it,” said Robin Silver, co-founder of the Center for Biological Diversity. “Instead of doing something about it and downsizing the fort, the military chose to fabricate environmental clearance studies and manipulate federal wildlife officials. Now that it has suffered yet another defeat, perhaps the Hold will finally take action to protect the last free-flowing desert river in the southwest.

The court found that Fort Huachuca ignored a hydrological study on the effects of groundwater pumping attributable to Fort on local groundwater levels, which showed a drop of more than 60 feet in some areas.

The court also said the fort had overstated groundwater credits for fallow farmland near Hereford. In memos obtained under the Freedom of Information Act, Fort Huachuca officials said they convinced Fish and Wildlife Service officials to issue Fort water retirement credit by “postulating post water credits”, where they “leveraged creative solutions to achieve ‘net-zero'”. ‘ in the use of water.

However, the decision will allow Fort Huachuca to claim a water credit for future water conservation – although it won’t prevent the river from completely drying up – and will spare the Service from declaring that the San Pedro and its wildlife are in danger. The law and case law require that a determination of danger can only be avoided by concrete and contemporary actions, and not by hypothetical future actions. The Center and Maricopa Audubon plan to appeal.

In other memos obtained under the Public Records Act, a Fish and Wildlife Service biologist said “groundwater pumping at Fort Huachuca alone…causes danger.” The same biologist summed up why the agency continues to produce bio opinions which are then thrown out by the court: “Clearly the Fort does not take us (FWS) seriously…they think they have enough incursions policies with our Washington and regional offices that we, the field office, will be rolling.

“It’s absurd that we had to go to court four times to undo the lies of the Department of Defense and defend Arizona’s last free-flowing river,” said Maricopa Audubon President Charles Babbitt. “Fisheries and wildlife officials must stand firm and defend this spectacular birding Mecca for future generations, the river can no longer tolerate any further delay in the protection it so desperately needs.

The military has been told by the courts that its Fort Huachuca-related activities have been killing the San Pedro since at least 1995, when a federal judge said, “The military must not turn a blind eye to this problem…where the Uncontrolled drying up of the aquifer poses a real threat to the riparian zone.

Based on a study by the U.S. Army Corps of Engineers, the Department has known for more than 50 years that Fort Huachuca’s large manpower is unsustainable due to groundwater depletion and effects on the San Pedro River. .

The San Pedro River is the last free-flowing desert river in the southwest. Endangered species dependent on them include Southwestern Willow Flycatchers, Huachuca Water Pennyfish, Desert Pupfish, Loached Minnows, Spikedaceous, Yellow-billed Cuckoos, Eryngo’s Arizona and northern garter snakes of Mexico.

Friday’s decision stems from a lawsuit filed in March 2020 by the Center and the Maricopa Audubon Society. The organizations are represented by EarthJustice.

Gel Documentation Systems Market Size, Growth and Forecast

0

New Jersey, United States – The research study on the Gel Documentation Systems Market offers you detailed and precise analyzes to strengthen your position on the market. It provides the latest updates and powerful insights into the Gel Documentation System industry to help you improve your business tactics and ensure strong revenue growth for years to come. It sheds light on the current and future market scenarios and helps you understand the competitive dynamics of the Gel Documentation Systems market. The market The segmentation analysis offered in the research study shows how different product segments, applications, and regions perform well in the gel documentation system market.

The report includes verified and revalidated market figures such as CAGR, gross margin, revenue, price, production growth rate, volume, value, market share and annual growth. We have used the latest primary as well as secondary research techniques to compile this comprehensive Gel Documentation Systems Market report. As part of the regional analysis, we have explored key markets such as North America, Europe, India, China, Japan, MEA and others. Leading companies are profiled based on various factors including markets served, production, revenue, market share, recent developments, and gross margin. There is a section dedicated to market dynamics which analyzes in depth the Drivers, Constraints, Opportunities, Influencers, Challenges and Trends.

Get Sample Full PDF Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://www.verifiedmarketreports.com/download-sample/?rid=40916

The report provides an excellent overview of the key macroeconomic factors having a significant impact on the growth of the Gel Documentation Systems market. It also provides absolute dollar opportunity analysis which can be crucial for identifying revenue generating and sales increasing opportunities in the Gel Documentation Systems market. Market players can use the qualitative and quantitative analysis provided in the report to thoroughly understand the Gel Documentation Systems market and make great strides in the industry for growth. The overall size of the Gel Documentation Systems market and that of each segment studied in the report are precisely calculated based on various factors.

Key Players Mentioned in the Gel Documentation Systems Market Research Report:

Bio-Rad, Thermo Fisher Scientific, GE Healthcare, VWR International, Corning, Syngene, Analytik Jena, Gel Company, ProteinSimple, ATTO, Vilber Lourmat, Carestream Health, Wealtec, Royal Biotech, Cleaver Scientific, LI-COR, Isogen, SIM Lab , DNR bio-imaging systems, Tanon

Gel Documentation Systems Market Segmentation:

By Product Type, the market is primarily split into:

• Multifunctional product
• Base product

By application, this report covers the following segments:

• Hospitals and diagnostic centers
• Pharmaceutical and biotechnology companies
• Molecular biology laboratories
• Education and Research Center
• Others

In this report, researchers focused on social media sentiment analysis and consumer sentiment analysis. For social media sentiment analysis, they focused on trending topics, mentions on social media platforms including percentage of mentions, trending brands and consumer perception of products on media platforms social, including negative and positive mentions. As part of the consumer sentiment analysis, they looked at the impact of certifications, claims and labels, factors influencing consumer preferences, key trends, consumer preferences, including futuristic approach and historical scenarios, influential social and economic factors, specification development and consumers. buying habits.

Get a discount on the purchase of this report @ https://www.verifiedmarketreports.com/ask-for-discount/?rid=40916

Scope of the Gel Documentation Systems Market Report

ATTRIBUTES DETAILS
ESTIMATED YEAR 2022
YEAR OF REFERENCE 2021
FORECAST YEAR 2029
HISTORICAL YEAR 2020
UNITY Value (million USD/billion)
SECTORS COVERED Types, applications, end users, and more.
REPORT COVER Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends
BY REGION North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
CUSTOMIZATION SCOPE Free report customization (equivalent to up to 4 analyst business days) with purchase. Added or changed country, region and segment scope.

Geographic segment covered in the report:

The Gel Documentation Systems report provides information on the market area, which is further sub-divided into sub-regions and countries/regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate of each region, country and sub-region over the estimated period.

• North America (USA and Canada)
• Europe (UK, Germany, France and rest of Europe)
• Asia-Pacific (China, Japan, India and the rest of the Asia-Pacific region)
• Latin America (Brazil, Mexico and rest of Latin America)
• Middle East and Africa (GCC and Rest of Middle East and Africa)

Answers to key questions in the report:

1. Who are the top five players in the Gel Documentation Systems market?

2. How will the gel documentation systems market develop over the next five years?

3. Which products and applications will capture the lion’s share of the gel documentation systems market?

4. What are the drivers and restraints of the Gel Documentation Systems Market?

5. Which regional market will show the strongest growth?

6. What will be the CAGR and size of the Gel Documentation Systems market throughout the forecast period?

For more information or query or customization before buying, visit @ https://www.verifiedmarketreports.com/product/global-gel-documentation-systems-market-2019-by-manufacturers-regions-type-and-application-forecast-to-2024/

Visualize the Gel Documentation Systems Market Using Verified Market Intelligence:-

Verified Market Intelligence is our BI platform for market narrative storytelling. VMI offers in-depth forecast trends and accurate insights on over 20,000 emerging and niche markets, helping you make critical revenue-impacting decisions for a bright future.

VMI provides a comprehensive overview and global competitive landscape with respect to region, country, and segment, as well as key players in your market. Present your market report and results with built-in presentation functionality that saves you over 70% of your time and resources for presentations to investors, sales and marketing, R&D, and product development. VMI enables data delivery in Excel and interactive PDF formats with over 15+ key market indicators for your market.

Visualize the Gel Documentation Systems Market Using VMI@ https://www.verifiedmarketresearch.com/vmintelligence/

Most Popular Reports

Global Off-Road Robot Market Size and Forecast

Global Currency Sorters Market Size and Forecast

Global Spray Dryer Market Size and Forecast

Global Truck Mounted Concrete Pump Market Size and Forecast

Global Thermopile Microbolometer Infrared Detectors Market Size and Forecast

Global Coin Sorters Market Size and Forecast

Global Commercial Boiler Market Size and Forecast

Global Gel Documentation Systems Market Size and Forecast

Global Rehabilitation Robotics Market Size and Forecast

Global Gas Compressor Market Size and Forecast

About Us: Verified Market Reports

Verified Market Reports is a leading global research and advisory company serving over 5000 global clients. We provide advanced analytical research solutions while delivering information-enriched research studies.

We also provide insight into the strategic and growth analytics and data needed to achieve business goals and critical revenue decisions.

Our 250 analysts and SMEs offer a high level of expertise in data collection and governance using industry techniques to collect and analyze data on over 25,000 high impact and niche markets. Our analysts are trained to combine modern data collection techniques, superior research methodology, expertise and years of collective experience to produce informative and accurate research.

Our research spans a multitude of industries, including energy, technology, manufacturing and construction, chemicals and materials, food and beverage, and more. Having served many Fortune 2000 organizations, we bring a wealth of reliable experience that covers all kinds of research needs.

Contact us:

Mr. Edwyne Fernandes

USA: +1 (650)-781-4080
UK: +44 (753)-715-0008
APAC: +61 (488)-85-9400
US Toll Free: +1 (800)-782-1768

E-mail: sales@verifiedmarketreports.com

Website: – https://www.verifiedmarketreports.com/

Manipur Jobs: Manipur University Recruitment

0

Applications are invited for various project-based positions at Manipur University.

Manipur University, Canchipur is inviting applications from eligible candidates for the Department of Biotechnology (DBT), New Delhi, GOI funded project “DBT-BUILDER-Manipur University – Interdisciplinary Life Sciences Program for the advanced research and education”.

Job Name: Project Scientist (Level-1)

Number of positions: 1

Salary: Rs. 56,000/- + 8% HRA (Rs. 60,480/-) and 5% increase every 2 years of experience

Qualifications:

a) Doctor of Science or Master of Engineering or Technology degree from a recognized university or equivalent.

b) Life science/pharmaceutical candidates with knowledge of molecular biology techniques are preferred.

c) Applicants with a background in Instrumentation Science are preferred over those with a Masters in Engineering or Technology
diploma.

Read also: Assam Career: NIT Silchar Recruitment

Job name: Scientific Administrative Assistant

Number of positions: 1

Salary: Rs. 18000/- + 8% HRA

Qualifications:

a) Graduated in any discipline

b) Candidates with basic computer knowledge like Microsoft Word, PowerPoint, Microsoft Excel, etc. are preferable.

Job Name: Technical Assistant

Number of positions: 1

Salary: Rs. 20000/- + 8% HRA and 15% increment after 3 years

Qualifications:

a) Graduate (B.Sc) in Science / or 3-year degree in Engineering and Technology

b) Applicants from the life sciences with basic knowledge of handling scientific equipment and computer skills such as
Microsoft Word, Powerpoint, Microsoft Excel etc. is preferable

c) Applicants with a background in instrumentation science are preferred over those with an engineering or technology degree
diploma

Read also: NECTAR Recruitment 2022: Apply for Project Coordinator, Project Assistant and MTS positions

Job Name: Field Assistant

Number of positions: 1

Salary: Rs. 20000/- + 8% HRA and 15% increment after 3 years

Qualifications:

a) Graduate (B.Sc) in science

b) Candidates from a life science background with experience in fieldwork/field studies and experience in handling small animals are preferred.

How to register : Applicants may submit electronic copies of the plain paper application along with supporting documents, including a full CV (CV format is provided in Appendix-I), certificates of relevant experiences, grade sheets and testimonials, etc. to email kbsingh@manipuruniv.ac.in no later than April 20, 2022.

Detailed announcement : Click here

Read also: Assam Career: Assam Petro-Chemicals Limited Recruitment

Habitat projects across the state benefit both fish and anglers | Adventure

0

When you hear habitat project, fish is probably the last thing that comes to mind. However, creating habitat for fish is very important.

“The goal of fish habitat projects in the state is to increase spawning areas and boost food sources for all fish in the lakes, as well as improve fishing in general,” said Jacob Miller, warm-water fisheries biologist for the Department of Game and Fish. .

Several years of survey data collected on sport fish species at Bill Evans Lake have suggested that sport fish lack essential food sources, such as plankton, crayfish, minnows and bluegills. growth during the early stages of life. In 2020, the ministry carried out a restoration project to improve fish habitat at Bill Evans Lake Wildlife Management Area near Silver City.

Bill Evans Lake was purchased in 1972 from Phelps-Dodge Corp. The lake sits atop a mesa and provides fishing access and wildlife habitat. The reservoir is 300 feet above the Gila River. Water is regularly pumped from the river below to maintain lake levels and suitable habitat for warm and cold water fish.

The Bill Evans Lake project has improved habitat for several species of sport fish, such as largemouth bass, channel catfish, rainbow trout and bluegill by increasing spawning areas for adult fish and hiding places for juvenile fish. Man-made structures that are less likely to be snagged by anglers have been sunk at strategic points near the shore to attract fish, improving angling and catch rates in Bill’s Lake WMA Evans.

In unison with the habitat project, the department also plans to build a new boat launch and alter much of the shoreline around Bill Evans Lake to improve angler access to the areas by smoothing the slope of the shoreline, adding walking paths, improving the road around the lake and adding rock/gravel fishing jetties.

Similar habitat projects are underway at Lake Carlsbad and Lower Tansill Lake. With assistance from the New Mexico Chapter of the BASS Nation and the City of Carlsbad, the department began improving fish habitat structures in these lakes. These habitat projects aim to increase spawning areas, increase food sources for all fish in the lakes, and improve fishing in general.

Other habitat structures made of logs, large branches and pallets will be installed later this year and a map showing the locations will be provided on the ministry’s website at bit.ly/3r3bXs3, as will one showing some great fishing grounds at Lake Bill Evans.

Ross Morgan is a spokesperson for the New Mexico Department of Game and Fish.

Traditional indigenous agriculture may be key to sustainability in India

Conservation specialist Joli Rumi Borah has discovered that a traditional Indian farming method that feeds millions of people in the Global South also has carbon, biodiversity and cultural benefits.

Borah, currently a postdoctoral researcher at the University of British Columbia, Vancouver, Canada, says carbon stocks and biodiversity have recovered where shifting cultivation, called jhum by the indigenous Naga people, was found in Nagaland, northeast India.

“My research has shown that farmers in northeast India have adopted various innovative methods to improve crop yield and forest regeneration,” she says, adding that this was evident in the high levels of stocks of carbon and the diversity of birds in the jhum culture landscapes in Nagaland.

Borah, who studied jhum as part of his doctoral research at the University of Sheffield, UK, suggested that there was significant conservation value in jhum cultivation, which is an important traditional agricultural method that covers an area of ​​280 million hectares and provides sustenance for 200 to 300 million people in the countries of the South.

” Manage effectively jhum cultivation is crucial to reducing carbon emissions and biodiversity loss while ensuring food security for local communities,” she says, adding that the project’s biggest challenge was the region’s extreme remoteness and lack of previous studies.

“Living and working with the indigenous Naga communities of Nagaland has helped me realize the importance of community conservation for positive societal and environmental outcomes,” she says, “I learned that contrary to widely held perceptions of jhum cultivation as a primitive and ecologically unsustainable practice, it is a dynamic and complex system that is well adapted to high rainfall and environmental conditions in mountainous regions and less harmful to the environment and biodiversity compared to the permanent agriculture (for example, plantation of oil palms or rubber trees). ).”

Communities close to nature

Borah was born and raised in the Brahmaputra Valley of Assam, northeast India.

“Growing up in this biodiversity-rich region, I developed a fascination with nature from an early age,” she says, adding that local concerns drove her from the start of her STEM journey.

“During undergrad, I wrote a dissertation on human-elephant conflict, a major concern in and around my home town of North Lakhimpur, and co-founded a conservation NGO to help raise awareness about biodiversity conservation,” she said.

Borah would then receive a full scholarship to do a Masters in Wildlife Science at the Wildlife Institute of India, Dehradun, India.

“Being from the South, I have witnessed the impact of some of the global challenges such as deforestation, food insecurity and climate change on local communities. Therefore, finding nature-based solutions to these challenges is very personal to me,” she said. says, “Breaking down linguistic and economic barriers and building fair and meaningful partnerships with local communities and scientists in the Global South will also help make science more inclusive and equitable.

During two years, as a project assistant at the National Center for Biological Sciences in India, studying the impacts of logging on bird communities in the Eastern Himalayas of northeast India, she experienced first-hand how the indigenous Bugun tribe worked together with the government and scientists to conserve this biodiversity hotspot.

“It inspired me to pursue a doctorate in conservation science to find such ways to reconcile biodiversity conservation and human well-being,” she says.

Borah has also been actively working to break the language barrier by communicating science in my mother tongue, Assamese, on various platforms such as blogs, podcasts, magazines and Assamese Wikipedia over the past decade.

“This can be a crucial step in decolonizing science by incorporating multiple ways of knowing and doing,” she says.

Rajeev Varshney is another Indian scientist who studies the relationship with cultures and communities.

MORE FORBESThis Indian scientist’s secret to a better life: the humble chickpea

He’s spent decades learning all about the chickpea, probing the depths of its genome to unlock the secrets of yield, nutrition, drought tolerance, and pest and disease resistance.

FSU professor receives $1.8 million grant

Xiaobing Zhang, an assistant professor in the FSU program in neuroscience and the department of psychology, received a five-year grant to study how the brain regulates eating behaviors.

The grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (an institute within the National Institutes of Health) and is worth $1.8 million. The National Institute of Diabetes and Digestive and Kidney Diseases conducts and supports biomedical research and receives federal funding. Zhang’s project is titled “Serotonin signaling in the uncertified zone and the paraventricular thalamus regulate eating behavior” and will examine a relatively understudied question.

In a press release, Zhang said previous studies showed that food intake is controlled by the brain. The brain must initiate food consumption based on the metabolic signals that the body sends to it. There is little knowledge in the scientific community about the role neuroplasticity and brain dysfunction play in the development of eating disorders in people due to the complexity of the neural pathways the brain uses to integrate related signals. emotions, rewards and satiety in everyday life.

Zhang’s particular research is important for helping scientists understand how central serotonin signaling affects eating control. The research will also help reveal the potential relationship between serotonin dysfunction and overeating, which is a significant issue in the world of health, as obesity is linked to leading causes of death in the United States such as accidents. cerebrovascular disease, diabetes and heart disease, according to the CDC.

The goal of Zhang’s research is to identify novel serotonin pathways and their role in regulating food intake. Serotonin extends to many regions of the brain such as the cortex, limbic system, thalamus and hypothalamus. The presence of serotonin allows the brain to regulate highly critical functions. If there is a disconnect, the brain might be unable to regulate functions such as emotion, motivation, and behavior.

“We are very pleased with this NIH award to support our research to further investigate neural signaling that regulates food intake by targeting the incerta area and the paraventricular thalamus, two brain areas with inhibitory neural connections for control. diet revealed by our previous findings,” Zhang said. . “We hope to understand how and when these pathways are activated for feeding control. More importantly, we hope to reveal how these pathways are impaired by a chronic high-fat diet that leads to overeating and obesity.

According to the Centers for Disease Control and Prevention, the age-adjusted adult prevalence of obesity rose to more than 40% in 2018. Zhang believes this research will help scientists examine obesity by understanding better how the brain’s serotonergic systems impact eating. behaviours.

“Eating behavior and energy balance studies represent a historic strength at FSU,” Psychology Department Chairman Frank Johnson said in a press release. “It’s exciting to see Xiaobing build on this tradition, taking his research and our mission to educate students in important new directions.”

The new NIH grant will use electrophysiological techniques to record the electrical activity of neurons and optogenetic techniques to better understand how serotonin affects food intake. There is an abundance of electrophysiological techniques available, which are normally used by scientists to determine how neural disorders occur. Optogenetic techniques involve the activation of specific neurons through the use of light.

“This project highlights some of the important translational research being conducted by members of the neuroscience program,” said Linda Eckel, director of the FSU neuroscience program. “This groundbreaking work should reveal how dysfunctional serotonin signaling promotes overeating and unhealthy weight gain, with the long-term goal of identifying new pharmacological targets for the treatment of eating disorders and obesity. .”

North Dakota sheep close to unlikely benchmark as they recover from illness | State and Region

0

Bighorn sheep are battling in North Dakota, rebounding from a crippling disease outbreak in the Badlands and thriving on the Fort Berthold Indian Reservation.

Bighorn sheep numbers in the state are approaching a benchmark that seemed unlikely just a few years ago, when the disease raised concerns about a potential long-term population decline.

There are nearly 450 bighorn sheep among populations managed by the North Dakota Game and Fish Department, National Park Service, and Three Affiliated Tribes Fish and Wildlife Division. The next target is 500 sheep, with an end goal of around 600, according to big game and fish biologist Brett Wiedmann.

“If at some point we hit 600, that would be maxed out,” he said. “Bighorns, if the abundance gets too high, then you really run the risk of disease.”






North Dakota Department of Game and Fisheries Big Game Biologist Brett Wiedmann


ASHLEY SALWEY, ND GAME & FISH DEPT.


sheep survey

Eight years ago, an outbreak of deadly bacterial pneumonia hit the West Badlands sheep population, but bighorn sheep have since rebounded to record numbers for two consecutive years.

People also read…

The Game and Fish Department’s 2021 bighorn sheep survey, supplemented by the lamb recount this month, found 335 bighorn sheep in western North Dakota, up 4% from to the 2020 record of 322 and 15% above the five-year average.

Biologists counted 99 rams, 175 ewes and 61 lambs. Not included in the count are about 40 sheep in the North Unit of Theodore Roosevelt National Park and bighorn sheep introduced to the Fort Berthold Indian Reservation two years ago.

“We were encouraged to see the number of adult rams increasing to near record highs, and adult ewes were at record numbers,” Wiedmann said. “Most encouraging was a record number of lambs matching a record recruitment rate.”

Recruitment refers to the number of lambs that become a permanent part of the flock.

The Northern Badlands population increased 6% from 2020 and was the highest number on record. The herd south of Interstate 94 continues to struggle and is at its smallest size – 12 – since bighorn sheep were reintroduced there in 1966. That’s three fewer than last year.

The southern herd has been decimated by disease over the years, and Game and Fish hopes to eventually wipe it out and start over, transplanting sheep from the Rocky Boy Indian Reservation in Montana. Flocks of domestic sheep in southwestern North Dakota have hampered the plans because they can spread the pneumonia bacteria to wild sheep.

“Our fear is that the rams will end up wandering over to these domestic sheep and bringing back these deadly pathogens,” Wiedmann said. “Better to go into standby mode until conditions change in the future.”

The 30 bighorn sheep transferred in January 2020 from the Rocky Boy Reservation to the Fort Berthold Reservation have thrived, nearly doubling their population in just two years, to 58. State and tribal wildlife officials call this a “performance exceptional demographic”.

sheep rally

The outbreak of bacterial pneumonia in Badlands sheep in 2014 killed about three dozen animals that year and a handful the following year. Game and Fish canceled bighorn sheep hunting season in 2015 for the first time in more than three decades. The agency reinstated hunting the following year, but warned it can take up to 15 years for the disease to work its way out of a herd.

The sheep have rallied, however, and the survey has now seen increased numbers for four consecutive years.







charlie bahnson.jpg

Charlie Bahnson, wildlife veterinarian at the North Dakota Game and Fish Department


SUPPLIED, ND GAME & FISH DEPT.


Officials found a low prevalence of the bacteria when monitoring sheep last winter, but biologists observed several bighorn sheep coughing during the 2021 survey, indicating the population has not completely eliminated the deadly pathogen, according to game and fish veterinarian Dr. Charlie Bahnson.

A bighorn sheep hunting season is tentatively scheduled for this fall. Season status will be determined on September 1, following a summer population survey.

Game and Fish typically awards fewer than 10 unique licenses per year. Five licenses were awarded last year, including one that is traditionally auctioned by the Midwest Chapter of the Wild Sheep Foundation to raise funds for sheep management. Four hunters managed to harvest a ram.

Bighorn hunting is hugely popular in North Dakota, and the permit lottery has set application records for four straight years, according to Wiedmann.

There were 19,127 applicants last year, according to Randy Meissner, hunting and fishing licensing manager, meaning nearly 4,800 hunters were vying for each available license handed out by the department. This year, 19,426 hunters applied, even though there is no guaranteed season.

Contact editor Blake Nicholson at 701-250-8266 or blake.nicholson@bismarcktribune.com.

Plant compound shows promise for alleviating food allergies

0

The researchers combined advanced computational methods with experimental studies to better understand, at the cellular level, how the plant compound formononetin could be used to treat food allergies. With nearly 10% of the world’s population affected by sometimes life-threatening food allergies, new treatments are needed.

Formononetin is found in plants and herbs such as red clover and green beans and has been shown to have anti-cancer properties. It is a phytoestrogen, which means it is similar in structure to the hormone estrogen and can bind to estrogen receptors in the body.

Ibrahim Musa, New York School of Medicine

This protein-protein interaction network was constructed by mapping potential targets in food allergy, IgE and mast cells in the Strings database. The size of the node from large to small is proportional to its degree value in the network. The circles represent the therapeutic targets and the purple lines represent the interaction between the nodes.

“Our results show that formononetin is a particularly good therapeutic candidate for the treatment of food allergies,” said Ibrahim Musa, a doctoral candidate in pathology, microbiology and immunology at New York Medical College. “Our research has also revealed new mechanisms and targets that can be used to design future drugs for the treatment of food allergies and other allergic disorders or to prevent the severe anaphylaxis seen in allergic diseases.”

Musa will present the new research at the annual meeting of the American Society for Biochemistry and Molecular Biology during the Experimental Biology (EB) Congress 2022which will be held from April 2 to 5 in Philadelphia.

Food allergies occur when the immune system treats a food or something in a food as a threat. This causes the immune system to produce immunoglobulin E (IgE) antibodies which react to food and can cause allergic symptoms such as hives, asthma, itching, difficulty breathing or diarrhea.

In previous studies, researchers have identified formononetin as a potential therapeutic agent for allergies because it decreases IgE production. To find out more, the researchers turned to an approach known as systems pharmacology. This involved using data from publicly available databases to identify gene and protein targets regulated in food allergy and mast cell disease. Mast cells also play an important role in IgE-mediated allergic diseases.

Once they identified gene and protein targets, the researchers validated them using cultured cell lines commonly used in allergy studies. These cellular experiments showed that formononetin influenced the expression of gene and protein targets identified using systems pharmacology.

“Our study demonstrates that systemic pharmacology can be used to predict drug/compound-target interaction,” Musa said. “Furthermore, the mechanism of action identified for formononetin is also important for other allergic diseases such as allergic asthma and hay fever. This suggests that formononetin or other therapeutic candidates that decrease IgE production might be useful in treating these diseases.

The researchers have developed a mouse model of peanut allergy which they plan to use to study formononetin and identify potential side effects.

Ibrahim Moussa will present this research from 12:30 p.m. to 1:45 p.m. on Tuesday, April 5 at Exhibit/Poster Hall AB, Pennsylvania Convention Center (Billboard number A235) (abstract).

UF and Scripps Florida Complete Integration to Create Scientific Research Powerhouse

Two of the nation’s most respected research institutes have completed their transaction that adds a power plant in Florida intended to accelerate the pace of biomedical discovery that benefits patients. Effective April 2, the Florida campus of Scripps Research is integrated and will now be part of the University of Florida Academic Health Center as UF Scripps Biomedical Research.

The transaction between these two leading organizations – Scripps Florida with its outstanding global reputation for biomedical research and UF Health, which has extensive expertise in clinical and biomedical research – results in a facility capable of translating biomedical discoveries into better outcomes. for patients in Florida and around the world, leaders from both organizations said.

“For patients and scientists alike, this is a memorable day. When fundamental scientific discoveries move quickly from the bench to the bedside, all of humanity sees a benefit,” said David R. Nelson, MD, senior vice president of health affairs at UF and president of UF Health. “Scripps Florida scientists have an impeccable reputation in their fields. Integrating them into UF’s research and teaching enterprise will foster many scientific and clinical breakthroughs.

Scripps Research, located in La Jolla, Calif., began working with Florida State in 2003 to establish a branch campus in Jupiter. Since then, Scripps Florida researchers have made groundbreaking discoveries that have led to hundreds of patents and numerous spin-off companies. Their work has also been heavily funded: The roughly 45 researchers at Scripps Florida make up one of the top research centers supported by the state’s National Institutes of Health. Discussions to integrate UF and the Scripps Florida campus began in mid-2021 and were formalized in November. Operations at Scripps Research’s main campus are unaffected by the transition, and the more than 175 active faculty continue to pursue critical scientific discovery and drug development.

“Our Jupiter campus has specialized resources that enable drug discovery that is more generally associated with the pharmaceutical industry and all of this happens in a not-for-profit academic setting,” said Patrick Griffin, Ph.D., Chief Scientific Officer. and professor of molecular medicine. for UF Scripps Biomedical Research. “Our new connection to UF Health’s clinical and scientific expertise provides an exceptional opportunity to accelerate scientific discovery for the benefit of those in need.”

With the integration of the former Scripps Research campus into UF, UF Scripps Biomedical Research combines the clinical expertise of a top 5 public university with the creative energies of one of the world’s leading biomedical research organizations, said Nelson.

“Together, UF Health and UF Scripps Biomedical Research can more effectively combat disease threats, address persistent medical challenges, and create new science education opportunities. Ultimately, this guarantees generations of people in Florida and elsewhere a brighter, healthier future,” Nelson said.

Work to recruit other prominent biomedical scientists to the faculty is underway, as are efforts to add staff specializing in artificial intelligence and computational biology.

“UF Scripps Biomedical Research is poised to build on a strong legacy of innovation at the University of Florida and Scripps Research, translating the art and science of discovery into enormous benefits for the State of Florida. , the nation and the world,” Mori said. Hosseini, chairman of the UF board of directors. “The amazing discoveries that I know will come from this team will bring hope and healing to millions of people.”

UF President Kent Fuchs said UF Scripps Biomedical Research is ushering in a new era of even more scientific collaborations that will also include other institutions in the state university system such as Florida International and Florida Atlantic universities. . Recent collaborations between UF and FAU have included research on Alzheimer’s disease and work on emerging trends in drug abuse.

“I’m really excited about the prospect of former Scripps Florida faculty joining UF. The breakthroughs our combined efforts will bring will exemplify one of our most important missions: to put science at the service of some of the world’s most pressing problems,” said Fuchs.

UF Scripps Biomedical Research will also build on Scripps Research’s longstanding commitment to training future generations of research scientists. The Florida branch of Skaggs Graduate School of Chemical and Biological Sciences continues to operate as part of Scripps Research’s bicoastal graduate program, with continued support from UF Health. It has approximately 85 doctoral students taught by faculty members in Florida and works closely with the graduate faculty at Scripps Research in California.

Additionally, UF Scripps Biomedical Research will launch a new program to foster scientific careers among recent college graduates. The Post-Baccalaureate Research and Education Program, or PREP, is an immersive, year-long research experience that equips recent bachelor’s graduates with additional academic and laboratory skills in preparation for applying to a high-calibre, research-oriented doctorate. programs. The deadline to apply to join the first PREP class is April 15.

UF Scripps Biomedical Research maintains its presence on the three-building, 30-acre campus in Jupiter, Florida, which opened in 2009. Scientists there joined UF faculty while maintaining an additional affiliate title of Scripps Research.

The Scripps Florida-UF Health integration was facilitated by Herbert Wertheim, a UF alumnus, Scripps Research board member, and honorary president of UF’s Herbert Wertheim College of Engineering.

Media contact: Doug Bennett at dougbennett@ufl.edu or 813-786-2164

Study sheds light on why immunodeficiency only affects one identical twin

Scientists have long wondered about the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukemia Research Institute in Spain and their collaborators has found that the answer lies both in alterations in immune cell-cell communication and in the epigenome, the host of biological processes that regulate how our genes work.

The study, published today (April 1, 2022) in Nature Communication, is the first cell atlas to categorize common variable immunodeficiency (CVID) at single-cell resolution. The researchers found that ‘communication problems’ resulting from defects in B cells and other types of immune cells impair the immune response, highlighting a number of pathways that are promising targets for epigenetic treatments. Furthermore, they also identified major defects in the epigenome.

Common Variable Immunodeficiency (CVID) encompasses a range of immune disorders caused by a reduced ability to produce protective antibodies, which makes the individual vulnerable to persistent or repeated infection. These people usually have low levels of immunoglobulins, more commonly called antibodies, due to problems with the B cells that create them.

Although identical twins share the same genome, most will be born with a small number of genetic and epigenetic differences and the number of variations will increase over their lifetime. But when a twin experiences a health problem that his sibling does not, in most cases, genetic differences alone cannot explain why it happened.

About 20% of CVID cases can be attributed to a defect in a gene associated with the disease. But with four out of five cases remaining largely unexplained, scientists predicted that other factors must be involved. This was confirmed by a recent study, which linked CVID to DNA methylation, an epigenetic process that ups or downs the level of a particular gene.1.

In this new study, researchers from the Wellcome Sanger Institute and the Josep Carreras Leukemia Research Institute generated single-cell data to investigate epigenetic factors involved in CVID. Samples were taken from a pair of identical twins, only one of whom suffered from CVID, as well as from a larger group of CVID patients and healthy individuals.

Analysis of identical twin participants revealed that not only did the brother with CVID have fewer B cells, but the B cell defects lead to epigenetic issues with DNA methylation, chromatin accessibility and transcriptional defects in memory B cells themselves.2. Additionally, the researchers discovered massive defects in the intercellular communication necessary for the normal functioning of the immune system.

Dr Javier Rodríguez-Ubreva, first author of the study from the Josep Carreras Leukemia Research Institute, said: “The human immune system is not a static entity and communication between immune cells is vital to that it works efficiently. individuals how cells talk to each other and from there identify where communication breaks down in individuals with Common Variable Immunodeficiency (CVID). B cells to mature and produce antibodies.”

The researchers compared the epigenetic changes and cell-to-cell communication problems found in the twin with CVID with a larger CVID cohort and found that the issues were the same, providing a strong model for characterizing the disease. The challenge now will be to use this knowledge to develop new treatments.

Dr Esteban Ballestar, lead author of the study from the Josep Carreras Leukemia Research Institute, said: “This is the first of many studies that will examine common variable immunodeficiency (CVID) and other primary immunodeficiencies with the aim of identifying new therapies for the treatment of these disorders We already have viable options, such as immunoglobulin replacement therapy, which I hope can be adapted to treat specific defects B lymphocytes that we have identified here.

In addition to immunoglobulin replacement therapy, epigenetic drugs can also be used to treat immune disorders and the results of this study highlight a number of biological pathways meriting further investigation for new drug targets.

Dr Roser Vento-Tormo, lead author of the Wellcome Sanger Institute study, said: “This is the first cell atlas to categorize common primary variable immunodeficiencies and will be a valuable contribution to the Human Cell Atlas initiative to map each cell type. in the human body. What this study in particular shows is how quickly Cell Atlas data can be applied to better understand specific health conditions and open up new avenues of treatment.

Remarks:

1 This previous study is available here: https://www.nature.com/articles/ncomms8335

2 Chromatin is a complex of DNA and proteins. It forms the structure in which genetic information is packed.

Funding:

This research was supported by Wellcome; the Josep Carreras Foundation; the Spanish Ministry of Science, Innovation and Universities; UK Biotechnology and Biological Sciences Research Council, Jeffrey Modell Foundation and Medical Research Council.

The Start-up Index: a fundraising tool for start-ups and biotech SMEs

0

The process of building a successful innovative business from scratch is an extremely difficult undertaking for entrepreneurs – each step is filled with challenges, like finding a solution that actually fills a gap in the market. The Technology Innovation Agency (TIA) has partnered with the BIO Africa Start-up Index to provide support for start-up companies.

The index serves as a tool for the creation of new businesses by providing several sources of information on entrepreneurs. It establishes an ecosystem for start-ups that fosters strategic partnerships, attracts investment, promotes growth and stimulates the development of fledgling companies.

Start-ups within the BIO Africa ecosystem are listed in the Start-Up Index. In this way, the registered company has access to reference consulting services, exposure to international partners, financing and funding opportunities and connection to the BIO Africa Ecosystem network. It is essentially a virtual accelerator or incubator, with the following enterprise support services:

  • Market registration. Innovators Market Corner is a virtual e-commerce platform providing access to markets.
  • BIO Africa Academy, a training center offering various training and customized courses for entrepreneurs from some of the best business schools, such as Emory University’s Goizueta Business School. Additionally, it provides technical training opportunities through partners such as the International Center for Genetic Engineering and Biotechnology (ICGEB). There is also a BIO Africa Convention webinar series.
  • The Knowledge Resource Center is essentially an innovation exchange, providing up-to-date knowledge resources for scientists and innovators. It is organized by prominent local scientists and based at Emory University.
  • The Communication Hub, which underpins the ecosystem, provides advanced marketing, brand development and communication support to start-ups.

These services are provided at a subsidized cost to start-ups as part of the TIA’s mandate to build a vibrant local bioeconomy.

If your start-up is in the pharmaceutical or biotechnology sector, you can contact AfricaBio at [email protected] to learn more.

CapeBio technologies boost diagnostic capacity in Africa

Biotechnology has contributed to the development of more than 1,200 diagnostic tests used in clinical practice today. With just a blood sample or oral swab, many of these tests can diagnose conditions faster and with greater accuracy than ever before. Many of these diagnostic tools are now portable, allowing doctors to perform tests, interpret results, and determine treatment on the spot. These tools have had a profound effect on access to healthcare in Africa, where healthcare infrastructure is often underdeveloped.

CapeBio, a South African biotechnology company, has received approval to manufacture polymerase chain reaction (PCR) Covid-19 test kits from the South African Health Products Regulatory Authority ( SAHPRA). The test kits, which were co-developed by CapeBio and the Council for Scientific and Industrial Research (CSIR), will help reduce South Africa’s dependence on imports by making the kits more accessible to the country and to the rest of the continent.

In a radio interview, CapeBio CEO Daniel Ndima said the kits will help South Africa become less dependent on imports: “Yes, the product adds value to our country because it basically guarantees that there is an adequate supply of these test kits. I would also like to clarify that while we normally use the term rapid test to refer to home antibody tests, this one is a polymerase chain reaction test that allows people to receive results faster.

By developing local value chains, Ndima hopes to help make South Africa and the continent better able to deal with global challenges such as the Covid-19 pandemic. He said global trade restrictions and the limits they have placed on Africa’s ability to respond appropriately to the pandemic indicate the need to strengthen the local research, development and manufacturing industry. biochemicals. Beyond building Africa’s capacity to manage crises like pandemics, Ndima wants to improve the overall quality of life for South Africans through scientific advances, as well as create jobs for life science graduates. Unemployed.

CapeBio continues to pioneer genome editing and genome engineering in Africa by providing novel proteins and enzymes derived from native microbial diversity, namely The Cape Floral Kingdom. Officially launched as a private company in 2018 through a successful research and development project funded by CSIR and the Department of Science and Innovation (DSI), CapeBio is still shaping the African continent for the future using innovative biodiscovery to unleash the power of ancient genomic data.

Sawubona Mycelium promotes responsible and sustainable organic production

Sawubona Mycelium is a biotechnology company that recognizes the power of microorganisms to create sustainable and responsible manufacturing. The company was founded by Neo and Busi Moloi in 2018, with the aim of combining their passions for fermentation and medicinal mushrooms. Using fermentation, the two biotechnologists intend to produce mushroom-derived bioactives that are useful in a variety of applications.

For the first time in the history of Africa, Sawubona Mycelium produced 800 liters of liquid cultured mushrooms called Enokitake for bio-based cosmetics. CSIR has helped Sawubona Mycelium scale up the production of high-value products from Enokitake mycelium using a liquid culture method, bringing the global mega-trend of mushroom ingredients to South Africa with the help of CSIR Biomanufacturing Industrial Development Center (BIDC).

“As fermentation scientists, we have been interested in using fungi to develop high-value ingredients for cosmetics, functional foods, and pharmaceutical applications. When we finally found an approach to achieve this thanks to the support received from the Technology Innovation Agency, we felt that as part of our process of scaling up for commercialization, it would be important to test the efficacy of our product at scale,” said Neo Moloi of Sawubona Mycelium. As part of the production process, the company also produced enough biomass to convert it into dried mushroom powder, useful in food products such as thickeners and supplements in the form of immuno-boosters.

“We are currently working on a purification method that will be suitable for the cosmeceutical industry. The incorporation of active ingredients derived from fungi into skin care products to produce clean, more effective and safe to use beauty products has become a global phenomenon. As Sawubona Mycelium, we aim to continue harnessing natural flora and botanical extracts, which also includes the use of native southern African fungi to produce fermented bio-based cosmetic products for the South African market,” said said Busi Moloi.

ICGEB and BIO Africa host the first international edition of “ICGEB Science & the City South Africa”

Concerns about an underinformed or misinformed public on scientific issues are not new, as disconnects between public opinion and scientific consensus on topics such as vaccine safety, evolution and climate change exist. since a long time. In recent times, we are also facing the challenge of an overabundance of misinformation, where false or inaccurate information is presented as fact.

On March 29, 2022, the International Center for Genetic Engineering and Biotechnology (ICGEB), in partnership with the BIO Africa Convention, hosted its first international edition of ICGEB Science & the City at the Center for the Book in Cape Town.

Moderated by Dr Nhlanhla Msomi, ICGEB South African Governor, AfricaBio Chairman and biotechnology expert, the panel of experts included Dr Lara Donaldson, ICGEB Cape Town Group Leader, Systems Biology plants ; Professor Mosa Moshabela, Deputy Vice-Chancellor, Research and Innovation at the University of KwaZulu-Natal; Dr David Phaho, Deputy Vice Chancellor, Research, Technology Innovation and Partnerships at Cape Peninsula University of Technology; and Dr. Rasigan Maharajh, Chief Director of the Economic Research and Innovation Institute at Tshwane University of Technology.

The launch event theme was Myth Busters: Discrediting Misinformation in Science, and covered the following key topics:

  • The importance of discrediting misinformation in science
  • The role of science and scientists in the fight against disinformation
  • The impact of misinformation on the public health system
  • Common Misinformation/Myths and How to Eliminate Them
  • Tools to distinguish between facts and fake news – breaking the cycle of misinformation – which sources are trustworthy.

Science has a specific role and a variety of functions to benefit our society, such as creating new knowledge, improving education and increasing the quality of our lives. To face the challenges of sustainable development, governments and citizens must understand the language of science and acquire a scientific culture.

Amid the rise of fake news, fake science news is an underexplored type of news that poses threats. Although fake science news can spread like wildfire on social media, we all have a responsibility to think before we share content, because fake news is harmful; it creates anxiety and undermines public confidence in national authorities.

According to Donaldson and Phaho, when confronted with what we suspect is fake news, we can:

  • Judgment and verification of facts;
  • Debunk some of the myths caused by fake news;
  • Speak up when you see misinformation;
  • Present the facts in simple and
  • Use tools to spot techniques used to create fake news.

Moshabela added that “public health systems are complex” and there are many ways to get the public to understand scientific language with a focus on providing scientists and scientific institutions with opportunities and resources. to have meaningful conversations with the public, such as:

  • Increase awareness and understanding of public engagement and its benefits
  • Demonstrate excellence in public engagement
  • Train scientists to communicate with non-scientific audiences, and
  • Capacity building to conduct public participation in scientific activities.

One of the most important takeaways from the event is the need to connect scientific research to the public. Ongoing conversations between science and society need to be convened and facilitated to leverage relevant information and expertise from multiple perspectives.

If your start-up is in the Pharmaceutical and Biotechnology sector, you can contact AfricaBio at [email protected] to learn more.

Brown is admitting 2,546 students to the undergraduate class of 2026

0

Students in the admitted class of 2026 hail from all 50 U.S. states and countries around the world, with the largest number of students from China, the United Kingdom, Canada, India, Singapore, and Ukraine , respectively.

A growing set of financial aid initiatives to support Brown students has also played a role in significantly increasing applications, Powell said, and encouraging students from an increasingly wide range of backgrounds. financial to apply. Building on the work of the Brown Promise initiative, which replaced loans with scholarship funds in all University-conditional undergraduate financial aid scholarships four years ago, the University will cover full tuition for families earning $125,000 or less with typical assets beginning in the 2022-23 academic year. This change — the result of eliminating consideration of home equity in Brown’s financial aid calculations — is expected to provide thousands of additional dollars in average annual scholarships for aided students and increase the number of families who will receive assistance from Brown.

Separately, two years after expanding its blind-needs policy to military veterans in a bid to double veteran enrollment, Brown this year set a goal to expand blind-needs consideration to international students. . The University is increasing its financial aid budget for international undergraduate students, with the goal of going completely blind for international students starting at Brown in the fall of 2025. This would eliminate the ability or inability to pay tuition. tuition as a factor in the admissions process, placing Brown in a very small group of colleges and universities nationwide that are blind to the needs of international students.

Of the 2,546 students admitted by Brown, 96 percent are in the top 10 percent of their high school classes. Nineteen students were admitted to the Brown-RISD Dual Degree Program and 84 students were admitted to the Liberal Medical Education Program, an eight-year program leading to both a bachelor’s degree and an MD from Brown’s Warren Alpert Medical School.

While all have the opportunity to explore degree programs within Brown’s Open Curriculum, the top 15 concentrations considered by students include: Engineering/Biomedical Engineering; computing; economy; political science; biology; biochemistry and molecular biology; international and public affairs; neuroscience; applied mathematics; public health; psychology; health and human biology; physics, English; and history.

Applicants began logging into a secure website at 7 p.m. Eastern Time on Thursday, March 31 to find out the status of their applications. Following the release of admissions decisions, Brown will host three admitted student programs on campus for the Class of 2026. A Day on College Hill (ADOCH) sessions will be held on April 8, 13, and 22 for students who choose to visit Providence in person. . The University will also continue to support admitted students with virtual programming that provides opportunities to explore, learn, ask questions, and connect on campus while showcasing Brown’s vibrant community.

Admitted students have until Monday, May 2 to accept the University’s offer of admission. Brown anticipates a cohort of approximately 1,700 students, including 15 admissions to the Brown/RISD dual degree.

AVANTIS INVESTORS LAUNCHES ITS FIRST RESPONSIBLE ETFS

0

Launch of Responsible US Equity ETF and Responsible International Equity ETF the 17th of Marchwhile the Responsible Emerging Markets ETF is listed today.

“We are excited to offer three new, broadly diversified and tax-efficient ETFs to enable investors to make sustainable investments – socially and environmentally responsible investments,” said Edouard Repetto, Chief Investment Officer of Avantis. “We’ve priced these strategies in line with our conventional equity ETFs because we believe investors hoping to integrate their ESG considerations into their investment portfolios shouldn’t face higher fees.”

The ETFs will be co-managed by Repetto and Senior Portfolio Managers Matthew Dubin, Michael Firestein, Daniel OngCFAand Ted Randall.

Here is information on the new ETFs:

name

Expense ratio

Strategy

Avantis Responsible US Equity ETF

.15%

The fund invests primarily in a diversified group of US companies across all market sectors and industry groups. The fund may invest in companies of any market capitalisation.

The portfolio management team limits its investment universe of companies by selecting those that raise concerns based on the team’s assessment of several ESG metrics.

Avantis Responsible International Equity ETF

.23%

The fund invests primarily in a diversified group of non-US companies across countries, market sectors and industry groups. The fund may invest in companies of any market capitalization.

The portfolio management team limits its investment universe of companies by selecting those that raise concerns based on the team’s assessment of several ESG metrics.

Avantis Responsible Emerging Markets Equity ETF

.33%

The fund invests primarily in a diversified group of emerging market-related companies across all market sectors, industry groups and countries. The fund may invest in companies of any market capitalization. The portfolio management team limits its investment universe of companies by selecting those that raise concerns based on the team’s assessment of several ESG metrics.

The new funds join Avantis Investors’ lineup of 11 ETFs, most of which have matching mutual funds: Avantis Core Fixed Income; Avantis Core Municipal Fixed Income; Avantis Emerging Markets Equity; Avantis International Equity; Avantis International Small Cap Value; Avantis Short Term Fixed Income; Avantis US Equity; Avantis US Small Cap Value; Avantis International Large Cap Value ETF; Avantis Real Estate ETF; and Avantis US Large Cap Value ETF .

Avantis Investors, created to help clients achieve their investment goals with a focus on providing well-diversified investment solutions that fit seamlessly into asset allocations and combine the potential for added value with the indexing reliability, is led by Repetto and the COO Patrick KeatingCFA, CPA.

On Investments of the American Century
American Century Investments is a leading global asset manager focused on delivering investment results and building long-term client relationships while supporting cutting-edge medical research. Founded in 1958, American Century Investments’ 1,400 employees serve financial professionals, institutions, corporations and individual investors from offices located in new York; London; Frankfurt; hong kong; sydney; Mountain View, California.; and Kansas City, Mo. Jonathan S.Thomas is President and Chief Executive Officer, and victor zhang holds the position of Chief Investment Officer. Providing investment results to clients enables American Century Investments to distribute more than 40% of its dividends to the Stowers Institute for Medical Research, a 500-person nonprofit basic biomedical research organization. The Institute owns over 40% of American Century Investments and has received dividends from $1.8 billion since 2000. For more information about American Century Investments, visit www.americancentury.com.

*Assets under supervision at 09/02/2022

You should carefully consider the investment objectives, risks and charges and expenses of the fund before investing. The prospectus or simplified prospectus of the fund, which can be obtained by visiting www.AvantisInvestors.com or by calling 1-833-9AVANTIS, contains this and other fund information and should be read carefully before investing. Investments are subject to market risk.

Exchange-traded funds (ETFs) are bought and sold through exchange transactions at market price (not net asset value) and are not individually redeemed by the fund. Shares may trade at a premium or discount to their net asset value in the secondary market. Brokerage commissions will reduce returns.

AVSU, AVSD and AVSE only: The portfolio management team limits its investment universe of companies by selecting those of concern based on the team’s assessment of several environmental, social and corporate governance (ESG) measures . Portfolio managers use ESG data from third-party sources, along with proprietary ratings, to decide which stocks should be excluded due to ESG concerns. Because the portfolio managers select securities based on ESG characteristics, the fund may exclude securities from certain issuers or industry sectors for non-financial reasons and therefore the fund may behave differently or maintain a different profile. risk different from that of the market in general or compared to funds that do not use similar ESG screens. Investing based on ESG considerations can also prioritize long-term returns over short-term ones. Due to the lack of regulation and uniform reporting standards regarding the ESG characteristics of issuers, ESG data may be inconsistent or inaccurate from one source to another. Additionally, all relevant ESG data considered by the team may not be available for an issuer.

AVSU, AVSD and AVSE only: Historically, small cap stocks have been more volatile than stocks of larger, more established companies. Smaller companies may have limited resources, product lines and markets, and their securities may trade less frequently and in more limited volumes than securities of larger companies.

AVSD and AVSE Only: International investing involves special risks, such as political instability and currency fluctuations.

AVSE Only: International investing involves special risks, such as political instability and currency fluctuations. Investing in emerging markets may heighten these risks.

These funds are actively managed ETFs that do not seek to replicate the performance of any specific index. In determining whether to buy or sell a security, portfolio managers consider, among other things, various fund requirements and standards, as well as economic conditions, alternative investments, interest rates and various credit measures. If the portfolio manager’s considerations are inaccurate or misapplied, fund performance may suffer.

Investment returns and the principal value of securities investments will fluctuate. The value at redemption may be more or less than the original cost. Past performance is not indicative of future results.

This information is for educational purposes only and does not constitute tax advice. Please consult your tax advisor for more detailed information or advice regarding your personal situation.

  • IRS Circular 230 Disclosure: American Century Companies, Inc. and its affiliates do not provide tax advice. Accordingly, any discussion of U.S. tax matters contained herein (including any attachments) is not intended or written for use, and may not be used, in connection with the promotion, marketing or endorsement by anyone not affiliated with American Century Companies, Inc. of any matters discussed herein or for the purpose of avoiding US penalty taxes.

Exchange Traded Funds (ETFs): Foreside Fund Services, LLC, distributor, not affiliated with American Century Investment Services, Inc.

Mutual Funds: American Century Investments Services, Inc., Distributor

©2022 American Century Proprietary Holdings, Inc. All rights reserved.

Contact: Laura Kouri
(816) 516-7729
Media line
(816) 340-7033

SOURCE American Century Investments

Insilico Medicine identifies a potential double p

0

image: Insilico Medicine identifies potential dual-use therapeutic targets
to see Continued

1 credit

March 29, 2022, New York — Insilico Medicine, an end-to-end artificial intelligence (AI)-focused drug discovery company, today announced that it has created a unique approach to identify potential drug targets with dual use for aging and age-associated diseases with PandaOmics, its proprietary AI-based biological target discovery platform. Research supporting this approach has been published in Aging (March 2022).

People all over the world are living longer. According to the World Health Organization (WHO), one in six people worldwide will be 60 or older by 2030. However, aging increases vulnerability to a wide range of human disorders, including cancers, diabetes , cardiovascular diseases and neurodegenerative diseases. . About two-thirds of the 150,000 people who die every day worldwide suffer from age-related diseases.

Recent research on aging suggests that targeting the aging process itself could improve many age-related pathologies. The proposed research by Insilico Medicine scientists aims to use AI to identify potential targets that are implicated in multiple age-associated diseases and also play a role in the fundamental biology of aging. The results of this research may have substantial benefits for the discovery and development of therapies for aging and age-related diseases.

Insilico Medicine used its PandaOmics platform to perform target identification for 14 age-associated diseases (AADs) and 19 non-age-associated diseases (NAADs) across multiple disease domains to identify associated disease targets at the age. In a comprehensive assessment, 145 genes were considered potential aging-related targets and mapped into corresponding aging characteristics, including 69 high-confidence targets with high potential pharmacogability, 48 medium novel targets with high pharmacogability medium to high potential, and 28 very novel targets with medium potential pharmacogability.

“The development of interventions that target multiple age-associated diseases and aging itself could lead to unprecedented health benefits, not only by treating diseases, but also by extending lifespan and providing new candidates for drug reuse,” said Alex Zhavoronkov PhD, CEO of Insilico Medicine. “The current study also demonstrated the power of the PandaOmics AI-powered target discovery platform to identify novel dual-use targets not only for specific disorders, but for multiple disease types, enabling biologists and clinicians to further investigate their therapeutic potential in a cost- and time-saving way. »

A list of potential dual-use aging therapeutic targets for drug discovery has been disclosed in the article.

The paper is available here: https://www.aging-us.com/article/203960/text

About PandaOmics

PandaOmics enables systems biology research on multiple data types, including multi-omics and textual data, and deploys AI-powered analytical capabilities to facilitate the rapid discovery of new targets or the prioritization of established targets against existing ones. diseases of interest. PandaOmics can serve as a business intelligence tool at the target identification stage of drug discovery to optimize portfolio development with strategies that can maximize novelty and trust.

About Insilico Medicine

Insilico Medicine, an end-to-end clinical-stage artificial intelligence (AI)-focused drug discovery company, connects clinical trial biology, chemistry and analytics using novel AI systems. generation. The company has developed AI platforms that use deep generative models, reinforcement learning, transformers and other modern machine learning techniques to discover new targets and design new molecular structures with desired properties. Insilico Medicine offers breakthrough solutions to discover and develop innovative drugs against cancer, fibrosis, immunity, central nervous system (CNS) diseases and age-related diseases.

For more information, visit www.insilico.com.

For media inquiries, please contact media@insilicomedicine.com.


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

UCF recognized for academic excellence and the advancement of professional careers in engineering, research and innovation

0

UCF is one of the top universities in the nation for students who want to further their education and advance their careers in a wide range of professional fields, including emergency and crisis management, high-tech research, and fields engineering.

Take it from US News & World Report’s 2023 Best Graduate School Rankings, which is based on in-depth reputation and statistical surveys of more than 800 institutions. Located in one of the nation’s major metropolitan cities, UCF is close to a wealth of internship and employment opportunities with many of the nation’s most successful companies.

The rankings are the latest recognition of UCF’s commitment to academic excellence, its commitment to advancing students’ professional careers, and an institutional priority to make significant societal contributions. Earlier this year, US News & World Report recognized UCF as one of the top 10 universities in the nation for Online Bachelor Programs. Last fall, the publication named UCF a national leader in innovation and social mobility. Taken together, the rankings show that UCF is the perfect place for those looking to take their professional career to the next level.

In the annual rankings announced today, UCF Master in Emergency and Crisis Management #3 ranked program in the nation, placing in the nation’s top ten for the fifth year in a row. UCF was No. 12 for Atomic/molecular/optical physics. Four fields of study within public administration ranked among the top 40 in the country. Nine UCF engineering programs were in the top 50 for public institutions and the top 100 for all institutions, public and private. Overall, nearly 40 UCF programs were ranked among the top 150 in their respective fields.

Emergency and crisis management ranked top three – again

Ranking third in the country, the Master in Emergency and Crisis Management The program is the highest ranked program in the university. The program has been UCF’s highest-ranked graduate program for the past four years. For the fifth straight year it has ranked in the top 10, the UCF program is the only Florida program to rank in the top 10 in this category for 2023.

Earning an average annual salary of approximately $75,000, demand for emergency management practitioners is expected to increase 4% through 2029. UCF’s program prepares its students, both those working in the industry and those seeking to enter it, to secure management roles in prominent local and national entities. These include the City of Orlando, Lockheed Martin, the National Military Command Center, the US Department of Homeland Security and the Seminole County Office of Emergency Management.

Program leadership says UCF prepares its students to meet job demands like few other universities. UCF focuses on a whole community approach to all phases of emergency management while emphasizing ethical and culturally competent leadership in public service.

“The ever-increasing number of man-made and natural disasters necessitates the need for professional emergency management practitioners to guide communities across our nation through times of tragedy and distress,”

– Qian Hu, program director

“The ever-increasing number of man-made and natural disasters necessitates the need for professional emergency management practitioners to guide communities in our country through times of tragedy and distress,” says Qian Hu, Program Director and associate professor in the UCF School of Public Administration. . “For nearly 20 years, UCF has been training individuals to meet the demands of threats to our homeland. At UCF, our students receive hands-on, innovative experience that qualifies them to be leaders in crisis management anywhere in the world. »

In addition to the Emergency and Crisis Management Graduate Program, the following academic areas within the UCF School of Public Administration have been ranked in the top 40 in their respective fields:

No. 13 – Non-profit management

No. 30 – Public finances

No. 29 – Public management and leadership

No. 39 – Best Public Administration, Overall

A national research leader:

Signaling the strength of interdisciplinary research at UCF, the university ranked #12 in the Atomic/Molecular/Optical (AMO) Category. The ranking recognizes the high quality of collaborative teaching and research conducted by UCF’s Department of Physics as well as CREOL, the College of Optics and Photonics. In ranking 12th, UCF finished in a statistical tie with such notable private research universities as the University of Chicago, Duke, and Princeton.

“UCF’s consistent and ongoing investments in AMO physics and laser science, both in the Physics Department and at CREOL, enable our students to work and collaborate on interdisciplinary research at the forefront of these fields” ,

-Zenghu Chang, Pegasus Professor of Physics, Optics and Photonics

Earlier this year, UCF physics professor Michael Chini led a UCF team that developed the world’s first optical oscilloscope, an instrument capable of measuring the electric field of light, based on materials completely solid. A research team led by physics professor Li Fang has received a nearly $2 million grant from the US National Science Foundation to develop a first-of-its-kind infrared laser system. A team of physics and CREOL professors won UCF an invitation to join LaserNetUS, a US Department of Energy consortium of the nation’s premier laser facilities. Recently, ficonTEC, a world leader in photonics manufacturing based in Germany, partnered with UCF to establish a site in Central Florida and provide CREOL students and researchers with access to sophisticated industrial production tools through a new laboratory in the college.

“UCF’s consistent and ongoing investments in AMO physics and laser sciences, both in the Department of Physics and CREOL, enable our students to work and collaborate on interdisciplinary research at the forefront of these fields” , says Zenghu Chang, Pegasus Professor of Physics and Optics and Photonics

Overall, 2021 has been a banner year for UCF’s research efforts. From innovative jet propulsion systems to explorations into the behaviors of office spaces, UCF’s research efforts focused on work that combated threats and sought opportunities to advance society. An internationally recognized space pioneer, UCF conducts innovative applied research, including more than 12 projects related to NASA’s Artemis mission. Last year, UCF ranked 25th among public universities for producing patents and 60th in the world, according to the National Academy of Inventors and the Intellectual Property Owners Association.

A leader in engineering:

Among engineering programs, UCF’s College of Engineering and Computer Science ranked #43 in public institutions and #73 overall. The university ranked ahead of several other institutions in Florida, including Embry-Riddle Aeronautical University, FAMU-FSU College of Engineering, University of Miami, and University of South Florida.

Nine individual engineering programs and fields were ranked among the top 50 among public institutions. They have all been ranked in the top 100 among public and private institutions. The computer science program saw the college’s biggest one-year national leap, rising eleven spots to No. 69 overall.

A complete list of UCF Engineering Rankings follows:

No. 36 – Industrial Engineering (No. 26, among public institutions nationwide)

No. 49 – Materials Science and Engineering (No. 31, among public institutions nationwide)

No. 50 – Computer Engineering (No. 29, among public institutions in the country)

No. 53 – Electrical Engineering (No. 30, among public institutions in the country)

No. 55 – Aerospace Engineering (No. 36, among public institutions nationwide)

No. 66 – Environmental Engineering (No. 41, among public institutions in the country)

No. 69 – Computer Science (No. 48, among public institutions in the country)

No. 73 – Global Engineering (No. 43, among public institutions in the country)

No. 75 – Mechanical Engineering (No. 45, among public institutions in the country)

Other UCF 2023 rankings:

Across the UCF community, a wide range of other programs and academic fields have been recognized among the nation’s top 150 in their respective fields. They were:

#16 – Medical schools, with most graduates practicing in areas of shortage of medical professionals

No. 22 – Criminal Justice

No. 46 – Health Care Management

No. 52 – Nursing, Doctor of Practice

No. 55 – Speech therapy

No. 57 – Physiotherapy

No. 58 – Global Education

#72 – Statistics

No. 79 – Social work

No. 83 – Physics

No. 87 – Medical schools, research

No. 106 – Sociology

No. 110 – Global Mathematics

No. 115 – Global Chemistry

No. 120 – Clinical Psychology

No. 121 – Medical schools, with most graduates practicing in rural areas

No. 122 – English

No. 127 – Part-Time MBA

N° 131 – Global geology

No. 140 – Global Psychology

N° 144 – Global biology

###

A marine biologist obtains a grant to carry out monitoring

0

image: Adrienne Correa, a marine biologist and assistant professor of biosciences at Rice University, won a National Science Foundation CAREER award for following her lab’s 2021 discovery that coral predators may play a role in maintaining the health of coral reefs.
to see Continued

Credit: Brandon Martin/Rice University

HOUSTON – (March 28, 2022) – Rice University marine biologist Adrienne Correa has won a prestigious National Science Foundation CAREER award for following her lab’s 2021 discovery that coral predators may play an important role in maintaining healthy coral reefs.

The award comes as a marine heatwave on Australia’s Great Barrier Reef causes widespread coral bleaching, a stress response in which corals evict their symbiotic tenants, the algae that give them color and help to feed them. This is the fourth mass bleaching event on the Great Barrier Reef in the past seven years, and bleaching events around the world are increasing in frequency and severity. Bleaching degrades coral reefs, and Correa’s lab is looking for factors that can limit or reverse that damage.

In a surprising twist on coral reef symbiosis, Correa and his students discovered that the feces of coral-eating fish are highly concentrated with live microorganisms that are essential for coral health, and the activities of these fish could help baby corals grow and potentially help reefs respond. to climate change.

“What we’re really trying to figure out, zooming in to 50,000 feet, is ‘Do coral-eating fish droppings help corals survive? said Correa, an assistant professor in Rice’s Department of Biosciences.

The CAREER awards are highly competitive and include a five-year grant, this one for $982,000, to support early-career faculty who have the potential to serve as academic role models and leaders in research and education. The NSF began giving out the awards in 1995 and only awards about 500 each year across all disciplines. Correa is Rice’s 100th CAREER award and the 10th of 2022, the most the university has received in a year.

The symbiotic relationship between corals and dinoflagellate algae is central to Correa’s CAREER research. Each coral can potentially host multiple species of dinoflagellates, and Correa’s lab and others have shown that symbiont diversity can help corals survive stressful conditions like those associated with warming oceans.

About half of corals obtain their algal partners from their environment, rather than being born with them. Enter the coral-eating fish, which gather millions of symbionts by bite. Despite the damage these bites inflict on individual corals, their overall effect on reef health could be positive. To avoid being eaten by larger fish, coral predators rush from coral to coral between stings, and this constant movement could help them deliver concentrated packs of living symbionts each time they drop a pellet. of poop.

“If we find that the droppings of coral-eating fish are beneficial to corals, in terms of maintaining this symbiotic partnership, then we can start to leverage this information to mitigate damage to reefs,” Correa said. “For example, we could try to place more coral-eating fish on the reefs to propagate beneficial symbionts to the corals. This research could also give us a better understanding of how corals use the microbial probiotic solutions that researchers are currently testing.

Correa’s lab will test these ideas in experiments at Rice and the long-term ecological research station on the coral reefs of Mo’orea in French Polynesia.

“Every day, adult corals take in some symbionts and spit out others,” she said. “And sometimes the symbiotes they expel are healthy and in good shape; other times they are not. One of the questions is therefore “How important are the symbionts of fish excrement, compared to those released by corals?”

Under certain conditions, faecal symbionts might be more important to coral uptake and survival than symbionts discarded by other adult corals, and research recently funded by Correa is designed to unravel these conditions.

For example, Correa and his team want to know if symbionts in the droppings of coral predators can help reefs recover from bleaching.

A number of studies have shown that certain species of symbionts are better able to tolerate warming ocean conditions. Correa said many aspects of bleaching are not well understood, but there is evidence that corals are more likely to expel unhealthy symbionts that are struggling to survive.

“During bleaching conditions, some coral-eating fish have been observed to focus their feeding on corals that are not bleached,” Correa said. “It is possible that these fish collect and distribute symbionts that have beneficial adaptations to heat stress or are at least healthier. Not all corals can function with all types of symbionts, however, while coral-eating fish activity may help corals survive stress, it alone will not protect reefs from climate change.

His CAREER-funded research will test whether these coral-eating fish droppings help bleached corals survive and recover.

“We will compare the responses of corals exposed to both feces from coral-eating fish and feces from coral-eating fish as well as experimental controls,” Correa said. “We’ll see if droppings from coral-eating fish help corals improve faster or improve their chances of survival.”

The educational component of his research for the CAREER award has two components. Each summer, his lab will host a Houston Independent School District environmental science teacher who will help conduct research and use the experience to design classroom teaching modules. The grant also includes funds to help undergraduate students in the Rice Emerging Scholars Program work in the lab for multiple consecutive years.

Although the NSF grant does not include funds for RESP students to travel to Moorea, Correa said she would like to seek other funding to try to make this happen if students are interested.

“RESP students will really have a long-term, immersive experience in the lab, and I would be very happy to see them in the field as well,” she said. “Learning to deepen their research experience will help them focus on what scientifically excites them and show them that they can achieve it.”

-30-

Grant Information:

“CAREER: Testing the Effects of Predator-Derived Feces on Host Symbiont Acquisition and Health,” NSF Ocean Science Division.

https://www.nsf.gov/awardsearch/showAward?AWD_ID=2145472

Upload images:

https://news-network.rice.edu/news/files/2022/02/0214_CORREA-career-lg.jpg
CAPTION: Adrienne Correa, marine biologist and assistant professor of biosciences at Rice University, won a National Science Foundation CAREER award for following her lab’s 2021 discovery that coral predators may play a role in maintaining the health of coral reefs. (Photo by Brandon Marin/Rice University)

https://news-network.rice.edu/news/files/2022/03/0214_CORREA-career-cg1-lg.jpeg
CAPTION: Rice University graduate student Carsten Grupstra takes notes while tracking coral-eating fish in Mo’orea, French Polynesia, October 2020. (Photo by Alex Veglia/Rice University)

https://news-network.rice.edu/news/files/2022/03/0214_CORREA-career-chaetodon-lg.jpeg
CAPTION: Chaetodon lunulatus, a coral predator photographed in Mo’orea, French Polynesia, in October 2020. (Photo by Alex Veglia/Rice University)

Further information:

Correa Research Group: www.owlnet.rice.edu/~ac53/index.html

BioSciences at Rice: biosciences.rice.edu

Wiess School of Natural Sciences: naturalsciences.rice.edu

This press release can be viewed online at news.rice.edu.

Follow Rice News and Media Relations via Twitter @RiceUNews.

Located on a 300-acre wooded campus in Houston, Rice University is consistently ranked among the top 20 universities in the nation by US News & World Report. Rice has highly respected schools of architecture, business, continuing studies, engineering, humanities, music, natural sciences, and social sciences and is home to the Baker Institute for Public Policy. With 4,052 undergraduate students and 3,484 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6 to 1. Its residential college system creates close-knit communities and lifelong friendships, one reason for which Rice is ranked #1 for many race/class interactions and #1 for quality of life by the Princeton Review. Rice is also ranked as the best value among private universities by Kiplinger’s Personal Finance.


NUS-Monash University collaboration produces universal flu vaccine candidate

0

Assoc Prof Sylvie Alonso (L) and Assoc Prof Mireille Lahoud (R)

Influenza, commonly referred to as “the flu”, is a major global public health problem and a huge economic burden on societies. Seasonal influenza epidemics affect between 13 and 100 million people each year, including three to five million cases of severe illness and 300,000 to 600,000 deaths worldwide. This represents a major global public health concern and an extraordinary economic burden for all societies. Pandemics are less common, but they are generally more severe and pose a greater threat. Over the past century, there have been at least four devastating pandemics caused by the influenza A virus that have claimed the lives of hundreds of millions of people.

Although vaccination is arguably the most effective way to prevent influenza, current vaccination strategies suffer from certain limitations, the main one requiring that current influenza vaccines be updated annually to match circulating strains. This results in low vaccination coverage rates and low coverage due to inaccurate prediction of circulating strains. Widely protective and “universal” influenza vaccines that do not need to be updated annually have therefore been sought.

The highly conserved M2e peptide is one of the leading universal candidates for influenza; this peptide shares a sequence conserved with nearly all known human strains of influenza A. However, its limited ability to elicit a strong and durable immune response has been a major obstacle to its clinical development.

Researchers from the Yong Loo Lin School of Medicine at the National University of Singapore and Monash University in Melbourne published an article in the latest issue of Proceedings of the National Academy of Sciences of the United States of America where they successfully leveraged a novel vaccine platform to deliver M2e to immune cells. This allowed them to prove that a single immunization containing M2e was able to trigger long-lasting immune responses that could effectively protect against multiple strains of influenza.

The team was also able to demonstrate that this vaccination approach significantly enhanced protective immune responses in the context of pre-existing influenza immunity. This scenario is particularly relevant in adult and elderly populations, where individuals have been repeatedly exposed to influenza viruses in the past and have low levels of M2e-specific antibodies in their bloodstream.

This vaccine approach has the potential to minimize the amount of M2e vaccine antigen (substance that triggers the body’s immune response against itself) and the number of injections needed for effective and long-lasting protection. It also removes the need for strong adjuvants (a substance that enhances the body’s immune response to an antigen), thereby reducing potential side effects, especially in more vulnerable populations.

Beyond influenza, this vaccine platform could be used to fight a multitude of diseases, including infectious diseases such as COVID-19. The current COVID-19 pandemic has highlighted the importance of developing versatile and powerful platforms for the rapid deployment of vaccines against all highly virulent diseases. This new discovery could lend itself to the further development of vaccines against this new disease or any other future disease. The team is currently working on a COVID-19 vaccine candidate using the same strategy.

“This trip has been very exciting. All of this work is the result of a strong, long-standing partnership with Assistant Professor Mireille Lahoud of Monash University’s Biomedicine Discovery Institute (BDI) and support from both institutions,” said Associate Professor Sylvie Alonso of NUS. Medical. Assoc Prof Alonso is the co-director of the Infectious Diseases Translational Research Program (ID TRP) at the school and has a keen interest in vaccines and therapeutics.

“We are delighted to continue our strong collaboration with Interim Professor Sylvie Alonso at NUS. In the world we live in, this vaccine platform offers a key opportunity to develop vaccines and immunotherapies to address future global health threats,” said Associate Professor Mireille Lahoud, who leads the Immunoreceptor Laboratory. dendritic cells with Monash BDI.

“A Single Shot Vaccine Approach for the Universal Influenza A Vaccine Candidate M2e” is published online at: http://www.pnas.org with DOI number 10.1073/pnas.2025607119.

Current flu vaccines have shortcomings (Image credit: NUS Yong Loo Lin School of Medicine)


For media inquiries, please contact:

Gwen KHOO

Assistant Director, Communications
Yong Loo Lin School of Medicine
national university of singapore

Tel: +65 8368 2356

Email: gwen.khoo@nus.edu.sg

About National University of Singapore (NUS)

The National University of Singapore (NUS) is Singapore’s flagship university, offering a holistic approach to education, research and entrepreneurship, with an emphasis on Asian perspectives and expertise. We have 17 faculties across three campuses in Singapore, with over 40,000 students from 100 countries enriching our vibrant and diverse campus community. We have also implemented our NUS Overseas Colleges program in over 15 cities around the world.

Our multidisciplinary and hands-on approach to education, research and entrepreneurship enables us to work closely with industry, government and academia to solve critical and complex issues affecting Asia and the world. Researchers from our faculties, 30 university-level research institutes, research centers of excellence and corporate laboratories focus on topics such as energy; environmental and urban sustainability; disease treatment and prevention; active aging; advanced materials; risk management and resilience of financial systems; Asian studies; and Smart Nation capabilities such as artificial intelligence, data science, operations research and cybersecurity.

For more information about NUS, please visit www.nus.edu.sg

About NUS Yong Loo Lin School of Medicine (NUS Medicine)

NUS Yong Loo Lin School of Medicine is Singapore’s first and largest medical school. Our enduring mission is centered on developing highly competent, values-driven, and inspired healthcare professionals to transform the practice of medicine and improve health worldwide.

Through a dynamic and forward-looking five-year program that is interdisciplinary and interprofessional in nature, our students have a holistic learning experience that exposes them to multiple facets of healthcare and prepares them to become visionary leaders and compassionate doctors and nurses. of tomorrow. Since the founding of the School in 1905, more than 12,000 graduates have passed through our doors.

In our pursuit of health for all, our strategic research programs focus on innovative, cutting-edge biomedical research with collaborators around the world to deliver high-impact solutions to benefit human lives.

The school is the oldest tertiary institution of the National University of Singapore and a founding institutional member of the National University Health System. It is one of the leading medical schools in Asia and ranks among the best in the world (Times Higher Education World University Rankings 2022 by subject and Quacquarelli Symonds (QS) World University Rankings by subject 2021).

For more information on NUS medicine, please visit http://nusmedicine.nus.edu.sg

About the Monash Biomedicine Discovery Institute at Monash University

Committed to making the discoveries that will alleviate the future burden of disease, Monash University’s Monash Biomedicine Discovery Institute brings together more than 120 world-class research teams. Spanning seven discovery programs in the fields of cancer, cardiovascular disease, development and stem cells, infections, immunity, metabolism, diabetes and obesity, and neuroscience, Monash BDI is one of Australia’s largest biomedical research institutes. Our researchers are supported by world-class technology and infrastructure, and partner with industry, clinicians and researchers around the world to improve lives through discovery.

USBiological (USA), Abbexa Ltd (UK), Biobyt (UK), Lifespan Biosciences (USA), Boster Biological Technology (USA), etc. – ChattTenn Sports

0

crimp nipples market

Proteoglycans (Mucoproteins) Market: Key Insights

The latest research report, titled “Global Proteoglycans (Mucoproteins) Market Insights 2022 and Forecast 2028, this includes an overview and an in-depth study of the factors which are considered to have a greater influence on the future development of the market, such as Market Size, Market Share, Different Industry Dynamics, Proteoglycans (Mucoproteins) Market Companies, Country Country Markets Regional Analysis, Value Chain Analysis, Consumption, Demand, Key Application Areas, etc. The study also talks about crucial pockets of the industry such as products or services offered, downstream domains, end users, historical data regarding revenue and sales, market background and more.

Proteoglycans (Mucoproteins) Market: Competition Landscape and Key Developments USBiological (US), Abbexa Ltd (UK), Biobyt (UK), Lifespan Biosciences (US), Boster Biological Technology (US), DSHB (US), Biosensis (US) United States), Aviva Systems Biology Corporation (United States), Bio-Rad (United States), Bioss Antibodies (United States), Fitzgerald Industries International (United States), Genetex (United States), Novus Biologicals (United States USA), Proteintech (USA), ProSci (USA), RayBiotech (USA), Thermo Fisher Scientific (USA) and more…

Get Exclusive Sample Pages of Proteoglycans (Mucoproteins) Market – COVID-19 Impact and Global Analysis with Strategic Insights on: https://www.globmarketreports.com/request-sample/208186

Our research analyst has put together a free copy of a sample PDF report to suit your research needs, also including an impact analysis of COVID-19 Proteoglycans (Mucoproteins) Market Size

The COVID-19 outbreak:The global Proteoglycans (Mucoproteins) market study covers the current status, percentage share, future patterns, development rate, SWOT examination, sales channels, to anticipate the growth scenarios for years 2022-2028. It aims to recommend market analysis with respect to growth trends, prospects, and the contribution of players to the development of the market.

Market is split by Type, can be split into: Above 90% Above 95% Above 99% OtherThe market is split by Application, can be split into: Biopharmaceutical companies Hospitals Bioscience research institutions Other

Global Proteoglycans (Mucoproteins) Market by Geography:

Asia Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia and Australia)• Europe (Turkey, Germany, Russia UK, Italy, France, etc.)• North America (United States, Mexico and Canada.)• South America (Brazil, etc.)• The Middle East and Africa (GCC countries and Egypt.)

Years Considered to Estimate Market Size:Historical year: 2015-2022Year of reference : 2022Estimated year: 2022Forecast year: 2022-2028

Direct purchase of a copy of the Functional Protein Market Research at:https://www.globmarketreports.com/buynow/208186/global-Proteoglycan(Mucoproteins) Market-market

Reasons to buy:

  • Acquire strategically important competitor information, analysis and intelligence to formulate effective R&D strategies.
  • Recognize emerging players with a potentially strong product pipeline and create effective counter-strategies to gain competitive advantage.
  • Classify potential new customers or partners into the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying the best manufacturer.
  • Formulate corrective measures for pipeline projects by understanding pipeline depth of Proteoglycans (Mucoproteins) market.
  • Develop and design licensing and out-licensing strategies by identifying potential partners with the most attractive projects to enhance and expand business potential and reach.
  • The report will be updated with the latest data and delivered to you within 2-4 business days of ordering.
  • Suitable to support your internal and external presentations with reliable high quality data and analysis.
  • Create regional and national strategies based on local data and analysis.

Some highlights from the table of contents:

1. Proteoglycans (Mucoproteins) Market Overview1.1 Introduction1.2 Scope1.3 Assumptions1.4 Players Covered1.5 Market Analysis by Type1.5.1 Global Proteoglycans (Mucoproteins) Market Size Growth Rate by Type (2022-2028)1.5.2…1.6 Market by Application1 .6.1 Global Proteoglycan (Mucoproteins) Market Share by Application (2022-2028) 1.6.2 Application 12. Executive Summary3. Proteoglycans (Mucoproteins) Market Analysis by Type (History 2016-2022)3.1 Global Proteoglycans (Mucoproteins) Market Size (Million USD) Analysis 2016-20224. Proteoglycans (Mucoproteins) Market Analysis by Application (History 2016-2022)4.1 Global Nanoscale Smart Materials Market Size (Million USD) Analysis 2016-20225. Proteoglycans (Mucoproteins) Market Analysis by Regions (Historical 2016-2022)5.1 Global Proteoglycans (Mucoproteins) Market Size Analysis (Million USD) 2016-20225.1.1 Proteoglycans (Mucoproteins) Market Share by Regions (2016-2022)5.1.2 United States5.1.3 Europe5.1.4 China5 .1.5 Japan5.1.6 India5.1.7 Rest of the world6. Analysis of Key Companies/Company ProfileContinued………..

For more information with full table of contents: https://www.globmarketreports.com/industry-reports/208186/swage-nipples-market

Report customization: Global Market Reports provides customization of reports according to your needs. This report can be customized to meet your needs. Get in touch with our sales team, who will guarantee you get a report tailored to your needs.

Get Customization [email protected]: https://www.globmarketreports.com/request-customization/208186

Contact us:Glob Market Reports17224 S. Figueroa Street, Gardena, CA (CA) 90248, United StatesCall: +1 915 229 3004 (WE)+44 7452 242832 (UK)Website: www.globmarketreports.com

Waskom ISD Students Receive 7 ESC GT Summer Camp Scholarships | News

0

WASKOM – Two Waskom ISD Elementary students from the Gifted and Talented program have been selected to receive Region 7 Educational Services Center scholarships to pay for enrollment in the GT summer camp of their choice.

“I am so proud that LynnLee and Jaxon are receiving G/T Summer Scholarships. Both of these students work hard to excel on our campus. They are valued members of our campus community and contribute positively to their classrooms. They both deserve the awards. I look forward to hearing about your summer camp experiences. I know you will represent our campus and our district well. Well done,” Waskom Elementary Principal Andrew Jones said.

Jaxon Bower received a $150 scholarship to attend the Minecraft camp at LeTourneau University in Longview. In his application, Jaxon said he was creative and loved building things. Minecraft will allow him to use his imagination to create new structures. He would like to create and build (real things) one day. He is excited to learn new things about Minecraft and make new friends who have the same interests as him.

LynnLee Green received a $960 scholarship to attend the Adventures in Marine Biology marine camp in Galveston. On her application, LynnLee said, “I enjoy visiting aquariums, reading books, watching animal shows and meeting new people. This camp will help me learn more about marine biology and prepare me to become a future marine biologist.

LynnLee’s mother, Jenny Green, said LynnLee has always been infatuated with marine life. She’s been saying for three years that marine biology is what she’d like to do with her life and she can’t think of a better way to feed her spirit than a camp centered on what she loves.

Jaxon and LynnLee GT teacher Carrie Moro said, “I am thrilled with the opportunities these scholarships will provide for our students and look forward to hearing about their adventures. Waskom ISD is grateful to ESC 7 for providing our students with this opportunity/experience.

Waskom Elementary vice-principal Lauren Boone agreed.

“I’m incredibly proud of LynnLee and Jaxon for receiving scholarships for the summer camps they selected,” she said. “They are both very creative, leaders at Waskom Elementary School, and well deserving of this opportunity. I’m excited to see how they can use their talents and what they learn from these camps to grow as students. and gifted and talented learners.

“I am not a biologist”: Quotes of the week

0

Last week was dominated by Justice Ketanji Brown Jackson’s Supreme Court nomination hearing. Republican senators on the Senate Judiciary Committee questioned her on everything from her conviction in child pornography cases to critical race theory to her definition of a ‘woman’ during a three-day deadly encounter . Here are the quotes of the week.

“There was a big push on the left to weed out a candidate from my state. And I don’t like that very much.”
– South Carolina GOP senator. Lindsey Graham criticized an alleged left-leaning takedown of his preferred high court pick, Judge J. Michelle Childs, on the first day of Jackson’s Senate confirmation hearings.

“I’m not interested in trapping Judge Jackson. I’m interested in her response because I found during our time together that she was extremely thoughtful, extremely accomplished, and I suspect she has a coherent vision and explanation and way of thinking about it. that I can’t wait to hear, and I think she deserves the chance to talk about it.
– GOP senator from Missouri. Josh Haley on his line of questioning before Jackson’s hearing.

“No one is going to investigate your dating habits with teenagers. No one is going to ask you with mock severity, ‘Do you like beer?’ »
– Texas GOP senator. Ted Cruz returns at the controversial hearing of current judge Brett Kavanaugh.

“We’ve had 115 justices on the Supreme Court, and we shouldn’t diminish the accomplishments of most of those 108 white men. They were extraordinary patriots who helped shape this country. But now we’re witnessing the most high court of our country on a hopeful day like this.”
– Democratic Senator from New Jersey. Cory Booker takes note of the potentially historic appointment of Jackson, who would be the first black woman on the court.

“It is extremely humbling to be considered for Judge Breyer’s seat, and I know I could never fill his shoes. But if confirmed, I hope to carry on his spirit.”
Judge Ketanji Brown Jackson opening statement before his hearing in the Supreme Court.

“I am not a biologist.
jackson responses to Tennessee GOP Sen. Marsha Blackburn after the judge was asked to provide a definition of the word “woman”.

“Mr. President, I think you have on the whole provided both sides with an opportunity to be heard and to ask questions. But unfortunately I have noticed that after each round of questioning from this side of the aisle, you choose to editorialize and contradict the points being made by that side of the aisle.”
– Texas GOP senator. John Corny take Judiciary Committee Chairman Senator Dick Durbin is in charge of how he conducts the proceedings.

“How would you feel if I had received a letter from someone accusing you of something, a crime or misconduct, for weeks, and I gave it to Senator Durbin, just before the end of this hearing, and does not allow you to comment on the reproach? What would you think of that?”
Graham hinted at Kavanaugh’s treatment during his bruising confirmation hearing.

“I think the best way to deter people from using a computer and seeing thousands and hundreds – and over time, maybe millions, the population as a whole – of children being exploited and abused at every time someone clicks on it is putting their *a* in jail, not supervising their computer use.”
Graham tears to jackson for what he alleged were lenient sentences for child pornographers.

“The jackassery we often see here is partly down to people looking for short-term camera opportunities.”
– GOP senator from Nebraska. Ben Sasse makes a plea to keep the cameras out of the courtroom.

“I know the young senator from Texas needs to be on TV.”
– Democratic Senator from Vermont. Patrick Leahy fires a veiled shot at Cruz.

“It’s his decision based on the law. If you have spent time studying the Supreme Court Justice, this is the one studying correctly. If he sees that it does not respect the Constitution, he will vote against it. If that’s the Constitution, that’s what his job should be, that’s him.”
– House Minority Leader Kevin McCarthy says Supreme Court Justice Clarence Thomas shouldn’t have to recuse cases linked to the Jan. 6 riot on Capitol Hill despite news from his wife, Ginni Thomas, prompted former White House chief of staff Mark Meadows to press ahead with his actions in an attempt to nullify the presidential election of 2020.

“At least at the moment they don’t seem to want to pursue Kyiv so aggressively or, frankly, not at all. They are more focused on Donbass.
– A senior US defense official that Russia’s actions in Ukraine have met with fierce resistance.

“They canceled Joanne Rowling, the children’s author – her books are published all over the world – because she did not meet the requirements for women’s rights.”
– Russian President Vladimir Poutine insists his country is a victim of cancel culture – just like the Harry Potter author.

“Criticisms of Western cancel culture are perhaps no better made by those who are now massacring civilians for the crime of resistance, or imprisoning and poisoning their critics.”
JK Rowling seems to suggest she doesn’t need Putin to fight her battles.

“I was nose diving and kind of at the one yard line of where you don’t want to be for your family and your future.”
– WWE Legend Triple H reveals how much he died of a heart attack in September. He revealed that he had retired from in-ring fighting.

College retains Academic Bowl title after latest round of sudden death

0
March 25, 2022

Team Maroon from the College of Liberal Arts and Sciences emerged victorious in the 2022 ASU Academic Bowl, beating Team WP Carey School of Business in a seven-round final with a score of 205-105 Thursday night at the campus of Temple.

The Annual Academic Bowl is a three-day event held in the Student Pavilion. Each 15-minute round includes two teams of four; there were 10 teams in total.

A moderator asks two types of questions: “throwing” questions are worth 10 points each, and “bonus” questions are worth between 10 and 30 points. If each team answers a toss correctly, they will receive a bonus question.

The College Championship team included Malachi Vaughn, Grayson Billett, Ally Finkbeiner and Daniel Pace-Farr. At stake are bragging rights and scholarships: the top four teams share $50,000 in scholarships, the winners share $26,000 and the runners-up $13,000.

College Maroon team members Malachi Vaughn (left) and Ally Finkbeiner watch Daniel Pace-Farr and Grayson Billett answer a question during the 2022 ASU Academic Bowl Thursday at the Student Pavilion. Photo by Charlie Leight/ASU News

The College of Liberal Arts and Sciences entered the sixth round with an advantage and were one win away from being named champions, but WP Carey School of Business forced a sudden death final in the seventh round.

Billett, a first-year actuarial science student, said he participated because he wanted to represent the Order to the highest standards.

“This victory is incredible; it justifies everything I do here at ASU and what the school stands for – the values ​​and the academic education they provide,” Billett said. “It’s just great to have been able to do that with my team.”

For Finkbeiner, a second-year student in biological sciences (conservation biology and ecology) and economics, this was her first participation. She said it was an unforgettable experience.

“I think the best part of this experience has been meeting new people, and it means a lot to be part of this team,” she said.

A student behind a desk frowns as he reacts to a bad question

Jaik Havlick of the WP Carey School of Business team shows his frustration during Thursday night’s finale. Photo by Charlie Leight/ASU News

Prior to the Academic Bowl, Finkbeiner had participated in school geography bees and wanted to experience a similar event like this at the college level.

“I love being on stage, like asking your question properly. You kind of get a little rush of thrills, and it really boosts your confidence,” she said.

Due to the pandemic, there had been no Academic Bowl the previous two years. The College had won the most recent Academic Bowl before that.

Pace-Farr, a senior math and chemistry student, was part of the 2019 team that won the grand prize. He said he was happy that his team was able to “continue the legacy they left behind in 2019”.

“I’m happy that we were able to continue the program’s winning streak and that we were able to get everyone to compete in a competitive format,” Pace-Farr said.

Finkbeiner said the victory after the break meant a lot and that she hopes it will “encourage more people to join us in the years to come”.

Two students bump fists while standing behind desks.

A congratulatory punch between Daniel Pace-Farr and Grayson Billett shows victory is assured at the 2022 ASU Academic Bowl. Photo by Charlie Leight/ASU News

The winning team’s preparation process involved doing weekly practice for two hours each session, testing each other’s knowledge, and timing each question to get used to the pressure of the rounds. Pace-Farr introduced his teammates to the quiz-bowl format.

Vaughn, a freshman in Applied Mathematics for Life and Social Sciences, said he prepared for this moment by “collecting facts all his life and putting them to good use.”

“My favorite part is probably how many questions I was tested on, and therefore being able to test my knowledge in all sorts of different areas,” Vaughn said.

Finkbeiner said she got to know her teammates’ strengths and weaknesses during each training session and formed a close bond with them.

The team is looking forward to defending its title next year; until then, the College can enjoy its bragging rights.

Student teams stand on a stage

The four finalist teams – one from the WP Carey School of Business and the Ira A. Fulton Schools of Engineering, and two teams from the College of Liberal Arts and Sciences – pose for a photo after the 2022 ASU Academic Bowl on Thursday at the Student Pavilion at Temple. The top four teams shared $50,000 in prize money, with the winners sharing $26,000 and the runners-up winning $13,000. Third place received $7,000 and fourth place $4,000. Photo by Charlie Leight/ASU News

Top photo: The winners of the College Maroon team (L to R: Malachi Vaughn, Ally Finkbeiner, Daniel Pace-Farr and Grayson Billett) hold the President’s Cup after the 2022 ASU Academic Bowl on Thursday at the Student Pavilion on the Tempe Campus. The maroon team from the College of Liberal Arts and Sciences took top honors in a head-to-head with the WP Carey School of Business team. Four-person teams of college athletes competed in rounds of quick quizzes on topics ranging from political science to pop culture and everything in between. Photo by Charlie Leight/ASU News

AAMC responds to House GOP RFI on treatments

0

On March 18, the AAMC responded to a request for information (RFI) from the Subcommittee on Treatments of the Healthy Future Task Force, a group of House Republican lawmakers seeking input from stakeholders on a variety of policy issues. The response underscored the AAMC’s commitment to advancing medical research and innovation, as well as ensuring patient access to new drugs, therapies and treatments.

The letter to the subcommittee chairs, Reps. Bruce Westerman (R-Ark.), Brad Wenstrup (R-Ohio), and John Joyce (R-Ohio) highlighted key regulatory flexibilities that allowed providers to take advantage of technology and improve patient care, such as through telehealth, the acute hospital care at home program and telemonitoring of patients. The letter also underscored the need for sustained and predictable growth in funding for the National Institutes of Health (NIH) and other federal agencies that fund basic research, which is the foundation for treatments, diagnoses, preventative measures and innovative treatments.

The letter urged the subcommittee to work with the Centers for Medicare & Medicaid Services to explore new, alternative reimbursement models for curative therapies, while preserving and strengthening critical safety net programs like the underwriting program. 340B drugs and the Medicaid Drug Reimbursement Program. “A growing number of patients receiving care at AAMC member facilities cannot afford the cost of their treatment. … The AAMC supports efforts to reduce prescription drug costs and improve access to care for patients,” the letter states.

The response also urged the subcommittee to encourage the adoption of new and innovative drugs, devices and diagnostics through regulatory flexibility. Specifically, the AAMC recommended that the subcommittee permanently expand the telehealth flexibilities introduced during the COVID-19 public health emergency, which have expanded access to care for patients in rural and underprivileged communities. served. In addition, the letter recommended extending the waiver of the Acute Hospital Home Care Program, which gives hospitals the flexibility to provide care outside of the hospital setting. The letter pointed out: “As teaching hospitals have grown to meet the capacity demands imposed on them by the [public health emergency], [Acute Hospital Care at Home] have become a valuable resource for both alleviating capacity issues and providing patients with access to care.

Key recommendations were also presented to maintain U.S. leadership in medical research and innovation, including reliable growth in NIH funding. The letter observed, “To be able to meet future infectious disease challenges, the government must continuously invest in sustained and predictable growth in biomedical research funding, through the NIH as well as other research agencies. federal institutions that fund basic research, interdisciplinary work, and translational science. In addition, to increase the efficiency of medical research, the letter recommended that Congress avoid delayed appropriations cycles, which create significant uncertainty in NIH operational planning.

The response concluded by outlining key recommendations for increasing access to medical research and diversifying participation in clinical trials, including opportunities to reduce regulatory burden. research.

The letter advocated community-based research methods, which are instrumental in recruiting trial participants from historically marginalized communities. The letter stated: “The AAMC encourages community participation in the design, implementation and evaluation of clinical research and recommends the specific inclusion of local community partners in discussions regarding the improvement of public awareness of clinical trial opportunities.”

The Healthy Futures Task Force is one of the seven Republican task forces created by House Minority Leader Kevin McCarthy (R-Calif.) to identify problems facing the United States and develop policy solutions. The AAMC has previously responded to inquiries from the Modernization Sub-Committee and the Security Sub-Committee [refer to Washington Highlights, March 11, Feb. 11].

Updated Overview of Future Stills Market Trends, Scope, Top Players from 2016 to 2028

0

The Global Still image market The report emphasizes on a detailed understanding of some crucial factors such as size, share, sales, forecasted trends, supply, production, demand, industry, and CAGR to provide a comprehensive perspective of the overall market. Further, the report also highlights challenges impeding market growth and expansion strategies employed by leading companies in the “Still Images Market”.

The Global Still Images market research report analyzes the main players in key regions such as North America, South America, Middle East and Africa, Asia-Pacific. Provides insights and expert analysis on important market trends and consumer behaviors, as well as insights into key market data and brands. It also provides all the easily digestible information.

Get Sample Full PDF Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://reportsglobe.com/download-sample/?rid=311457

The authors of the report draw up an encyclopedic assessment of the most important regional markets and their evolution in recent years. Readers are provided with accurate facts and figures on the Still Imagery market and its important factors such as consumption, production, revenue growth, and CAGR. The report also shares gross margin, market share, attractiveness index, and value and volume growth for all segments studied by analysts. It highlights key developments, product portfolio, markets served and other areas depicting business growth of major companies profiled in the report.

The report has been prepared using the latest primary and secondary research methods and tools. Our analysts rely on government documents, white papers, press releases, reliable investor information, financial and quarterly reports, and public and private interviews to gather data and information about the market in which they operate.

Still Image Market Segmentation:

Still Image Market, By Application (2016-2027)

  • Royalty Free (RF)
  • Right-Handed (RM)

Still Image Market, By Product (2016-2027)

Key Players Operating in the Still Images Market:

  • 123RF
  • Adobe Stock
  • The time of dreams
  • Getty Images
  • Shutterstock
  • Alamy
  • AP pictures
  • Can store photos
  • Depositphotos
  • Dissolve
  • Envato
  • Photo search
  • PIXTA
  • Pond5

The Still Images Market report has been segregated into distinct categories such as product type, application, end-user, and region. Each segment is rated based on CAGR, participation, and growth potential. In the regional analysis, the report highlights the potential region, which is expected to generate opportunities in the global Keyword Market in the coming years. This segment analysis is sure to prove to be a useful tool for readers, stakeholders, and market players to get a complete picture of the global Keyword Market and its growth potential in the coming years.

Get | Discount on the purchase of this report @ https://reportsglobe.com/ask-for-discount/?rid=311457

Scope of the Still Images Market Report

ATTRIBUTES

The description

ESTIMATED YEAR

2022

YEAR OF REFERENCE

2021



















previous post
E-Learning Market Overview, High Growth Opportunities, Segmentation, Trends by 2022-2028 | Pearson, Huawei Learning Service, EduCare, GC Solutions, ANU, SweetRush, EI Design, Kineo, InfoPro Le…




Next post
Booming Canine Lymphoma Treatment Market Globally with Leading Key Players – Oasmia Pharmaceutical, Merck, VetDC, Aratana Therapeutics, HylaPharm





























How the Career Path to Principal Investigator is Narrowing

0

Credit: SolStock/Getty

A study conducted over more than two decades at a major European research institute recorded a marked decline in the percentage of trainees who become principal investigators (PIs) in academia.

The European Molecular Biology Laboratory (EMBL), based in Heidelberg, Germany, tracked the career outcomes of 2,284 researchers who obtained doctoral or postdoctoral positions at one of EMBL’s six campuses between 1997 and 2020. .

The pre-print study, which was published this month, found that the road to a PI role has clearly narrowed. Among researchers whose career paths could be verified by online searches, 44% of those who completed their postdoc between 1997 and 2004 became a CP within five years.1. For those who finished after 2013, only 30% were CP five years later. Study co-author Rachel Coulthard-Graf, career development advisor at EMBL, says that while she wouldn’t discourage anyone who aspires to become a principal investigator, she wants researchers to know that there are many other career options. Being a PI “remains a realistic career option,” she says, “but we want to be transparent.”

The career paths of EMBL graduates also varied by gender. Of those who had completed postdoctoral positions in the lab, 26% of women and 35% of men were NPs within five years. And EMBL postdocs were more likely to have non-science research roles if they were women (17%) than if they were men (11%).

Fifteen percent of the study’s alumni currently work as researchers in industry and 15% work in other science-related roles; these include positions in patent law and science communication, and senior positions in funding agencies. The study did not distinguish between permanent positions and short-term contracts, so it is unclear how many respondents experienced real job security.

About 10% of alumni could not be located through online searches, so their current status is unknown. Some are likely out of the job market, although Coulthard-Graf suspects some are still employed in science but lack a strong online presence.

Branching out

The findings underscore the importance of training for careers beyond academia, says Marta Agostinho, executive director of EU-LIFE, an alliance of 15 European life science research centers based in Barcelona, ​​Spain. . “Due to a reduced funding landscape, science careers in academia are outrageously competitive,” she says.

Agostinho says that while many universities could improve their professional training, interns don’t always have the time or permission to make the most of available resources. PIs are under pressure to keep their labs as productive as possible, she says, so they’re often reluctant to let their interns take time off for professional training. She also notes that in the past, the success of a PI was often measured largely by the number of trainees who became Principal Investigators themselves. Today, however, NPs are beginning to gain recognition for supporting interns moving on to other sectors. “Our perception of success is broadening,” she says.

A study published in February used US National Science Foundation data from 2008 to 2018 to track the career trajectories of nearly 41,000 postdocs in the life sciences and just over 40,500 postdocs in the physical sciences and in engineering.2. The analysis revealed high mobility between sectors of government, industry and academia, another sign that postdocs have career options beyond the traditional linear path from graduate student to lab leader.

The study, published in PLoS ONE, tracked the outcomes of postdocs working in a wide variety of fields and sectors. Most postdocs had jobs in academia, including 72% of those in physical sciences and engineering and 80% of those in life sciences. The rest worked in government, industry, or nonprofit organizations in the United States, or held positions overseas.

make the change

The researchers in the sample showed a willingness and ability to change sectors when moving from training to full-time employment. Of those who had accepted postdoctoral positions at public physical science or engineering institutions, 28% had moved into a full-time government position within five to six years of obtaining their doctorate. However, a further 22% had left government for tenure-track positions in academia, 12% had held other academic positions, and 39% worked in industry. “It was more movement than expected,” says study lead author Maya Denton, a science education researcher at the University of Texas at Austin.

In addition to being a starting point for a wide variety of professional roles, postdoctoral positions in government seemed to increase earning potential. For example, public sector postdocs who pursued a career in industry earned between US$4,500 and $7,350 more per year than university postdocs who followed the same path. “There may be a salary advantage to starting out as a postdoc in government,” Denton says. She adds that one of the potential lessons from the study is that the US government could support young researchers and their future careers by creating more postdoctoral opportunities in this sector.

Flexibility

The startling range of career outcomes could offer some comfort to doctoral students who feel pressured to find the perfect postdoctoral position immediately after graduation, says study co-author Maura Borrego, also an education researcher scientist at the University of Texas at Austin. She says many graduate students worry that their first postdoctoral fellowship will lock them into a path from which they cannot escape. “If people have this information, maybe they can be open to more possibilities,” she says.

Some career paths tended to be more linear than others. For example, 84% of industrial postdocs in the physical sciences and engineering stayed in industry five to six years after graduation. It’s not possible to know from the data how many of these postdocs were targeting industry from the start, says Borrego. “We don’t know what people’s goals were.”

Joyce Main, a higher education researcher at Purdue University in West Lafayette, Indiana, says her studies of postgraduate career paths have also found significant mobility.3. “I see a lot of sectors changing over time,” she says.

Postdocs often earn less during their training than other researchers with PhDs who find permanent employment right after graduation, but Main says a postdoctoral position can still be a reasonable career move, especially for those wishing to consider a wide range of career options. “Getting a postdoc is a good step,” she says. “That means you increase your network, get additional mentorship, and work on projects that can help you develop your skills and research opportunities.

IIT Delhi Scientists to Help School Children Learn About Vaccines and Viruses at Their 7th SciTech Spins Conference

0

The Indian Institute of Technology (IIT) Delhi will soon host the seventh SciTech Spins conference. During the lecture, Manidipa Banerjee, Professor at Kusuma School of Biological Sciences, IIT Delhi, will deliver the lecture titled “Virus vs. Host: Nanoscale Warfare” for school children on March 26. The lecture will also be streamed live on ITI Delhi’s official YouTube channel.

As per the notification issued by IIT Delhi, the conference will discuss issues such as what do viruses look like, how do they infect human cells despite our immune system, how do vaccines protect against viral infections, how new virus strains are generated, why can’t virus drugs be developed quickly?

“As we live in the 3rd year of the ongoing COVID-19 pandemic, it is necessary to reflect on the structure and functions of viruses, which make them such deadly nanomachines capable of stopping all human activities and causing destruction. significant damage. During the SciTech Spins conference for students, I will discuss highlights of virus-host interaction at molecular or nanoscale,” said Prof. Manidipa Banerjee, IIT Delhi.

The lecture will also be streamed live on the official YouTube channel of ITI Delhi (https://youtu.be/9cZL2RzHJKA).

The SciTech Spins lecture series is an academic outreach initiative of IIT Delhi for students, especially in grades 9-12. The Institute issues electronic certificates to all registered students nominated by their respective schools who attend the conference.

These students will also be invited to “Open House”, an annual intellectual festival organized by IIT Delhi, which provides an ideal platform for students to connect with some of the leading scholars in the field of science and technology. Schools can contact the Associate Dean, Academic Outreach & New Initiatives, IIT Delhi (adoni@iitd.ac.in; acadoutreach@iitd.ac.in) to nominate their students for the SciTech Spins lecture series.

Read all the latest Ukraine-Russia war news, breaking news and live updates here.

Researcher wins three NIH grants to fight mosquito-borne viruses

0

West Nile virus, Usutu virus, Zika virus and St. Louis encephalitis virus are all transmitted by mosquitoes and pose a significant threat to human health.

Nisha Duggal, assistant professor of biomedical sciences and pathobiology at the Virginia-Maryland College of Veterinary Medicine, recently received three R21 grants from the National Institutes of Health (NIH) totaling $825,000 to fight the transmission of these diseases, develop therapies and predict future disease in humans.

“Mosquito-borne viruses are emerging globally, with an increasing host range and disease potential. With this funding, we determine who is most at risk of transmission and seek to develop future vaccines and therapeutics,” said Duggal, who is also an affiliated faculty. member of the Center for Emerging, Zoonotic, and Arthropod-borne Pathogens and of the Fralin Life Sciences Institute.

Duggal’s long-term goal is to understand how viral adaptation during emergence affects virus transmission and pathogenesis. His interests are in emerging viruses, host-virus co-evolution, virus transmission and immunity in birds.

With these grants, Duggal and his research team will address the transmission and pathogenesis of Usutu virus, West Nile virus, and St. Louis encephalitis virus in mosquitoes and birds; study the sexual transmission of the Zika virus in humans; and using molecular virology and phylogenetics tools to predict future viral emergence and disease.

“Nisha’s innovative research on these medically important mosquito-borne viruses fits neatly into an important thematic area of ​​vector biology and vector-borne diseases within the Center for Emerging, Zoonotic and Arthropod “borne Pathogens. These grants will allow Nisha to continue her ongoing research collaborations inside and outside of Virginia Tech and further establish her as a rising star in the field of emerging viral and vector-borne diseases.” , said XJ Meng, university professor emeritus and acting executive director of the Fralin Life Sciences Institute.

West Nile virus and Usutu virus research

West Nile virus and Usutu virus are closely related mosquito-borne viruses that cause diseases of the human nervous system. West Nile virus emerged from Africa and Europe in the United States in 1999, and is now the most common mosquito-borne disease in the Americas; however, no vaccine or treatment is available. The Usutu virus is emerging in Europe, where it has been introduced at least three times from Africa by migratory birds, and cases of human illness are on the rise.

For this project, Duggal is developing a reverse genetics system by turning viral RNA into DNA that can be more easily manipulated for experiments. Duggal hopes to find cross-reactivity in immune responses to determine if future vaccines can be used for both viruses. The long-term goal is the development of therapies to reduce the disease.

Zika virus research

Zika virus disease outbreaks have been recorded in Africa, the Americas, Asia and the Pacific. The Zika virus is also transmitted from mother to fetus during pregnancy and through sexual contact, transfusion of blood and blood products, and organ transplantation.

Duggal and his team plan to use this grant to identify the infectivity of Zika virus in semen and the window of time during which infection is possible between sexual partners. Upon successful completion of the proposed research, the anticipated impact of this work will be the identification of the cellular source of Zika virus in semen and the ability to assess and prevent the risk of sexual transmission of Zika virus.

Research on West Nile virus, St. Louis encephalitis virus and Usutu virus

West Nile virus, St. Louis encephalitis virus, and Usutu virus are closely related mosquito-borne viruses that persist in overlapping cycles of bird and mosquito transmission, with spillover effects on humans.

Duggal and his team will study North American birds and mosquitoes to identify possible transmission cycles. The long-term goal of this project is to understand the factors that influence the emergence of new viruses in order to predict future epidemics in humans.

“These projects require a lot of collaboration, and we are excited to partner with Dr. James Weger-Lucarelli from Virginia Tech and Dr. Angela Bosco-Lauth from Colorado State University to advance this research. It is important to track viruses of concern. in order to prevent future pandemics”,


Nisha Duggal, assistant professor of biomedical sciences and pathobiology, Virginia-Maryland College of Veterinary Medicine

Atlas Antibodies, Aviva Systems Biology Corporation, LifeSpan BioSciences, Inc., Sapphire Bioscience, Generon, BosterBio, Sigmaaldrich, R&D Systems – ChattTenn Sports

0

the Cetirizine Hydrochloride The market is globally one of the leading markets involving the development of innovative techniques and an extremely categorized sector. After an in-depth investigation conducted on the Cetirizine Hydrochloride market industries, the market report provides detailed information, based on the export and import related data as well as current industry trends on the global market. The report deeply observes the competitive structure of the Cetirizine Hydrochloride market globally. The Cetirizine Hydrochloride market report includes the detailed summary of various competitive firms, manufacturers, organizations and other players who hold major weight in the global market in terms of demand, sales and revenue by providing reliable products and services to customers around the world.

Key players profiled in the report include

Key players covered in Cetirizine Hydrochloride report are Atlas Antibodies, Aviva Systems Biology Corporation, LifeSpan BioSciences, Inc., Sapphire Bioscience, Generon, BosterBio, Sigmaaldrich, R&D Systems

Request Sample Report + All Related Charts & Graphs @https://www.maccuracyreports.com/report-sample/486308

The global Cetirizine Hydrochloride market report provides notable insights about the Cetirizine Hydrochloride market by fragmenting the market into different segments. The global Cetirizine Hydrochloride market report delivers a comprehensive overview of the market’s global development including its features and forecast. It requires in-depth research studies and analytical power to understand the technology, ideas, methodologies, and theories involved in understanding the market.

Additionally, the report features comprehensive analytical studies of the limiting and growth factors. The report provides a detailed summary of the Cetirizine Hydrochloride market’s current innovations and approaches, overall parameters, and specifications. The report also gives a comprehensive study of the economic fluctuations in terms of supply and demand.

Cetirizine Hydrochloride Market

Tablet, capsule, solution.

Application as below

Hospital, Clinic, Pharmacy

Apart from this, the report includes the Cetirizine Hydrochloride market study based on geographic and regional location. Geographic Segmentation, By Region, North America (US, Canada), South America (Argentina, Chile, Brazil, etc.), Asia-Pacific (India, China, Japan, Singapore, Korea, etc.), Europe (UK, France, Germany, Italy, etc.), the Middle East and Africa (GCC countries, South Africa, etc.) and the rest of the world.

Key Points of the Cetirizine Hydrochloride Market:

CAGR of the Cetirizine Hydrochloride Market over the forecast period 2020-2026.

Accurate information on the factors that will contribute to the growth of the market over the next six years.

Forecasts of future industry trends and changes in customer behavior.

Prospects of market size and its contribution to the parent market.

The growth and current state of the market in the COVID-19 pandemic situation.

Market competitive landscape analysis and detailed vendor information.

A comprehensive description of the factors that will challenge the growth of market vendors.

The global Cetirizine Hydrochloride report indicates the status of the industry and regional and global basis with the help of graphs, diagrams and figures to make it easy and better understandable.

Please click here today to purchase the full report @ https://www.maccuracyreports.com/checkout/486308

The cetirizine hydrochloride report confirms the facts below:

Historical Industry Demand Trends and Future Development Study – Cetirizine Hydrochloride market investors will make their business decisions based on historical and projected Cetirizine Hydrochloride market performance in terms of growth trends, contribution to revenue and growth rate of the Cetirizine Hydrochloride market. The report offers an analysis of the Cetirizine Hydrochloride industry from 2016 to 2019, based on categories such as product type, applications/end users, and regions.

Market Drivers, Limitations and Opportunities – The market is deeply assessed by the current market situation such as market growth factors and restraints. Additionally, we can discuss here the latest industry news and its impact on Cetirizine Hydrochloride business.

Industry Chain Analysis- The study of industry chain structure incorporates details related to supplier and buyer information. Further, the report categorizes major manufacturers in the Cetirizine Hydrochloride business on the basis of their production base, cost structure, Cetirizine Hydrochloride production process, raw material expenditure, and labor expenditure. work.

Future project opportunity – The Cetirizine Hydrochloride market report includes a detailed explanation about the past and present market trends along with its future analysis that may concern with the Cetirizine Hydrochloride market growth.

Note – To provide a more accurate market forecast, all our reports will be updated prior to delivery considering the impact of COVID-19.

Shedding light on protein aggregation in Par

0

image: The image shows a human iPSC-derived neuron overexpressing the LIPA-α-synuclein construct. Upon exposure to light, we observe the formation of LIPA-α-synuclein aggregates (green) in the soma and neuronal processes (MAP2; magenta).
to see Continued

Credit: Maxime Teixeira (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)

A new system to control protein aggregation in a model of Parkinson’s disease could answer long-standing questions about how the disease begins and spreads, according to a new study published March 9.and in the open access journal PLOS Biology by Abid Oueslati of Laval University, Quebec, Canada, and his colleagues. The first results suggest that the aggregation of the protein alpha-synuclein plays an essential role in the disruption of neuronal homeostasis and the triggering of neurodegeneration.

Parkinson’s disease is a neurodegenerative disease, clinically marked by tremors, stiffness and slowed movements, as well as a host of non-motor symptoms. In affected neurons, molecules of a protein called alpha-synuclein can be seen clumping together, forming characteristic aggregates called Lewy bodies. But it has been unclear whether alpha-synuclein aggregation contributes to disease development or progression, and when it may act in the toxic disease cascade, or whether the aggregates are innocent bystanders. from another malicious process, or are even protective. These elements have been difficult to determine, in part because aggregation in cellular and animal models has not been controllable over time or space.

To solve this problem, the authors turned to optobiology, a technique in which a protein of interest is fused to another protein that changes conformation in response to light, allowing the behavior of the target protein to be manipulated. selectively and reversibly. Here, the authors fused alpha-synuclein to a protein known as cryptochrome 2 protein, from a mustard plant. They found that when light of the correct wavelength fell on the mustard protein, its conformational change triggered the aggregation of its partner alpha-synuclein.

The aggregates that formed were reminiscent of Lewy bodies in several important ways, including that they included several other key proteins in addition to alpha-synuclein found in Lewy bodies in people with Parkinson’s disease, and that the alpha-synuclein in the aggregates adopted the characteristic beta-sheet conformation seen in many misfolded protein diseases. The aggregates induced the dislocation of several cell organelles, as Lewy bodies have recently been reported to do as well. They also induced misfolding of alpha-synuclein molecules not attached to the cryptochrome protein, mimicking the spread of prion-like aggregation seen with alpha-synuclein in diseased brain and animal models.

Finally, the authors delivered the alpha-synuclein-cryptochrome fusion protein genes to mice directly into the substantia nigra, the brain structure most affected by Parkinson’s disease, and surgically placed an optical fiber to deliver of light to the targeted cells. Light treatment resulted in the formation of alpha-synuclein aggregates, neurodegeneration, disruption of calcium activity in downstream neuronal targets, and Parkinsonian-like motor deficits.

“Our results demonstrate the potential of this optobiological system to reliably and controlled induce the formation of Lewy body-like aggregations in model systems, to better understand the dynamics and timing of body formation and propagation. de Lewy, and their contribution to the pathogenesis of Parkinson’s disease. illness,” Oueslati said.

Oueslati adds: “How do alpha-synuclein aggregates contribute to neuronal damage in Parkinson’s disease? To help answer this question, we have developed a novel optogenetic-based experimental model allowing the induction and real-time monitoring of alpha-synuclein clustering in vivo.

#####

In your coverage, please use this URL to provide access to the article available for free in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001578

Quote: Bérard M, Sheta R, Malvaut S, Rodriguez-Aller R, Teixeira M, Idi W, et al. (2022) A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson’s disease. PLoS Biol 20(3): e3001578. https://doi.org/10.1371/journal.pbio.3001578

Author countries: Canada, United States, Republic of Korea

Funding: This work was supported by Parkinson Society Canada, the CHU de Québec Foundation, and Canadian Institutes of Health Research (CIHR) grants to AO. AO was supported by the Junior1 and Junior 2 salary grants from the Fonds de Recherche du Québec – Santé (FRQS) and the Parkinson Society of Quebec. The in vivo Ca2+ imaging experiments were supported by the Canadian Institutes of Health Research (CIHR) grant to AS. MB was supported by scholarships from the CHU de Québec Foundation, the Laval University Faculty of Medicine (Pierre J. Durant Doctoral Recruitment Scholarship) and the FRQS. FC is the recipient of a research chair from the Fonds de Recherche du Québec en Santé (FRQS) and has received funding from the Canadian Institutes of Health Research (CIHR). The master’s is supported by CIHR and FRQS postdoctoral fellowships. EAF is supported by a CIHR Foundation grant (FDN-154301) and a Canada Research Chair (Tier 1) in Parkinson’s disease. MKSP was supported by a Frederick Banting and Charles Best Canada Graduate Scholarship and an FRQS Doctoral Training Fellowship. MET is a Tier 2 Canada Research Chair in Neurobiology of Aging and Cognition. TMD is supported by funds from McGill Healthy Brains for Healthy lives and a CIHR project grant (PJT–169095). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Why do we no longer hear about cloning?

0

“People ask me, ‘Why is it so expensive?’ and I tell them because there are so many complicated steps involved in the whole process,” says Rodriguez. “It’s definitely an emotional reason for pet customers. They want to be able to keep that strong emotional bond they have with the animal.”

The industry has since expanded elsewhere in the world. Sooam Biotech in South Korea offers dog cloning services, as does Sinogene in China.

However, many scientists remain uncomfortable with the whole premise. Lovell-Badge argues that there is “no justification” for cloning pets because even though the resulting animals will be genetically identical, they will not have the same behavioral characteristics and personalities because all creatures are the same. produces both genes and their environment.

“People really want their pet to know them and know certain tricks, etc.,” says George Church, a professor of genetics at Harvard Medical School. “In that sense, it’s kind of taking advantage of people’s grief.”

Reviving extinct species

In the years following Dolly’s cloning, the central question was whether scientists would ever extend the technology to humans, and the many moral and ethical issues that would raise.

But while a human embryo was successfully cloned in 2013, the process of creating a full human was never attempted due to likely public outcry. Chinese scientists cloned the first primates in January 2018, the long-tailed macaques Zhong Zhong and Hua Hua, but there are currently no suggestions that this work will continue in other primate species.

Instead, most funds are spent on using cloning to resurrect animals on the verge of extinction. Efforts are underway to clone both the giant panda and the northern white rhino – a species for which only two animals remain on the planet – while for the past two years ViaGen has cloned the black-footed ferret and Przewalski’s horse, which are in danger.

Church leads the most ambitious project, a quest to revive the woolly mammoth, a species that lived around 4,000 years ago. His disextinction company Colossal has already raised £11 million ($14.5 million) to back the idea, which will involve creating an elephant-mammoth hybrid by taking skin cells from Asian elephants and using cloning technology to reprogram them with mammoth DNA.

Gary W. Wester | Obituary

0

January 19, 1948 – March 15, 2022

NORMAL – Gary W. Wester, 74, of Normal, IL, passed away peacefully on March 15, 2022 at the Hospice of the Golden Isles in Brunswick, GA.

Gary was born on January 19, 1948 in Kalamazoo, MI to Frederick and Dorothy (Dokey) Wester. He married Karen Boone on December 13, 1974 in Kalamazoo, MI. Gary graduated from Western Michigan University with a Ph.D. in Biological Sciences and a Master of Science in Computer Science. Gary taught at Waycross (GA) College and Illinois Wesleyan University and was a longtime employee of State Farm Insurance. Upon his retirement in 2010, he pursued his passion for watercolor and pastel painting.

Gary is survived by his wife, Karen; their three children: Heather (Rodger) Foltz of Chandler, AZ, Tennille (Kevin) McBride of Le Roy, IL, Chad Wester of Bloomington, IL; and his granddaughter, Svitlana McBride, stationed in Wiesbaden, Germany, with the U.S. Army. He is also survived by his brother, Mark (Liz) Wester of Aix-en Provence, France and several nieces and nephews. He was predeceased by his parents and his sister, Susan (Jack) Shipe.

There will be a private memorial service for him at a later date. He loved dogs and cats which were an important part of his life. In lieu of flowers, memorials can be made to Pet Central Helps of Normal, IL or an animal shelter of your choice.

Closed Loop Medicine Announces Completion of Precision Medicine Clinical Trial for Patients with High Blood Pressure

0

The study aims to validate the development of a new combination product that links a drug to a smartphone app, allowing patients to personalize and optimize their treatment regimen to treat hypertension and prevent heart attacks and strokes cerebrovascular

The trial, called PERSONAL COVID BP, was partly funded by Innovate UK and led by the William Harvey Clinical Research Center at Queen Mary University of London

The last of 200 patients with hypertension completed the 14-week treatment phase as well as the required follow-up period of 2-4 weeks

Full study results are expected in Q2 2022 and will be presented to the American College of Cardiology (ACC) for presentation at the ACC Annual Scientific Session in April 2022 in Washington DC

Closed Loop Medicine Ltd, a leader in the development of products combining single prescription medicine and digital therapy (DTx) to enable precision dosing and care, today announced that the last patient has completed participation in a clinical trial of the company’s integrated precision care product solution for hypertensive patients.

Closed Loop Medicine develops digital drug and therapeutic combinations focused on dose optimization to improve patient outcomes, support clinicians, and enable evolution towards a value-based medicine proposition for healthcare systems. health by providing precision care at the population health scale.

The clinical trial, called PERSONAL COVID BP, aimed to determine if a combination product that combines a drug with a smartphone app can allow patients to personalize and optimize their treatment regimen for treating hypertension. Importantly, the technology in the study allowed patients protected against COVID-19 to report symptoms related to COVID-19 infection as well as monitor their blood pressure remotely, daily, from their residence. The company quickly evolved its approach to continuing studies during the COVID-19 lockdown, redesigning studies to run remotely and through technology development, including using the Decentralized Clinical Trials Platform uMED.

The interventional arm of the study exceeded its enrollment goal of 200 patients, with patients receiving drug therapy while using an app to monitor blood pressure and any potential side effects. The data from this study is being used to drive the development of the company’s highly innovative product that will provide precise blood pressure control at the population health scale. Product will save lives by tackling the Western world’s number one killer (1), high blood pressure – which even in the pre-vaccination year of COVID-19 in 2020 killed more people than cancer or COVID-19 (2).

Preliminary data from this study will be presented at the ACC’s 71st Annual Scientific Session, April 2-4, live in Washington, DC. They will also be published online in the Journal of the American College of Cardiology (JACC).

The trial is partly funded by Innovate UK and was conducted by the William Harvey Clinical Research Center in Queen Mary University of Londonwhich is part of the Biomedical Research Center of the Barts NHS Trust National Institute for Health Research in London, UK.

Following Closed Loop Medical’s success in securing a place in the Association of British HealthTech Industries (ABHI) American Accelerator Program earlier in January 2022, the company is exploring other clinical opportunities within the US healthcare system to support the development of its new precision care product for patients with hypertension.

Dr. Hakim Yadi OBE, CEO and Co-Founder of Closed Loop Medicine commented:

This represents a key milestone for the company, the last patient treated and follow-up treatment completed in our interventional clinical study. Our goal is to improve patient outcomes while helping healthcare systems better manage patients with long-term conditions through linked remote monitoring and precision medication intervention. The trial design allowed for greater patient participation in the comfort and safety of their own home. I am delighted that we were able to complete the recruitment, despite the constraints of the COVID-19 pandemic. We look forward to presenting the results of this important trial alongside our partners at Queen Mary University of London.

Dr David Collier, the principal investigator of the trial from Queen Mary University of London, commented:

This is an important study in that it allows patients and doctors to collect real-world data to help better inform treatment decisions and monitor patient outcomes. Some of the drugs we use are great at preventing heart attacks and strokes, but frequently cause unwanted side effects, which is what this trial aims to address. We demonstrate through this study that there is no one-size-fits-all solution, but by using technology in this combined way, we can personalize treatment for the individual. This personalization appears to have the potential to change participants’ relationship to treatment, as they see the effect of different levels of treatment on their blood pressure while carefully checking for adverse effects. This “personalized dose-response curve” has meaning for participants and clinicians and we are delighted to confirm its impact on the whole group. »


“The participants, some over 80, became very attached to their remote app and despite it prompting them to record their blood pressure daily for three months, they were upset that they had to delete it at the end. of the essay. “It was like an angel on my shoulder” said one participant.

Alaskan sea otters have individual feeding habits

0

Article body copy

As sea otter populations rebound in the northeast Pacific, shellfish farmers, crab fishermen and others are concerned about how their voracious eating habits – which can see them consume around a quarter of their body weight each day – could affect the richness of the ocean. Scientists have studied the effect of sea otters on major shellfish populations, hoping to better predict the results of ongoing reintroduction efforts, which began in the 1960s.

A recent study, however, adds a wrinkle to this effort. As Nicole LaRoche, a graduate student at the University of Alaska Fairbanks, and her colleagues have shown, there are significant differences in eating habits from one sea otter to another.

Alaska’s dark, freezing winters make it difficult to study sea otter feeding habits year-round. But LaRoche and his team overcame that by watching the otters feed during the warmer months and then measuring changes in carbon and nitrogen isotopes of otter whiskers collected by the US Fish and Wildlife Service. Agency officials routinely collect whiskers for scientific purposes when capturing sea otters or recovering carcasses. Since sea otter whiskers tend to grow at a steady rate, measuring changes in the length of a whisker can give scientists a way to see if what otters eat changes throughout life. winter.

The researchers weren’t able to match warm weather observations with winter whisker measurements for specific sea otters, but they did find individual dietary variance.

Through warm-weather observation, LaRoche and his colleagues found that sea otters depend on crabs, sea cucumbers, mussels, snails, sea urchins and various types of clams. Butter clams, in particular, seem to be a favorite of the foraging otters they have observed. Sea otters “get what they pay for,” says LaRoche. Butter clams “are easy to dig, they won’t swim, and they pack a lot of calories for each.”

It’s tempting to interpret these individual differences between what sea otters eat as food preferences, but LaRoche says competition with other otters and prey availability also play a role in determining which otter eats what. .

Previous research has shown that sea otter feeding habits can change as the regional population grows, says Tim Tinker, a wildlife biologist with the United States Geological Survey who was not involved in the study. When sea otters spread into a new area, juvenile males arrive first and seek out large, high-calorie prey like Dungeness crabs. As females and then cubs are added to a growing colony, otters begin to eat a wider variety of prey. This means that the early impact of sea otters on some prey species may be high, but should stabilize over time.

“What [this] the paper,” says Tinker, “is to dig a little bit into how diets are starting to diversify.”

LaRoche hopes that a new understanding of clam consumption by sea otters in Southeast Alaska, in particular, will draw attention to the need to balance the demands of hungry otter populations with those of hunters. subsistence farmers who also collect clams.

“People tend to think of sea otters affecting commercial fishing like crab and sea urchin, which they do,” LaRoche says via email. “But I think the focus should be more on personal use, especially subsistence use. Commercial rigs, especially crab, have the ability to fish much deeper than otters typically dive, but subsistence use is usually in the same area that sea otters also forage.

Despite the difficulties that may arise from the rebound in the sea otter population, LaRoche hopes that researchers will continue to pin down the nuances of their interactions with various species and hopefully find new ways to help sea otters, their prey and humans to coexist.

‘Drop everything’: Huntsville company helps employees flee war-torn Ukraine

0

Refugees want to work.

It’s the startling reality against a grim backdrop for Glenn Bilawsky, CEO of Huntsville-based Discovery Life Sciences, which also has a location in war-torn Ukraine. His company has been rushing to evacuate employees for the past three weeks.

There are other stories, too, like the top Ukrainian site official ending a Zoom call with Bilawsky with a simple “I gotta go” as Russian rockets exploded in nearby buildings.

Related: How to Help Ukraine: Resources to Donate, Volunteer

Related: Ash Wednesday focus turns to prayer for Ukraine

Related: ‘My heart is still in Ukraine’: Alabama minister returns from war zone

So far, Discovery has relocated 20 of its 64 employees to Ukraine. The others wanted to stay in the country or had no choice but to join the army. Bilawsky said no company employees or their family members were injured or killed.

And company employees in Huntsville and elsewhere around the world have contributed a portion of their salary as well as accrued vacation time by reaching out to fellow Ukrainians.

But these colleagues want to work.

“I mean, they’re passionate about it,” Bilawsky said. “They just want — after everything they’ve been through to cross the border and everything — and they said, you know, where can we work?

“And then we talked about the lab in Germany, and they got on a bus with their kids and everything and went to a country that they didn’t even speak the language of, but they wanted to go there and they wanted to work again. They wanted to get back to doing what they’re doing to improve health care and improve science.

That’s what they do at Discovery Life Sciences. Its home offices in Huntsville are located on the HudsonAlpha Institute of Biotechnology campus in Cummings Research Park and Discovery describes itself as the world’s largest biological sample inventory and supply network. This network, among other things, helps in the search for a cure for cancer.

The Discovery Life Sciences site in Kyiv, Ukraine. (Discovery of life sciences)

Beyond its five national sites, Discovery also has sites in Germany and Bulgaria as well as in the Ukrainian capital of kyiv.

Bilawsky said the evacuation of employees began when Russia invaded Ukraine on February 24. And the CEO immediately reached out to Christiaan Neeleman, the company’s president of European operations.

Bilawsky recounted, “I said, ‘Christiaan, drop everything about business. And I want you to put together a team of all the resources you need in the business. And let’s put a plan in place and understand the situation on the ground in Ukraine and what we can do.

This led to Tetyana Yurkovska, medical director general of the Ukrainian site.

“Literally the day of the attack, she called me on a Zoom call from her phone,” Bilawsky said. “We were face to face. They had packed their car. They had filled cans of petrol for extra fuel as they were unsure if they would have (enough) fuel to get to the border and cross the border or not and with all the personal belongings they possibly could to assemble.

“And while we were on the phone, there’s a rocket attack that landed and a helicopter shot down there about two miles from her house. And the abject fear on her face as we’re on a Zoom call face to face, the reality of what was going on. It’s one thing to see him on the news and all that, but she was telling me that she was ready to go and where they were going. And she would keep in touch. And everything all of a sudden there was a huge explosion. And just the shock on her face and the tears welling up in her eyes. And she said, ‘Glenn, I have to go. I have to go fast, in all security. It just brought the reality of the hopelessness of the situation and the danger, it couldn’t be more apparent. The only way it could be more apparent is if I stood next to her.

You can help.

Discovery is setting up a 501(c)(3) as a way to accept donations to go directly to their Ukrainian employees. The non-profit organization, which is expected to be active every day, will be known as Discovery Cares (discoverycares.com). The email address is DiscoveryCares@dls.com. The website will go live as soon as the nonprofit launches, Bilawsky said.

Yurkovska and her family managed to get to safety and took refuge in Poland. Once there, Bilawsky said Yurkovska began making arrangements for other employees to join her in Krakow, Poland. In addition to the 20 employees, 24 family members of those employees also fled Ukraine, Bilawsky said.

“As soon as she arrived, she started renting apartments and looking around the city for furnished apartments,” Bilawsky said. “We just said to Tetyana rent as many as you need so people as soon as they get there they have a place they can go and shelter and have a place to live and have a kitchen and start feeding themselves and all the things they need. He’s an amazing, amazing person.

In addition to accepting donations through its nonprofit organization, Discovery matches $3 with every $1 employee donation. Corporate matching will not be in effect for outside donations. The company also offers free air tickets to Ukrainian employees and their families to anywhere in the world.

Bilawsky praised the support the company has received both from its employees and from outside the company to ease the uproar of evacuations – from the European law firms the company works with to its accounting agencies.

“All we had to do was raise the flag and say we have people who need help,” Bilawsky said. “And I find it incredible how many people have come forward, both inside and outside the company, and offered to help. So I said I couldn’t take credit for how well it went or frankly how fast it happened because there are people on the ground in the world and especially our staff in Europe, they just went above and beyond.

Biden signs budget bill with help from Ukraine but no virus money – The McPherson Sentinel

0

Associated press

WASHINGTON (AP) — President Joe Biden on Tuesday signed a bill providing $13.6 billion in additional military and humanitarian aid to Ukraine as part of a $1.5 trillion public spending measure. dollars that omits the COVID-19 aid the White House urgently needs.

COVID-related spending has been a casualty of negotiations over the government’s larger bill. The White House had asked for $22.5 billion for vaccines and treatments, but that amount was reduced in talks to $15.6 billion and eventually dropped altogether as grassroots Democrats rebelled against the proposed cuts in state aid to pay for new spending.

“We have made tremendous progress in our fight against COVID-19 but our job is not done,” Biden tweeted on Tuesday. “We need Congress to immediately provide $22.5 billion in emergency funding to support our nation’s response to COVID-19.”

During a Tuesday call with governors, White House COVID-19 coordinator Jeff Zients stressed the “serious implications” the lack of additional funding would have on the nation’s response, including federal support for states, according to an administration official.

The White House says that without additional funding, the federal government will stop accepting new applications next week for treatment of uninsured people for COVID-19 and that state funding for life-saving monoclonal antibody treatments will be reduced by 30% to extend their supply. The administration says it also needs more money to buy more antiviral pills and prophylactic treatments for the immunocompromised, as well as to buy more vaccine doses in case regulators recommend additional booster shots. or a variant-specific callback, if applicable.

“With the increase in cases overseas, scientific and medical experts have made it clear that over the next two months there may also be an increase in COVID 19 cases here in the United States,” said White House press secretary Jen Psaki. “Waiting to provide funding until we are in a worse situation, but the virus will be too late. We need funding now.

The $1.5 trillion bill to fund the government for the current year through September 30 is enacted five months late. But the money earmarked for Ukraine to fight Russia’s invasion has become a bipartisan rallying point for the measure as Congress has urged Biden to take more aggressive action against Russian President Vladimir Putin.

“Putin’s aggression against Ukraine has united people across America, united our two parties in Congress, and united the freedom-loving world,” Biden said.

About half of the $13.6 billion would arm Ukraine and cover Pentagon costs for sending US troops to other Eastern European countries that could see the war spread beyond their borders. Much of the rest is earmarked for humanitarian and economic aid, bolstering the defenses of regional allies, and protecting their energy supplies and cybersecurity needs.

The government’s $1.5 trillion spending bill includes an increase of nearly 7% for national initiatives, with bolstered spending on schools, housing, childcare, renewable energy, biomedical research , community law enforcement grants and feeding programs. It is also disbursing money to minority communities and historically black colleges, renewing efforts to prevent domestic violence against women, and requiring infrastructure operators to report serious hacking incidents to federal authorities.

Republicans secured a nearly 6% raise for the defense and prevailed by retaining decades-old restrictions against using federal money to pay for nearly all abortions.

Emerging Tech Trends Report Predicts Dark Future

0

Amy Webb is the CEO of the Future Today Institute, which serves as a management consultancy for a wide variety of government agencies and private companies. “These are the people who are held back by filmmakers and producers of TV commercials setting their plans for the future and wanting to know what it should look like,” said Webb, who calls himself a “Quantitative Futurist” from the Institute. . , which has a diverse list of high-profile clients, including Fox Entertainment, Sony, Cisco, Pepsi and the State Department. Each year, the Future Today Institute publishes its “Emerging Tech Trends Report”. Webb, who is also a professor at NYU Stern School of Business, “kicked off” this year’s report on the 15th with a talk at SXSW 2022 this week. Concisely enough, the talk was titled “Amy Webb Launches 2022 Emerging Tech Trends Report.”

The top trends covered reflected top trends throughout SXSW 2022, including Artificial Intelligence, Metaverse/Web 3, and Synthetic Biology. All of them, Webb said, have widespread applications and everything could go very well or very badly, depending on how things turn out.

“We are getting closer to the day when AI systems can make their own decisions. Panic ? asked a title card in Section IA. Facial recognition is just the beginning – eventually smell and even breathing will be used for recognition purposes.

And there are retail apps. Webb presented a scenario where someone shopping for a wedding dress could share prompts with a screen and ask the AI ​​to “create images that match your description.” Select the ten that most closely resemble what you would be willing to wear. Other prompts can further refine the choices. It’s easy to imagine a similar type of AI-generated smart home setup or home theater setup based on a customer’s answered prompts.

Webb walked through an “optimistic scenario” for where things will end with AI in five years, in 2027.

“The AI ​​content is identified in some way, as are the teams that created the models. We’ve gone for transparency. There are guardrails to use and certain types of invisible and invasive biometric systems – not just facial recognition – have been banned from use in public spaces,” she predicted. “Searching is so much better; it’s a lot more intuitive, and it’s a lot more accessible, now that people can have a conversation and do a visual search.

Webb’s “doomsday” scenario for the AI, however, was very different.

“The problems we have in 2022 are only exacerbated by the year 2027,” she said. “Misinformation is everywhere, but now it comes in the form of images and videos, which have been specifically crafted by AI systems and no one can tell the difference. And worse, they have been crafted to arouse our trust, make us believe and ultimately make us really angry. Unacceptable amounts of data are collected about us, without any transparency. Your data is held by third parties, who can resell it, and it is impossible to be anonymous.

On the surface, Webb’s latest scenario does indeed look like an exponentially worse version of what we’re experiencing today, only AI designs the content and humans can’t tell the difference. While AI-generated content is often easy to spot today, it’s not hard to imagine a world in which it becomes more professional since five years isn’t a long time when it comes to machine learning and of technology.

Webb saw an 80% chance for the “catastrophic” scenario and 20% for the “optimistic” scenario.

The next big trend was the metaverse, which was a major talking point throughout the SXSW 2022 conference schedule. Generally used to describe online 2D and 3D environments, including virtual reality, the “metaverse” , as Webb explains, is “an umbrella term for technologies that bridge the gap between the physical and digital worlds.” She called it part of Web 3.0, “the next evolution of digital infrastructure.”

According to Webb, the metaverse will allow people to present different versions of themselves in different scenarios, and they’ll likely use it for everything from business meetings to dating to hangouts.

The biggest questions about the Metaverse, aside from how quickly the technology can keep up, is how it will be standardized.

“It’s the infrastructure and the protocols that matter,” said a slide from the presentation. The key questions to ask, Webb said, are “who are the people building these new spaces? Are they optimized for everyone? What if metaverse spaces are not interoperable? Who decides on the standards? »

Webb shared examples of some wild metaverse innovations in the works, including something called “Targeted Dream Incubation” (TDI), which is an actual version of technology from the movie Inception.

As with AI, Webb presented optimistic and doomsday scenarios for the metaverse, looking ahead to 2032.

“We stopped saying Web 3.0 was totally decentralized,” Webb said of the optimistic scenario, referring to the oft-quoted promise that blockchain technology will completely eliminate the middleman, even as nearly all financial entities and corporations, including many CE makers, are diving into NFTs, smart contracts, and cryptocurrency. “Instead, we clarified that blockchain, new forms of security, would allow consumers to have much more control over their data. And we trusted. We did this using zero-knowledge proofs, which is a cryptographic tool that allows a third party to prove that a statement is true without needing to observe a bunch of data. We also focused on radical inclusivity.

As for the disaster scenario?

“Online dating is an apocalyptic hell of doom. We look back on ‘The Tinder Swindler’ and laugh at how things were simpler back then. Many of us now have a dozen iterations of ourselves, which we authenticate using Digital ID, but since no one has thought of it, we are constantly stuck juggling different digital identities and trying to remember which is which.

“And those metaverse town halls that everyone was so excited about? Well, they’re still run by the same people, but they still have the same issues. She saw the “catastrophic” scenario have a probability of 70%, against 30% for “optimistic”.

Regarding the part on synthetic biology, Webb noted that “computers and biology have become one”.

She noted that one in five Americans have paid a private company to sequence their DNA. And while the Chinese government is the entity on the planet with the most DNA, 23andMe and Ancestry.com are right behind it in second and third place, respectively.

Overall, Webb concluded his presentation with a few key points:

“We are in a period of acceleration; prejudices persist and we must address them: decentralization will benefit some but not all; we have no safeguards or national plans; and we will have to redefine what is “real”. »

Whether the glass is half full or half empty, the next few years will require vigilance, effort and perseverance to realize Webb’s “optimistic” predictions.

FDA approves Bristol Myers Squibb drug Lag-3, approving first new class of checkpoint inhibitors in 8 years – Endpoints News

0

For the first time in nearly a decade, the FDA has approved a new type of checkpoint inhibitor to treat certain cancer patients.

The drug, developed by Bristol Myers Squibb and known as relatlimab, is approved for patients with metastatic melanoma or melanoma that cannot be treated with surgery. It is given in combination with Opdivo, Bristol’s best-selling PD-1 inhibitor.

Marketed as Opdualog, the antibody combo will cost $27,389 per infusion. A Bristol spokesperson said the price is in line with other combination treatments for metastatic melanoma.

Relatlimab is notable because it has the same primary mechanism of action – known as checkpoint blockade – as successful CTLA-4 and PD-1 immunotherapies, such as Yervoy and Keytruda. But it attacks a new target on T lymphocytes, called Lag-3.

This is the first new checkpoint target to reach patients since the first PD-1 drugs were approved in 2014. Researchers hope this could be the start of a series of new immunotherapy targets that are improving responses and expanding the use of checkpoint therapies, though they caution that the field has faced more than its share of failures in recent years.

Like the two previous drug classes, relatlimab is designed to dampen the immune system, freeing it to attack tumors. Bristol Myers has shown it can do this in a pivotal trial of 714 patients with stage III and stage IV melanoma, notably without triggering any adverse side effects.

The study randomized patients to receive either a combination of Opdivo and relatlimab or Opdivo alone. Patients who received the combination took on average 10.4 months for their cancer to progress, compared with 4.6 months for Opdivo alone.

The progression data is similar to what researchers see when they combine Opdivo and Yervoy, Bristol Myers’ CTLA-4 inhibitor, but this combination can be highly toxic, leaving oncologists to prescribe it only at a subset. set of patients.

Relatlimab, however, showed relatively few adverse events. The most common were elevated liver enzymes and fatigue, each occurring in just over 1% of patients.

This means oncologists can now prescribe Lag-3/PD-1 to patients who are too sick or unwilling to deal with the side effects of CTLA-4. Executives and other researchers warn, however, that they will need more and longer-term data before concluding that the Lag-3 combo is the new standard of care.

If future survival data for the Lag-3 combo resembles that of the CTLA-4 combo, it would strengthen “as a new standard of care for patients with previously untreated advanced melanoma,” two British researchers wrote on the cancer in a New England Journal of Medicine editorial. “It is unlikely that there will be a head-to-head trial between the two combinations, as the difference in toxic effects is stark.”

Bristol Myers is currently conducting additional trials testing Lag-3 in lung, colon and other cancers in hopes that it will prove effective there as well. However, some experts doubt that it proves effective in many other types of cancer, and companies developing rival Lag-3 drugs, such as Regeneron, have focused their efforts on skin cancer.

“My understanding from what has at least been made public is that there is no indication of a slam dunk, where you get the same kick in activity, as melanoma,” Israel Lowy said. , Head of Oncology at Regeneron. Terminal News in January.

Miriam Merad, director of the Mount Sinai Institute for Precision Immunology, agreed, telling Endpoints at the time, “I think it’s going to be very tumor-specific.”

Stocking program has some success at SML | Local News

0

Jason Dunovant

Bass are getting bigger at Smith Mountain Lake, according to reports. Anglers are beginning to reap the rewards of a years-long effort to grow largemouth bass, but there are concerns that striped bass growth is stalling.

The growth of largemouth bass can be directly attributed to the annual stocking of F1 tiger bass which was first introduced to the lake in 2015. The bass is a genetic mix of northern bass that grows faster and Florida bass that gets bigger.

A group of local fishermen and business owners first worked with the Virginia Department of Wildlife Resources to secure the stocking permits. Due to its early success, DWR continued funding the project after the first three years.

The stocking of 20,000 to 70,000 tiger bass has continued every year since 2015. Since then, the bass have started to have a real impact on the size of largemouth bass caught in the lake.

“We’re getting into weights that we haven’t seen in a long time,” said Dewayne Lamb, owner of Captain’s Quarters and promoter of the Tiger Bass.

People also read…

At a recent fishing tournament at the lake, the largest bigmouth caught weighed well over 8 pounds. Lamb said the big winning fish usually weighed no more than 5 or 6 pounds just a few years ago. He attributes the jump in size directly to the introduction of the tiger bass.

Dan Wilson, a biologist for the DWR, said they have also seen a steady growth in the fish population in the lake over the years, which has led them to continue funding the project. While sampling largemouth bass 4 pounds or more from Smith Mountain Lake, Wilson said the percentage of tiger bass steadily increased.

In 2019, 2% of bass over 4 pounds sampled were tiger bass. In 2020, Wilson said that number jumped to 10% and last year jumped again to 13%. He said striped bass are indistinguishable from other bass and genetic testing is being done to confirm.

Wilson said the stockpiling of tiger bass will continue as long as the DWR continues to see results in samples taken from the lake. The current plan is to continue until at least 2025, he said.

Another long-stocked fish at Smith Mountain Lake is striped bass. The bass has been stocked since the lake was first filled over 50 years ago. More than 300,000 are deposited each year around the lake.

“The striped bass numbers are as good as they’ve ever been,” Wilson said.

Although the number is high, it is feared that their growth has diminished. Wilson said this was likely due to too many strippers competing for a limited amount of food. Striper stocking was reduced last year due to size reduction.

A pest infestation drastically reduced the number of large striped bass in 2003 and DWR has been working to bring them back up ever since. Even with the stocking, Wilson said it’s unlikely the lake will ever see a striper as large as was caught in the 1980s and 1990s when some as large as 50 pounds were caught.

Wilson said it was unrealistic to find tracers of this size because there are more anglers looking for them on the lake and technology has improved to locate them. “It’s harder for them to live long enough to reach those sizes,” he said.

Lamb disagrees with current striped bass assessments. He said the lows should be increased based on discussions he has had with other anglers.

“I’m finding it harder and harder to catch big numbers,” Lamb said. He said if locals, such as fishing guides who know the area, are struggling to catch 8 or 10 striped bass, it will likely be difficult for new anglers to catch just one.

While many tournaments are held at Smith Mountain Lake to catch largemouth and smallmouth bass, Lamb said many tourists come to the lake to catch striped bass. Having good numbers and large sizes is important for tourism, he said.

Lamb said he would like to see 500,000 or more striped bass stocked in the lake over the next few years to help boost populations. He said that even if storage was increased this year, it would likely take 3-5 years to see results.

Piers Nye obituary | Biology

0

My friend and mentor Piers Nye, who died at the age of 75 from pulmonary fibrosis, was a professor of physiology at Oxford University for over 40 years and a medical researcher. His lab was full of his homemade equipment, which he said was held together with “chewing gum and bits of string.” He was a talented mentor to students and junior colleagues and worked to expand access to college among underrepresented groups.

Piers was born in Perth, Scotland. His father, Leslie Nye, was an insurance executive. After Piers’ mother, Grace (née Evershed), died aged 14, he was brought up in Aldeburgh, Suffolk, by Janet, one of his three older sisters, and her husband, Ian Tait. , both general practitioners.

He attended Marlborough University, Wiltshire, but resumed his postgraduate studies at Ipswich Civic University. “Hoping to feed the world”, Piers took a degree in agriculture at Pembroke College, Oxford, graduating in 1968, and briefly researched in Swaziland, but, influenced by his respect for Janet and Ian, concluded that the research medicine would be a better use of its energies. He did a doctorate in physiology at the University of California, Davis, where he raised goats, which he completed in 1977.

Back in England the same year, Piers hitchhiked to a job interview in Bristol when, during a stopover in Oxford, he was persuaded to apply there for a position as a demonstrator at the University Physiology Laboratory (ULP ). Oxford thus became his homeland for more than 40 years, since he became lecturer at Balliol (1984-87), lecturer at the ULP (1984-91), then a scholarship holder at Balliol. In 1998, he became director of the university’s physiological sciences course, until 2011; he also taught medical students.

Piers also undertook research on the carotid body, an organ in the neck that senses chemical changes in the blood (mainly changes in oxygen levels), and on the blood vessels of the lungs, and the control of breathing during exercise.

He has mentored a wide range of biological scientists – up to 85 students personally at any one time – and organized events to broaden access to Oxford. He retired from the ULP in 2012, but continued as a lecturer and Emeritus Scholar at Balliol. In 2015, he was awarded the University of Oxford Excellence in Teaching Award.

He continued to teach and examine until the summer of 2021.

Piers had a wide range of interests beyond his work, including the blues, human rights, and liberal politics. He was good at photography and computers. Her clothes came from the local charity shop; he cut his hair. He supported his students when they flourished, but even more so when they were sick, struggling or lost.

He married Rosie Painter in 2003. She survives him and their two children, Hamish and Henry; two children, Oscar and Lisa, from a previous marriage to Mimi Maeda, which ended in divorce; his granddaughters, Ruby and Maya, and his two sisters, Janet and Harriet.

Awake Prone Positioning for Nonintubated Patients with COVID-19-Related Acute Hypoxemic Respiratory Failure: A Systematic Review and Meta-Analysis

0
Ehrmann et al (2021)
11
  • Ehrmann S
  • Li J
  • Ibarra Estrada M
  • et al.
Awake prone positioning for COVID-19 acute hypoxemic respiratory failure: a randomized, controlled, multinational, open-label meta-trial.

United States, Mexico, Canada, Ireland, France and Spain Multicenter RCT Intensive care unit, intermediate care unit, emergency department and general services 564 participants were given an awake prone position for as long and as frequently as possible; median daily duration 5 0 h (IQR 1 6–8 8) plus usual care 557 participants received usual care (HFNC) Treatment failure within 28 days of enrollment, defined as intubation or death 28 days intubation; mortality; use of the NAV; length of hospital stay; time to HFNC withdrawal in patients who have succeeded in treatment; duration of IMV in intubated patients surviving to day 28; mortality in IMV patients; predefined security results; physiological response to awake prone positioning, including ROX index Taylor et al (2021)
12
  • Taylor SP
  • Bundy H
  • Smith WM
  • Skavroneck S
  • Taylor B
  • Kowalkowski MA
Awake-prone positioning strategy for non-intubated hypoxic patients with COVID-19: a pilot trial with integrated implementation evaluation.

United States Monocentric RCT General room 27 participants received an awake prone position plus usual care 13 received usual care (room air, nasal cannula, HFNC or NIV) Results relating to the successful implementation of a future definitive RCT Until discharge or death S/F; time on S/F 6 L/min; intubation; length of hospital stay; hospital mortality at 48 hours; safety results Johnson et al (2021)
13
  • Johnson SA
  • Hortons DJ
  • More complete MJ
  • et al.
Patient-directed prone positioning in awake COVID-19 patients requiring hospitalization (PAPR).

United States Monocentric RCT General room 15 participants received awake prone positioning every 4 h, lasting 1–2 h or as long as tolerated; median total duration 1 6 h (IQR 0 2–3 1) plus usual care 15 participants received usual care (room air or nasal cannula) Change of P/F at 72 h after admission 28 days The change of P/F at 48 h; the need for endotracheal intubation; transfer to intensive care; escalation in the oxygen delivery system; the duration of the stay; duration of stay ; ventilator-free days; hospital mortality Rosen et al (2021)
14
  • Rosen J.
  • von Oelreich E
  • Fors D
  • et al.
Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial.

Sweden Multicenter RCT USI and general room 36 participants received an awake prone position for at least 16 h/day; median daily duration 9 0 h (IQR 4 4–10 6) plus usual care 39 participants received usual care (HFNC or NIV) Intubation within 30 days of enrollment 30 days Duration of awake prone positioning; use of the NAV; NIV delay for patients included with HFNC; use of vasopressors or inotropes; CRRT; ECMO; ventilator-free days; days without VIN or HFNC; length of stay in hospital and intensive care; 30-day mortality; WHO ordinal scale for clinical improvement at 7 and 30 days; adverse events Kharat et al (2021)
15
  • Kharat A
  • Dupuis-Lozeron E
  • Singer C
  • et al.
Self-pronation in COVID-19 patients on low-flow oxygen therapy: a cluster-randomised controlled trial.

Switzerland Monocentric RCT General room 10 participants received an awake prone position, self-pronation for 12 h/day, and alternate body position every 4 h; median total duration 4 9 h (SD 3 6) plus usual care 17 participants received usual care (nasal cannula) Oxygen requirements assessed by nasal cannula oxygen flow at 24 h 28 days S/F ratio at 24 h; 24-hour respiratory and heart rate; patient trajectory (transfer to intensive care unit) and potential adverse effects related to the procedure as defined by neck pain; positional discomfort and gastroesophageal reflux; intubation; dead at 28 days Jayakumar et al (2021)
16
  • Jayakumar D
  • Ramachandran Dnb P
  • Rabindrarajan Dnb E
  • Vijayaraghavan MD BKT
  • Ramakrishnan Ab N
  • Venkataraman Ab R
Standard care versus awake prone position in non-intubated adult patients with acute hypoxemic respiratory failure secondary to COVID-19 infection – a multicenter feasibility randomized controlled trial.

India Multicenter RCT intensive care 30 participants received awake prone positioning for at least 6 h/day plus usual care 30 participants received usual care (nasal cannula, face mask, mask without rebreather, HFNC or NIV) The proportion of patients adhering to the protocol Until discharge or death Proportion of patients requiring increased respiratory support; number of hours lying down and maximum hours of continuous prone positioning in a day; length of stay in intensive care; ICU mortality; adverse events Gad et al (2021)
17
Awake prone positioning versus noninvasive ventilation for COVID-19 patients with acute hypoxemic respiratory failure.

Egypt Monocentric RCT intensive care 15 participants received awake prone positioning for 1-2 h each session 3 h apart during waking hours for the first 3 days plus usual care 15 participants received usual care (mask without rebreather) Improvement of oxygenation and avoidance of intubation in the first 3 days after admission to intensive care .. Stay in intensive care and stay in hospital Fralick et al (2021)
18
  • Fralick M
  • Colacci M
  • Munshi L
  • et al.
Prone Positioning of Patients with Moderate Hypoxia Due to COVID-19: A Multicenter Pragmatic Randomized Trial [COVID PRONE].

Canada, United States Multicenter RCT General room 126 participants received an awake prone position four times a day (up to 2 h for each session) and they were encouraged to sleep in the prone position at night; median total duration 6 h (IQR 1 5–12 8) in the first 72 h and 0 h (IQR 0–12) from 72 h to 7 days; plus usual care 122 participants received usual care (nasal prong, venturi mask, HFNC) A composite of in-hospital death, mechanical ventilation, or worsening respiratory failure defined as requiring at least 60% fractional inspired oxygen for more than 24 h 30 days Components of the composite analyzed individually; time spent lying down; change of S/F; recovery time (defined as being in room air for at least 24 h); time to discharge from hospital; and the rate of serious adverse events Garcia et al (2021)
19
  • Garcia MA
  • Rampon GL
  • Doros G
  • et al.
Rationale and design of the awake prone position for early hypoxemia in the COVID-19 study protocol (APPEX-19).

United States Multicenter RCT General room 159 participants received awake prone positioning in up to four daily 1–2 h sessions, and up to 12 h at night plus usual care 134 participants received usual care (room air, nasal cannula, mask or HFNC) Progression of acute respiratory failure, composite outcome of either respiratory deterioration (i.e., progression to mask without rebreather, HFNC, NIV, IMV, or requiring oxygen boost ≥ 2 L/min compared to their initial value) or admission to the ICU 14 days (or until discharge or death) Respiratory deterioration; admission to ICU; receipt of IMV; hospital mortality; diagnosis of ARDS; self-reported median dyspnea (Borg score); safety results; and respect for the awake positioning on the stomach Harris et al (NCT04853979) Qatar Multicenter RCT General room 31 participants received awake prone positioning for at least 3 h/day and up to 16 h/day plus usual care 30 participants received usual care (nasal cannula, mask without rebreather, HFNC or NIV) Escalation of respiratory support within 30 days of study 30 days Incidence of intubation within 30 days of enrollment; use of nasal prongs, Hudson mask, mask without rebreather, NIV and IMV in each group during the first 3 days of the study; physiological response to the mean supine position on days 1-3; P/F or S/F ratio and ROX index at baseline, 1 hour after the first prone position and daily for 4 days; tilt tolerance time; 28-day mortality; length of stay in intensive care unit and hospital; duration of IMV; moving devices; adverse events

Bruker appoints Philip Ma to its board of directors | national company

0

BILLERICA, Mass.–(BUSINESS WIRE)–March 16, 2022–

Bruker Corporation (Nasdaq: BRKR) today announced that its Board of Directors has appointed Philip Ma, Ph.D. to serve on its Board of Directors, effective April 1, 2022.

This press release is multimedia. See the full version here: https://www.businesswire.com/news/home/20220316005639/en/

Dr. Philip Ma is CEO, President and Founder of PrognomiQ (Photo: Business Wire)

Dr. Ma is Chief Executive Officer, Founder, and Director of PrognomiQ, a private healthcare company that develops transformative next-generation multiomics products to enable early detection of cancer and selection and monitoring of cancer treatments. Prior to PrognomiQ, Dr. Ma was Chief Commercial Officer, President and Co-Founder of the proteomics company Seer. Previously, he was Vice President of Digital Health Technology and Data Science at Biogen. Prior to joining Biogen, Dr. Ma was a senior partner at McKinsey & Company, where he served global leaders in the pharmaceutical and biotechnology industries, leading the West Coast healthcare practice and the global personalized medicine practice. Dr. Ma was a macromolecular crystallographer at the Massachusetts Institute of Technology, where he earned his Ph.D. in biology. Philip also holds an AB degree in Biochemistry from Harvard University and an M.Phil in Economics from Oxford University, where he was a Rhodes Scholar.

“We are very pleased to welcome Philip to Bruker’s Board of Directors. Philip brings a wealth of experience in life sciences, multiomics technology, cancer biomarker diagnostics and the global biopharmaceutical industry, including his recent experience as a co-founder of two highly innovative companies Philip also has extensive knowledge of molecular biology, proteomics and the latest in big data software and artificial intelligence/deep learning applications “Said Frank H. Laukien, Chairman, President and CEO of Bruker. “The addition of Philip to our Board of Directors is timely as we continue to advance our Project Accelerate 2.0 multiomics life science initiatives and clinical research tools. Philip shares our entrepreneurial culture of “Innovation with Integrity” and our goals of serving life science and medical research customers with differentiated, high-value systems and solutions to enhance value for all Bruker stakeholders.

“I am delighted to join Bruker’s Board of Directors at this important time in the company’s development. The future of life science research increasingly focuses on further exploring the interaction of proteins, nucleic acids and metabolites from a systems biology view of key mechanisms, including that of disease. The research and diagnostic products that Bruker provides today, and develops, will greatly enable this vision of research and healthcare. I look forward to working with Frank and the Bruker team to plan and work towards this exciting future,” commented Dr. Ma.

About Bruker Corporation

Bruker enables scientists to make groundbreaking discoveries and develop new applications that improve the quality of human life. Bruker’s high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at the molecular, cellular and microscopic levels. Working closely with our customers, Bruker enables innovation, improved productivity and customer success in life science molecular and cellular biology research, applied and pharmaceutical applications, microscopy and nanoanalysis, as well as in industrial applications. Bruker offers differentiated, high-value life science and diagnostic systems and solutions in the areas of preclinical imaging, clinical phenomics research, proteomics and multiomics, space biology and unicellular, structural functional biology and condensates, as well as clinical microbiology and molecular diagnostics. For more information, please visit: www.bruker.com.

Forward-looking statements

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934. , as amended. All forward-looking statements contained herein are based on current expectations, but are subject to risks and uncertainties that could cause actual results to differ materially from those indicated, including, but not limited to , the risk factors discussed from time to time in our filings. with the Securities and Exchange Commission, or SEC. These and other factors are identified and described in greater detail in our filings with the SEC, including, without limitation, our Annual Report on Form 10-K for the fiscal year ended December 31, 2021, as as updated by our quarterly reports on Form 10-Q. We expressly disclaim any intention or obligation to update these forward-looking statements other than as required by law.

Show source version on businesswire.com:https://www.businesswire.com/news/home/20220316005639/en/

CONTACT: Justin Ward, Senior Director, Investor Relations and Corporate Development

Bruker Corporation

Phone. : +1 (978) 663–3660

E: Investor.Relations@bruker.com

KEYWORD: UNITED STATES NORTH AMERICA MASSACHUSETTS

INDUSTRY KEYWORD: ONCOLOGY HEALTH CLINICAL TRIALS RESEARCH SCIENCE PHARMACEUTICALS BIOTECHNOLOGY

SOURCE: Bruker Corporation

Copyright BusinessWire 2022.

PUBLISHED: 03/16/2022 09:46 / DISK: 03/16/2022 09:46

http://www.businesswire.com/news/home/20220316005639/en

‘How I Met Your Father:’ Every Reference To ‘HIMYM’ In Season 1

0

The long-awaited sequel to the fantasy how I Met Your Mother just aired its Season 1 finale. Naturally, reviews from fans and critics are split. Some fans dislike the new writing and the departure from the source material, and others are connecting with the new direction and characters. Either way, every viewer showed up to see how how i met your father would reference and compare How I Met Your Mother.

RELATED: Huh Turns Out ‘How I Met Your Mother’ Told Us the Mother’s Name in Season 1

Aside from the general plot and setup, how i met your father doesn’t share many similarities to its predecessor’s world, but fans who paid attention and have extremely inappropriate knowledge of how I Met Your Mother noticed some callbacks and similarities between the shows.

Both shows kick off with a proposal


how i met your mother proposal

how I Met Your Mother started with Marshall (Jason Segel) practicing his proposal to Lily (Alyson Hannigan), which he will propose later. how i met your father begins the same way: Sid (Suraj Sharma) talks about his proposal plans and later, carries them out.

The theme at the heart of both shows is love. Keeping a married or engaged couple in the mix makes sense to give a unique perspective on events. The audience gets the vision of the unique characters and those who are engaged.

COLLIDER VIDEO OF THE DAY

Goliath National Bank is still there


GNB HIMYM 2x1

Barny (Neil Patrick Harris), Marshall and Ted (Josh Randor) all worked for Goliath National Bank at some point How I Met Your Mother. Marshal sells himself as a lawyer to the soulless corporation, Ted designs the new GNB headquarters, and Barney…please.

In episode 8 of How I met your father, Ellen (Tan Tran) chooses an outfit for an interview she has later. Where is she applying? The headquarters of Goliath Market. This confirms that the Goliath National Bank has expanded, and it might even be possible that Ellen starts working at the headquarters that Ted designed.

The two main couples start with friend zoning


how-i-met-your-father-Jesse-and-Sophie

In the first episode of the series, Jesse (Chris Lowell) almost instantly develops feelings for Sophie when he encounters her driving Uber. In the next episode, Jesse reveals to Sophie that he likes her. Sophie responds, “maybe we could be friends who are messes, instead of two messes trying to date.” Most of the season continues with Sophie and Jesse in the friend zone.

how I Met Your Mother started with an almost identical situation with its main couple: Ted and Robin (Cobie Smulders). Just like Jesse, Ted instantly falls in love with Robin. Likewise, the second episode ends with the pair agreeing to just be friends. This series of repeated events is too specific not to be a direct nod.

Jesse and Sid’s apartment is Ted and Marshals


Apartment HIMYF

Any HIMYM one worthy fan recognized the classic apartment set revealed at the end of the season premiere. Jesse and Sid bring the gang to their apartment as the traditional theme song plays. Jesse mentions that they got the apartment from an “old married couple who posted it on the Wesleyan alumni group.” This is another reference as it is heavily implied that Lily and Marshal were that couple, as they are both Wesleyan graduates.

RELATED: 10 Most Shocking ‘How I Met Your Mother’ Twists, Ranked

Although still the same, the apartment is painted differently and has a more modern feel. The original swords also make a return. While in most backgrounds from the original show, swords are best known from Ted and Marshal’s epic sword fight in Season 1, Episode 8, “The Duel.”

Sophie sings almost as much as Marshall


Best night ever

Marshall is one of the most lovable characters ever written. up there with Joey from Friends. One of his most endearing traits is his love of singing. Marshall would do random songs and sing mundane chores. He also loves dancing which gave him the dancer’s hip, but it’s neither here nor there.

In the second episode of the season, Sophie sings when it is revealed that her comforting song is “Drops of Jupiter”. She still sings a few times throughout the season. This lovely yet simple detail looks very Marshall inspired.


Sophie’s date is a marine biologist, just like…


how-i-met-your-father-ian-sophie-date-episode-1

The show begins with a date between Sophie and Ian, a gorgeous marine biologist – wait for it! Ian recognizes how fake it seems because it’s too good to be true. This is a reference to two different characters in how I Met Your Mother.

RELATED: ‘How I Met Your Father’: A Difficult But Promising Attempt To Step Out From The Shadow Of ‘HIMYM’ | Review

First, The Slutty Pumpkin (Season 1, Episode 6) is a marine biologist who travels to Antarctica to study penguins (and drink Tootsie Rolls). Second, Maggie (Season 5, Episode 10) is also a marine biologist. These two women were considered the ultimate dream girls. This shows that only an ultimate dream date would be a marine biologist.

Jesse and Ted’s “cool shirts”


HIMYM The Ted and Jesse Shirt

This one might be overkill. In episode 4 of season 1 of HIMYM, Ted is wearing a brown shirt he had forgotten about before. The brown shirt ends up giving him confidence and is referenced as a “nice shirt” the entire episode. how i met your father apparently refers to this.

Episode 2 features the gang going to a club and Jesse thinking the event is a setup for him to date, Sophie. Jesse wears a brown shirt until the date and Sophie comments on how good it looks, and like Ted’s shirt, it is considered nice for the rest of the episode. If it’s intentional, it’s extremely subtle.

The Captain and Becky make an appearance


how-i-met-your-father-the-captain

The most apparent connection to the original series is when The Captain (Kyle McLachlan) and his wife Becky (Laura Bell Bundy) appear (boats, boats, boats!). This duo is extremely emblematic for HIMYM; The captain’s sea-themed rants helped, and Becky’s boats led to some of the show’s funniest moments.

The beginning of episode 9 in how i met your father begins with the Captain in bed with someone and Becky walking over them; she then apparently asks for a divorce. The scene is abrupt and is interrupted when Future-Sophie (Kim Cattrall) stops the story and says they will be more important in the future. Fans can only hope for more character revivals in future seasons of ‘How I met your father’.

KEEP READING: 15 Memorable ‘How I Met Your Mother’ Guest Stars Who Could Appear on ‘How I Met Your Father’


the-munsters-cast-social-star
Images from ‘The Munsters’ reveal first look inside 1313 Mockingbird Lane

1313 Mockingbird Lane has never looked better!

Read more


About the Author

Jerome Canada Research Institute for Advanced Biological Sciences and Technology Discovers BCL2A1 Regulator Gene for Treatment of Triple-Negative Breast Cancer | national

0

TAKOMA PARK, Md.–(BUSINESS WIRE)–March 15, 2022–

The Jerome Canada Research Institute for Advanced Biological and Technological Sciences (JCRI-ABTS), today announced that its recent paper, “BCL2A1 REGULATES CANADY HELIOS COLD PLASMA-INDUCED CELL DEATH IN TRIPLE-NEGATIVE BREAST CANCER (TNBC)”, was published in Scientific Reports, a Nature Portfolio journal. This new discovery marks a significant advance in cold plasma technology for the treatment of cancer.

JCRI-ABTS scientists have demonstrated that a combination of Canady Helios™ Cold Plasma (CHCP) and anti-BCL2A1 treatment may be beneficial and provide a new treatment option for triple-negative breast cancer and other tumor cancers solid.

BCL2A1 expression plays an important role in cell survival after CHCP treatment in breast cancer cells and is potentially regulated by TNF-alpha. Silencing BCL2A1 by siRNA treatment or by downregulating its expression by CPI203 treatment in combination with CHCP significantly increases the potency of CHCP treatment.

Breast cancer is the leading cause of cancer death in women. Triple negative breast cancer (TNBC) has a very poor prognosis and frequent relapses occur early compared to other cancer subtypes. CHCP shows promise as a therapy for a variety of poor prognosis breast cancer types and BCL2A1 could be a potential companion diagnostic biomarker.

According to Jerome Canady, MD, Scientific Director, “We investigated the expression profile of 48 apoptotic gene markers and 35 oxidative markers after CHCP treatment in this study, and we are pleased to report the cell death induced by Canady Helios Cold Plasma in TNBC cell lines. ”.

Dr. Taisen Zhuang, USMI CTO, said, “These outstanding results, discovered by our scientists, provide a solid theoretical foundation and will drive the commercialization process for Cold Plasma Oncotherapeutics™. Patients with TNBC will benefit from our cold plasma technology in the near future.”

JCRI-ABTS and its sister company USMI recently successfully completed a Phase 1 clinical trial using Canady Helios™ Cold Plasma (CHCP) for the treatment of recurrent and Stage 4 solid tumors (FDA IDE #G190195).

About JCRI-ABTS

JCRI-ABTS is a state-of-the-art BSL 2 translational molecular research laboratory focusing on plasma oncotherapy (a novel cancer treatment modality) using Canady Helios™ cold plasma to study the potential of cold atmospheric plasma to selectively treat cancer

About American Medical Innovations

US Medical Innovations, LLC (USMI) is a privately held US biomedical device company and a wholly owned subsidiary of US Patent Innovations, LLC. USMI focuses on the development of innovative and affordable plasma and robotic electrosurgical devices and strives to develop innovative devices in the field of plasma technology for cancer eradication.

See the source version on businesswire.com: https://www.businesswire.com/news/home/20220315005579/en/

CONTACT: US Medical Innovations, LLC

Kenniah Chestnut, Esq. Vice President of Corporate Affairs

301-270-0147

KChestnut@usmedinnov.com

www.usmedinnovations.com

KEYWORD: UNITED STATES NORTH AMERICA MARYLAND

INDUSTRY KEYWORD: ONCOLOGY HEALTH MEDICAL DEVICES GENETIC RESEARCH SCIENCE BIOTECHNOLOGY

SOURCE: American Medical Innovations, LLC

Copyright BusinessWire 2022.

PUBLISHED: 03/15/2022 09:30/DISC: 03/15/2022 09:32

http://www.businesswire.com/news/home/20220315005579/en

Copyright BusinessWire 2022.

Experts examine the successes and failures of the COVID response so far

0

The World Health Organization declared COVID a pandemic on March 11, 2020. In the two years since, countries have diverged on their containment strategies, introducing many different ways to mitigate the virus, with effects variables. Here, four health experts examine what worked well, where scientists and policymakers went wrong, and what needs to be done to protect human health from now on.

Andrew Lee, Professor of Public Health, University of Sheffield

Most governments have not responded well to the pandemic. The first answer needed to be decisive, fast, communicated transparently and delivered at scale. Often this was not the case.

Before the arrival of effective treatments or vaccines, brutal measures such as confinement were necessary to minimize the loss of life. Indeed, in places like New Zealand, Taiwan and South Korea, where the spread of infection was initially low, lockdowns have been effective and virus removal possible. Countries that have successfully pursued elimination strategies have seen a drop in the number of cases and deaths, buying time until vaccine protection arrives.

However, we are now in a different phase of the pandemic. Vaccines have significantly changed the risk. Elimination of the virus also appears unfeasible at present, with widespread transmission in virtually every country. The value of lockdowns and travel restrictions is now significantly reduced and their wider societal harms need to take into account.

Lockdowns played a key role at the start of the pandemic. Ryan DeBerardinis/Shutterstock

To live safely with the virus, we must learn from the past two years. This includes getting away from presenteeismthat drives people to go to work or school when they are sick, as well as to appreciate the importance of ventilation and face masks to reduce the spread of airborne disease. The threat of new variants has not gone away, so genomic surveillance of the virus will still be needed on a global scale.

We must also learn from our mistakes. Narrow hospital-centric outlook meant that we did not sufficiently protect vulnerable and disadvantaged people, such as residents of nursing homes, people with disabilities learning disabilities, ethnic minorities and the poor. We also didn’t realize early enough that the pandemic was a “syndemic” – interact with and amplify many other illnesses, such as poor mental health, smoking and alcohol-related illnesses.

Sheena Cruickshank, Professor of Biomedical Sciences, University of Manchester

Immunological discoveries have been key in the fight against COVID. Overall, they would not have happened without the cooperation of scientists from all disciplines and all nations – and without the help of the public around the world. Scientific collaboration has been one of the main successes of the pandemic.

Early access to the genetic code of the coronavirus, combined with our knowledge of other members of the virus family (such as Mers and Sars), allowed work on vaccines to start quickly. Knowing that the virus was using its spike protein to enter our cells then gave us an initial target for vaccines.

Decades of experience in vaccine development, along with investments from governments and the pharmaceutical industry, as well as the participation of hundreds of thousands of volunteers in clinical trials, then accelerated the development of vaccines at an astonishing degree. When it comes to vaccine development, the world has got it right.

Understanding the immune response to COVID has helped us understand why certain groups (like the elderly) are much more vulnerable to severe infection. National studies have used their size and scope to identify biomarkers that correspond to the protection or serious illness in COVIDwhich can improve patient outcomes and inform new treatments.

Rapid advances in biomedical research have been a remarkable triumph of the pandemic. Eugene Lu/Shutterstock

However, lives continue to be lost due to the lack of equity in vaccines, with many countries still being deprived of vaccines and medicines that could help them. Lives have also been lost due to misinformation – fueling mistrust, vaccine hesitancy and the promotion of unsafe or inappropriate “cures” for COVID. Much remains to be done to ensure good access to vaccines and their use around the world.

KK Cheng, Professor of Public Health and Primary Care, University of Birmingham

Very few countries with strong public health traditions have avoided the disasters of the pandemic. Why?

One explanation is that most developed countries were completely untouched by the 2003 Sars epidemic and were only slightly affected by the 2009 swine flu pandemic. Complacency crept in and there was also a general lack of experience in managing a pandemic.

Additionally, at the start of 2020, there were two widely held beliefs: first that the coronavirus, like the flu virus, simply could not be contained, even for a few months; and second, extreme restrictive measures, which we now call “lockdowns,” would be impractical in liberal democracies. Both turned out to be wrong.

In the UK, failure to appreciate the importance of early action, such as in the case of wildfires, has also led to delays in introducing or strengthening control measures by fear of negative economic impacts. These high-level issues have culminated in disasters downstream, including inadequate testing capacity, lack of PPE in health and care facilities, inadequate infection control in care homes, testing systems and dysfunctional traceability and the failure of home isolation of cases.

The potential benefits of island states have also, in many cases, been squandered by loose border controls. Australia and New Zealand showed countries like the UK what was theoretically possible to contain the virus – at least in the early stages of the pandemic.

A persistent global failure is the inequitable distribution of vaccines. Always only 13.7% people in low-income countries have received at least one dose.

Trish Greenhalgh, Professor of Health Sciences in Primary Care, University of Oxford

We initially assumed that the pandemic would be solved by evidence-based medicine – a school of research dominated by the search for generalizable truths (“how large is the effect of intervention X on outcome Y in disease Z? “). Although this approach helped to find effective treatments for COVID, it confused us to assess non-pharmaceutical interventions such as masks.

Some countries have struggled to reach consensus on whether people should wear masks – and who should wear them. FamVeld/Shutterstock

While being obsessed with the need for controlled experiments (“masked” versus “masked”), we suppressed our scientific imagination. We have not questioned enough the novelty of COVID and the significance of its unique patterns of spread, such as superspreader events, asymptomatic transmission and the much higher chances of catching COVID inside versus outside. All these things should have raised hypotheses very early on about a airborne transmission mechanism and the potential value of masks.

We also viewed masks too simplistically, not understanding them as a complex procedure in a complex system. The masks vary in quality and efficiency and can be mounted good or bad. They protect other people as well as the wearer – therefore their population-level effects must be mathematically modeled rather than simply tested in one-off experiments. Moreover, hiding (or refusing to hide) is a social practice, linked to identity and values; many people refused to mask up, and clashes has become, unfortunately, part of the masking.

Two years ago, I wrote my first academic paper on COVID, advocating for the use of precautionary principle and the introduction of public masking “just in case”. It took another four months – and 40,000 deaths – before the UK did.

Covid vaccination for children in the 12-14 age group could start this week



Latest stories

Alt. Agriculture plays about to appear on sanctions (GENH, RKDA, SNES, EVGN, CLXT, AGFS, VEGI)

0

Geopolitical concerns over the Russian invasion of Ukraine are just the latest in a series of macro events that are pushing agricultural stocks higher. Supply chain issues, rising energy costs and rising global demand are driving higher commodity prices and therefore higher incomes for US agriculture.

The United States Department of Agriculture (USDA) reports that net farm income increased by $23.9 billion in 2021, a 25% year-over-year (YOY) increase. iShares MSCI Agriculture Producers ETF (NYSEARCA: VEGI) recently hit an all-time high. This is not surprising considering that Ukraine and Russia together export 29% of the world’s wheat.

While investors have upped the agricultural games from producers to cultivators to ancillary games as the industry booms, some of these stocks may be overweight. As noted, VEGI has reached an all-time high, so perhaps it’s time to look at alternative farming games that still have wiggle room based on a rise in commodities.

Knowing that money can flow to alternative farming games, here are sub-$5 stocks in the radar space as they can bring bigger gains at a faster rate than their bloated blue chip counterparts.

HEMP ON WHEAT

Generation Hemp, Inc. (OTCMKTS: GENH) is one of the most interesting ways to play in this agricultural bull market. GENH is a midstream hemp cultivation company with several verticals using hemp. The industrial hemp market size is expected to reach USD 16.75 billion by 2030, registering a CAGR of 16.8% according to Research and Markets.

GENH is probably the best pure hemp game under $1.

When it comes to inflationary food prices, especially wheat, with Ukraine and Russia accounting for nearly 30% of global wheat production, hemp is an intriguing substitute. Wheat germ and hemp seeds are high in calories, however, hemp seeds actually contain 54% more calories than wheat germ – wheat germ contains 360 calories per 100 grams and hemp seeds contain 553 calories. For macronutrient ratios, wheat germ is much heavier in carbs, much lighter in fat, and similar to hemp seeds for protein. Wheat germ has a macronutrient ratio of 24:54:23 and for hemp seeds 21:6:73 for protein, carbohydrates and fat from calories.

Generation Hemp, Inc. (OTCMKTS: GENH) operates through its wholly owned subsidiary GENH Halcyon Acquisition, LLC, from a facility located in southwestern Kentucky.

GENH’s modular drying operation, using four belt dryers. Each dryer is equipped with variable temperature settings that allow for a more efficient drying process while protecting the valuable cannabinoid and terpene properties of the plant. These modular systems can produce approximately 1,200 pounds of evenly dried hemp per hour.

In 2020, the company processed over 6 million pounds of wet hemp for various customers in Kentucky and Tennessee and was expected to have dried approximately 11 million pounds of wet hemp in 2021.

BIOTECH IN AGRICULTURE

Arcadia Biosciences (NASDAQ:RKDA) is another alternative way to play on rising wheat prices. It specializes in the development of health and wellness products. Earlier this year, he received Notice of Allowance for a US patent titled “Wheat having resistance to glyphosate due to alterations in 5-enol-pyruvylshikimate-3 phosphate synthase.” Recently, the company published a paper titled “Methods of Increasing Fiber in a Grain of Wheat”. While wheat alternatives like hemp are one way to play on rising prices, a biotech company looking to increase production from growing wheat like RKDA is another option.

Another alternative biotech game that helps to maximize agricultural production. Proper pest management is the key to optimal crop production.

Evogene Ltd. (NASDAQ: EVGN) is a diversified biotech stock with some agricultural innovations in its portfolio. AgPlenus Ltd. creates a new mode of action (MoA) herbicide – in 2022 – the company plans to enter into additional collaboration agreements and expand its dataset for APTH1, AgPlenus’ new lead MoA protein for the development of new herbicides.

Evogene’s (NASDAQ: EVGN) other agrobiotech subsidiary, Lavie Bio Ltd., is working on an inoculant (bio-stimulant) for spring wheat. At the end of 2021, Lavie Bio began marketing its result™ inoculant aimed at improving yield based on microbes. Initial product penetration into the spring wheat market is planned for the upcoming 2022 planting season and will be limited to target regions in North Dakota. The company is also working on a fruit rot bio-fungicide program – Following the completion of three consecutive years of vineyard trials, conducted in Europe and the United States, Lavie Bio has prioritized LAV311 as its lead candidate for final development and submission of a regulatory filing, which is expected to be filed with the US Federal Environmental Protection Agency (EPA) and California EPA in 2022.

Calyxt (Nasdaq: CLXT) is a plant-based synthetic biology company. The company leverages its proprietary PlantSpring™ technology platform to engineer plant metabolism to produce innovative, high-value plant-based chemicals for use in customer materials and products. As plant-based solutions, the company’s synthetic biology products can be used to help customers achieve their sustainability goals and financial goals. Calyxt’s diverse offerings are primarily delivered through its proprietary BioFactory™ production system.

ESG AGRICULTURAL GAMES

AgroFresh (NASDAQ: AGFS) is an AgTech playhouse whose mission is to “prevent food loss/waste and conserve the planet’s resources by providing a range of science-based solutions, data-driven digital technologies and services high quality customer”. AGFS has a portfolio that includes plant-based coatings, equipment and proprietary solutions that help improve the freshness supply chain from harvest to home.

Generation Hemp, Inc. (OTCMKTS: GENH) is also an ESG play as it uses its hemp hurd to create a greener crypto mining sector. has partnered with Massachusetts-based Cryptech Solutions, ASICS’ largest volume reseller in North America, to build “green energy” factories and Bitcoin mining farms that use hemp as their primary source of energy. energy. Last Friday, GENH announced the first bitcoin mining facility through a joint venture “JV” to be housed at Generation Hemp’s 48,000 square foot facility in Hopkinsville, Kentucky, which also houses a mining operation. hemp drying through its wholly owned subsidiary GENH Halcyon Acquisition.

Be sure to start your research today.

More information about GENH here: https://capitalgainsreport.com/2022/03/08/generation-hemp-uses-hurd-to-clean-spills-and-comfort-animals/

_____

Disclaimer: Capital Gains Report ‘CGR’ is responsible for the production and distribution of this content. CGR is not operated by a licensed dealer, dealer or registered investment adviser. It should be expressly understood that in no way does the information published here represent a recommendation to buy or sell a security. Our reports/press releases are commercial advertising and are for general information purposes ONLY. We are engaged in the business of marketing and advertising companies for monetary compensation. Never invest in stocks featured on our site or in emails unless you can afford to lose your entire investment. The information made available by CGR is not intended to be, nor does it constitute, investment advice or recommendations. Contributors can buy and sell titles before and after any particular article, report, and publication. Under no circumstances CGR. be liable to any member, guest or third party for any damages of any kind arising from the use of any content or other material published or made available by CGR., including, without limitation, any loss of investment, loss of profit, loss of opportunity, special, incidental, indirect, consequential or punitive damages. Past performance is a poor indicator of future performance. The information in this video, article and related newsletters is not intended to be, nor does it constitute, investment advice or recommendations. CGR. strongly urges you to conduct a full and independent investigation of the respective companies and consider all relevant risks. Readers are encouraged to consult the SEC’s periodic reports: Forms 10-Q, 10K, Form 8-K, Insider Reports, Forms 3, 4, 5, Schedule 13D. For certain content, CGR., its authors, contributors or agents, may be compensated for the preparation of research, video graphics and editorial content. CGR was compensated three thousand dollars via wire transfer by Generation Hemp, Inc. to produce and syndicate content for GENH. In connection with this content, readers, subscribers and website visitors should read the full disclaimers and financial statement found on our website.

The Private Securities Litigation Reform Act of 1995 provides investors with a safe harbor regarding forward-looking statements. Any statements that express or imply discussions regarding predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions or future events or performance are not statements of historical fact and may be forward-looking statements. Forward-looking statements are based on expectations, estimates and projections at the time the statements are made, which involve a number of risks and uncertainties that could cause actual results or events to differ materially from those currently anticipated. . Forward-looking statements in this action can be identified by the use of words such as plans, foresee, expect, anticipate, estimate, believe, understand, or by statements indicating certain actions and quote; can, could or could happen. Understand that there is no guarantee that past performance will be indicative of future results. Investing in microcap and growth stocks is highly speculative and involves an extremely high degree of risk. It is possible that an investor’s investment may be lost or depreciated due to the speculative nature of the companies featured.

Media Contact
Company Name: Capital Gains Report
Contact: Marc McKelvie
E-mail: Send an email
Town: FORT MYERS
State: FLORIDA
The country: United States
Website: http://capitalgainsreport.com/

UW-Stevens Point students boost state-threatened prairie chicken population

0

WISCONSIN RAPIDS, Wis. (WSAW) – Students at UW-Stevens Point have partnered with DNR to help increase the population of the state’s endangered prairie chicken species. The president of the Wildlife Society who leads the “Adopt a Wildlife Area” project said they started the project in 2017 and have just committed for another three years.

Since they started volunteering, there has been an increase in the number of prairie chickens in the Buena Visa Wildlife Area in Wisconsin Rapids. It’s about 12,500 acres.

“You know, we’re just people. We only have our hands and feet and we try to do a lot of the work that tractors can’t do,” said Brilyn Brecka, president of the Wildlife Society and co-lead of Adopt a Wildlife Area at the UWSP.

They eliminate invasive woody species such as willow and cherry.

“Cut down brush and treat it with herbicide to promote grassland growth for the greater prairie chicken,” Brecka said.

Staring at their habitat helps them see each other from afar. The Buena Vista in Wisconsin Rapids is the property with the largest concentration of prairie chickens in the state, about 200 to 250, according to Brecka.

Volunteers work nearly 70 hours combined on Sundays alone.

“We provide lots of hands-on opportunities to gain experience doing things they will do when they graduate,” Brecka said.

Jeffrey Edwards has been co-lead of the Adopt a Wildlife Area project for about three years.

“It’s what I want to do in my life and as a career I work in a kind of habitat management,” Edwards said.

Edwards said the project allows him to make a difference now and helps him achieve his long-term goals.

“Having these skills is going to make me more comfortable handling these things. As a co-leader, I’m also able to help lead the volunteers,” Edwards said.

Brecka said if you have land that looks like Buena Vista, you can help too. Talk to a wildlife biologist about checking out your property to see what you could do.

If you want to see the prairie birds dance, there’s a Prairie Chicken Festival in Wisconsin Rapids on April 9. Click here for more information.

Copyright 2022 WSAW. All rights reserved.

N&O and Herald-Sun receive grant that will help expand science coverage in the Triangle

0

title=

In this file photo, scientists work in a laboratory at Research Triangle Park.

AskBio

The News & Observer and Herald Sun will soon be expanding their coverage of science and research in the Triangle by adding a dedicated science reporter to the team.

The position will be funded by grants from the Burroughs Wellcome Fund and Duke Health.

With support from Journalism Funding Partners and other organizations, N&O and McClatchy newspapers across the Carolinas are increasingly partnering with philanthropic foundations and community supporters to help add reporting capacity on issues of concern. key public interest.

A grant from the 1Earth Fund supports coverage of stories on climate change and the environment, and a grant from Innovate Raleigh pays for the cost of N&O’s coverage of the local tech scene.

The Burroughs Wellcome Fund is a private, not-for-profit foundation based in Research Triangle Park. It supports biomedical research, STEM education and the career development of scientists.

In all of these partnerships, The N&O assesses and hires journalists and retains control of all editorial content.

“We are grateful to the Burroughs Wellcome Fund and Duke Health for recognizing that credible, independent information and information about critical issues can help solve intractable problems,” said Bill Church, editor of The News & Observer and Herald-Sun. “We are delighted to be able to expand our reporting in this area.”

Those interested in learning more about N&O’s philanthropy-funded journalism program can visit www.newsobserver.com/philanthropy/ or contact Adam Waxman, Regional Director of Journalism Development, at awaxman@newsobserver.com

Growing program cuts textbook costs for UNK students | Local News

0

TYLER ELLYSON, UNK Communications

KEARNEY — Kim Carlson doesn’t require students to buy expensive textbooks for most of her classes.

Instead, the University of Nebraska Kearney biology professor uses a variety of free or low-cost resources to educate them.

As a member of UNK’s Open Educational Resources Committee — and a parent whose wallet is directly affected by soaring college textbook prices — Carlson recognizes the need to remove this financial barrier.

Simply put, “There are kids who can’t afford these books,” she said.

According to the US Bureau of Labor Statistics, the cost of college textbooks increased 88% between 2006 and 2016. The Education Data Initiative reports that the average full-time undergraduate student spends more than $1,200 on books and other course materials every year, forcing some of them to work overtime, skip meals or ignore other expenses to pay the bill.

One in five students surveyed by the Education Data Initiative said the cost of books and materials directly influenced their decision on which courses to take.

People also read…






Rochelle Reeves


“Our students shouldn’t have to choose between food security and textbooks, and they shouldn’t have to choose their careers based on the cost of books,” said Rochelle Reeves, associate professor and curricula librarian at the UNK.

Reeves is another member of the Open Educational Resources (OER) committee, a group working to expand the use of free and reduced-cost learning materials at UNK, where the average student pays around $1,000 per year for books and supplies.

Since colleges and universities cannot control the price of traditional textbooks, the OER program focuses on removing them from the equation.

OER uses free, publicly available teaching and research resources, as well as materials available through the Calvin T. Ryan Library at no additional cost to students, to make coursework more affordable. This includes open-access textbooks, e-books, videos, modules, tests, journals, websites, and other tools.

To qualify as an OER course, the cost of a student’s materials cannot exceed $40, excluding lab kits.

For her genetics course, Carlson worked with a company called Skyepack to design a custom e-book using her own presentations and notes, along with other open-access materials. Instead of paying nearly $300 for the latest edition of a textbook, her students get unlimited access to the e-book for just $39. The process cost Carlson nothing.







Kim Carlson

Kim Carlson


“The students really, really like it,” she said. “My class grades are much better and the students are more actively engaged.”

Carlson, co-chair of UNK’s biology department, believes the new class format makes her a more effective instructor. OER gives professors more control over the content of their courses, allowing them to select materials that are both relevant and interesting to students.

“It’s great fun to change up and refresh,” said Carlson, who convinced a few co-workers to create their own e-books for upcoming classes.

Supported by a system grant from the University of Nebraska, UNK launched its OER program in 2015 as a pilot project that included four introductory courses in biology, English, political science, and teacher training.

The campus-wide initiative has grown steadily since then.

From fall 2015 to fall 2021, a total of 86 courses were offered through OER, with over 2,600 students enrolled in these courses. There are 57 courses with a combined enrollment of nearly 1,800 students designated as OERs this semester. Now part of the Office of Graduate Studies and University Outreach, the program has saved UNK students more than $500,000.







UNK - Open Educational Resources


Communications UNK


“I think we have good momentum, but we want to see even more growth,” Reeves said.

Known systemwide as Open Nebraska (ONE), the program is a priority project for NU System Chairman Ted Carter, who continues to support initiatives that make higher education more accessible. OER and a companion e-book program have saved NU students more than $9 million system-wide.

This semester, NU campuses began using a new grading system that allows students to see which courses are using free or reduced-cost materials when they register.

Support is also available for teachers.

Each faculty member participating in the OER program is assigned a librarian and an instructional designer to help them set up their courses and identify resources. Professors also receive stipends to convert their courses to OER.

Carlson and the other committee members know that OER doesn’t work for every course, but they would like to see affordable materials offered in as many courses as possible.

“It’s the best thing for our students,” Carlson said.

Pulmonary Surfactants Market Share, Size, Key Players, Trends, Competitive & Regional Forecast To 2027 – The Bollywood Post

0

The latest market analysis report published by Reports and Data, titled “Global Pulmonary Surfactants Market – Forecast to 2028”, examines the Pulmonary Surfactants industry in depth to provide essential data and insights for targeted readers. The report consists of quantitative and qualitative market research carried out by our market experts. the Pulmonary surfactants The industry report emphasizes current and upcoming market revenue growth opportunities and trends. Additionally, the report offers key insights into industry statistics along with a wide range of dynamic factors including drivers, restraints, risks, challenges, threats, supply and demand ratios, production and manufacturing capacities, sales and distribution networks, costs and demand. volatility, import/export ratios, profit margins and macroeconomic and microeconomic factors. The report includes product type outlook, application spectrum, end-use outlook, technology landscape, regional market analysis, and competition overview. Our market experts have determined the current financial positions of key industry players in the report relying on advanced analytical tools such as Porter’s Five Forces analysis, SWOT analysis and investment assessment .

For a sample copy of the report, click @ https://www.reportsanddata.com/sample-enquiry-form/3669

The revenue growth of the global market is majorly attributed to factors such as increasing prevalence of chronic and acute diseases across the globe, growing demand for personalized medicine, increasing research and development activities in pharmaceutical and biotechnology sectors and the rapid integration of emerging digital technologies such as artificial intelligence, Internet of Things (IoT), big data analytics and blockchain in the healthcare sector.

The rapid spread of COVID-19 around the world, the substantial increase in the number of patients, the significant changes in the demand and supply of healthcare solutions in the time of COVID-19, the growing trends in Telehealth and telemedicine and growing need for advanced point-of-care diagnostics are among the other key factors further fueling the market revenue growth. Increasing government funding for COVID-19 vaccine development, increasing attention to new drug discovery and development, and increasing government attention to strengthening the healthcare supply chain system create new revenue growth opportunities for the market.

Key Companies Featured in the Report:

Chiesi Farmaceutic

Lyomark Pharma

AbbVie

ONY Biotech

Aviva Systems Biology Society

Windtree Therapeutic

Competitive outlook of Global Pulmonary Surfactants Market

The globla Pulmonary Surfactants Market study focuses on the revenue growth trajectories of key companies in this market. This section of the report throws light on the highly competitive landscape of the Pulmonary Surfactants Market, highlighting the major players. The report further examines the strategic initiatives undertaken by each of these market players including mergers and acquisitions, collaborations, joint ventures, new product launches, new business deals, and technological innovations.

To learn more about the report, visit @ https://www.reportsanddata.com/report-detail/lung-surfactants-market

By Administration (Revenue, USD Million; 2017-2027)

By Application (Revenue, USD Million; 2017-2027)

  • Hospital
  • Special clinic
  • recovery center

Global Pulmonary Surfactants Market Report: Table of Contents

  • Industry Overview
  • Market dynamics
  • Market segmentation
  • Regional outlook
  • Competitive landscape
  • Latest developments
  • Research Methodology
  • List of tables and figures

Download the summary @ https://www.reportsanddata.com/download-summary-form/3669

Regional Outlook of the Global Pulmonary Surfactants Market

  • North America
  • Europe
    • UK
    • Germany
    • France
    • Italy
    • Spain
  • Asia Pacific
    • India
    • China
    • Japan
    • Australia
    • Rest of Asia-Pacific
  • Latin America
    • Brazil
    • Argentina
    • Peru
    • Mexico
    • Rest of Latin America
  • Middle East and Africa
    • Saudi Arabia
    • South Africa
    • EA
    • Rest of the Middle East and Africa

Request report customization @ https://www.reportsanddata.com/request-customization-form/3669

Thank you for reading our report. Contact us if you have any further questions about the report and its customization. Our team will ensure that the report is well tailored to meet your needs.

Explore the latest trending research reports by reports and data

About reports and data

Reports and Data is a market research and consulting firm that provides syndicated research reports, custom research reports and consulting services. Our solutions are uniquely focused on your goal of locating, targeting and analyzing changes in consumer behavior across demographics, across industries, and helping customers make smarter business decisions. We offer market intelligence research ensuring relevant and factual research across multiple sectors including healthcare, touchpoints, chemicals, commodities and energy. We are constantly updating our search offerings to ensure that our clients are aware of the latest trends existing in the market. Reports and Data has a strong base of experienced analysts from a variety of areas of expertise. Our industry experience and ability to develop a workable solution to any research problem gives our clients the ability to secure an edge over their respective competitors.

Contact us:

Jean W
Business Development Manager
Reports and Data | The Web: www.reportsanddata.com
Direct line: +1-212-710-1370
E-mail: [email protected]
LinkedIn | Twitter | Blogs

Chronicle: Participate in season framing meetings | Outside

0

Later this month, the Wyoming Game and Fish Department will host season-defining meetings across the state. These meetings provide an opportunity for wildlife managers to present initial proposals for the fall hunting season to the public as well as to obtain feedback from hunters on the proposals and local management issues of concern. These proposals relate to conservation orders for big game, wild turkey, upland game birds, small game, migratory game birds and light geese.

Seasons are set each year to allow wildlife managers to adjust season dates, durations or permit allocations based on the most recent status of wildlife populations.

The development of hunting season proposals incorporates data collected over the past year, including biological data collected from animals harvested at checkpoints and through field checks in the fall of 2021. These data includes sex and relative age, antler or horn measurements, hunting area where the animal was harvested, disease sampling and more.

In addition, from last fall until February, ground and aerial surveys of big game populations were carried out. Biologists and game wardens record the number of animals they observe and classify them by sex and age class. Fawns and calves counted in post-hunting season surveys give an indication of production that year, while a count of yearlings reveals how many survived their first winter and were recruited into the population; essential information to determine the well-being of a big game herd.

Hunter catch data is also an important part of establishing seasons. After the hunting season, a random sample of hunters receives a harvest survey in the mail. The survey asks them to voluntarily report whether or not they harvested an animal, the number of days they hunted before harvesting an animal, the hunting areas they hunted and other questions about their hunt . The Department attempts to obtain a statistically relevant sample size of harvest data relative to the number of licenses sold for each hunting area and license type.

Additionally, hunter and landowner feedback submitted at meetings or online is reviewed by local wildlife managers. Where appropriate, changes to proposals based on this feedback may be made before they are presented to the Wyoming Game and Fish Commission. All written comments from the public are also given to them for consideration. The Commission will review the proposals and comments and finalize the seasons at its April meeting.

Establishment meetings for this year’s season will begin with a series of open houses in local communities. The Sheridan Season Open House will be held Tuesday, March 22 from 4-7 p.m. at the Sheridan Regional Office at 700 Valley View Drive. The meeting will be informal, with time for the public to visit and ask questions of game wardens and biologists. Recorded presentations of this year’s proposals from each wildlife biologist district will be available at www.wgfd.wyo.gov for early viewing. Printed information packets about the proposals will be available at the meeting.

A final meeting to gather information and present regional proposals will be held on March 29 at 6:00 p.m. at the Sheridan regional office. A Zoom link to join virtually is available at wgfd.wyo.gov/get-involved

If you are unable to attend the meetings, written comments will be accepted until 5:00 p.m. on April 1. WY 82604

Christine Schmidt is a Public Information Specialist for the Sheridan Region of the Wyoming Game and Fish Department.

Russian bioweapons conspiracy theory finds support in US

0

Russia’s baseless claims about secret US biowarfare labs in Ukraine are also taking root in the United States, uniting COVID-19 conspiracy theorists, QAnon adherents and some supporters of former President Donald Trump.

Despite rebuttals from independent scientists, Ukrainian leaders, and White House and Pentagon officials, the online popularity of the claims suggests some Americans are willing to trust Kremlin propaganda over the US media and government. .

Like any effective conspiracy theory, the Russian claim rests on certain truths: Ukraine maintains a network of biological labs dedicated to pathogen research, and these labs have received funding and research support from the United States. United.

But the labs are Ukrainian-owned and operated, and the work is not secret. This is part of an initiative called the Biological Threat Reduction Program which aims to reduce the likelihood of deadly disease outbreaks, whether natural or man-made. American efforts date back to the 1990s to dismantle the former Soviet Union’s weapons of mass destruction program.

“The labs are not secret,” Filippa Lentzos, senior lecturer in science and international security at King’s College London, said in an email to The Associated Press. “They are not used in connection with biological weapons. This is all misinformation.

That hasn’t stopped the claim from being embraced by some on the far right, by Fox News hosts, and by groups pushing debunked claims that COVID-19 is a bioweapon created by the United States. .

On the day of Russia’s invasion of Ukraine, an early version appeared on Twitter – in a thread espousing that the Russian offensive was targeting “American biolabs in Ukraine” – and was quickly amplified by the Infowars conspiracy theory website. It has spread across mainstream and low-key social platforms, including Telegram and Gab, which are popular with far-right Americans, COVID-19 conspiracy theorists and followers of QAnon, the baseless hoax that Satan-worshipping pedophiles covertly shape world events.

Many accounts posting this allegation cite Russian propaganda outlets as sources. When Kremlin officials repeated the conspiracy theory on Thursday, saying the United States was developing bioweapons targeting specific ethnicities, it took minutes for their quotes to appear on American social media.

Several Telegram users who quoted the comments said they trusted Russian propaganda rather than independent American journalists or their own democratically elected officials.

“I can’t believe everything our government says!” a poster wrote.

Others quoted the claim while repeating Russia’s talking points about the invasion.

“This is not ‘war,’ this is a much needed cleanup,” wrote a member of a Telegram group called “Patriot Voices” that is popular with Trump supporters. “Ukraine has a ton of US government-funded bioweapons labs that have created deadly pathogens and viruses.”

Leading television pundits and political figures have helped spread this claim even further. Fox News host Tucker Carlson devoted segments of his shows Wednesday and Thursday to promoting the conspiracy theory. On Wednesday, Donald Trump Jr. said conspiracy theories around the labs turned out to be “fact” in a tweet to his 7.3 million followers.

Both Carlson and Trump misrepresented congressional testimony from a State Department official claiming that the United States was working with Ukraine to secure material in biological labs, suggesting this indicated that the labs were being used at improper purposes.

However, it is not surprising that a biological research facility contains potentially hazardous materials. The World Health Organization said on Thursday it had asked Ukraine to destroy any samples that could pose a threat if released, intentionally or accidentally.

While misinformation poses a threat in itself, the White House warned this week that the Kremlin’s latest conspiracy theory could be the prelude to a chemical or biological attack that Russia blames on the United States or Ukraine.

“Frankly, this influence campaign is entirely consistent with Russia’s longstanding efforts to accuse the United States of sponsoring biological weapons work in the former Soviet Union,” the director said Thursday. US National Intelligence Agency Avril Haines in testimony before the Senate Intelligence Committee. “So it’s a classic Russian gesture.”

The conspiracy theory has also been picked up by Chinese state media and was further amplified this week by China’s Foreign Ministry, which repeated Russia’s claim and called for an investigation.

Milton Leitenberg, arms control expert and senior research associate at the Center for International and Security Studies at the University of Maryland, noted that Russia has a long history of disinformation. In the 1980s, Russian intelligence spread the conspiracy theory that the United States created HIV in a lab.

Leitenberg said many Russian scientists had visited a similar public health laboratory in the Republic of Georgia, but Russia continued to spread false claims about the facility.

“There’s nothing they don’t know about what’s going on there, and they know nothing they’re claiming is true,” Leitenberg said. “The important thing is that they know it, without a doubt.”

While gaining traction in the United States, the bioweapons claims are likely aimed at a domestic Russian audience, as a way to build support for the invasion, according to Andy Carvin, senior researcher and editor of the Digital Atlantic Council’s Forensic Research Lab, which tracks Russian disinformation.

Carvin noted that the Kremlin also spread hoaxes about Ukrainian efforts to obtain nuclear weapons.

“It’s a rinse and repeat cycle to hammer out those narratives, especially for domestic audiences,” Carvin said.

___

Klepper reported from Providence, RI Fichera reported from Philadelphia. Associated Press reporter Nomaan Merchant contributed to this report from Washington.

Size of the biobank market worth $106.9 billion by 2028 at a CAGR of 6.2%: Grand View Research, Inc.

0

San Francisco, March 11, 2022 (GLOBE NEWSWIRE) — The Global biobank market the size is expected to reach USD 106.9 billion by 2028, according to a new report by Grand View Research, Inc. The market is expected to grow at a CAGR of 6.2% from 2021 to 2028. Biobanks continue to evolve with the introduction of new technologies such as NGS and the increased focus on genomic medicine. The availability of several types of biospecimens to cater to several fields including drug discovery, diagnostics and others has accelerated the diversification of biorepositories, thereby boosting the market.

Main information and conclusions of the report:

  • The biobanking equipment segment accounted for the maximum revenue share in 2020 due to the high cost of instruments coupled with an increase in the number of biorepositories.
  • The biobanking and storage services segment accounted for the largest revenue share of 36.0% in the market.
  • This is due to the higher penetration of these services and the increased need for preservation of biological samples for the development of precision medicine and disease-specific research.
  • Human tissue is the most stocked sample for clinical research, resulting in the dominance of this type of sample in the market.
  • The virtual biobanking segment is expected to witness the fastest growth rate over the forecast period owing to the increasing demand for 3D biospecimens coupled with the need for rare disease data for biomedical research.
  • The therapeutic applications segment accounted for the largest share of revenue in 2020 due to the growing popularity of cell therapies for cancer treatment.
  • Several pharmaceutical/biotech companies have established their private banks to support clinical trials and development of cell therapies, which has led to revenue growth in this segment.
  • North America led the market with its extensive network of biospecimen storage centers in the United States
  • In addition, a high number of COVID-19 cases in the United States and increased R&D programs have resulted in the creation of new biodepositories, thereby generating revenue in North America.
  • In Asia-Pacific, the market is expected to register the fastest growth owing to the ever-expanding pharmaceutical field and clinical research in Asian countries.
  • Key players are committed to expanding their global reach by partnering with global distributors, merging and acquiring other players, and entering into a strategic alliance with research communities.

Request a free sample or view the report summary: “Biobank Market Size, Share & Trends Analysis Report By Product, By Service (Cold Chain, Lab Processing), By Biological Sample Type, By Biobank Type (Virtual, Physical), By Application, By Region & Segment Forecast, 2021-2028“, published by Grand View Research.

Biobanking Market Growth and Trends

The quality of biological samples can significantly influence disease testing as well as preclinical and clinical research. Regulators have played a critical role in driving the adoption of biobanking services by establishing guidelines for effective sample management. For example, the US Centers for Disease Control and Prevention (CDC) has issued guidelines to minimize human risk when handling COVID-19 specimens.

This serves as a model for other biodeposits. Moreover, as the number of research studies and clinical trials related to COVID-19 increases, the demand for high-quality biological samples is expected to increase significantly in the near future, driving market growth. Additionally, population-based cohort studies are facilitated by biodeposits to estimate true seroprevalence. Health Catalyst, Inc., through its Touchstone platform, provides nationwide data related to COVID-19 information. These factors are expected to contribute to the flow of revenue in this space.

Segmentation of the biobank market

Grand View Research has segmented the global biobanks market on the basis of product, service, type of biological sample, type of biobanks, application, and region:

Biobanking Product Outlook (Revenue, USD Million, 2017 – 2028)

  • Biobank equipment
    1. Temperature control systems
      1. Freezers and refrigerators
      2. Cryogenic storage systems
      3. Thawing equipment
    2. Incubators and Centrifuges
    3. Alarms and monitoring systems
    4. Accessories and other equipment
  • Consumables for biobanks
  • Laboratory Information Management Systems

Biobanking Services Outlook (Revenue, USD Million, 2017 – 2028)

  • Biobanks and repository
  • Laboratory processing
  • Qualification/Validation
  • Cold chain logistics
  • Other services

Biobanks Biospecimen Type Outlook (Revenue, USD Million, 2017 – 2028)

  • Human tissues
  • Organs
  • Stem cells
    1. Adult stem cells
    2. Embryonic stem cells
    3. IPS cells
    4. Other stem cells
  • Other biological samples

Biobank Type Outlook (Revenue, USD Million, 2017 – 2028)

  • Physical/real biobanks
    1. Tissue biobanks
    2. Population-based biobanks
    3. Genetics (DNA/RNA)
    4. Disease-based biobanks
  • Virtual biobanks

Biobanking Applications Outlook (Revenue, USD Million, 2017 – 2028)

  • Therapeutic
  • Drug Discovery and Clinical Research
  • Clinical diagnosis
  • Other Apps

Biobanking Regional Outlook (Revenue, USD Million, 2017 – 2028)

  • North America
    1. we
    2. Canada
  • Europe
    1. Germany
    2. UK
    3. France
    4. Spain
    5. Italy
  • Asia Pacific
    1. Japan
    2. China
    3. India
    4. Australia
    5. Singapore
  • Latin America
    1. Brazil
  • Middle East and Africa
    1. South Africa

List of Biobanking Market Key Players

  • ThermoFisher Scientific, Inc.
  • Merck KGaA
  • QIAGEN
  • Hamilton Company
  • Forward
  • Tecan Trading SA.
  • Danaher Company
  • Becton, Dickinson and company (comics)
  • BioCision
  • Taylor–Wharton
  • Charles River Laboratories
  • lonza
  • STEMCELL Technologies Inc.
  • Biovault family
  • PromoCell GmbH
  • Precision Cellular Storage Ltd. (Virgin Health Bank)

Check out other related studies published by Grand View Research:

  • Synthetic biology marketThe global synthetic biology market size is expected to reach USD 31.97 billion by 2027, registering a CAGR of 20.8% over the forecast period, according to a new report from Grand View Research, Inc. market impact. For example, the technique is used for the development of biofuel from microorganisms in the field of bioenergy.
  • Next Generation Sequencing Data Analysis Market – The global next-generation sequencing data analysis market size is expected to reach USD 1.72 billion by 2028, according to a new report by Grand View Research, Inc. It is expected to grow at a CAGR of 15, 02% from 2021 to 2028. Key drivers contributing to the expansion of the market include increasing adoption of sequencing platforms for clinical diagnostics due to significant reduction in installation cost.
  • Gene Amplification Technology Market – The global gene amplification technology market size is expected to reach USD 30.80 billion by 2028, according to a new report by Grand View Research, Inc. The market is expected to grow at a CAGR of 2.0% by 2021 to 2028. The major factors driving the market are expansion of molecular diagnostics and genomics research, introduction of new and advanced products, and growing acceptance of personalized medicine.

Browse Grand View Research results Biotechnology industry Research reports.

About Grand View Research

Grand View Research, a US-based market research and consulting firm, provides syndicated and custom research reports and consulting services. Registered in California and based in San Francisco, the company has more than 425 analysts and consultants, adding more than 1,200 market research reports to its extensive database each year. These reports offer in-depth analysis of 46 industries in 25 major countries around the world. Using an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and assess upcoming opportunities.

Contact:

Sherry James
Corporate Sales Specialist, USA
Grand View Research, Inc.
Phone: 1-415-349-0058
Toll Free: 1-888-202-9519
E-mail: sales@grandviewresearch.com
The Web: https://www.grandviewresearch.com
Grand View Compass | Grand View Pipeline
Follow us: LinkedIn | Twitter

main logo

Faculty Senate hears a presentation on faculty compensation and discusses the need to improve faculty retention

0

Tufts administration and faculty are reviewing faculty compensation and promotion policies, with an emphasis on hiring and retaining talented faculty. mike howardthe executive vice president of Tuftsand Kim Ryan, vice president of human resourcesmade a presentation on the subject to the University Faculty Senate to her February Meet.

Anne Mahony, The Senate secretary and senior lecturer in classical studies, explained what prompted the Faculty Senate’s discussion of retention in an interview with The Daily.

“We thought about [faculty] retention for a long time. It’s hard to keep a good faculty. There are so many other places teachers can go,” Mahoney said. “And for some disciplines, for example, you can make a lot more money in non-academic work. Veterinarians, for example, can make a lot more money – and sometimes with less stress – in private practice than they won’t earn as teachers in veterinary school.

The cost of living in Boston has also presented a barrier to hiring and retaining faculty, as Ellen Pinderhughes, Eliot-Pearson Faculty Senator and Professor of Child Studies and Human Development, underlined during the meeting of the Senate of the Faculty.

The inability of the university to increase faculty salaries in proportion to the rising cost of living “resulted in a salary that…leaves Tufts vulnerable to faculty being – appropriately, through my lens – recruited from other institutions,” said Pinderhughes.

There were few faculty involved in conversations about hiring and retention before the eestablishment of the Faculty Senate in the spring of 2017. Faculty members hope to become more involved in setting faculty compensation policies now that the Faculty Senate exist.

“The faculty of the university as a whole has only really been able to come together and discuss things in the last five years since we had a senatee,” Mahoney noted.

In his presentation to the Senate, Ryan describes the objectives of the university’s merit-based faculty compensation policy.

“First and foremost, it’s really about attracting and motivating talent,” Ryan say it Senate of the University Faculty. “And what I mean by that is…we have a competitive rate [of compensation] …to get people into college.

Mahoney acknowledged that the university sometimes struggles to offer competitive salaries to faculty with job prospects in non-academic fields.

“We don’t always have the resources to pay as much as we would like and as much as we think we should,” Mahoney said. “We try to stay close to the market, but it can be difficult because again, [with] engineering or biology or veterinary medicine or human medicine, the market is so much wider than what other colleges do.

Ryan explained that to Tufts, hiring decisions are made at the discretion of the relevant academic department, and salary decisions are made by the deans of the individual schools that make up the university.

Mahoney says that most universities make hiring decisions at the departmental level because expertise in the relevant discipline is needed to determine which candidate is most qualified. Tufts is unique in that salary decisions are made by individual school deans rather than central administration.

“Tufts is quite decentralized. Harvard has a similar structure. … But in other schools – the schools where I was a student or where I had jobs as an instructor – things are much more centralized. Deans are less powerful and more decisions are made centrally,” Mahoney told the Daily.

Mahoney says that this decentralized approach has advantages.

“The benefits are that decision-making is closer to where things are happening,” she explained. “If something needs to be done in [the School of] Arts and sciences, we don’t have to coordinate with headquarters, we don’t have to coordinate with the provost or the vice president of finance or anything. We just do it. Dean Glaser and his team are doing what needs to be done.

There are also downsides to decentralization, and Tufts actively considering moving away from the decentralized model.

“If you’re not careful, you end up with a bunch of different schools all going in different directions, and nobody looking at the big picture,” Mahoney noted. “When times are good, when there are good returns on staffing, when enrollment is healthy, [the decentralization] doesn’t matter much because things run smoothly. In times of crisis, things have to be a bit more centralized.

President of the Senate Jette Knudsen, a professor of politics and international trade to Fletcher Schoolexpressed concern about the February senate meeting that tthere is little transparency in the decentralized model about how faculty salaries and promotions are determined. Mahoney later explained to The Daily that Knudsen repeatedly received increases without knowing the criteria that determine when and by how much his salary was increased.

Ryan replied to by Knudsen concerns.

“There is definitely a gap in faculty expectations…and guidelines for merit increases, compensation, promotion and tenure,” she acknowledged. “It’s something that [Vice Provost] Kevin [Dunn] and I’m going to tackle the provost. … In fact, Mike Howard and I also had a discussion with [University President] Tony [Monaco] on this subject.”

Mahoney explained to daily how salaries are currently determined: Non-tenured professors such as full-time lecturers generally receive a standardized salary set in their contracts. However, department chairs have the discretion to determine tenured faculty salaries based on the work they publish, their teaching ability, course enrollment, and collegiality toward their colleagues, among other factors.

Course evaluations play only a small role in salary decisions, Mahoney, because research indicates that they reflect students’ implicit biases.

“It’s not just a Tufts thing; it’s universal” said Mahoney. “Teachers get comments about how cute and motherly they are. Male teachers receive feedback on their skill level. And don’t even get me started [on] faculty of color, who also tend to come under fire in course evaluations.

After an unprecedented bear year, the Sitka Bear Task Force meets again

0
14 brown bears were euthanized in Sitka in 2021, the biggest year on record. (Photo courtesy of Meredith Redick)

The first spring brown bears have been spotted in Sitka. Not a moment too soon, the assembly is relaunching a bear task force to address growing bear-human conflicts within the community.

The new task force will spend six months investigating Sitka’s bear history, reviewing the work and suggestions of the last task force established in 2005, as well as studying bear deterrence efforts in other communities. Assemblyman Crystal Duncan, who sponsored the talking point with Rebecca Himschoot, said the decision followed Sitka’s worst year for bear killings in 30 years.

“We want to prevent that,” Duncan said. “And we know it has to start now.”

Last year’s bear activity was unprecedented. Fourteen bears were euthanized in Sitka last year, more than double any year on record since 1980. The Sitka Tribe of Alaska asked the Assembly to prioritize the issue of community bears during the government-to-government meeting this winter. And on March 8, ADF&G wildlife biologist Stephen Bethune told the gathering that the community needed to find a way to solve its litter problem.

“If there is a silver bullet, it won’t solve the problem entirely. But if there was one, one method that is going to have a significant impact on our problems, it’s bear-resistant containers,” he said.

This data, collected by the Alaska Department of Fish and Game, shows the number of recorded bears euthanized in Sitka by year. Wildlife biologist Stephen Bethune included this slide in his presentation to the assembly to demonstrate that 2021 was unprecedented, with 14 bears killed. (Town of Sitka)

City administrator John Leach said that whatever the bear task force proposes, there will be a price for the city to consider.

“We’re talking about bear-proof boxes, they’re expensive,” Leach said. “We may not be able to do this in the whole community and we can target areas with high bear traffic. But this has a cost. »

“And if the community wants it, we have to bear that cost. I don’t mean that… there’s a pun there,” Leach said. “But we have to absorb that cost somehow if we’re not able to find it through a grant.”

The task force will be comprised of representatives from ADF&G and the city, Sitka Tribe, BIHA, and Sitka National Historical Park, among other agencies.

The city is also looking for two volunteers to join the task force. Find information on how to apply here.

The City and Borough of Sitka (CBS) is looking for two volunteers to serve on recovery
Sitka Bear Task Force (SBTF). The SBTF will consider previous suggestions from the working group, investigate
efforts in other communities to reduce bear-human conflict, and provide recommendations in return
to the SCB Assembly in six months. Applications will be accepted until March 15, 2022 and
can be found online at www.cityofsitka.com or at the City Clerk’s Office at City Hall, 100
Lincoln Street. Call 907-747-1826 or email Clerk@cityofsitka.org for more information.
Publication: March 11 and March 14

People without jobs or secure housing have wo

0

People without jobs or with less secure housing have worse outcomes when treated for depression with talk therapy or antidepressants, compared to more socially advantaged peers, according to a study by researchers from UCL.

The authors of the new study published in JAMA Psychiatry say addressing employment and housing needs can be helpful alongside treatments for depression in supporting the mental health of socioeconomically disadvantaged people.

The researchers combined evidence from nine studies, which included a total of 4,864 people who had been treated for depression, where data was available on socio-economic factors such as employment and housing.

They found that after three to four months of treatment, unemployed patients had 28% worse symptoms of depression than those who worked. Homeowners’ depression symptoms were 18% better than people who were homeless or living in hostels or with family and friends.*

Lead author Dr Joshua Buckman (UCL Psychology & Language Sciences and Camden & Islington NHS Foundation Trust) said: “We found that people who are unemployed or who live in less secure accommodation have worse outcomes when being treated for depression. Additional support to access employment or housing could also lead to improved mental health.

“Based on our results, we cannot confirm whether helping to improve people’s working and housing conditions would directly improve their mental health, or whether it would make them more likely to undergo treatment. For example, it may be easier to keep all of their appointments if they can stay in the same place regularly without having to move.

“We hope that further research will provide insight into how best to meet the mental health needs of socially disadvantaged people.”

People who were unemployed or had less secure housing had worse outcomes, even compared to people who had a similar severity or number of symptoms when they started treatment. The researchers adjusted for other factors known to influence treatment outcomes, such as a range of mental illness characteristics, in addition to age, sex, marital status and, in most studies , physical health conditions and social support.

They also looked at whether financial hardship or education was associated with treatment effectiveness, but found no significant effect for either factor, and these factors did not explain neither are the links with employment and housing status.

After the first few months of treatment, the differences between the groups continued to widen, as after nine to 12 months the unemployed patients had 37% more severe symptoms than the employed patients.

Treatments for depression given varied somewhat across studies, including a few common antidepressants, cognitive behavioral therapy (CBT), computerized CBT, structured physical activity, collaborative care, and other options, but outcomes were consistently worse for people without jobs or secure housing. .

Co-lead author Professor Stephen Pilling (UCL Psychology & Language Sciences) said: “Clinicians can easily ask their patients about housing status and employment, and our findings suggest this should then inform their plans for processing. If possible, a referral for support in finding secure housing or employment may be beneficial, or knowing that these patients are less likely to get better, clinicians could consider more intensive treatment or give priority to a follow-up appointment soon after starting treatment to see if it is having the desired effect.

Co-author Professor Glyn Lewis (UCL Psychiatry and Camden & Islington NHS Foundation Trust) said: “Social disadvantage can increase the risk of mental illness, so it is of particular concern that in addition to this underlying risk higher, those without a job or in secure housing are also less likely to recover from depression.

The study was funded by Wellcome with support from the MQ Foundation, Royal College of Psychiatrists, National Institute of Health Research (NIHR), NIHR Biomedical Research Centers at University College London Hospitals and South London and Maudsley NHS Foundation Trust and King’s College London and the Alzheimer Society, and involved researchers from UCL, Camden & Islington NHS Foundation Trust, UCLA, King’s College London, Vanderbilt University and the Universities of Southampton, Exeter , York, Bristol and Pennsylvania.

* Renters performed worse than homeowners, but better than people living in other less secure housing situations.


Warning: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Physics and biology together explore the mechanisms of life — ScienceDaily

0

Each of our cells contains about 40 million proteins which together perform all the tasks the cell needs to survive. For smooth action, the right proteins must be concentrated in precise amounts, at a precise time and in a precise place. However, establishing such a delicate distribution requires an extremely precise process, occurring at tiny spatial resolutions that standard cell biology tools are often unable to detect. To understand how this mechanism works, researchers from the University of Geneva (UNIGE) have developed a new approach combining experiments in genetics and cell biology with physical modelling. Thanks to specific algorithms, they simulated the formation of protein gradients in 3D and over time and were able to explain these complex mechanisms. Moreover, their innovative model can be adapted to other biological systems to study protein dynamics. These results can be read in the Proceedings of the National Academy of Sciences.

Like a drop of ink in a glass of water, proteins can diffuse and distribute themselves evenly throughout the cell. However, for a number of tasks, proteins must form gradients. “Protein gradients, which result from the uneven distribution of proteins in specific cellular areas, are central to many cellular and body functions,” says Monica Gotta, a professor in the Department of Cellular Physiology and Metabolism and the Center for Translational Research in Onco-Hematology (CRTOH) of the UNIGE Faculty of Medicine, which directed this work. “For example, protein gradients are important for cell differentiation, the process by which the different cell types that make up a complex organism emerge from a single cell, the fertilized egg.”

A use of chance

The PLK-1 protein, a key regulator of cell division, is known to be most concentrated on the anterior side of the embryo. But how to set up this mechanism, and what would be the consequence if the smallest detail went wrong? The usual tools of biology not being sufficient to answer this question, Monica Gotta was happy to welcome in her team a physicist, Sofia Barbieri, post-doctoral researcher in the Department of Cellular Physiology and Metabolism of the Faculty of Medicine of the UNIGE. “By compiling everything that is known about this biological process and new hypotheses on the mechanisms, I developed a statistical model of protein gradient formation based on probabilistic mathematics”, explains Sofia Barbieri. “I used specific calculation algorithms, called Monte Carlo simulations, named after the famous city in the game.” These algorithms are used to model phenomena with a high level of complexity, such as finance, trading or particle physics.

The team was able to simulate protein gradients, not only in 3D, but also over time. Such a model however required several iterations between the optimization of the parameters and the comparison with the biological data. The researchers built a first version of the model integrating all the known physical and biological elements of the system, then introduced specific parameters necessary to test several hypotheses concerning the unknown variables. They simulated possible physical and biological outcomes that reproduced computationally protein dynamics and gradient establishment in the cell, and tested them in real life with in vivo experiments using the embryos of a small worm, the C.elegans nematode.

Complex protein interactions at play

Thanks to the continuous interaction between modeling and cell biology, the UNIGE researchers were able to determine how the PLK-1 gradient was established and maintained over time. Indeed, PLK-1 must bind and unbind dynamically from MEX-5, another protein crucial for development in the C.elegans embryo, to counteract its natural tendency to diffuse homogeneously in the cell. MEX-5 indeed has the ability to change its diffusivity depending on its position in the cell and to interact with other proteins, which is essential to enrich PLK-1 where it is needed. “But surprisingly enough, MEX-5 is not as effective at its task, because a large amount of PLK-1 is not bound to MEX-5!” points out Sofia Barbieri.

This study provides a unique quantitative model for understanding dynamic protein interactions and can be adapted to other cells or proteins whose complex mechanisms cannot be tested with standard cell biology experiments. “Our work shows that interdisciplinary collaborations are increasingly important to advance research! concludes Monica Gotta.

Source of the story:

Materials provided by University of Geneva. Note: Content may be edited for style and length.