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Mott Center Continues 50th Anniversary Celebration Year – News from the School of Medicine

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Visitors were treated to tours of the labs at the CS Mott Center for Human Growth and Development during the center’s open house on June 9.

The CS Mott Center for Human Growth and Development at Wayne State University School of Medicine continues to mark 50 years of research that saves and improves lives.

The year-long celebration kicked off with an open house and facility tours on June 9. More than 70 people attended the event, which included remarks from Dean of the Wael Sakr School of Medicine, MD; Vice President of Research Stephen Lanier, Ph.D,; Gil Mor, MD, Ph.D., John M. Malone Jr., MD, Endowed President and Scientific Director of the CS Mott Center; and Stanley Berry, MD, acting chair of obstetrics and gynecology.

Visitors learned about the center’s basic and gynecological cancer research and toured the facility’s labs to learn about cutting-edge research being done, and mingled at a reception.

Dean Sakr spoke about the future of research and the role played by the Mott Center.

“In terms of Wayne State’s accomplishments in certain research pursuits, the Mott Center is definitely one of the most self-sustaining,” he said. “There is a diversity of research on human growth and development, male and female infertility, and the human sperm microbe using pioneering research. They all complement each other and really extend to collaborations with many other entities.

The centre, which opened in 1973, is an internationally renowned research facility established to promote research training relating to women’s and children’s health, with a focus on reproductive biology, immunology , oncology, toxicology and prenatal medicine. Its scientists integrate basic, translational and clinical research with the goal of improving women’s health.

Mott Center Director Gil Mor, MD, Ph.D., and Dean Wael Sakr, MD

“I had known about the Mott Center for many, many years in my career,” Dr. Mor said. “I knew it was an amazing place and I hope it will be. This has impacted the community and the field of obstetrics and gynecology in many ways.

This work continues, Dr. Mor said, while training future generations of medical researchers, both in the labs and as part of the Discovery to Cure program. The Discovery to Cure Program is a high school internship created by Dr. Mor at Yale University in 2003 with the goal of providing high quality life science research experience to qualified high school students by exposing them to careers in biomedical research. In 2019, with the appointment of Dr. Mor as director of the CS Mott Center, he launched the program in Detroit, with the first group of interns welcomed in the summer of 2021.

Located at 275 E. Hancock in Detroit, the center championed a lifespan perspective to reproductive health and an ecological approach to growth, development, and well-being. Its faculty is committed to a personalized approach to medical treatment and care. The main mission of the Mott Center is to promote basic and clinical biomedical research on reproduction and development. It offers an integrated doctoral program integrating the teaching, research and physical resources of the Department of Physiology and the Department of Obstetrics and Gynecology. The program offers interdisciplinary doctoral training in reproductive sciences.

The center was renovated during a five-phase reconstruction from 2001 to 2008. In addition to the laboratories and offices of individual obstetrics and gynecology researchers, the center houses the research laboratories of the Perinatology Research Branch of the National Institute of Child Health and Human Development, the Reproductive Biology and Medicine Branch Implantation Laboratory, NICHD Intramural Research Division, Wayne State University Genomics Facility, a bioinformatics center and a systems biology section. It also contains one of the clinical research areas of the Department of Obstetrics and Gynecology.

Former Dean Jack Sobel, MD, explains the work of the Clinical Research Center.

The center, in conjunction with the Barbara Ann Karmanos Cancer Institute, also created the Ovarian Cancer Research Interest Group. The group seeks to bring together scientists and doctors working in the field to merge the individual expertise of each researcher in order to quickly find solutions to deal with the disease.

The event included visits to laboratories and the Clinical Research Center, led by Dr. Sobel. Laboratory presentations were given by research group leaders including J. Richard Pilsner, Professor and Robert J Sokol, MD, Chair of Molecular Obstetrics and Gynecology and Director of Molecular Genetics and infertility; Jayanth Ramadoss, Ph.D., professor of obstetrics and gynecology and physiology; and Ayesha Alvero, MD, M.Sc., professor of obstetrics and gynecology.


Upcoming events as part of the 50th anniversary celebration include:

Discovery to Cure Graduation – August 19

Michigan Alliance for Reproductive Technologies and Sciences Symposium – September 16

Colloquium – April 2023

50th anniversary celebration – June 2023

Gala – June 2023

To see more photos, visit here.

Professor Emma Johnston Children’s Book Profiles

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“It has been a pleasure to be part of this series of children’s fiction books which serves to promote reading and inspire the next generation of scientists and inventors,” said Professor Johnston. “I am a passionate environmental scientist and an advocate for greater diversity in our research community. I hope this book helps open the door to a career in research for a wide range of children across the country.

“I haven’t shared my life story yet. It reveals a strong marine theme, from early childhood growing up in a peninsula town, swimming, snorkeling and sailing, to my adventures diving under the Antarctic ice floe, and subsequent efforts to translate the marine sciences in marine solutions. This collaboration with author Dee White is part of why I love research so much and how people can use research to inform the restoration and conservation of our precious marine environments.

About Professor Johnston’s STEM research

Professor Johnston’s research focuses on global change, including marine debris, microplastics, the impacts of bushfires on marine ecosystems and securing the environmental future of Antarctica. This is research that is carried out in field environments as diverse as Sydney Harbour, Antarctica, the Great Barrier Reef and temperate Australian estuaries. While at UNSW, his research group studied the ecology of human impacts in marine systems, combining the diverse disciplines of ecology, microbiology and ecotoxicology to expand fundamental understanding and provide management recommendations.

She has led major research projects for industry, government, the Australian Research Council and the Australian Antarctic Science Program and contributed to the development of international and national research strategies, priorities and plans. She is a champion of sustainability and diversity and the lead author of Australia’s State of the Environment Report 2021. She is also a trusted advisor working for various government and industry bodies.

Professor Johnston is a Fellow of the Australian Academy of Sciences (AAS), the Australian Academy of Technology and Engineering (ATSE) and the Royal Society of New South Wales. She was appointed an Officer of the Order of Australia (AO) in the 2018 Queen’s Birthday Honors for “distinguished service to higher education, in particular marine ecology and ecotoxicology, as a scholar, researcher and administrator, and to scientific institutes”.

She is a regular media commentator and, as co-presenter of the Foxtel/BBC Coast Australia television series, has helped bring Australian marine science to international audiences.

The book’s author, Dee White, has written over 20 books published in the US, UK, Canada, Israel, Australia and New Zealand. She has three generations of scientists in her family, cares deeply about the environment, and is fascinated by how things work. Ms. White loves writing books that empower readers and inspire them to explore the world outside of their own experiences.

Screening for cancer with locust brains | MSUToday

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Saha and her team chose to work with locusts as a biological component for several reasons. Locusts have served the scientific community as model organisms, like fruit flies, for decades. The researchers gained a significant understanding of their olfactory sensors and the corresponding neural circuits. And, compared to fruit flies, locusts are larger and more robust.

This combination of features makes it relatively easy for MSU researchers to attach electrodes to the brains of locusts. The scientists then recorded the insects’ responses to samples of gases produced by healthy cells and cancer cells, then used these signals to create chemical profiles of the different cells.

MSU Professor Christopher Contag, who is the director of the Institute of Quantitative Health Sciences and Engineering.

This isn’t the first time Saha’s team has worked on something like this. In 2020, while at Washington University in St. Louis, he conducted research that explosives detected with locusts, work that was considered in an MSU search committee recruiting Saha, said IQ director Christopher Contag.

“I told him, ‘When you come here, we’ll find the cancer. I’m sure your locusts can do it,” said Contagioninaugural James and Kathleen Cornelius Chair, who is also a professor in the Department of Biomedical Engineering and the Department of Microbiology and Molecular Genetics.

One of Contag’s areas of research was to understand why oral cancer cells had distinct appearances under his team’s microscopes and optical tools. His lab found different metabolites in different cell lines, helping to explain the optical differences. Some of these metabolites turned out to be volatile, meaning they could be airborne and sniffed.

“The cells looked very different metabolically, and they looked different optically,” Contag said. “We thought it made a lot of sense to look at them from a volatile perspective.”

Several locusts rest on a fence.

Locusts are grasshoppers that have earned a distinct name thanks to their swarm-forming social behavior. Credit: Derrick L. Turner

Saha’s locust detectors provided the ideal platform to test this. The two Spartan groups collaborated to study how well locusts could differentiate healthy cells from cancerous cells using three different oral cancer cell lines.

“We expected cancer cells to appear different from normal cells,” Contag said. “But when the insects were able to distinguish three different cancers from each other, it was amazing.”

Although the team’s findings focused on cancers of the mouth, the researchers believe their system would work with any cancer that introduces volatile metabolites into the breath, which is likely most types of cancer. The team begins a collaboration with Steven Chang, director of the Henry Ford Head and Neck Cancer program, to test its detection system with human breath.

The researchers also want to incorporate the chemical sensing power of bees into the lap. The MSU team has already obtained promising results using bee brains to detect volatile biomarkers of lung cancer.

Again, people don’t have to worry about seeing swarms of insects in their doctors’ offices. The researchers’ goal is to develop an enclosed, wearable sensor without the insect, just the biological components needed to detect and analyze volatile compounds – perhaps before other, more invasive techniques can reveal the disease.

“Early detection is so important, and we should use every tool possible to achieve it, whether designed or provided by millions of years of natural selection,” Contag said. “If we are successful, cancer will be a treatable disease.”

Other MSU contributors to the project include research associate Ehsanul Hoque Apu (now a researcher at Michigan Medicine); doctoral students Michael Parnas and Alexander Farnum; undergraduate research assistant Noël Lefevre; and Elyssa Cox, head of Saha’s Olfactory Sensory Systems Bioengineering Laboratory, or BOSS.

This copper nanowire spray makes any surface antimicrobial

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Since copper has long been known to destroy viruses and bacteria on contact, it is often applied by professionals to frequently touched surfaces, such as doorknobs. A new copper nanowire spray could allow ordinary people to apply the same treatment to already existing surfaces.

Ames National Laboratory from the United States Department of Energy (DOE), Iowa State University and the University at Buffalo have partnered to develop the technology. It advances earlier Ames research that produced copper ink for printing circuits on flexible electronic equipment.

Two different spray varieties, each with advantages and disadvantages, are being evaluated by scientists. One uses pure copper nanowire segments 60 nanometers wide (one-hundredth the width of a human hair), while the other uses copper-zinc nanowire elements of the same size.

Both versions hold the wires in a carrier solution, such as water or ethanol. The liquid produces a thin antimicrobial coating after being sprayed onto a surface material such as glass, plastic or stainless steel and allowed to cure at room temperature.

Lab tests revealed that copper discs sprayed with the coating killed the SARS CoV-2 virus (which induces Covid-19) as completely as an uncoated copper disc. However, the coating completed the task in just 20 minutes as opposed to the regular disk’s 40 due to the larger surface area offered by the nanowires.

Spraying pure copper nanowires inactivated the virus twice as fast in the first 10 minutes as its copper-zinc equivalent. The copper-zinc coating, however, required less frequent reapplication because it remained effective longer. For this reason, researchers consider it the ideal possibility of practical use. An article on the research was published on February 21, 2022 in RSC advances.

In 2020 we saw copper being used to kill cancer cells. An interdisciplinary team of scientists from the University of Bremen, KU Leuven, University of Ioannina and the Leibniz Institute for Materials Engineering successfully killed tumor cells in mice using compounds from nanoscale copper as well as immunotherapy.

The research team conducted studies on lung and colon cancer. The group of physicists, biomedical researchers and chemical engineers discovered that these tumors were sensitive to copper oxide nanoparticles made of copper and oxygen.

Once inside living organisms, the nanoparticles will dissolve and become toxic. The researchers created the nanoparticles using iron oxide, allowing the team to kill cancer cells without harming healthy cells.

Defend the Ground | Mirage News

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Soil is too often seen as “just dirt,” says Dr. Oliver Knox. On the other hand, scientific perspectives may dissect the soil into its component parts and overlook the larger importance of the relationships between these parts.

The UNE Associate Professor of Soil Systems Biology argues for a higher view of soil, as the largest living ecosystem on the planet and the foundation of all human endeavour.

Soils have received new attention in recent years due to their ability to sequester carbon from the atmosphere. Dr. Knox has reservations about this narrow focus.

When addressing the Gwydir Regional Carbon Forum on Wednesday August 3, Dr Knox will not present a specific case for soil carbon. Instead, it will present the case for building carbon-rich soil systems.

“I’m not sure how much carbon can be put into the ground, and I’m not sure that should be our goal,” he says. “I think we should be looking for ways to protect and nurture our soil ecosystems, rather than focusing on one particular part of them.”

“As long as we focus on practice systems that have the goal of protecting this precious and limited resource, we are headed in the right direction.”

Dr. Knox has gained local fame as a proponent of the “Soil Your Undies” method of visualizing soil health. The method is refreshingly simple: Participants bury cotton underwear in different soils, then dig them up after eight weeks to assess how much the cotton has degraded.

In healthy soil, vigorous microbial activity will have returned much of the cotton to the soil. Sometimes only the elastic waistband remains. In less healthy soils with less ability to recycle nutrients, degradation is visibly reduced.

The Dr Knox Soil Your Undies Challenges have been running since 2018, in collaboration with CottonInfo, UNE SMART Farms and UNE Discovery. Through the challenges, he has graphically demonstrated to over 500 groups of farmers, schools, and Landcare groups the nutrient-cycling power of healthy, living soil. Soil your Undies has also made its way to Africa.

His work on this and other programs has earned Dr. Knox nominations for the 2022 CSD Cotton Researcher of the Year and the General Jeffrey Soil Health Awards.

Working with soils allows Dr Knox to see the damage being done to this fundamental resource, “but I can also see the opportunities we have to address it.”

“Certainly here in Australia, most agricultural industries have taken up this challenge and are doing all they can to produce more with less. I don’t think the public necessarily believes or actually knows about these stories, maybe as much as they should. But we can still do more. »

He is encouraged by the innovative work being done by individual farmers, some of whom have been encouraged to discuss their work after being prompted by a Soil Your Undies exercise.

“They understood the problem and adapted their systems to meet a niche challenge in their valleys. Other farmers can then see that it’s not something forced on them from a research station miles away – it’s actually a local success story. I think there’s tremendous power in that.

Dr. Knox never sees the end of the need for continuous innovation by farmers and soil science to continually discover how soils work. But he thinks the biggest need right now is commitment, to take the work of innovators and scientists further into the paddock.

“It’s about taking those ideas that we think will work and being there to support farmers who want to make those changes in practice but are unsure of their ability to do so. I know that most farmers recognize the importance of their soils and want to protect them. They just need encouragement.

Ultimately, Dr. Knox observes, there are few higher priorities than protecting the soils we have left.

“Let’s not send people into space,” he said. “Let’s invest in the protection of our soils. Therein lies the future of humanity.

/Public release. This material from the original organization/authors may be ad hoc in nature, edited for clarity, style and length. The views and opinions expressed are those of the author or authors.View Full here.

Human Resources shares designated academic leaves for 2022-23

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Editor’s Note: The following message was sent to the CSU community on August 2, 2022

Dear teachers and staff,

The following days are the days Colorado State University will be closed in the 2022-2023 fiscal year to observe designated holidays.

2022-2023

Monday, September 5, 2022
Thursday, November 24
Friday, November 25
Wednesday, December 21
Thursday, December 22
Friday, December 23
Monday, January 2, 2023
Monday January 16
Monday, May 29
Monday, June 19
Monday July 4 was also a public holiday.

Some university departments may have responsibilities that require employees to work alternate hours. These departments may establish vacation schedules that deviate from the official University holiday schedule, with the approval of Human Resources. For more information, please refer to pages 2-12 and 3-19 of the Human Resources Manual. The manual is available online at https://hr.colostate.edu/hr-community-and-supervisors/operations/manuals-policies-and-forms/.

Hourly student, non-student and administrative professional employees are not eligible for vacation pay. If student, non-student and administrative professional hourly employees work on a public holiday, they are paid only for the work actually performed on the day of the public holiday. State-graded hourly employees earn prorated paid time off. Please contact Human Resources if you have any questions regarding vacation payment.

Time off given to employees to attend religious services, such as Good Friday, must be counted against annual leave, or the employee may make up that time during the same work week. Time off for church services is not permitted by Governor’s Executive Order dated December 1, 1972.

Thanks,

Robyn Fergus
Vice President of Human Resources

New ropeless fishing technology that can help save whales tested off NL

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ST. JOHN’S, NL — A renowned whale expert says last month’s deployment of ropeless fishing gear off Newfoundland was symbolic for him. Michael Moore, biologist in the United States

ST. JOHN’S, NL — A renowned whale expert says last month’s deployment of ropeless fishing gear off Newfoundland was symbolic for him.

Michael Moore, a biologist at the US-based Woods Hole Oceanographic Institution, said in an interview that he first discussed ropeless fishing 43 years ago in Newfoundland with the late biologist Jon Link.

Lien is known for founding the Newfoundland and Labrador Whale Release and Strandings group and releasing hundreds of whales tangled in fishing ropes.

In July, tech company Jasco Applied Sciences partnered with the Miawpukek First Nation in Newfoundland to test the company’s ropeless traps, which anglers can retrieve from the water using buoys. rather than ropes and buoys.

John Moloney, the company’s engineering manager, explains that the traps are fitted with inflatable bladders that anglers can trigger when it’s time to bring them to the surface.

Moore says that although ropeless gear technology is still in its infancy, he is heartened to see it being used off Newfoundland, where he began to dream of its potential to save whales and serve fisherman.

This report from The Canadian Press was first published on August 2, 2022.

The Canadian Press


It’s your company

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It is an honor and a privilege and, to be honest, also a bit daunting to take on the role of President of the American Society for Biochemistry and Molecular Biology. I joined the society, then the American Society of Biological Chemists, as a graduate student in the 1980s. I have participated in several capacities over the years, never imagining myself president; yet here I am.

Maybe it’s not that surprising. My scientific pedigree includes two presidents of the ASBMB. My graduate and postdoctoral advisors have held the position: Daniel E. Koshland Jr. in 1973 and Gregory A. Petsko from 2008 to 2010. In addition to being outstanding scientists and fantastic mentors, both have served or continue to serve the scientific community in many ways, and by example, they have instilled the value of service in their trainees. Commitment to service is part of my scientific heritage.

I hope that contributing to the community is part of every scientist’s identity. Not only does it benefit the community, but it can also be personally rewarding to contribute beyond the limits of one’s own research. I suspect this is one of the many reasons you joined the ASBMB. Would you like to become more involved in the activities of the society? If so, I’d love to help you explore how.

But before diving into future service, I want to reflect on the past. Barbara Gordon retired in early 2021 after nearly 50 years with the company – 18 as Chief Executive. Her enthusiasm and dedication to the ASBMB are well known to all who have had the pleasure of meeting her. Barbara was named an ASBMB Fellow this year, becoming the first Affiliate to be so honoured. We wish him a happy retirement.

And I would like to express immense gratitude to Toni Antalis, our outgoing president, who guided the ASBMB during the two difficult years of the pandemic. Despite the physical isolation and boredom of seemingly endless Zoom meetings, the ASBMB has maintained remarkable momentum on recent initiatives. It is reassuring to have Toni’s continued guidance as we move forward.

The pandemic has highlighted the importance of basic and applied scientific research and the community of scientists who have quickly reoriented their work and collaborated effectively to meet emerging needs. The BMB discipline, with a mechanistic aim, has been at the heart of diagnostic and therapeutic advances. However, the pandemic has also illustrated the need for a better understanding of science and the scientific process in the public and government sectors. Public funding of scientific research must be a priority. Appropriately training the next generation of bioscientists for diverse careers will ensure a strong pipeline for the scientific workforce, and the pipeline must be broadened by promoting diversity, equity and inclusion.

A 2020 survey of ASBMB members indicated that, besides funding, the professional issues of most concern were the public perception of science (including science literacy and how to communicate with the public); work-life balance; and diversity, equity, inclusion and justice in the scientific community.

The ASBMB has initiatives that address all of these areas and provide ways for members to participate. However, members are not always aware of these initiatives or how to engage with them.

For example, the main concern of the members was the public perception of science; 41% of respondents ranked it first.

However, 22% indicated elsewhere in the survey that they were unaware of, or could participate in, ASBMB-supported science outreach activities; 29% said they were unaware of or could participate in advocacy activities such as our annual Capitol Hill day and advocacy training program; and 29% indicated that they were unaware of the ASBMB’s Art of Science Communication course or that they could participate.

Myself, I have not always been aware of what the ASBMB does. For years I paid my dues, published articles in the Journal of Biological Chemistry, attended the occasional annual meeting, and leafed through the latest issue of ASBMB Today if time permitted. It wasn’t until I joined committees that I began to understand what the ASBMB is.

I joined the Council in 2008 and have been continuously involved since then as a member of the Education and Professional Development Committee, or EPD; the finance committee; and the Accreditation Steering Group. I got to know the ASBMB. I was integrated into an incredible network of people and learned a lot that can be directly applied in my career as an academic researcher. My desire to teach initially motivated me to pursue higher education, and my participation in EPD reconnected me with my interest in education. Through EPD activities, I have learned the challenges and best practices in education, knowledge that I regularly apply in my role teaching medical students, as coordinator of the summer research program of undergraduate at my center, as co-director of a T32-funded graduate training program, and as chair of our university’s academic planning committee. Yes, I gave time, but I received much more in return.

In future posts, I plan to introduce you to the ASBMB committees through interviews with committee chairs. We will focus on some of the society’s many initiatives and provide a personal perspective from the scientists who direct the activities of the ASBMB. I hope some of these topics will match your passions. You may want to become more involved in society by communicating with committee members or volunteering to serve on a committee yourself. In March, ahead of the ASBMB’s annual election in June, we solicited nominations, including self-nominations, for vacant committee positions. We look forward to expanding representation and welcome your participation.

So get involved and contact us. The ASBMB is your company. Its impact is determined by what we do together.

Stanford Medicine Magazine Explores What Molecules Reveal About Us and Our Health | Information Center

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“Indeed, basic scientists at Stanford have made extraordinary contributions to biomedicine,” Lloyd Minor, MD, dean of the School of Medicine, said in a letter published in the issue. “Their hard-earned discoveries often open up whole new fields of study. And with each advance, they forge new paths for future discoveries.

The problem includes:

An article describing how moving its medical school to the Stanford University campus inspired Stanford medical students, researchers, and physicians to join forces with high-tech powerhouses to accelerate molecular discoveries that could revolutionize the practice of medicine.

· A look at how cryogenic electron microscopy is expanding our understanding of diseases and how to treat them.

· A sampling of a dozen Stanford Medicine researchers on their favorite molecules that reveals what amazes them about their tiny objects of study.

The story of how two researchers discovered that circles of free-floating DNA, or extrachromosomal DNA, help cancerous tumors evade treatment in some patients, a revelation that led scientists to watch these culprits who hid in plain sight

· An exploration of new thinking about pain, starting with the concept that not everyone experiences pain in the same way. In this article, Stanford Medicine pain experts discuss the approaches they use to individualize pain remedies, from designing new drugs to developing online pain management courses to assessment of the usefulness of psychedelics.

· A story about how a mother’s decision to donate her daughter’s tumor for research after she died of a rare brain cancer opened the door to cancer immunotherapy.

· An article describing the link between neurotransmission and excessive mucus secretion – which can cause serious illness in some – and how leveraging these similarities could lead to a solution.

The problem also seems at neuroscientist Serge Pascathe pioneering development of a cell culture method that allows scientists to watch parts of a human brain grow and form connections in real time, ushering in a new era of brain science; an effort led by a group of black women to create a peer navigation program for black women with breast cancer; and the perspective of psychologist Keith Humphreys, president of the Stanford-Lancet Commission on the Opioid Crisis, calling on disparate groups to work together to put patients first in solving the crisis.

Stanford Medicine The magazine is available online at stanmed.stanford.edu as well as in print. Printed copies of the new issue are sent to subscribers. Others can request a copy by emailing medmag@stanford.edu.

Medication side effects across identified pediatric developmental stages

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Side effects of pediatric drug treatment are responsible for nearly 10% of childhood hospitalizations, nearly half of which are life-threatening. Despite the need to know more about these drugs and the adverse effects they may have on children, little evidence is currently available.

Clinical trials remain the gold standard for identifying adverse drug events (ADRs) for adults, but they present both ethical and methodological concerns for the pediatric population. Rapidly changing biological and physiological developments only increase the challenges of understanding the potential impacts of different drug treatments at different stages of childhood.

Researchers at Columbia University Irving Medical Center have developed a new algorithm that identified nearly 20,000 ADE signals (information about a new or known side effect that may be caused by a particular medication) across the seven stages of pediatric development and matched them to made freely available. This process is enhanced by a new approach that allows neighboring development stages to improve signal detection power, helping it overcome limited data within individual stages.

This use of predictive modeling on real-world data may help fill a critical gap in healthcare research around the understudied pediatric community.

DBMI associate professor Nicholas Tatonetti and Nick Giangreco, a recent PhD graduate in systems biology at Columbia University, shared these findings in the study A Pediatric Drug Effects Database to Assess the Mechanisms ontogenetics of child growth and development, recently published in Medium.

“For many reasons, children have never been included in clinical trials,” Tatonetti said. “There are many ethical issues with including children in trials, and there are several limitations when children are included, which make it difficult to assess drug efficacy and safety.”

Due to these factors, few drugs are specifically approved for use in children, although once drugs are approved for adults, doctors may prescribe them “off label” to children.

“Because drugs are not studied and approved directly in children, doctors must rely on guidelines for adults,” he added. “Essentially, treating children as if they were just little adults is often an incorrect assumption. This study is an attempt to systematically elucidate potential side effects when drugs are used off-label in children.”

The study goes beyond simply differentiating side effects in children from those in adults. It focuses on ADEs across seven developmental stages, beginning in neonatal term through late adolescence, and is informed by sharing information from neighboring developmental stages. For example, the development of infants and toddlers is close enough that there are more common characteristics than there would be for infants and those in early or late adolescence.

“Before, kids were basically grouped together,” Tatonetti said. “There were only a few studies that focused only on children, and they basically focused on people 18 and under or 21 and under in a group. The innovation here uses known developmental stages and our newly introduced DGAMs (Generalized Additive Disproportionality Models) to improve power and enable this analysis.”

Tatonetti pointed out that these signals are not validated and are primarily intended for researchers. Parents should consult their pediatrician about specific side effects of medications.

Giangreco, currently a quantitative translational scientist at Regeneron, noted one of the many side effects identified by this model.

“We have corroborated that the FDA found that the asthma drug montelukast caused psychiatric side effects,” he said. “We also saw this in our database, but we were able to identify certain developmental stages where the risk was greater, particularly the second year of life.”

The study also incorporates pediatric enzyme expression data and found that dynamically expressed pharmacogenes in childhood are associated with pediatric ADEs.

“It was a biologically inspired modeling strategy,” Giangreco said. “We used what we knew about biological processes occurring during childhood and formed the modeling strategy. These safety signals came from this prior knowledge of the biological processes that occur. Our data-driven approach really tried to capture what we thought were the biologically important and physiologically dynamic processes that occur during childhood and use them to unravel observations across developmental stages.”

The model was run on a database of 264,453 pediatric reports in the FDA Adverse Event Reporting System (FAERS). The study result is available through KidSIDES, a free and publicly accessible database of pediatric medication safety signals for the research community, as well as the Pediatric Medication Safety Portal (PDSportal), which will facilitate the evaluation of drug safety signals throughout the growth and growth of the child. development.

“The primary intent is for other researchers to use it, to track any signals they might observe,” Tatonetti said. “If they are experts in a particular drug use or a particular disease area and have observed these types of effects, they could follow them and be reassured, or could look at what other evidence there is for this effect. when we aggregate them.. Clinicians can use it as a gut check. Maybe they’ve seen an effect, or they’re wondering if others are seeing that effect, and they can check the PDSPortal to see if d others see this effect or to prompt them to write another case report to the FDA.”

Meet the Farmer: Arturo Nieves

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How long have you been cultivating?

Arturo Nieves

Nieves started his career in aquaculture in 2004

I graduated from the Autonomous University of Sinaloa – Faculty of Marine Sciences, graduating in 2004. I have 19 years of experience, working in different phases of Pacific White Shrimp farming.

I started my professional career as an assistant in a shrimp larvae production laboratory. Later, a great friend of mine, biologist Thomas James, approached me to run a new hyper-intensive shrimp farming project in raceways called Granjas Ojai.

Subsequently, I had the opportunity to manage various projects ranging from low salinity well water recirculation systems, to the management of pre-breeding in earthen tanks and nurseries in tanks covered with plastic geomembrane. I currently manage semi-intensive cultures.

I also had the opportunity to work for a shrimp feed company, as Technical Services Coordinator for Mexico, during this period I had the opportunity to learn more about the new technologies, new management strategies and the challenges we face.

How big is your farm and what species do you produce?

Our company has 280 hectares of ponds. There is a section where we have installed automatic feeders and in the rest of the sections we use blowers or mechanical feeding. Our ponds have an average size of 5 hectares. We typically produce two crops of Pacific Whiteleg Shrimp per year.

Shrimp pond with automatic feeders
Ponds at Aquacultores del Mar Azul

Aquacultores del Mar Azul has 280 hectares of ponds and produces two shrimp crops each year

Our first cycle runs from March to early June. Stocking densities range from 100,000 to 130,000 organisms per hectare. Our goal is to produce 15 g of shrimp in 90 days of culture.

Our second cycle runs from mid-June to November. For the second cycle, we tend to increase the density to a range of 130,000-150,000 organisms per hectare, our goal is to harvest 28-30 grams of shrimp in 165 days of cultivation, with two partial harvests during of the cycle.

Aquacultores del Mar Azul is a family business founded in 2005 by Efren Laija. At first it started with 26 hectares of ponds and over the years the company grew in terms of area and technology implementation. Currently our production is 700 tons per year and our goal for 2022 is to reach 1,200 tons. All our production is sold on the national market.

Why did you decide to pursue a career in aquaculture?

man holding a cup of shrimp larvae
Nieves examining prawn PLs

Nieves has been interested in aquaculture since he was young

My interest in aquaculture was sparked at a young age. My father worked in the capture of wild shrimp larvae which were delivered to collection centers and then sold to shrimp farmers.

I became interested in learning more about agricultural techniques and enrolled in technical training on water resource management in San Blas town, Nayarit state. During this period, I practiced in different local aquaculture farms and once my technical baccalaureate was finished, I decided to go study outside my state to continue my specialization in shrimp farming.

What are your biggest challenges at work?

Disease management is one of the biggest challenges we have as growers right now. 2013 was one of the most difficult years for us, as we had high mortalities caused by the Vibrio bacteria. Only 30 percent of the crop reached harvest size.

To overcome epidemics and improve production, we sought to understand why this vibriosis caused such high mortality, especially in the early stages of cultivation. Over the years, we have learned to manage our production system and prevent these mortalities, reaching 70% survival in 2021.

shrimp removed from water
Pacific white leg shrimp

Nieves worked to keep mortality levels low in shrimp ponds

Our work is focused on maintaining good water quality and maintaining physico-chemical parameters at appropriate levels. One of the parameters that we constantly manage is the alkalinity, which we try to correct every week. We have also implemented the use of organic acids and essential oils in our diets for the early stages of shrimp farming. We have improved our water exchange protocols and our pathology lab checks are done weekly, allowing us to make more accurate management decisions.

With all the work that has been done, we have managed to be recognized and certified as a company with good security practices, by our local agencies. We produce shrimp without the use of antibiotics and our results have encouraged neighboring farms to follow our practices.

Another big challenge we have is the cost of production. Currently, all inputs have seen price increases. This pushed us to look for new ways to produce more efficiently. Producing more in the same growing area is one of our short and medium term objectives, for which investments have been made to improve farm infrastructure. Increasing the depth of the ponds, improving the borders of the ponds and improving the slopes of the ponds for harvesting are some of our improvements.

We have built nurseries so that we can have staggered storage and we have also invested in better pumping systems, achieving greater efficiency in diesel fuel consumption. Our next step is to be able to bring electricity to certain areas of the farm, to avoid the use of diesel fuel.

The investment in training and improving working conditions has been very crucial, which has allowed us to grow year after year.

Overall, by avoiding high mortalities and being more efficient with our production costs, we will be more profitable and remain competitive.

What is the aquaculture achievement you are most proud of to date?

At each stage of my career, there have been many accomplishments and moments of satisfaction, but undoubtedly the greatest has been to be able to improve the working conditions of our staff: including providing better facilities to work in, improving work culture, providing training, better wages and benefits and the opportunity to grow within the company.

harvest shrimp pond
Harvesting a shrimp pond

Nieves is proud to have improved the working conditions of its employees

This was an important point to be able to grow as a person and to be able to grow the company.

What advice would you give to other farmers to get good production and profits?

We have understood that the best way to manage our ponds is to measure the parameters and interpret the information. Every farm is different and even every pond behaves differently, but constant monitoring has allowed us to understand our systems and prevent potential losses.

I would advise other farmers to emulate our efforts to invest in proper infrastructure, acquire new technologies and invest in personnel. These points have been fundamental for us and we will continue to build on them to keep moving forward.

What factors influence your decisions about other farming practices?

juvenile shrimp
juvenile shrimp

Nieves noted recent genetic improvements in shrimp larvae

The genetic characteristics of growth and disease resistance of our larval suppliers have improved year after year. We work with different laboratories, depending on our planning for the year and our market strategy. This is how we make the decision to store more or less organisms per hectare, and from which larval supplier.

On the question of food, our management is based on the adequacy of the size of the pellets with the size of the organism. Throughout the crop cycle, there are two 8-10 day overlaps in pellet changes. Adequate management of these changes has allowed us to have a better homogeneity in the distribution of the weight of the population. To expand on this, our feeding management for the early stages is with 0.8mm extruded diets for 1.0g shrimp, later we use 1.2mm diets for up to 6, 0 g of prawns (up to this size our diets have a mixture of acids and essential oils) and we finish until harvest with a grain size of 1.8 mm.

Enrique Guemez Sorhouet

Enrique Guemez Sorhouet holds a bachelor’s degree in biochemical engineering and a master’s degree in natural resource management with a specialization in aquaculture. He has been involved in aquaculture in production, business development, sales and research. He is a strong proponent of sustainable aquaculture and works in Latin America and the United States.

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Meet the Farmer: Leakey Amolloh

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Meet the Farmer: Kenechukwu Nwobodo

Kenechukwu Anthony Nwobodo, 32, started and runs a catfish farming business, DieuMerci, in Lagos, Nigeria.

Meet the Farmer: Yit Tung

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James Lovelock – Darwin’s Heir

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Gwynne Dyer is a UK-based Canadian journalist and longtime commentator on international affairs.

OPINION: Jim Lovelock was a latecomer. His first book, “Gaia: A New Look at Life on Earth”, was published in 1979, when he was already 60 years old.

By the time of his death on July 27, his 103rd birthday, he had written ten other books on Gaia, the hypothesis that has become the key academic discipline of Earth system science.

This gives him a strong claim to be Charles Darwin’s rightful heir.

Just as Darwin’s theory of evolution in the 19th century shaped our understanding of how life became so diverse, our understanding of the present is shaped by Lovelock’s idea that the millions of living species function as a self-regulating mechanism that keeps the planet cool enough for abundant life. life.

READ MORE:
* AND can he see us? Study reveals many stars with privileged view of Earth
* Jack Lovelock: The Man, The Myth, The Mystery
* British scientist still controversial at 100

The conundrum that started Lovelock on this path was the fact that solar radiation has increased by 30% since life first appeared on Earth 3.7 billion years ago, while the planet’s average temperature , despite occasional huge increases or decreases, has consistently come back cramped. range most suitable for life.

What made this happen?

Together with American biologist Lynn Margulis in the 1970s, he developed a tentative description of the superorganism he named ‘Gaia’ and wrote his first book.

Most scientists treated him with disdain because he was not a biologist, but also because ‘Gaia’ had ‘New-Age’ connotations that he was unaware of. (Jim was not a hippie.)

By 1988, however, the scientific world was beginning to take the theory seriously.

In 2001, a special congress of more than 1,000 physicists, biologists and climatologists declared that the planet “behaves like a unique self-regulating system composed of physical, chemical, biological and human components”.

“Gaia” (by the more dignified name of Earth System Science) had achieved the status of scientific orthodoxy.

Meanwhile, Lovelock had been granted honorary environment saint status by the Greens, although he saw most of their priorities as mere distractions and some, such as their hostility to nuclear energy, such as potentially fatal blunders.

Jim Lovelock’s direct predictions of global climate catastrophe were once considered exaggerated, but he understood what was really happening.

In his first book, in 1979, he gave a warning that I can still quote verbatim forty-three years later.

Lovelock's theory that the Earth is a self-regulating superorganism was initially dismissed by scientists, but has recently gained traction in the scientific community.

123RF/Supplied

Lovelock’s theory that the Earth is a self-regulating superorganism was initially dismissed by scientists, but has recently gained traction in the scientific community.

“The greater the proportion of the earth’s biomass occupied by humanity and the animals and crops needed to feed us, the more involved we become in the transfer of solar and other energy through the whole system…We We’ll have to exercise caution to avoid the cyber disasters of runaway positive feedback or sustained oscillation…

“If…man had intruded on the functional powers of Gaia to such an extent that he disabled her, then he would wake up one day to find he had the permanent job of a planetary maintenance engineer. ..and the incessant complex task of keeping all global cycles in balance would be ours.

“Finally, we should ride this strange craft, ‘spaceship Earth’, and whatever was left of the tamed and domesticated biosphere would indeed be our ‘life support system’…(We would be faced) with the final choice permanent enslavement to the prison carcass of spaceship Earth, or gigamort to allow survivors to restore a Gaian world.

Apocalyptic but precise, and yet he never despaired.

I didn’t meet him for the first time until twenty years after this book, but each time I went down to Devon to see him, his natural cheerfulness kept breaking his professional pessimism. Finally, I asked him the question.

He replied, “Why do I oscillate between being cheerful and being pessimistic? My role, really, my main job, is to be a prophet, and that’s the only way to make prophecies. You have to build scenarios in your mind: it could go this way or it could go this way, and only then can you get a more balanced picture of what the future could be.

“The behavior of the Earth itself is sufficiently uncertain, but the behavior of people is the greatest uncertainty of all. I mean, we could be well on our way to solving all of these problems, and then some dumb, silly war or a pandemic breaks out and it all takes our minds off it. We are the joker of the peloton.

We are not on track to fix all these problems, of course. We are off the right track, as Jim well knew, but he gave us the vital context for a self-regulating Gaian system. Without it, we wouldn’t even know where to start trying to undo the damage we’ve caused.

He was also a brilliant inventor: his “electron capture detector” confirmed the existence of the ozone hole and made him financially independent. He had a side business as an actual Q, a gadget maker for MI5. But above all he was a warm, gentle man with a mischievous sense of humor.

It was a privilege to know him.

Apply for 14 positions on saitikschooljhansi.com | Check eligibility, other details here

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Recruitment at Sainik School 2022: Sainik School, Jhansi (UP) is inviting applicants to apply for TGT Maths (Regular) and other positions. Eligible applicants can apply through the school’s official website at sainikschooljhansi.com. The deadline to apply for the positions is until August 22, 2022. This recruitment campaign will fill 14 positions in the organization. Selection will be made on the basis of performance in the “written test, skills test, practical test and interview (if applicable)”.Read also – UPSC recruitment 2022: Apply for 16 positions until August 11 | Check salary scale, application link here

Sainik School Recruitment 2022: Check Important Dates

  • Deadline to apply: August 22, 2022

Sainik School Recruitment 2022: Check Vacancy Details

Position name and vacancy number

  • TGT (Gen Science): 01 post
  • TGT Hindi (Regular): 02 posts
  • TGT Maths (Regular): 01 position
  • TGT (Social Sciences) (Regular): 02 posts
  • TGT (English) (Regular): 01 post
  • TGT Sanskrit (Regular): 01 post
  • Art Master (Contractual): 01 position
  • Music Teacher (Contractual): 01 post
  • Librarian (Contractual): 01 post
  • Biology Laboratory Assistant (Contractual): 01 post
  • PTI-Cum Matron (Contractual): 01 post
  • Head of Office (Contractual): 01 post

Sainik School Recruitment 2022: Check Eligibility Criteria

Sanskrit TGT (regular): Four years of integrated NCERT Regional College of Education curriculum in relevant subject with at least 50% marks overall. OR Baccalaureate with at least 50% marks in the subject/subject combination concerned and in total. AND B. Ed or equivalent degree from a recognized university. Candidates who wish to apply for the positions mentioned above can check the educational qualification, age limit and other details here. Also Read – TNPSC Recruitment 2022: Apply for 1089 Positions at tnpsc.gov.in | Check salary, notification here

Sainik School Recruitment 2022: Check Pay Scale

  • TGT (Gen Science): Pay Level-7, Rs.44900
  • TGT Hindi (Regular): Pay Level-7 Rs. 44900
  • TGT Maths (Regular): Base salary Rs. 44900
  • TGT (Social Science) (Regular): Pay Grade-7, Rs.44900
  • TGT (English) (Regular): Pay Level-7, Rs.44900
  • TGT Sanskrit (Regular): Pay Level-7, Rs.44900
  • Master of Art (Contractual): Only Consolidated Rs.35000/- per month
  • Music teacher (contractual): only Rs.28000/- per month
  • Librarian (contractual): Only consolidated Rs.35000/- per month.
  • Biology Laboratory Assistant (Contractual): only consolidated Rs 20,000/- per month
  • PTI-Cum Matron (Contractual): Only Consolidated Rs.25000/- per month
  • Office Superintendent (Contractual): Only Consolidated Rs 28,000/- per month.

Sainik School Recruitment 2022: How to Apply Offline?

  • Eager candidates should apply to the Principal of Sainik School Jhansi (Uttar Pradesh) through the offline mode only on the prescribed format available in the “Recruitment” tab of the school website www.sainikschooljhansi.com with self-attested copies of certificates and testimonials.
  • In the absence of testimonials/mark sheets/certificate, the application will be rejected. The candidate must mention his percentage obtained in each examination starting from the 10th class standard / class until the highest qualification obtained.
  • Applicants are required to send their application by Registered Mail / Express Mail (by Indian Postal Services) only. The school declines all responsibility in the event of postal delays.

Read also – SEBI Grade A recruitment 2022: register for 24 positions until July 31 | Check salary scale, notification here

Biology meets AI | Philstar.com

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At the World Economic Forum, Nokia CEO Pekka Lundmark said he expects 6G, or sixth-generation mobile networks, to be operational by the end of the decade.

But he doesn’t think the smartphone will be the most common interface by then.

Nokia and other tech companies like Huawei expect 6G technology to be in the market around 2030. They also predict that by then the world will shift from using smartphones to using smart glasses. and other face-worn devices. Some of these things, Lundmark said, would even be built right into our bodies.

Elon Musk’s Neuralink is working to produce electronic devices that can be implanted in the brain and used to communicate with machines and other people. Another possibility is to implant chips in people’s fingers and use them to unlock items.

US tech giants such as Meta, Google and Microsoft are working on new augmented reality headsets that could replace the smartphone, according to a report from cnbc.com.

And all of this, the article notes, is happening as the world is just beginning to master 5G, which refers to next-generation mobile networks that deliver super-fast data speeds that promise to support technologies like as driverless cars and virtual reality.

In the same forum, Google’s chief financial officer, Ruth Porat, said things like having glasses and being able to translate while you talk with glasses are very close.

By 2030, Nokia’s Lundmark said there will be a digital twin of everything that would require massive computing resources, but to transmit all the computing bits the metaverse will need, the networks will need to be at least 100, even 1,000 times faster than they are today.

***

What is 6G exactly?

According to a research paper published on ericsson.com, 6G will enable movement across a cyberphysical continuum, between the connected physical world of senses, actions and experiences, and its programmable digital representation.

He explains that compared to the metaverse which is a virtual reality/augmented reality world where avatars interact, the cyberphysical continuum will provide a close connection to reality, where digital objects are projected into physical objects which are digitally represented, allowing them to coexist seamlessly as merged reality and enhance the real world.

For example, a digitized, programmable world provides interactive 4D maps of entire cities that are position and time accurate and can be viewed and edited simultaneously by large numbers of humans and intelligent machines for detailed business planning, notes the document. These cyber-physical service platforms, he said, can issue commands to large-scale steerable systems, such as public transport, waste management or water and heating management systems.

Another possible application, he said, would be in healthcare. The report explains that the advent of precision healthcare, enabled by miniature nodes measuring bodily functions and devices delivering medication and physical assistance, will be supported by a continuously analyzed online digital representation. This would require devices that can be safely integrated virtually anywhere and without maintenance.

The report also indicates that real-time 4D maps are needed to manage the heavy traffic of future cities with autonomous vehicles on the ground and in the air. A network sensor fabric, where precise measurements and global data are aggregated from sensing base stations and vehicle-borne sensors and then shared with trajectories, can be used to guide safe, clean and efficient transportation. .

Lifewire.com quoted Marcus Weldon of Nokia Bell Labs as saying that 6G will be a sixth sense experience for humans and machines where biology meets artificial intelligence or AI. Japan’s NTT Docomo predicts that 6G will enable cyberspace to support real-time human thought and action through wearables and microdevices mounted on the human body.

For its part, Huawei says 6G will go far beyond communications – it will serve as a distributed neural network that will provide communication links to merge the physical, cyber and biological worlds.

As someone pointed out, 6G technology will essentially make today’s science fiction an everyday reality.

“Imagine being able to see, hear, touch, smell and taste your virtual reality experience. Sounds fantastic for gaming, but imagine it applying to prosthetics. Prosthetic users could have seamless, perhaps even neurological, integration with their devices and instant response, perhaps using WiFi implants… Think super-efficient manufacturing or ports, or flow maintenance variable traffic depending on minute-by-minute traffic conditions… Autonomous or unmanned vehicles, planes are perhaps with the type of network coverage, data capacity and low latency in question”, according to an article on netscout .com.

Techmonitor.ai reports that mobile network operators around the world are investing heavily in 6G and that, according to GSMA Intelligence, around 10% of operators worldwide are conducting 6G research and development programs. Telecom company NTT has announced a pilot of 6G networks by 2025 while the South Korean government plans to launch its own 6G network in 2026. The EU has launched its large-scale 6G research and innovation program while other countries like the United States and Japan have expressed and invested in their own 6G research initiatives, the same report reveals.

Samsung Electronics for its part announced that it was setting out its vision for securing global frequency bands for 6G.

Meanwhile, the Oppo Research Institute said it believes 6G will reshape the way people interact with AI like never before, enabling AI to become a true technology in the service of the public that can be used by everyone.

Through 6G, he said smart devices will become important participants and users of AI, downloading and deploying AI algorithms at different levels of application to create new immersive experiences while constantly collecting data. to power more advanced AI models. For example, Oppo said that in the case of autonomous vehicles, 6G networks will be able to assign the greatest number of AI algorithms and the optimal communication connection depending on the location of the vehicle and the current physical environment. , such as time of day and weather. The vehicle will be able to immediately download and run AI algorithms that have been trained by countless other vehicles and devices, enabling the vehicle to provide the safest and most comfortable journey for the passenger.

Technology should be our slave and should not enslave us humans. Current technology may have reached its limits in terms of providing solutions to everyday problems. 6G and its applications may be exactly what we need.

For comments, send an email to [email protected]

Climate change and endangered islands threaten brown pelicans

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Birds and other creatures in Louisiana live under threat from climate change, endangered islands

CHAUVIN, La. — Sliding over the side of her small boat, seabird biologist Bonnie Slaton wades through waist-deep water, brown pelicans hovering above her head, until she reaches Raccoon Island.

During seabird breeding season, the place is a symphony of sound and movement – ​​one of the few remaining havens for the iconic pelicans.

The crescent-shaped island is a strip of land separating Louisiana from the Gulf of Mexico – a speed bump against storms that come in from the sea. An hour away by boat, the barrier island’s remoteness allows birds to nest on mangroves and sandy beaches at a safe distance from most predators.

A dozen years ago, there were 15 low islands with nesting colonies of the Louisiana state bird. But today, only about six islands in southeastern Louisiana have brown pelican nests – the others have disappeared underwater.

“Louisiana is rapidly losing land,” said Slaton, a researcher at the University of Louisiana at Lafayette. “Sea level subsidence and rise are a double whammy.”

The endangered islands threaten one of the most famous conservation success stories of the past century – the decades-long effort to bring pelicans back from the brink of extinction.

On land, brown pelicans are clumsy birds, their huge beaks and wings lending them what Slaton calls a “clumsy” look. But hovering low over the ocean, pelicans are majestic.

The same forces that are engulfing the coastal islands are also causing southern Louisiana’s saltwater marshes to disappear faster than anywhere else in the country. Scientists estimate that Louisiana loses a football field every 60 to 90 minutes.

“We are on the front lines of climate change. It all happens here,” said Jimmy Nelson, an ecologist at the University of Louisiana at Lafayette.

___

As Slaton and two other biologists walk the shore of Raccoon Island, the birds land in a swirling, plunging cacophony that heralds intruders. The calls of a thousand laughing gulls are loud enough to drown out human thought.

Slaton swaps out batteries and memory cards for 10 motion-activated trail cameras set up to observe pelican nests in varying habitats. Some circular cordgrass nests are built on top of mangrove stands, others on grassy mounds.

Camera data has shown that in recent years the main threat has been flooding – which can wash away entire nests, as happened in April 2021.

Passing a nest on the ground, Slaton bends down to watch two tiny gray and pink pelican chicks squirm with their eyes still closed. Within a week, the chicks are covered with fluffy white and gray feathers.

Observing a colony of seabirds reveals both the promise and the fragility of new life. Then, suddenly, the biologists wipe white drops from their foreheads.

The abundant bird droppings act as a natural fertilizer that helps shrubs and grass grow from the island’s sand and stones. Their roots slow erosion.

___

When Mike Carloss was a kid in Louisiana in the 1960s, he never saw brown pelicans.

Like bald eagles, their populations had been decimated by the widespread use of DDT pesticides that thinned eggshells and prevented healthy chicks from hatching.

The beloved pelicans had completely disappeared from Louisiana, their likeness appearing only on the state flag. But a long-running effort to save them has led to an inspiring comeback story.

After DDT was banned in the United States in 1972, biologists brought pelican chicks from Florida to repopulate empty islands across the Gulf of Mexico. More than 1,200 have been released in southeast Louisiana over 13 years.

One location was Raccoon Island, where Carloss, then a teenage field assistant with the Louisiana Department of Wildlife and Fisheries, tossed fish from the beach to feed the chicks.

“I kept these young pelicans on a remote island,” he recalls. “Somebody had to hand-feed them basically.”

As state wildlife biologist for more than two decades, Carloss then oversaw restoration projects on the island. But now he fears that if the islands continue to disappear, “we will be back to the 1960s era, and not because of poisonings”.

___

Protecting what remains depends on continued human intervention.

Today, one side of Raccoon Island is surrounded by granite breakwaters that divert the tides.

Erosion is a natural process and over thousands of years most barrier islands rise and fall. Unlike the volcanic islands, there is no bedrock here, only layers of silt washed into the Mississippi Delta.

But rising seas and increased frequency and intensity of storms with climate change are accelerating the pace. And the islands have been deprived of new sediment from the Mississippi because the course of the river has been controlled since the 1940s by levees to prevent flooding and facilitate navigation.

Every few years, government agencies strive to restore and maintain some barrier islands. The money comes from a legal settlement after the 2010 Deepwater Horizon oil spill. But that won’t last forever – and many sinking islands aren’t being restored at all.

Another day, the biologists steer their aluminum boat past an unrestored island called Philo Brice. Mangroves grow on the flooded lands and pelicans nest in the upper branches.

It’s still a decent breeding habitat, as long as the soil holds and the plants stay above water. “In five or 10 years, it may or may not be here. It’s that fast,” Slaton said.

—-

When biologist Juita Martinez conducted research on the Louisiana coast between 2018 and 2021, she found that the number of pelicans on another unrestored and flooded island, Felicity, dropped from 500 to around 20.

Brown pelicans can live for over 20 years, so the impact of reproductive issues takes time to become clear.

For now, pelicans are still common on the Louisiana coast, and their likenesses are everywhere – license plates, restaurant signs and university seals.

The brown pelican “is a symbol of Louisiana, just as the eagle is a symbol of America,” said Rue McNeil, executive director of the Northlake Nature Center in Mandeville, Louisiana.

But the future is uncertain.

Flying in a small plane low enough to see the heads of pelicans sticking out of the mangroves, the difference between Raccoon Island and the unrestored Philo Brice is stark: one is solid land, the other like soft bread dissolving into soup of blue.

“Murderer” Cells Murder Innocent Cells

Scientists have found that a quarter of testicular progenitor cells are “killed” by phagocytes, despite the fact that these cells are not doing anything “wrong”.

Research from the University of Haifa has identified killer cells.

A process that involves the “killing” of newly generated living cells was first discovered in recent research conducted at the University of Haifa. The research, which was described in the prestigious journal Scientists progressfound that throughout the process of cell differentiation in fruit flies, phagocytic cells consume and destroy healthy living cells.

“We found that phagocytes can function as ‘murderers’. It is well known that phagocytic cells swallow and dissolve dead cells, but we show for the first time that they also kill newly created normal cells. Essentially, we have characterized a novel cell death mechanism. The more we know about the mechanisms of cell death, the better we understand how to deal with various diseases, including cancer,” explained Professor Hilla Toledano, Head of the Department of Human Biology at the University of Haifa and author of the study. .

The origin of several bodily tissues, including skin, hair, stomach, and testicles, can be traced back to stem cells. By continually supplying new cells to replace old ones, these powerful stem cells enable tissue replenishment. Each stem cell in this process divides into two cells, one of which is saved for future use and the other grows to take the place of the lost cell in the tissue.

In the current investigation, Prof. Toledano, Prof. Estee Kurant and a group of scientists from the University of Haifa examined the sex cells of fruit flies. Since many molecular processes in fruit flies and humans are similar, they can be used as an effective model in this situation.

Fruit fly studies are useful because of the ability to monitor processes in living tissues and the simplicity of genetic alteration, which allows exact identification of cellular processes. Six Nobel Prizes have been awarded over the years to scientists who have discovered biological mechanisms in fruit flies that are conserved in humans.

As mentioned earlier, the division of a stem cell into two cells – a stem cell and a cell called a progenitor – triggers the process of sperm differentiation in male fruit flies. This process continues until the formation of functional sperm. Researchers already knew that a quarter of these progenitor cells perish and do not develop into sperm from previous studies. The goal of the current study was to better understand what happens to these cells.

The body has a well-established and crucial mechanism called cell death. Under normal circumstances, cells have the ability to “commit suicide” when a serious mutation has occurred or after they have achieved their goal. The phagocytes come to “eat” the dying cells, effectively carrying away their contents and dissolving them. We know that phagocytes sometimes “eat” immune system cells that have finished their work of defending the body against intruders.

In the current study, the researchers found that the phagocytes “kill” a quarter of the testicular progenitor cells, although these cells are not doing anything “wrong” and are simply differentiating; they are still new cells and they are not abnormal in any way.

In the first stage, the researchers inhibited the feeding abilities of the phagocytes and found no dead cells in the tissues. In other words, phagocytes are responsible for the death of progenitor cells.

In the second step, the researchers used real-time imaging to monitor living tissue and found that progenitor cells are swallowed alive by the phagocyte, and only then the death process is initiated. “We have discovered for the first time a process leading to the ‘killing’ of completely normal cells. We still don’t know why this is happening. Perhaps this process aims to provide nutrients to maintain a functional population of stem cells throughout the life of the organism,” Professor Toledano suggested.

In addition to understanding a new mechanism, this study may contribute to our ability to develop drugs and means to control cell death, and particularly, of course, to treat cancer. “Tumors are characterized by constant growth and disruption of the natural cell death process. If we manage to introduce into this process phagocytes capable of eliminating living cancer cells, we will be able to control the growth of the tumour. The more we learn about the mechanisms of cell death, the better we can harness these processes to get rid of cancer cells,” Professor Toledano concluded.

Reference: “Phagocytic cells of cysts in Drosophila testes eliminate germ cell progenitors via phagoptosis” by Maayan Zohar-Fux, Aya Ben-Hamo-Arad, Tal Arad, Marina Volin, Boris Shklyar, Ketty Hakim-Mishnaevski, Lilach Porat-Kuperstein, Estee Kurant and Hila Toledano, June 17, 2022, Scientific advances.
DOI: 10.1126/sciadv.abm4937

The prevalence of pediatric obesity rises to 21%


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The prevalence of pediatric obesity in the United States increased from 17% to 21% between 2011 and 2020, according to results published in JAMA Pediatrics.

Amanda E. Staiano, PhDassociate professor of pediatric obesity and health behavior at Pennington Biomedical Research Center in Baton Rouge, Louisiana, co-authored the letter.







“It’s really important in this country that we look at the prevalence of obesity to try to track the number of our obese children and adolescents,” Staiano told Healio.

“We’ve seen for several years, it’s been for decades now, that the prevalence of obesity, the number of obese children keeps increasing,” Staiano said. “But no one had looked to see in recent years if that was still the case, [or just looked] over the past decade, to see how we’re doing.

Staiano and co-author Kathy Hu examined data from the National Health and Nutrition Examination Survey (NHANES), a surveillance study conducted across the United States, examining the heights, weights and ages of the 14,967 children and adolescents included in the analysis.

“When you look at weight in children, you’re actually looking at a percentile, which means you’re comparing the child’s height and weight baseline data for the child’s age and sex,” said said Staiano. “All children above the 95th percentile are considered obese. So when these percentiles first appeared, one would expect only about 5% of children to be at above the 95th percentile. But what we’re seeing now is that 21% of kids are above the 95th percentile. That’s four times more than you would expect.

In 2011, 17% of children surveyed met the obesity percentile, a number that has risen to over 21% in 2021.

“What’s really troubling is that we know that when children develop obesity early in life, they are at a much higher risk of developing heart disease, diabetes, cancer, asthma and many other illnesses,” Staiano said. “We see that in children; even middle and high school students develop these diseases.

“We really need early prevention and treatment efforts to help these children get back on a healthier path, because it becomes increasingly difficult as they age and reach adulthood to help people lose weight,” Staiano said.

New DNA repair kit successfully repairs inherited disease in patient-derived cells

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Genetic mutations that cause debilitating inherited kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially revolutionary DNA repair kit. The advance, developed by scientists at the University of Bristol, is published in Nucleic Acids Research.

In this new study, the international team describes how they created a DNA repair vehicle to genetically repair faulty podocin, a common genetic cause of hereditary steroid-resistant nephrotic syndrome (SRNS).

Podocin is a protein normally located on the surface of specialized kidney cells and essential for kidney function. The defective podocin, however, gets stuck inside the cell and never makes it to the surface, eventually damaging the podocytes. Since the disease cannot be cured with drugs, gene therapy that repairs the genetic mutations that cause faulty podocin offers hope for patients.

Typically, human viruses have been used in gene therapy applications to perform genetic repairs. These are used as a “Trojan horse” to enter the cells containing the errors. Currently dominant systems include lentiviruses (LV), adenoviruses (AV), and adeno-associated viruses (AAV), all of which are relatively harmless viruses that readily infect humans. However, these viruses all share the same limitation in that they are space-limited inside their viral shells. This in turn limits the amount of cargo they can deliver, namely the DNA kit necessary for efficient gene repair, which greatly limits the scope of their application in gene therapy.

Applying synthetic biology techniques, the team led by Dr Francesco Aulicino and Professor Imre Berger of Bristol’s School of Biochemistry, re-engineered baculovirus, an insect virus harmless to humans that is not no longer constrained by limited cargo capacity.

“What distinguishes baculovirus from LV, AV and AAV is the lack of a hard shell encapsulating the cargo space.” said Dr. Francesco Aulicino, who led the study. The baculovirus shell resembles a hollow stick – it simply lengthens as the cargo increases. This means that a much more sophisticated toolkit for repairing a genetic defect can be provided by the baculovirus, making it much more versatile than commonly used systems.

First, the baculovirus had to be equipped to enter human cells, which it normally would not. “We decorated the baculovirus with proteins that allowed it to enter human cells very efficiently.” explained Dr. Aulicino. This modified baculovirus is considered safe because it can only multiply in the insect, but not in human cells. The scientists then used their modified baculovirus to deliver much larger pieces of DNA than previously possible, and integrate them into the genomes of a range of human cells.

The DNA of the human genome comprises 3 billion base pairs making up ~25,000 genes, which code for proteins essential for cellular functions. If faulty base pairs occur in our genes, faulty proteins are made which can make us sick, resulting in an inherited disease. Gene therapy promises to repair inherited disease at its very root, by rectifying these errors in our genomes. Gene-editing approaches, particularly CRISPR/Cas-based methods, have significantly advanced the field by enabling gene repair with base-pair precision.

The team used podocytes derived from patients with the pathogenic error in the genome to demonstrate the suitability of their technology. By creating a DNA repair kit, comprising protein-based scissors and the nucleic acid molecules that guide them – and the DNA sequences to replace the faulty gene, the team delivered with a single modified baculovirus a healthy copy of the podocin gene along with the CRISPR/Cas machines to insert it with base-pair precision into the genome. This was able to reverse the pathogenic phenotype and restore podocin to the cell surface.

Professor Imre Berger explains: “We had previously used baculovirus to infect cultured insect cells to produce recombinant proteins to study their structure and function. This method, called MultiBac, developed by the Berger laboratory, has been very effective in making very large multiprotein complexes with many subunits, in laboratories around the world. “MultiBac was already exploiting the flexibility of the baculovirus shell to deliver large chunks of DNA into cultured insect cells, instructing them to assemble the proteins we were interested in.” When the scientists realized that the same property could potentially transform gene therapy in human cells, they set to work creating their new system described in their publication.

Dr. Aulicino added: “There are many ways to use our system. In addition to podocin repair, we were able to show that we can correct many errors at very different locations in the genome simultaneously, using our unique baculovirus delivery system and the newest editing techniques available.

“SRNS is one of the most common genetic diseases affecting the kidney,” said Professor Moin Saleem, a leading expert in gene therapy for inherited kidney disease at Bristol Renal. “SRNS is characterized by kidney failure at an early age, resulting in a severe loss of quality of life for those affected.

Professor Gavin Welsh, Professor of Renal Cell Biology at Bristol Renal, concluded: “These results are very encouraging. This novel approach developed by the Berger team holds promise not only for SRNS, but also for a range of other genetic kidney diseases, where efficient gene repair is not feasible with current technology. The implementation of a new vector system for clinical applications is still a long time, but we believe that the advantages offered make it a very interesting undertaking. »

This research has received funding from the European Research Council (ERC), Kidney Research UK (KRUK) and the EPSRC/BBSRC Bristol Research Center for Synthetic Biology BrisSynBio.

Paper

“Highly efficient CRISPR-mediated large-DNA docking and multiplexed primary editing using a single baculovirus” by F Aulicino et al. in nucleic acid research.

coursera: Does a data scientist need to know storytelling? More answers can be found in Coursera’s recent career report on skills.

A recent Coursera career report analyzed data from their learners across countries. He has insights that can help pave the way for seekers.

We all want to be part of changing career goals. However, we miss to include some handy key points.

Finding a skills-based approach to jobs and adopting a multidisciplinary approach to developing these skills is the need of the hour. It’s time to skillfully time the clock.

What skills are needed for high-demand jobs?

Data scientist and data analyst professions:

With each business collecting more data than ever before, the need for data scientists and data analysts is only expected to increase. The data scientist’s key job is to find the right insights from the data that can lead to better decisions.

The report found that data management skills are already strong among students who enroll in these courses. But, there are additional skills that students can master for better results. They can try to improve their data visualization skills to present information well and work on telling a data story, in addition to reinforcing fundamental math, probability, and statistics.

Likewise, for data analysts, high-demand tools such as Python and Tableau on Coursera have proven useful for Coursera students.

NOT
New Era Engineering Skills:

For a software engineer looking to improve their skills, it is necessary to focus on practical coding, understand data pipelines, learn about systems engineering, data structures and operating systems in more to master programming languages.

Meanwhile, for machine learning engineering, it is necessary to learn computer and statistical programming in addition to mastering machine learning, probability, and statistics.

Marketing specialists:

Marketing is a rapidly changing discipline. Good marketing always relies on good storytelling. But the art and science of marketing has evolved now. While performance marketing and SEO and google adwords should be managed on one side, story and brand building should be done on the other. Marketers, Coursera reports, are therefore now focusing on building communication and data analysis skills. Modern marketing relies on stories and data-driven personalization.

Learning by doing:

To develop in-demand technical skills, learning alone is not enough. Practice, and that too, practice on real-world problems becomes an important ingredient in mastering a skill. Looking at data from their Guided Projects in India, Coursera reported that the following Guided Projects were the best:

  • Introduction to game development with Scratch
  • AWS S3 Basics
  • Create a complete website with WordPress
  • Google Ads for beginners
  • Get started with Azure DevOps maps
  • Create a resume and cover letter with google docs
  • Machine learning pipelines with Azure ML Studio
  • Developing a business website with WIX
  • Get started with Google Analytics
  • Business analysis and process management

For young professionals, their skills and competencies can arm them with better exposure to clear jobs.

While India is expected to have one of the best young working-age professionals in the world, in the next few years, this interconnection between skills and practical projects could help more people thrive in employment.

From individual skills to multidisciplinary skills:

Another key insight from the report relates to multidisciplinary pathways. These become increasingly critical when considering the links between skills and careers.

Needless to say, technology skills such as computer programming and statistics are sought after by students of all disciplines.

Additionally, engineering students seek to develop other skills. Math and science students try to focus on leadership skills and communication skills.

Those working to become teachers prioritize research, writing, and communication skills. Arts and humanities students also learn digital skills such as computer graphics, user experience, etc. These can help them enrich and advance their career options such as teaching while gaining a better understanding of human behavior.

Biological science students focus on data analysis, much like business students. The goal is to help them extract patterns from large-scale data. Health science students seek positions in data science.

While the power of deep expertise in a particular area is often seen as essential to success, given the complexity of jobs, multiple skills are needed to solve problems. Polymaths could rejoice.

A skills taxonomy is a means by which these different skills can be mapped for a job.

Our key learning is a taxonomy of skills. Not just for a job, but for investing in a personal skills taxonomy that can help each of us develop interconnected skills throughout our careers. This will further help us map new and uncharted territory with better questions, if not immediate answers.

Today, facets are emerging in the course of each profession. A skills roadmap could guide us on this journey.

Doing their MARC: the MARC program is recruiting its first cohort of students

Four students make up the first cohort of undergraduate students participating in the Maximizing Access to Research Careers (MARC) Nevada program. The program, sponsored by the National Institutes of Health, is designed to help develop a diverse pool of undergraduate students completing their bachelor’s degrees and transitioning into research-oriented graduate programs (Ph.D. . or MD/Ph.D. ) in biomedical sciences. The long-term goal is to develop a diverse pool of well-trained scientists.

The first cohort is made up of students Lauren Carriere, Jesus Diaz Sanchez, Jonathan Taasan and Kimberly Giannantonio. Participating MARC Nevada students will receive an annual stipend of $13,920 for their junior and senior years of college, partial tuition financial coverage, year-round research opportunities, and mentorship, among other benefits.

Professors from the College of Science and the Neuroscience Institute collaborated on the MARC grant proposal, including Institute Professor and Director James Kenyon and College of Science Associate Professor and Associate Dean Melanie Duckworth. The grant is an Institutional Training Grant, which is frequently renewed, meaning the University will likely be able to support more cohorts beyond the first five grants this year. The university hasn’t had an institutional training grant in more than a decade, Kenyon said.

“If the program is able to recruit good interns and fill all the slots, and the interns are successful, there’s a higher chance of it being renewed and renewed and renewed,” Kenyon said. MARC principal investigators (PIs) also hope to increase the number of trainees in subsequent grants.

The program has four PIs: Duckworth, Thomas Kidd Professor of Biology, Mary Burtnick Associate Professor of Microbiology and Immunology, and Wes Chalifoux Associate Professor of Chemistry.

CPs are excited to have the opportunity to support students. Burtnick stressed that the grant will give students a chance to really immerse themselves in research before applying to graduate schools. The current cohort has already begun their summer research projects.

“For me, it’s nice to have a program that’s really designed for students from underrepresented groups and to give them opportunities like this to excel,” Chalifoux said. The PIs also pointed out that Kenyon and the Institute for Neuroscience have done extensive work to finalize the proposal and ensure its success.

Students interested in the program can apply at the end of their second year of college. The College of Science will feature each student in this cohort in a profile on Nevada Today.

Computational Biology Market Analysis and Global Outlook 2022 to 2029 | Chemistry, Accelrys, Certara, Compugen – This is Ardee

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  • Chemical informatics
  • Accelrys
  • Certara
  • Compugen
  • Entelos
  • Insilico Biotechnology
  • Genedata
  • leadscope
  • Simulator More
  • Schrödinger
  • Rhenovia Pharma
  • Discovery of Nimbus

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Global Computational Biology Market Segment By Application:

  • Cellular and biological simulation
  • Pharmacogenomics
  • drug discovery
  • Drug development
  • Lead Optimization
  • Discovery of prospects
  • Pharmacokinetics
  • Disease modeling
  • Clinical tests

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ATTRIBUTES DETAILS
ESTIMATED YEAR 2022
YEAR OF REFERENCE 2021
FORECAST YEAR 2029
HISTORICAL YEAR 2020
UNITY Value (million USD/billion)
SECTORS COVERED Types, applications, end users, and more.
REPORT COVER Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends
BY REGION North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
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Regional analysis:

European market (Germany, UK, France, Russia, Italy)

East-Central and Africa Market (Saudi Arabia, United Arab Emirates, Egypt, Nigeria, South Africa)

South America market (Brazil, Argentina, Colombia)

North American market (United States, Canada, Mexico)

Asia-Pacific market (China, Japan, Korea, India, Southeast Asia)

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New studies bolster the coronavirus-out-of-the-wild theory

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INTERVIEW: Relations between Greece and Saudi Arabia are “more than excellent”, says Greek Development Minister Adonis Georgiadis

RIYADH: The visit of Saudi Crown Prince Mohammed bin Salman is a great honor for Greece which will strengthen an already “excellent” bilateral relationship, Greek Development and Investment Minister Adonis Georgiadis told Arab News.

“We are deeply honored that HRH Mohammed bin Salman has decided to travel to Greece for his first trip to an EU country since 2018,” he said ahead of the crown prince’s arrival in Athens on Tuesday.

The visit aims to strengthen the already strong ties between the two countries, which span politics, economy, trade, investment, defence, security, culture and tourism.

“This (visit) is very important for Greece and very important for our relationship because we honor and admire his leadership, his vision for the Kingdom of Saudi Arabia and the way the Kingdom is moving towards the new era of humanity in renewable energies, and new technologies,” said Georgiadis.

“I really believe that His Highness is a strong leader, and his decision to be here, I must repeat, is very, very important for us. The level of relations between Greece and the Kingdom of Saudi Arabia is more than “Excellent. And what we want to achieve is that the high level of our relations in the field of defense and politics in general is (imitated) on the economic level.

Speaking to Arab News via Zoom from Athens, Georgiadis said he was confident that Greek companies and investors would play a leading role in the development of NEOM – Saudi Arabia’s new smart city taking shape on the Red Sea coast and one of many giga-projects launched under the Kingdom’s Vision 2030 social reform and economic diversification program.

“This is not just an economic growth project. It is a project about the new era of humanity on planet Earth, with sustainable growth, respect for the environment and the use of high technology to improve the standard of living and the good -being humans,” Georgiadis said.

“So I’m sure a lot of Greek companies would be interested in participating in and being part of this huge NEOM project.”

Underlining the increasingly close diplomatic, security and commercial ties between the two nations, Georgiadis confirmed that several new memorandums of understanding would be signed by the Crown Prince and Greek Prime Minister Kyriakos Mitsotakis during a special ceremony at the museum of the Acropolis in Athens.

Opened to the public in 2009, the world-renowned Archaeological Museum houses Bronze Age, Roman and Byzantine artifacts unearthed at the site of the Acropolis, which is the country’s most prized antiquity and national monument.

Hosting the signing ceremony in this location will be symbolic.

“This has never happened before,” Georgiadis told Arab News. “We have never signed a Memorandum of Understanding with any other country in the world in the Acropolis Museum. And this is just a (message) from our Prime Minister to the Kingdom of Saudi Arabia to show how we think you are something very special to us.

Georgiadis will sign memorandums of understanding on investment and trade. “We will also have one in the field of defence, the field of high technology and the maritime sector. And then, of course, a very important memorandum of understanding for culture and cultural exchanges. (We) will have a very beautiful ceremony in our Acropolis.

In 2020, Greek exports to Saudi Arabia were valued at $339.04 million, while its imports from the Kingdom were worth $620.57 million, according to the UN Comtrade database. on international trade.

To boost bilateral investment, the Council of Saudi Chambers signed a memorandum of understanding last September to establish the Saudi-Greek Business Council.

“I am more than happy that the Saudi-Greek Business Council has been established,” Georgiadis said. “I am very honored that there are two very important people from Greece and the Kingdom, the leaders of this organization, from the Kingdom of Saudi Arabia, Ms. Lubna Olayan.”

Along with Greek entrepreneur and investor Achilleas Konstantakopoulos, Al-Olayan is the co-chairman of the Saudi-Greek Business Council.

Georgiadis added: “The Olayan family is a true friend of our country. They have been investing in Greece since the 1970s. They have stayed with Greece through all of our difficult times. We recognize this family, true friends and very important investors. And I’m proud and honored that they met me and worked with me.

“I think the reality that such important people have decided to be the leaders of the organization shows the level of commitment and the ambition that we have to follow all these projects and to establish a real friendship and cooperation between our two great countries.”

Georgiadis said he was confident that many more deals and partnerships would soon be announced, “from renewable energy to agriculture, food security and high technology”, and that there was “very high potential in the tourism industry and maritime transport”.

Last December, the two nations signed a maritime transport cooperation agreement to develop commercial maritime navigation, increase commercial vessel traffic and encourage trade.

In March, Saudi Arabia and Greece signed a memorandum of understanding paving the way for innovations in renewable energy, including green and blue hydrogen, and the development of a fiber optic cable network that will connect data from Southeast Asia to Central Europe.

“The cable, where they get the connection, Greece and Europe with the Kingdom of Saudi Arabia via Egypt, is a very important project,” Georgiadis said.

“You see, Greece and the Kingdom of Saudi Arabia share a unique location for their region – Greece as the entry point to the EU and based in the Mediterranean and Saudi Arabia as the best location that can unite the world Arabic and the Middle East with the Far East and Asia.

“So it’s very natural that this, both as good locations, through the use of high technology, can join forces for the good of humanity and for the global economy and their own brand. “

The Saudi-Greek Investment Forum, held in the Kingdom on March 13, showcased investment opportunities in both countries and resulted in hundreds of bilateral business meetings.

Georgiadis said he had high expectations for Saudi-Greek relations following the visit of Crown Prince Mohammad bin Salman and expected many more trade deals to follow.

“During our last visit to Riyadh, there were more than 200 B2B meetings between Greek private companies and Saudi companies. They were followed by (another) batch in Athens,” he said.

“So, you know, the results (of these) are going to come out in 24 hours.”

AHF: Access to Monkeypox vaccine must be guided by global equity and inclusion

KAMPALA, Uganda and WASHINGTON–(BUSINESS WIRE)–AIDS Health Foundation (AHF) today strongly criticized the World Health Organization (WHO) and the slow emerging collective global response to monkeypox. AHF is particularly concerned by news this weekend that doses of vaccines – in critical shortage around the world and with production delays of several months – have been ordered by the millions by wealthy Western countries, including the Canada, Great Britain, Germany and the United States, but NOPE the doses are targeted for Africa.

Associated press (via LA Times) reported Saturday on the WHO’s decision over the weekend to finally declare monkeypox a “public health emergency of international concern” (USPPI). The AP story documented the explosive growth of monkeypox cases around the world over the past two months, the critical supply of vaccines around the world, and raised the issue of vaccine equity, reporting:

Dr Placide Mbala, a virologist who heads the global health department at Congo’s National Institute for Biomedical Research, said he hoped all global efforts to stop monkeypox would be equitable.. Although countries like Britain, Canada, Germany and the United States have ordered millions of vaccine doses, none have gone to Africa.

“The emerging disparities in access to the monkeypox vaccine are reminiscent of the inequities that have plagued COVID-19 and demonstrate that the world is once again failing to maintain the spirit of international cooperation and solidarity to address the global public health threats,” said Dr Penninah Iutung, Head of AHF Africa office in Kampala. “HIV/AIDS and COVID-19 have shown us that discrimination and inequality can be catastrophic with lasting consequences on people and on an already strained health system,” she added. “We demand that the principles of fairness, equity and inclusion guide the deployment of monkeypox vaccines, which ensure equal access to vaccines for all who need them, no matter who or where they are. find.”

Since May, the monkeypox virus has broken out in several outbreaks or epidemics outside Africa, where it was long considered endemic in a handful of countries. Today it has become a global public health crisis, with more than 16,600 confirmed or presumptive positive cases reported in nearly 70 countries where it is not considered endemic, as of July 25, 2022. “Factbox: Cases of monkeypox around the world.” The vast majority of these infections occur in gay men and men who have sex with men.

“Despite navigating more than two years of COVID, global, American and global health leaders have once again been caught off guard and woefully ill-prepared, this time for monkeypox,” he said. declared the president of the AHF. Michael Weinstein from Los Angeles. “It also took until Saturday, more than two months since cases were first reported outside Africa, for the WHO to declare the virus a public health emergency of international concern. the rapid and uncontrolled spread of this virus, the WHO should immediately declare monkeypox what it really is: a pandemic. TO HAVE TO be shared equitably with low- and middle-income countries in Africa and elsewhere.

AIDS Health Foundation (AHF), the world’s largest AIDS service organization, currently provides medical care and/or services to more than 1.6 million people in 45 countries around the world in the United States, Africa, Latin America /Caribbean, Asia/Pacific and Eastern Europe. To learn more about AHF, please visit our website: www.aidshealth.orgFind us on Facebook: www.facebook.com/aidshealthFollow us @aidshealthcare or subscribe to our AHF podcast “AHFter the hours.”

Fish and Game tests new method for counting Nushagak River salmon

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The Alaska Department of Fish and Game changed the way it counts fish passing through the sonar site on the Nushagak River this year.

The sonar, located about 25 miles upstream from the commercial fishing district, allows technicians to get population estimates of Chinook, chum and sockeye salmon as they swim back to their spawning grounds.

But in a memo released quietly in mid-June, state biologists said a recent study showed the existing counting method may have underestimated Chinook and chum races. And they said they hope the new methodology will provide more accurate counts of salmon species in the future – which could be increasingly important as managers grapple with low numbers of king salmon on the Nushagak and around Alaska.

Bristol Bay area research biologist Jordan Head said sonar gives Fish and Game technicians a visual of fish swimming past them so they can count the run.

“It almost looks like an ultrasound, where you can see fish swimming past the sonar,” he said.

Sonar records 10-minute intervals, every hour, at two different sections of the Nushagak River – one near shore and one offshore. Head says sockeye usually swim close to shore while kings and pals are usually further offshore. But sonar does not differentiate between species.

“We see the fish go up the river as if on a [counting] round, but we can’t see what they are,” he said. “So we started a driftnet program. We derive several different gillnet meshes through each of these two strata on each bank.

Technicians analyze sonar and catches at these two locations to estimate how many of each species are coming up the river.

Until this summer, the department also took into account the number of fish swimming downstream – called downstream fish. Technicians would subtract this downstream count from the upstream count for their final estimate of upstream migrants for that time period.

“It works really well,” Head said. “But there are a lot of assumptions we make with it.”

He said that so far the sonar project has operated under two main assumptions. The first is that the number of fish downstream breaks down into the same species composition as the fish upstream. For example, if they split the upstream count to 90% sockeye, 7% chum, and 3% kings, they apply that ratio to the downstream count as well. The other hypothesis, Head said, is that fish swim both upstream and downstream in the same section of the river – either onshore or offshore.

“We always want to try to make as few assumptions as possible, especially when we can’t test the assumptions in our project design,” he said.

Head said the department’s study last year indicated subtraction may have underestimated Chinook and chum runs.

When the technicians did not subtract the downstream count, the number of Chinook runs increased by about 9%. The chum return increased by 3% and the sockeye return increased by 1%.

“What we think is happening up there, and why this change was made, is because you have sockeye escapements that have millions of fish, and you have king escapements that are are in, you know, a 50,000 fish range,” Head said. “And so if on average about 1% of the fish go back and go downstream, if we misapply those sockeye downstream as kings, that’s a big deal in the king count.”

The change comes as area managers, anglers and residents closely monitor escapement numbers after several years of low chinook runs in the Nushagak. This year just over 44,000 Chinooks have escaped, well below the minimum target of 55,000.

The Nushagak District Chinook harvest is 4,605 ​​fish so far. It is the biggest catch of all the districts in the bay. The bay-wide harvest of 7,558 Chinooks is well below the 20-year average of around 40,000 kings.

Head said they are still counting fish downstream this season and a report on the change will be available before the Alaska Fisheries Council meeting this winter.

He added that the count difference between the two methodologies varies each year. And so far this year, that hasn’t meant much of a difference.

“That may not be a best estimate. But scientifically speaking, we make fewer assumptions. And we have smaller errors – potential errors – associated with making fewer assumptions,” he said.

Head plans to reanalyze counts dating back to 2006 to see how the new counting method may affect the department’s escapement goals for the Chinook run.

“Hopefully in the next two weeks I can go out and do the Chinook post-season aerial surveys in the tributaries and kind of be able to tell us if it was better than last year, or if it was no better than last year,” he said.

Preliminary estimates of chinook escapements in Nushagak District should be available this fall.

There are a number of sonar sites across the state, some of which count salmon differently.

Sportfish area management biologist Colton Lipka says the sonar site on the Kenai River is similar to the Nushagak in that it captures 10-minute intervals every hour. But the Kenai sonar is dedicated to Chinook counting. They monitor the courses based on the size of the fish, counting salmon 34 inches and over.

“We know with fairly good certainty that it will be a king because the other species present would not be of this size. And because of the large proportion of big fish in Kenai Pass, we can then use that as an assessment metric,” he said.

Lipka said he started this program in 2017 to more accurately monitor the Chinook’s exhaust there. Before that, they monitored all species, but they changed to focus on kings. He says it works for the Kenai because of the larger population of big fish for that race.

Kenai is also facing a decline in Chinook returns, which have been declining since 2010. Again this week, sport and set net fishing was closed due to low returns.

This year, the comeback is estimated at 12,700, which is still below the breakaway target of 15,000 to 30,000. But Lipka said the season continues until August 20, so they hope that the race will increase.

How to turn muscle into a protein factory for

image: UMass Amherst authors Kevin Guay, Dan Hebert and Haiping Ke
see After

Credit: UMass Amherst

AMHERST, Massachusetts – In a major new development in the quest for better gene therapies to treat a host of diseases, researchers from the University of Massachusetts Amherst and UMass Chan Medical School recently announced that they have mapped the expression and maturation of the alpha-1 antitrypsin (AAT) protein with unprecedented clarity. The results, which detail the molecular folding of the protein, have been published in the Proceedings of the National Academy of Sciences and will help develop specific therapies to treat an inherited condition known as alpha-1 antitrypsin deficiency, as well as more effectively treat a wide range of genetic conditions.

A revolution in the treatment of diseases has taken place in recent years. It is now clear that there is a whole range of diseases, such as AAT deficiency, that arise when our own bodies produce dysfunctional proteins at the genetic level. Faulty production of AAT or insufficient amounts of AAT can cause serious lung and liver disease. These diseases must be treated either by delivering the missing proteins to the body or, even better, by teaching the body to make the missing proteins itself by introducing an intact copy of the specific protein-producing gene into the DNA of the correct cell. .

But it’s not an easy task to teach the body to make a missing protein. To do this, you must first introduce the correct protein-producing gene into the body, usually via an intramuscular injection – an injection – and into the specific cells that make that protein. Then you have to make sure that once the body starts making the protein it was missing before, that protein is correctly folded into its proper final shape – in the case of AAT, that shape looks like a loaded mousetrap ready to be suspended. Finally, this correctly folded protein must travel from the cell to where it is needed in the body.

It is a series of extremely complex problems that require a research team with expertise in molecular biology, cell biology, protein folding and gene therapy, as well as state-of-the-art research facilities in which to carry out the work, such as the Models to Medicine Center at UMass Amherst’s Institute for Applied Life Sciences, which houses the labs where much of the research has been completed.

“This project is the result of more than a decade of collaboration and spans the gamut from basic science in the lab to the bedside,” says Daniel Hebert, professor of biochemistry and molecular biology at UMass Amherst and one of the co-authors of the article. . Funding for the research was provided by the Alpha-1 Foundation and the National Institutes of Health.

Make a better mousetrap

It starts with Terence R. Flotte, Professor Celia and Isaac Haidak, Executive Vice Chancellor, Provost and Dean of TH Chan School of Medicine. Flotte, a pioneer in gene therapies, has developed a way to use the harmless adeno-associated virus, or AAV, as a vehicle to deliver gene therapies. “We have completed three clinical trials in which we inject AAV containing the normal version of the AAT gene into the muscle to create a ‘sustained release’ of the protein in patients with AAT deficiency,” says Flotte. “But until now, we didn’t understand how much AAT protein is processed in muscle at the biochemical level.”

However, not all cells in the body are able to make all the proteins the body needs. AAT, for example, is best made in the liver. But, since most hits happen in a muscle – think of hits you get in your arm – the team needed to figure out how to get muscle cells to act more like liver cells in their production of AAT, and then how to get the AAT. produced in the muscle to the lungs and liver, where it is needed.

It turns out that Hebert is an expert in these same questions, and, after confirming that muscle cells are poor producers of AAT, he helped develop a technique that increases AAT secretion in muscle cells. about 50% using some kind of chemical. , known as a proteostasis regulator, called suberoylanilide hydroxamic acid, or SAHA. “It’s a way of getting the muscles to do some of the work of the liver,” he says.

And yet, not all proteins are the same. Their shape is crucial in determining how, or if, a protein functions as it should. Throughout her career, Lila Gierasch, a distinguished professor of biochemistry and molecular biology at UMass Amherst, has focused on the process by which a protein takes on a specific shape, called the protein folding problem.

“These protein molecules are absolutely fascinating,” says Gierasch. “They look like little mousetraps and need to be metastable” – imagine a trap you just set waiting for a mouse. “It’s a very special shape, and it has to fit perfectly, otherwise the protein won’t work as it should.”

Although the team focused on AAT deficiency as a case study, their work shows that combinatorial treatments, which include both gene therapies and proteostasis regulators, can enhance the efficacy of gene therapies, not only for AAT deficiency, but for many genetic disorders. more generally.

“Our ultimate goal,” says Gierasch, “is to provide an easy injection that could cure a very difficult and potentially devastating genetic disease. It takes a broadly interdisciplinary team, with expertise acquired both in the laboratory and with the patient, to find an answer.

contacts: Daniel Hebert, dhebert@biochem.umass.edu

Daegan Miller, drmiller@umass.edu


Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Recombinant Protein Market Size, Scope, Growth Opportunities, Trends by Manufacturers and Forecast to 2029 – This Is Ardee

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Hospitals grapple with staffing shortages as federal Covid funds run out

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“We had to step up during the peaks and then try to figure out, ‘Are we keeping people or are we letting them go when we’re not peaking?'” said Julie Hirschhorn, director of pathology molecular at the Medical University of South Carolina. in Charleston. “Surges tend to be just far enough away that you don’t know what to do…It’s a tough new normal.”

The current wave, in which the new number of patients hospitalized with Covid-19 has increased by more than 40% in the past month, is also putting new pressure on facilities as federal funding for the pandemic response runs out. , leaving some with less flexibility to hire more staff if they need to.

In March, a funding deal to cover part of the White House’s $22.5 billion request fell apart because congressional Democrats objected to reallocating unspent funds pledged to states earlier. in the pandemic, while Republicans said they needed an accounting of the $6 trillion from Congress earmarked for pandemic relief in past funding bills before approving new funds.

“There is growing concern that that money is running out,” said Nancy Foster, vice president of quality and patient safety policy at the American Hospital Association. “He doesn’t really get enough attention.”

As of July 22, hospitals in nearly 40 states reported severe staffing shortages, while hospitals in all 50 states said they expected to do so within a week.

Several states with increasing numbers of Covid-19 cases have significant and growing problems, although factors beyond Covid are involved.

In California, for example, only eight hospitals described their staffing shortages as critical as of July 22, but 118 are expected to do so within the week. In Louisiana, only one hospital reported a critical shortage last week, but 46 expected to have one this week. More hospitals were also expecting shortages in Alabama, Florida, Kentucky, New Mexico, Tennessee and West Virginia — all states with rising case counts.

“While we have experienced staffing shortages before, we are acutely aware of staffing shortages in virtually every type of position within the hospital at this time,” said Foster. “If we have a large influx of Covid patients, it will be much more difficult to meet these demands than ever before.”

Chronic hospital staffing shortages will continue to be a long-term problem, administrators said, as even vaccines that have been shown to be highly effective in preventing serious illnesses do not keep everyone from going to hospitals. . There’s also Americans’ growing resistance to mitigation measures like social distancing and masking, and public officials’ reluctance to sound the alarm during a wave in which fewer people are getting seriously ill and dying than during of the previous ones.

Hospital intensive care units are not inundated with Covid-19 patients as they were in previous waves, and the average daily death toll hovers around 350, the Centers for Disease Control and Prevention says, well below thousands of Americans dying each day during past peaks.

But severe strains on the healthcare system persist without these grim tolls.

“I don’t think people appreciate the ramifications for allowing us to transmit the virus almost willy-nilly now,” said David Wohl, the infectious disease expert who leads the Covid-19 response at UNC Health in Carolina. North. “If there are supply chain issues, if there are delays in getting services, or if people say, ‘Well, I’m understaffed, I can’t do, “it’s because of the pandemic.”

“Stealing Peter to Pay Paul”

Staffing shortages in hospitals – from nurses to doctors to medical laboratory technicians – existed before SARS-CoV-2, a result of both aging healthcare workers and an aging population as a whole that increases the demand for care.

The pandemic has created something of a domino effect in the medical community, said Sherry Polhill, associate vice president of hospital laboratories, respiratory care and pulmonary function services at UAB Medicine in Birmingham, Ala.

This prompted older workers to quit their jobs early and created a boom in the lucrative traveling health care professional industry that diverted people from their staff work.

“You have this void of vacancies that you need to fill and you can’t do it easily,” Polhill said, adding that it could take years to fill the vacancies she has in her labs.

The shortfall hits hospitals – and their patients – in different ways, as BA.5 has been shown to be able to evade immunity and become the dominant strain in the country.

In North Carolina, where cases have risen nearly 20% in the past two weeks, UNC Health is struggling to meet growing patient demand for monoclonal antibody treatments.

Hospitals are still providing the antibody treatment to those taking drugs that could negatively interact with a simpler treatment, Paxlovid. Unlike Paxlovid, a pill that can be taken anywhere, the monoclonal antibodies are given by infusion, a labor-intensive process that requires careful infection control to treat patients at infusion centers who also treat immunocompromised people.

For this to work, Wohl said, the hospital has to borrow staff from other departments.

“We have to rob Peter to pay Paul,” he said. “If you have people working in an infusion center who do this, what was their daily work before Covid? Some of them worked in the emergency room. Some of them worked in the operating room. You just can’t take people out of those other critical functions and still have them working somewhere else.

Next door in South Carolina, staffing shortages at the Medical University of South Carolina have already prompted the hospital to stop testing all hospitalized patients for Covid-19 as it did earlier in the pandemic.

The facility received money from a Covid-19 Relief Act Congress passed in March 2020 to bolster its testing capacity with new equipment and staff.

Now that money has started to dry up and Hirschhorn has had to downsize its teams and employees. His lab, part of a network of them at the hospital, had 44 staff and contractors at the height of the pandemic, but only 10 full-time staff today. His Covid-19 testing capacity has increased from around 3,500 a day to 1,500.

The decision to halt routine Covid testing helped prevent the lab from being overwhelmed, even as the number of people hospitalized with Covid has increased 34% in South Carolina in the past two weeks. But Hirschhorn said it made her uncomfortable knowing she no longer had the resources to get back up and running if she needed to.

“We’re all trying to figure out what our lab looks like now and what we can do to help prepare for another surge, knowing that we won’t have the same staff we had in other surges,” he said. she declared. . “We are flying blind.”

Pandemic fatigue

This anxiety is prevalent in hospitals, where the pandemic has exacerbated the staffing shortages that preceded it.

“Medical laboratory scientists are unhappy right now,” said Susan Harrington, a Cleveland Clinic microbiologist and chair of the American Society for Clinical Pathology’s laboratory workforce steering committee. “They work too hard, and they work too hard for too long.”

“What is the end?” she asked. “I don’t really know the answer.”

Although hospital labs are, generally speaking, much more prepared to handle this wave of cases than they were in 2020, the Medical University of South Carolina is not alone in ending the testing of all hospitalized patients for Covid-19 due to staffing, said Jonathan Myles, president of the College of American Pathologists’ Council on Government and Professional Affairs.

A lack of local testing options creates greater danger to patients and the community, he said, especially in rural facilities operating in economically disadvantaged areas. “They operate with little means,” he said. “If you limit rural testing, you exacerbate the inequity of care.”

Large, urban hospitals may be in a better position to juggle periods of high transmission, but with more staff calling in sick and more patients testing positive, they too are under pressure.

In Los Angeles County, where the number of patients hospitalized with Covid-19 has increased dramatically since May despite the region’s high vaccination rate, Harbor-UCLA Medical Center has had to find ways to manage.

“People are getting Covid left and right,” said Anish Mahajan, the facility’s CEO and chief medical officer.

The hospital has so far coped with this surge in cases, he said, with longer wait times in the emergency room due to staff shortages and a greater number of patients. The hospital may need to prioritize urgent care cases again if things get worse.

The only real way to end uncertainty is to stop the virus, through vaccination and taking steps that stop its spread, he said, such as putting on masks when transmission is high.

“The more the virus is transmitted in our world, the more we are going to see the generation of future variants taking hold,” Mahajan said. “Maybe this variant doesn’t cause a lot of people to get sick in the hospital. But we don’t know what the next variants might do.

Roaring River divers also look for aquatic life when exploring the spring | Local News

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CASSVILLE, Mo. — While some anglers chase trophy trout, Fernando Calderon recently set his sights on smaller prey during a visit to Roaring River State Park.

With a special six-month permit granted by the Missouri Department of Natural Resources, effective in July and continuing through the end of the year, he joined a dive team searching for the bottom of the Roaring Spring. River. The team now has permission to collect cave organisms for research.

The clearance was good news for Calderon, a marine biologist and recent graduate of Texas A&M University. A diver himself, Calderon traveled from his home in Galveston, Texas to join divers at Roaring River to receive any specimens found.

Their mission, a priority for the KISS Rebreathers team, as well as the mapping of the source cave, was crowned with success.

“We were able to collect samples from three different species: two types of isopods, plus one amphipod,” Calderon said.

Isopods and amphipods are both segmented crustaceans but have differences in their legs and other body structures.

On Saturday, July 9, the last day of the hunt, Calderon was greeted by crowds of eager onlookers when he returned to the surface of Roaring River Spring with a test tube containing the morning’s catch in his hand. The tube was passed through the crowd so viewers could admire the isopod on its daylight debut.

KISS Divers Jon Lillestolen and Gayle Orner were thrilled to be part of the Underwater Species Collection. Orner, who has a background in biology, said it was the first time she had captured an organism underwater at this depth.

“It was a bit like capturing a bumblebee in a jelly jar when I was a kid,” she said.

Crustacean subsurface dwellers have been found at depths of 90 feet and 200 feet.

After collection, the creatures’ lives were sacrificed for scientific research.

“I euthanized them with pure ethanol,” Calderon said. “Ethanol appears to be the most effective in preserving genetic material.”

Calderon, who met members of the KISS Rebreathers dive team at an international cave diving conference in Marianna, Florida, in 2018, said a DNA study of the samples will begin in September, when he takes on a research position at Texas A&M.

“We should have results by the end of the year,” he said.

Calderon says the results should indicate whether the crustacean species are unique to Roaring River Spring or share genetic material with those found in other cave and spring systems in the area.

In addition to research on the organisms themselves, Calderon conducts tests on the properties of the water where the species have been found.

“We installed two temperature sensors at different depths in the cave to learn more about the environment the creatures like,” he said. “We will leave the sensors in place to record temperatures until our next visit in August.”

A multiparameter probe, an instrument capable of sampling a vertical profile of multiple water conditions, was also taken by Calderon.

“The probe collects data on salinity, water pressure, temperature, turbidity, and the oxygen and pH content of the water,” he said.

Due to Calderon’s presence, collecting specimens from Roaring River Spring was the priority of the KISS Divers’ visit in early July, but continued exploration of the spring remains at the top of their list.

In November of last year, the KISS team put Roaring River Spring on the map as the nation’s deepest explored spring reaching a depth of 472 feet, with more depths yet to be probed. High water flows earlier this year prevented further exploration, but they plan to resume searching for the bottom later this year.

In order to dive deep, KISS divers must first pass through a narrow restriction that exists at a depth of 225 feet. A dive team in 1979 and another in the 1990s were unable to cross this restriction due to the traditional and bulky dive equipment they were using. However, divers affiliated with KISS Rebreathers navigated through the once impenetrable passage in August 2021 through the use of compact, side-mounted rebreathing equipment designed by Mike Young, Chief Diver and CEO of KISS Rebreathers.

“It’s scary in there,” Young said after crossing the restriction for the first time, in reference to the room on the other side.

Although the water flow through the restriction was low enough to allow penetration when the KISS team visited in July, Mike Young was ill. Mapping diver Jon Lillestolen was the only member of the team present to experience the restriction, but for safety reasons he did not want to attempt the solo crossing.

“I stuck my head and shoulders out to look around,” he said. “There was a broken lifeline that we will need to fix, but water conditions look good for more deep diving when we visit in August, barring any flooding.”

KISS Rebreathers divers will return in the spring from August 19-21, when YouTube Dive Talk hosts Woody Alpern and Gus Gonzalez will also be in attendance.

Saturday, August 20 will also coincide with Kids Fishing Day at Roaring River State Park.

Catherine Toth Fox: Time to embrace tilapia despite its stigma in Hawaii

“Here, try this.”

I had just started dating this guy when he handed me a plate of salty, crispy fried fish bits, which he cooked himself.

I’m not a big fish eater, but I felt compelled to give it a try. I mean, the guy spent the whole afternoon scaling fish and risking his life with a deep fryer for me, obviously in an effort to impress me, so I should at least be polite.

And I was pleasantly surprised – not only by his cooking skills, but by the fish itself. The white meat was firm and flaky and tasted mild, if any.

“What kind of fish is this?” I asked, through a bite of fish and rice.

“Tilapia,” he replied.

I stopped chewing. Tilapia. The fish that lives in the Ala Wai channel. The one that if we ever caught him, we’d fire him and maybe wash our hands afterwards. This is what I ate?

Not enough. It turns out that the species of tilapia that occupies the murky channel – the black-chinned tilapia or Sarotherodon melanotheron – was imported by the state in the 1950s as live baitfish for the fishing industry. with tuna.

The guy – now my husband – had fried a Mozambique tilapia (Oreochromis mossambicus) that he had grown in an aquaponics setup in his backyard. Aquaponics is a combination of aquaculture – growing fish or other aquatic animals – and hydroponics – growing plants without soil – in a symbiotic system where water from fish effluent is used to grow vegetables .

Tilapia is one of the most popular seafood choices for American consumers. Getty Images

This is not unlike the native Hawaiian practice of loko i’a kalo, where fish were raised in wetland taro patches.

The beauty of this, he would later boast, is that you can grow both vegetables and protein in a system compact enough to fit in your garden or even your porch. Talk about food security.

I’ll be honest: if he had told me in advance that he would serve me tilapia for dinner, I might have faked a migraine. Like many locals, I grew up associating cichlid fish with disgusting habitats. And if you are what you eat, I wouldn’t eat a tilapia from a muddy canal.

But the tilapia that my husband farmed — and continues to help other aquaculture farms raise as an extension worker with Hawaii Sea Grant — don’t live in dirty environments or eat nasty microalgae. Rather, these fish are fed mostly vegetarian diets and live in clean tanks and ponds, making them one of the tastiest fish.

You do not believe me ? Ask James Beard Award-winning chef Alan Wong, who once served this fish alongside mahi mahi and opakapaka at a 2009 dinner party at his Honolulu restaurant. Most guests picked tilapia as their favorite, and Wong often featured tilapia — grown at a fish farm on Oahu’s North Shore — on his menu.

Tilapia is the second-highest-growing fish in the world, behind carp, and the third-highest-growing fish in the United States, according to the National Marine Fisheries Service, behind catfish and striped bass.

Tilapia is one of the most popular seafood choices for American consumers – we ate 1.07 pounds per person per year in 2020, behind only canned shrimp, salmon and tuna – and you can find this fish in grocery stores and restaurants across the country.

Not so much in Hawaii.

But hopefully that will change, because eating locally farmed tilapia (or any seafood) would help the state’s food security goal and reduce pressures on the world’s oceans.

According to a compelling study published in the journal Science in 2006, a team of international conservationists and economists concluded that all species of wild seafood – from tuna to sardines – will collapse by 2048, citing overfishing and climate change as threats. (“Collapse” is defined as a depletion of 90% of the species’ baseline abundance.)

“Unless we fundamentally change how we manage all ocean species together as functioning ecosystems, then this century is the last century of wild seafood,” said co-author Stephen Palumbi, professor of biological sciences at Stanford University in a press release.

It’s scary to think about, especially if you like ahi or mahi mahi, both of which are advised to be avoided by the Monterey Bay Aquarium’s Seafood Watch program. (Tilapia caught or raised in the United States is on its list of top picks.)

Tilapia, as a sustainable food source, has a lot to offer. The fish grow rapidly and tolerate a variety of water quality and salinity environments. The feed conversion rate—essentially the number of pounds of feed needed to make 1 pound of animal—is about 1.5 for fish. (By comparison, the number of cattle is between 6 and 10, which means it takes 6 to 10 pounds of feed to make 1 pound of beef.)

Tilapias are omnivorous and can eat 100% vegetable protein, which is better for the environment. And you don’t need to use fossil fuels to catch them, if they are stored in tanks or ponds. Eating locally grown foods – including fish – is also better for Hawaii.

We still import about 85% of what we eat from the mainland, and according to the Hawaii Department of Agriculture, about 63% of all seafood eaten in Hawaii is also imported. And there are more than a dozen Hawaiian farms raising tilapia for consumption, including Kunia Country Farms and Alii Agriculture Farms on Oahu and Kohala Mountain Fish Co. on the island of Hawaii.

So why not eat farmed tilapia in Hawaii? It’s simple: stigma — but one that can be changed with education and a willingness to try something different.

So the next time you see farmed tilapia on the menu, don’t panic. Try it. You might change your mind. I did it. I even married the guy afterwards.

The first case of polio in the United States in more than a decade – Speaking of research

July 23rd 2022

Not so long ago (1950), the lack of a polio vaccine led to debilitating developmental abnormalities in our population. Due to decades of research to develop the oral polio vaccine, children today know nothing of the fear that polio brought to the United States every summer until the 20th century. Swimming pools and cinemas were closed and children were kept inside their homes by frightened parents. Around the world, the disease has killed millions of people and left legions of others permanently disabled. In 1979, however, and thanks to Albert Sabin’s research on monkeys, a vaccine was developed and poliomyelitis was considered eradicated.

“On the contrary, my own experience of more than 60 years in biomedical research has amply demonstrated that without the use of animals and human beings, it would have been impossible to acquire the important knowledge necessary to prevent much suffering and premature deaths not only among humans but also among animals.

In my 1956 article in the Journal of the American Medical Association (Vol. 162, p. 1589), I stated that during the previous four years “about 9,000 monkeys, 150 chimpanzees, and 133 human volunteers were used so far in studies of various characteristics”. of different strains of poliovirus. These studies were needed to solve many problems before an oral polio vaccine could become a reality.

Albert B. Sabin, MD »

Now all that can change. We have seen a dramatic decrease in overall vaccination rates among children. In fact, the World Health Organization (WHO) and the United Nations International Children’s Fund (UNICEF) have reported the largest sustained decline in childhood vaccinations in about 30 years. Some of this is precipitated by the ongoing COVID-19 pandemic, the rest, however, stems from scare propaganda in the media, social media and other media channels where unverified information is quickly disseminated.

It is therefore not surprising that a young adult in Rockland County, New York became the first US resident in nearly a decade to contract polio. Officials say the person was unvaccborn and was likely exposed to a person who received a vaccine containing live weakened virus.

According at the BBC:

“Americans are typically vaccinated with a three- or four-dose regimen that begins at two months of age. According to the US Centers for Disease Control and Prevention, approximately 93% of toddlers have received at least three doses of the polio vaccine. But while the United States and other countries use vaccines made with an inactivated version of the virus, some countries give an oral vaccine that uses the virus in a weakened live form. This weakened virus can, in rare cases, mutate and risk a new epidemic. Like the Rockland County patient, the last reported case of polio in the United States – a seven-month-old child who moved to the state of Texas from India in 2013 – was a vaccine-derived strain.

We will repeat here what all readers of our blog know to be a fact, the only way to avoid contracting poliomyelitis is to get vaccinated. Without vaccines, our future is indeed dire.

Photo showing polio patients at the Rancho Los Amigos National Rehabilitation Center in California in 1953.

Greens called to reinstate Toi Te Taiao – The Bioethics Council

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The Green Party is called upon to support a new Toi Te Taiao with an expanded role to include other emerging technologies; Synthetic biology, artificial intelligence, nanotechnology and geoengineering.

In an open letter to Green Party members and MPs, former Green Party co-leader Jeanette Fitzsimons is credited for her policy work that ensures strong regulation of genetic engineering in Aotearoa. [1]

Jeanette advocated for the Royal Commission on Genetic Modification which led to the establishment of Toi Te Taiao – The Bioethics Council.

Toi Te Taiao was tasked with helping Aotearoa navigate the ethical issues of genetic engineering, including the use of human genes, but their work ended when Toi Te Taiao was abolished. [2]

Today, a new Technology Ethics Council is needed to address innovation challenges including “easy and cheap” gene editing, synthetic biology, nanotechnology, artificial intelligence and geo- engineering.

“These require deep and ongoing public engagement. The abolition of Toi Te Taiao has deprived us of a source of collective wisdom and genuine engagement with tangata whenua and civil society,” said Jon Carapiet. spokesperson for GE-Free NZ.

Another recommendation from the Royal Commission on Genetic Modification was that farm animals should not be genetically modified as “bioreactors” for the mass production of pharmaceuticals. But the Productivity Commission’s recent call for deregulation opens up the possibility of unacceptable cruelty to animals by GE already seen in AgResearch experiments. [3]

“When Jeanette began her work, it was knowing that commercial interests were already keen to commercialize these powerful emerging technologies,” said Jon Carapiet.

“To maintain public trust, an independent body, such as Toi Te Taiao, is needed to balance the voices of vested interests in both industry and academia.”

“Strict liability is also needed to rein in the risk appetite prevalent in the biotech and innovation sectors, driven by intellectual property, not the public interest.”

As technologies challenge the integrity of natural systems and of humanity itself, a technology ethics council is needed to guide how society manages risk while exploring opportunities and regulation in the workplace. public interest.

The medical use of GEs in humans shows benefits and there is a review of regulatory parameters in biomedicine. But the prospect of human genetic engineering also poses the threat of eugenics to humanity, including rainbow and LGBTQIA+ disabled communities, which must be addressed.

These are complex and ongoing issues to manage. Having an independent and ethical compass to guide us is vital.

[1] Open Letter to the Green Party – The Bioethics Council
[2] https://pep.org.nz/wp-content/uploads/2017/03/human-genes.pdf

[3]
https://www.nzherald.co.nz/nz/mutant-cows-die-in-gm-trial/UNAM73ED3VXZJFX7MXU7VYAZ74/

© Scoop Media

A 400 million year old fishapod brought it back to the water

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Our ancient ancestors, like all terrestrial life on Earth, evolved in the primordial seas of our planet before taking their first steps on earth. For vertebrates like us, the animal commonly associated with this evolutionary stride is the 375 million year old animal. Tiktaalik roseae.

For his act of faith in the Darwinian Bible, Tiktaalik received tongue-in-cheek reviews from internet members who blame the amphibious pioneer for all of life’s modern troubles.

Memes released over the past two years lament the adventure of the prehistoric creature and express the insincere desire to travel back in time and coax Tiktaalik back in the water.

Others wonder if it would have only led to a dystopia filled with war, rent, pestilence, and unjust bosses emerging beneath the waves of the ocean.

Oddly enough, minus the time-traveling millennia repelling fishapods (the first fish that evolved limbs for walking) in the water, the meme might actually parallel reality.


Read more: Dinosaurs invaded Earth after a winter of discontent


Research published in Nature on a new fossil shows a fishapod which seems to have joined Tiktaalik ashore – before deciding to go back to sea, saving his ancestors the pain of 21st life of the century.

Co-author of the new study and University of Chicago evolutionary biologist Neil Shubin was also a leader of the team that co-discovered Tiktaalik back in 2004.

Illustration of Qikiqtania wakei (center) in water with its larger cousin, Tiktaalik roseae. Credit: Alex Boersma.

The new fossil belonged to a similar creature called Qikiqtania wakei which would have been just over a meter long – small compared to Tiktaalik up to three meters.

QikiqtaniaThe fossils were found a few days before Tiktaalik was discovered. Qikiqtania is named after the Inuktitut word Qikiqtaaluk Where Qikiqtani, traditional names of the region where the fossil was found. The species designation “wake upis in memory of the late David Wake, an eminent evolutionary biologist from the University of California, Berkeley, USA.

However Qikiqtania sharing many of the same characteristics as its explorer cousin, the newly discovered animal’s body is more suited to life in water. Among the fossils are partial upper and lower jaws, parts of the neck and scales and, most importantly, a complete pectoral fin with a humerus lacking the muscular ridges that would indicate a limb built for walking on land.

QikiqtaniaThe upper arm of was smooth and curved, suggesting that he spent his life paddling underwater. The unique arm bones imply that it returned to water after its ancestors began using their appendages to walk.

“At first we thought it might be a minor Tiktaalik, because it was smaller and maybe some of those processes weren’t developed yet,” Shubin said. “But the humerus is smooth and boomerang-shaped, and it lacks the elements that would allow it to grow on land. It’s remarkably different and suggests something new.

3D reconstruction of the whole Qikiqtania wakei fossil. Credit: Justin Lemberg.

push in Tiktaalikthe shadow, the Qikiqtania the fossils were stored and largely forgotten for 15 years.

It wasn’t until March 2020 that a scan of one of the rocks revealed a pectoral fin. Too deep in rock to get a decent picture, and abandoned again when shutdowns forced labs to close, the fin remained high and dry until later that year.

“We were trying to collect as much CT data of the material as possible before the lockdown, and the very last piece we scanned was a large, unassuming block with only a few specks of scale visible from the surface,” says Col. author Justin Lemberg.

“We could hardly believe it when the first grainy images of a pectoral fin emerged. We knew we could collect better analysis of the block if we had time, but that was March 2020, and the University has closed all non-essential operations the following week,” adds Lemberg.

3D reconstruction of the pectoral fin of the Qikiqtania wakei fossil. Credit: Tom Stewart.

When the facilities reopened and analyzes could be performed after cutting the rock around the specimen, the nearly complete pectoral fin and upper limb emerged.

“That’s what blew us away,” Shubin said. “It was by no means a fascinating block at first, but we realized during the COVID lockdown, when we couldn’t get into the lab, the original scan wasn’t good enough, and we had to cut the block. And when we did, look what happened. It gave us something exciting to work on during the pandemic. It’s a fabulous story.

slightly older than Tiktaalik, Qikiqtania shares part of the evolutionary tree of life adjacent to early vertebrates with finger-like digits.

The discovery and analysis show that animals do not evolve in linear trajectories. It’s not as simple as drawing a straight line between modern organisms and some earlier forms. Qikiqtania shows that some creatures will wander off on different paths – some of which don’t work.

Tiktaalik is often treated as a transitional animal because it is easy to see the gradual pattern of changes from life in water to life on land. But we know that in evolution things aren’t always that simple,” says lead author Thomas Stewart. “We don’t often get a glimpse of this part of vertebrate history. We are now beginning to uncover this diversity and get a sense of the unique ecology and adaptations of these animals. It is more than a simple transformation with a limited number of species.

tom-stewart-with-qikiqtania
Tom Stewart, PhD, assistant professor of biology at Penn State University, holds the fossil specimen of Qikiqtania wakei. Credit: Tom Stewart.

So, to all the haters of the internet Tiktaalik, evolution also tried “back in the water”. And it’s thanks to these early fishapods that you can give the poor wet pioneers the middle finger in the first place!



Biologists and residents monitor seabird populations as hundreds more are found dead in southern Avalon

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A dead gannet in Point Lance, NL. (Patrick Butler/Radio Canada)

Dead and dying seabirds have appeared on the south coast of Newfoundland over the past two weeks, from the Cape St. Mary’s Ecological Reserve to the public beaches of St. Vincent’s, Point Lance and the southern peninsula. of Burin.

Tests are underway to determine the root cause of death, but Chris Mooney, an interpretive officer at the Cape St. Mary’s reservation, told CBC News it certainly appears avian flu is the problem.

Mooney, who has worked on the reserve for 21 years, says there was no update Thursday, but test results are expected to come back soon.

“I don’t know how long it takes for it to spread, but I hope it doesn’t spread too much. I hope we don’t lose a lot [of birds],” he said.

“It’s not good because we can’t do anything for them. All we can do now is monitor, keep numbers, talk to the Canadian Wildlife Service, talk to the university, [biologist] Bill Montevecchi and speak to corporate headquarters.”

Signs indicate that the number of dead birds is in the thousands. Mooney suggests that for every bird found on a beach, there are six to ten floating in the ocean. He hopes that the reserve does not face a similar situation where thousands of people died in early June in the Magdalen Islands in the Gulf of St. Lawrence.

Chris Mooney is an interpretive officer at Cape St. Mary’s Ecological Reserve. (Patrick Butler/Radio Canada)

Peter Corcoran has lived in Point Lance for over 50 years. On Thursday, he was on the 2.2 kilometer beach to take stock of the number of birds that had washed ashore over the past two days. Hundreds littered the sand.

“I would say there are almost 300 here now,” Corcoran told CBC News.

“Some wash up, some come in alive. They’ll stay alive for about 10 minutes I guess, then they’ll roll in the sand and die.”

Corcoran said people in his community were unsure what to make of the situation. He said some spoke with federal environmental officers who told them they had been monitoring for bird flu since the winter throughout Placentia Bay.

“I’ve been fishing for 35 years and I’ve never seen anything like it. Here in the winter you might get two, three or four birds, but that’s about it,” he said. .

Seabirds die of suspected bird flu off Newfoundland

Hundreds of dead seabirds are washing up in parts of Newfoundland and thousands more are expected to die in the ocean. Tests have not yet confirmed that bird flu is to blame, but experts believe it is responsible.

Watch the gannets

There are approximately 100,000 birds of different species living in St. Mary’s Reserve.

Mooney said most of the bird carcasses found are guillemots with around 20 gannets found. , meaning they’ll be crammed in for two more months, making possible the spread of bird flu all the greater.

Guillemots found on beaches appear to be healthy and full of food, Mooney said, but search teams are going to be affected due to the unknown origin of death.

Dozens of dead seabirds wash up on the shores of Newfoundland. This photo is from Point Lance in the southern Avalon Peninsula. (Patrick Butler/Radio Canada)

“Nobody knows. You don’t want to go down among the birds if it’s bird flu. Even though it’s not easily contracted by humans, you still don’t want to go down among them,” he said. .

Corcoran said puffins are also among the birds that wash up and tourists also pass by to enjoy the beach. He tried to get the authorities to come and clean up the mess.

“We have a lot of people walking on the beach. They’re scared to go there now,” he said.

“We’ve always had seven or eight bald eagles here in the spring in the seaweed, I haven’t seen one this year. Not one.”

Read more articles from CBC Newfoundland and Labrador

Marine research looks at how giant baleen whales filter out tiny organisms



How do giant, toothless baleen whales filter out thousands of pounds of tiny shrimp after swallowing seawater?

Cal State Fullerton postdoctoral researcher Shirel Kahane-Rapport delves into the biomechanics of these filter feeders and how they use baleen to filter food, such as zooplankton and small fish, from seawater. Answers might lead to better designed industrial filtration systems.

Kahane-Rapport is conducting her study under the mentorship of Misty Paig-Tran, associate professor of biological sciences. Paig-Tran’s FABB (Functional Anatomy, Biomechanics and Biomaterials) Laboratory uses a blend of anatomy and engineering techniques to answer biological questions about the performance of marine animals.

“Baleen whales are fascinating. But it’s amazing how little we know about some of the biggest and most charismatic animals on the planet,” Paig-Tran said. “Studying how large animals filter tiny organisms gives us great insight into building better and more efficient filters for human use.”

Shirel Kahane-Rapport holding a sample of baleen
Shirel Kahane-Rapport holds baleen, keratinous mouth tissue that hangs from the roof of the whale’s mouth.

Lead researcher Kahane-Rapport is conducting the study in collaboration with researchers at Stanford University, where she received her doctorate in June 2021, and the University of Washington.

Their research aims to define how body size affects the biomechanics and anatomical structures involved in water flow and prey capture in five species of rorquals, a family of baleen whales. This particular family of whales includes the blue whale (the largest of all whales and the largest animal of all time), the fin whale, the humpback whale, the gray whale and the minke whale.

In early July, Kahane-Rapport presented her research at the international conference of the Society for Experimental Biology in Montpellier, France. In August, she will present at the Society of Marine Mammalogy conference in Palm Beach, Florida.

She recently received a postdoctoral fellowship in biology from the National Science Foundation to continue her research at CSUF for the next two years. His research also includes collaboration with Paig-Tran on the biomechanics of other large filter-feeding animals such as manta rays.

Filter-feeding whales

This illustration shows the placement of the baleen in a blue whale, with the baleen plates hanging down from the gums and the fringe along one side forming the mat for the filtration of food, such as small krill, from the water The illustration highlights the measurements taken by the researchers, including the length of the plate, the thickness of the plate, the spacing between the plates and the diameter of the fringe.

Baleen whales have keratinous mouth tissue — the same protein as a human’s fingernail and hair — that hangs down from the roof of the whale’s mouth in bilaterally symmetrical supports, Kahane-Rapport explained. The larger patches of keratin are positioned near the lip and the smaller patches are closer to the tongue. When the whale swallows huge amounts of seawater, the hair-like baleen filters or filters food from the water.

“The edges of the baleen patch fray into hairs, or fringes, which interlock, creating a dense mat. This mat allows the huge amount of engulfed water to flow out of the mouth and enlarged throat, and retain captured prey,” added Kahane-Rapport, whose doctoral studies focused on large filter-feeding whales. . “We don’t understand the mechanics of this process.”

His study, which was submitted for publication in a peer-reviewed scientific journal, looked at different characteristics of baleen, such as the thickness, length and size of the keratin plates, as well as the spaces between each plate.

“We found that these characteristics that we measured were very different between species. This is something you would expect because they are different species, but our study shows it with statistical evidence,” she said.

Animated whale gif
A blue whale feeds on a patch of krill, displaying the unique foraging behavior of baleen whales. Credit: Alex Boersma

For researchers, one of the most complicated aspects of studying baleen whale filtration is understanding how water passes through the filter.

“When you study a filter, you first calculate the size of the hole – known as the pore – that water passes through. Then you can determine the volume and speed of water flow through the filter” , she explained.

“In the case of baleen whales, the filter is a mat of tangled hairs that emerge from the baleen. This mat has no pattern, structure, or clear pores, so the researchers were unable to calculate the volume and velocity of this filter.

Improved artificial filters

For their study, the researchers generated CT scans of the pile carpet. Using specialized CT software and an equation more often used by industrial filter engineers, they were then able to calculate all the small spaces that appear between the hairs and add them up to create an approximate cumulative pore size. .

“We found that larger whales – blue whales and fin whales – had smaller pore sizes than smaller whales, such as humpback whales,” Kahane-Rapport said. “As a result, our research could lead to the design of a filter that can be used to improve current man-made filtration systems, inspired by the massive amounts of water efficiently filtered and treated by these giant species.”

This study also allows scientists to better understand the feeding mechanisms of these ecologically important animals. Additionally, their work focuses on the risks whales face from human-made threats, such as pollutants in the water, including microplastics.

“Baleen whales are ecologically important animals, and by understanding them better, we can improve not only ocean life, but human life as well.”

Agri-genomics startup Piatrika Biosystems raises $1.2M in seed funding led by Ankur Capital

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Piatrika Biosystems Raises $1.2M in Seed Funding Led by Ankur Capital to Build Platform for Discovery of New Sustainable Crop Varieties

Piatrika Biosystems, an agri-genomics startup based in India and the UK, raised $1.2 million in a funding round led by Ankur Capital. The company brings sustainable seeds and agrochemicals to market faster and at lower cost. The investment will be used to build a strong product development team, also for further research, and to accelerate the production and commercialization of MVP.

To support an estimated world population of 9 billion by 2050, global food production must increase by around 50% to 70%. This growing world population along with the element of climate change will lead to unprecedented agricultural challenges in the coming decades if not addressed now. As the world is currently experiencing unprecedented issues around the global food supply, caused by an imbalance in the supply chain where there is excess production of some crops while there are nutritional deficiencies of others go. The issue goes beyond the simple need for social and economic sustainability and is about resilience to biotic/abiotic stress, over/under production of required nutrition, and exploring better alternatives like bioethanol, squalene, etc. from local cultures. In this reality, the need for precisely sustainable agriculture, coupled with an aggressive growth strategy, has necessitated a change in process management.

Founded in 2019 by Vasudev Kumanduri and Phani Yarlagadda, Piatrika Biosystems is also building an innovative new cloud-based Platform-As-A-Service (PAAS) for agro-genomics discoveries and plant breeding decision support , program design and monitoring. The seed discovery platform is supported by new technologies in computational biology and data science, the integration of these with the capture of autonomous phenotypic, temporal and spatial data for more accurate analysis helps improve the discovery process. The company aims to bridge the gap between scientific research and commercial enterprise solutions.

Vasudev Kumanduri, co-founder and CEO of Piatrika Biosystems, said: “There remains a significant gap between cutting-edge research and its practical implementation. This means that although there has been groundbreaking research in recent years in computational/genomic biology, data science, cloud and instrumentation, this important knowledge has not been applied in a practical way in a timely manner. in agriculture. There is an urgent need to translate these research advances into practical benefits for the farmer, the consumer and ultimately the planet through modern, sustainable and ethical food production. ”

Phani Yarlagadda, co-founder and COO of Piatrika Biosystems, said, “Weather, war and viruses have disrupted global food systems. This put immense pressure to produce more food using fewer resources. Seed companies and agricultural research institutes are looking for affordable, enterprise-grade plug-in solutions that can take advantage of recent technological advancements to optimize the processes involved in getting a seed from the lab to the farmer”

Ritu Verma, Partner at Ankur Capital, said, “We are thrilled to partner with Piatrika on their journey to activate and create new seeds through computational biology. With the challenges facing agriculture from both climate and increasing food demand, innovation in the seed sector is essential. With advances in computational biology, we see this as an essential tool to bring new seeds to market quickly. »

Piatrika Biosystems is incubated outside NIAB (Cambridge, UK) and ICRISAT (Hyderabad, India) and works with researchers, seed companies and research institutes. In June 2022, Piatrika Biosystems was selected as a case study by Food and Agriculture

(FAO) of the United Nations report and featured.

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Water test: One fish, two fish – where are all the whitefish? | New

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LANSING — Three men pull a tired cart full of scientific equipment across the sand of Muskegon’s Pere Marquette Beach. Dressed in layers against the cold of late spring, their camouflage-print thigh-high boots give their gait a rocker character not typical of beachgoers.

“It’s one of the most fun things we have to do in our job,” said Steve Pothoven, a fisheries biologist at the National Oceanic and Atmospheric Administration’s (NOAA) Great Lakes Environmental Research Laboratory in Muskegon. .

Pothoven and fellow researchers Jeff Elliott and Aaron Dunnuck work on Lake Michigan beaches in May and June, studying how well young whitefish mature into adults.

Lake Michigan and Lake Huron whitefish have a recruitment problem.

Since the early 2000s, fewer young whitefish reach adulthood. Fewer adults mean fewer fish to catch for commercial fishermen.

“We just don’t know much about these fish and what sustains them early in their lives,” Pothoven said.

They are studying the problem at familiar and popular beaches – places like Pere Marquette and Grand Haven State Park.

Dunnuck hits the water. Walking straight into the lake, he drags 150 feet of weighted seine on the bottom, the water rising to his chest. Turning left, he walks parallel to the shore, the net uncoiling, forming a crescent as he returns to shore. He and Elliot pull in the net, scooping up any fish in its path.

On land, they open the net to assess their catch.

That day is little.

A few small silver fish – what most people would call “minnows” – lay in the net.

They quickly identify and count all the fish, keeping the whitefish and discarding the rest.

Dunnuck returns to the water with a small net on a pole with a small pot on the end to sweep up the water. He collects zooplankton – food for baby whitefish – to see what there is to eat.

Back at the NOAA lab, Elliott examines zooplankton under a microscope, identifying the tiny animals based on differences in their otherworldly bodies. It will open the stomachs of young whitefish to compare what they eat with what lives in the water.

Understanding the decline in lake whitefish recruitment is important as fisheries managers and regulators approach the deadline to update a 2000 Consent Order regulating recreational and commercial fishing in Lakes Huron and Michigan. .

Prized for its mild flavor, finding whitefish on local restaurant menus is an important part of the “Up North” experience for summer tourists.

Lake whitefish account for 95% of commercially caught fish sales in Michigan, with a dockside value of just over $4 million, Sea Grant, Michigan reported in 2020.

For members of tribal communities, lake whitefish is much more than a source of income. Fish have been an integral part of their diet and culture for thousands of years.

Understanding why young whitefish are struggling in much of the Great Lakes is a major goal of state and tribal fisheries research.

“You have to remember that 99.9 percent of all fish eggs laid die,” said Mark Ebener, a fisheries biologist who worked 37 years for two Great Lakes intertribal organizations. He is the lead author of a 2021 study of declining lake whitefish recruitment published by the Great Lakes Fishery Commission.

Most evidence of low lake whitefish recruitment points to one culprit: invasive mussels.

The premise is that quagga mussels have fundamentally changed the way energy flows through the system, dramatically reducing zooplankton in coastal waters, Ebener said.

Zooplankton are the primary food source for baby whitefish.

The timing of the arrival of mussels and the decline in lake whitefish recruitment is likely more than a coincidence.

“Yeah, definitely, we think that’s one of the main causes of the decline in whitefish recruitment – the lack of zooplankton,” Ebener said.

With so many fish-loving people fighting so hard to defend themselves, a key question for traders is how much can be harvested each year if fewer reach adulthood.

It now takes longer for lake whitefish to grow large enough to be fished commercially and old enough to reproduce in the next generation.

“It used to only last two to three years and they were in the fishery, probably reproducing,” NOAA’s Pothoven said.

Due to the mussel’s impact on the base of the food web, it now takes at least five years, and possibly up to seven or more, he said.

“They don’t grow like they used to.”

Pothoven and a team attempt to understand the early life of lake whitefish.

The team is led by Kevin Donner, Great Lakes Fisheries Program Manager for the Odawa Indian Band of Little Traverse Bay in Harbor Springs.

“For us, when we started this in 2013, the whitefish was already in decline, but we didn’t know how much,” Donner said.

Predicting the future is always risky.

A major concern is that by the time they collect information on fish large enough to be caught commercially, six or seven years may have passed without anyone knowing that problems could arise when the fish were babies. No one was watching.

“So if something bad happens, for example today, let’s say no whitefish are born for whatever reason, we’re going to continue our merry way for seven years before someone has enough data to say, ‘Oh my God, something is wrong. .’ Donner said.

It could also go the other way.

If the group’s work pays off, it could calm nerves and better predict how many are available for commercial harvest years in advance.

Since 2013, the survey team has sampled beaches in the spring, primarily in the northern Lower Peninsula.

Lake whitefish spawn in the fall, favoring protective rocky coastal areas. When the eggs hatch in the spring, whitefish larvae survive on a yolk sac, a pouch protruding from their belly filled with fat and other goodies, until they have grown large enough to hunt on their own.

When this happens, they venture into open waters, many of them choosing the seemingly arid environment of popular sandy beaches.

“Most people wouldn’t even know whitefish larvae exist right around their ankles just before they were comfortable swimming in the lake,” Donner said.

There are places in the Great Lakes where baby whitefish are faring much better.

Ebener said, “Lower Green Bay is always good, Saginaw Bay is good, Lake Huron North Channel is good, Lake Superior is always good. The problems are in the open waters of the main basin of Lake Michigan, Lake Huron and Lake Ontario.

In areas where lake whitefish are doing best, mussels do not have the stranglehold they have on the open waters of Lakes Michigan and Huron.

It has always been risky to be a baby whitefish. Improving their chances of survival, even just a little bit, can pay off big, Ebener said.

If 99.995% of fish eggs don’t survive, even a tiny bump in surviving baby fish can be very important to the species, he said.

“It’s a numbers game.”

Kurt Williams writes for Great Lakes Echo.

Shark attack in Monterey Bay was as long as an SUV, say biologists – Monterey Herald

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PACIFIC GROVE — A great white shark that attacked and nearly killed a swimmer last month in Monterey Bay had “an estimated minimum length” of 14 to 15 feet long, state wildlife officials have concluded.

That size – roughly the length of a Toyota 4Runner – is typical of an adult white shark, experts said Monday. The shark bit Steve Bruemmer, 62, of Monterey, at 10:35 a.m. on June 22 while swimming about 150 yards off Lovers Point, a popular beach in Pacific Grove.

Bruemmer was released from hospital last week after being treated for severe lacerations to his legs and torso.

California Department of Fish and Wildlife biologists, working with Cal State Long Beach marine biologist Chris Lowe, estimated the shark’s size based on bite sizes on Bruemmer’s suit, along with photos of his injuries and a description. he provided in conversations with them, Lowe said Monday.

He noted that authorities searched for the shark after the attack, but had no luck.

“They had drones, they had people in the water, but nothing was spotted,” he said. “It could be anywhere.”

White sharks off California routinely travel hundreds of miles across the Pacific Ocean. Lowe said this one is unlikely to bite anyone else.

“The odds are very low,” he said. “We just don’t see that. People should continue to use the ocean. Realize that the sharks are still there. Understand that these events are truly rare.

The statistics confirm it. Since 1950, when modern records began, 15 people have died in California from shark attacks, most by great whites, according to the state Department of Fish and Wildlife. Millions of people go into the water each year to surf, swim, paddle board, spear fish and snorkel, making the risk of attack extremely low, experts say.

In May 2020, surfer Ben Kelly, 26, of Santa Cruz, was killed in a shark attack about 100 yards from Manresa State Beach in Aptos. Kelly bled to death after a great white shark bit him behind his right knee, hitting an artery. An investigation by state wildlife biologists found the shark to be at least 10 feet long.

During the Pacific Grove attack, Bruemmer, who regularly swims in the ocean with a swim club, said he was enjoying the day when suddenly his life changed.

“I was just gliding through the water looking at sea grasses and starfish,” he said in a video released last Thursday by the Natividad Medical Center in Salinas, the day he was well enough to return home. him after hospital treatment. “I was about 150 yards from the end near the beach when – just wham! I don’t even know exactly what happened, but it turns out that I was bitten fiercely by a shark across my thighs and abdomen.

“He grabbed me and pulled me up, then dunked me in the water,” added Bruemmer, a retired computer specialist from Monterey Peninsula College. “So of course he spat me out. I am not a seal. He is looking for a seal. We are not their food. He spit me out and he was looking at me, right next to me. I thought he might bite me again so I pushed him with my hand and kicked him with my foot and he walked away. I came to the surface and started screaming for help.

Moments after Bruemmer was attacked, bleeding badly and screaming for help, several nearby people rushed to his aid, including Aimee Johns, a Folsom nurse, and her husband, Paul Bandy, a Sacramento police officer in leave, who were paddle boarding in the area as part of a trip to celebrate their wedding anniversary. A nearby surfer, Heath Braddock, also came to help.

They put Bruemmer on two boards, took him to the beach and applied tourniquets. He was rushed to hospital, where he underwent a two-hour operation that used 28 units of blood. He was lucky the bites didn’t sever an artery, which would have been fatal, doctors said.

Since then, Bruemmer has had nothing but praise for his rescuers.

“How can you walk into bloody water with maybe a shark spinning under you to save a stranger?” he said. “They are amazing.”

Steve Bruemmer, 62, of Monterey, was attacked by a great white shark on Wednesday, June 22, 2022, while swimming in the ocean off Lovers Point in Pacific Grove along Monterey Bay. He survived but was seriously injured. (Photo: Molly Gibbs/Monterey Herald)

Scientists reveal the genetic architecture underlying alcohol and cigarette abuse

Have you ever wondered why one person can smoke cigarettes for a year and quit easily, while another person becomes addicted for life? Why can’t some people stop abusing alcohol and others can take it or leave it? One of the reasons is a person’s genetic propensity to abuse substances. UNC School of Medicine researchers led by Hyejung Won, PhD, are beginning to understand these underlying genetic differences. The more they learn, the more likely they are to be able to create therapies to help the millions of people struggling with addiction.

Won, an assistant professor of genetics and a member of the UNC Neuroscience Center, and his colleagues have identified genes linked to smoking and alcohol consumption. The researchers found that these genes are overrepresented in certain types of neurons, brain cells that trigger other cells to send chemical signals throughout the brain.

The researchers, who published their work in the journal Molecular psychiatry, also found that the genes underlying smoking were linked to pain perception and response to food, as well as the abuse of other drugs, such as cocaine. Other genes associated with alcohol use were linked to stress and learning, as well as the abuse of other drugs, such as morphine.

Given the lack of current treatment options for substance use disorders, the researchers also conducted analyzes of a publicly available drug database to identify potential new treatments for substance abuse. .

“We found that antipsychotics and other mood stabilizers could potentially provide therapeutic relief for people struggling with addiction,” said Nancy Sey, graduate student at the Won Lab and first author of the paper. “And we believe our research provides a good foundation for research focused on creating better treatments for drug addiction.”

Analyze the genome

Long-term substance use and substance use disorders have been linked to many common diseases and conditions, such as lung cancer, liver disease, and mental illness. Yet few treatment options are available, largely due to gaps in our understanding of the biological processes involved.

“We know from twin studies that genetics may explain why some people use and abuse substances, aside from environmental factors, such as family issues or personal trauma,” Won said. “Genetic studies such as genome-wide association studies (GWAS) provide a way to identify genes associated with complex human traits, such as nicotine addiction or excessive alcohol consumption. “

Using GWAS, Won added, researchers can identify regions of the genome that play a role in particular traits, compared to individuals who don’t exhibit the trait. Yet genome-wide studies can’t tell us much about how genes in these regions affect a trait. This is because these regions are often found in “non-coding” regions of the genome.

“Non-coding” refers to the fact that the genes in these regions do not translate – or code – their genetic information directly into the creation of proteins, which then perform a known biological function. Therefore, what is actually happening biologically in these “non-coding” regions remains mostly unknown.

“We wanted to know what was going on in those areas,” Won said. “So we developed Hi-C coupled MAGMA (H-MAGMA), a computational tool to help us better understand what we see in genome-scale studies.”

In a previous publication, Won’s lab showed how applying H-MAGMA to brain disorders identifies their associated genes and describes their underlying biology. And for this current paper, his lab extended the tool to smoking and alcohol consumption.

They developed H-MAGMA frameworks from dopaminergic neurons and cortical neurons – types of brain cells that researchers have long implicated in substance use. Focusing on these two cell types, Won’s team – led by Sey, an HHMI Gilliam Fellow – applied H-MAGMA to GWAS findings related to heavy smoking, nicotine addiction, problematic drinking and heavy drinking to identify genes associated with each trait.

Genes associated with alcohol consumption and smoking were also associated with other types of substances, such as morphine and cocaine. While the opioid crisis has caused a detrimental social burden, potent GWAS on cocaine and opioid use are not currently available. Won’s team therefore set out to determine whether genes associated with alcohol consumption and smoking may reveal the genetics underlying general addictive behavior, genetic findings that could be extended to other substances of abuse. abuse.

“Our analyzes showed that the expression of genes shared between smoking and drinking traits can be altered by other types of substances such as cocaine,” Won said. “By characterizing the biological function of these genes, we will be able to identify the biological mechanisms underlying addiction, which could be generalized to various forms of substance use disorders.”

In addition to the different types of excitatory neurons, Won’s team also identified other cell types, including cortical glutamatergic, midbrain dopaminergic, GABAergic, and serotonergic neurons associated with risk genes.

With these discoveries in hand, it is now possible for researchers at UNC and others to study the molecules that make addiction much less likely.

This research was supported by grants from the National Institute on Drug Abuse (R21DA051921, U01DA048279); the National Institute of Mental Health (R00MH113823, DP2MH122403); the NARSAD Young Investigator Award from the Brain and Behavior Research Foundation; the National Science Foundation Graduate Fellowship Program (DGE-1650116); the University of North Carolina at Chapel Hill; Howard Hughes Medical Institute James H. Gilliam Fellowship for Advanced Study Program; and the National Institute of General Medical Sciences (5T32GM067553).

U of M researchers discover protein that may be associated with better prognosis for women with ovarian cancer

Researchers at the University of Minnesota have found that a protein associated with metabolism, and once recognized as a potential therapeutic target for ovarian cancer, may instead be associated with a better prognosis for women with this cancer. .

Posted in Cancer Research Communicationsinvestigators from U of M School of Medicine and the Masonic Cancer Center focused on GLS1, a protein that plays a key role in the metabolism of glutamine, a nutrient used as an energy source in several cancers. Using tumor samples from patients with a specific subtype of ovarian cancer known as clear cell carcinoma, the researchers found that an overabundance of GLS1 was not correlated with a mutation. genetics that occurs in up to 60% of cases of clear cell ovarian cancer, as previously thought. .

“This study provides an example of the usefulness of clinical tumor samples from human patients for confirmation of preliminary results identifying potential drug targets,” said Martina Bazzaro, Ph.D.associate professor at the Masonic Cancer Center School of Medicine and one of the study’s lead authors.

The research is particularly timely because a drug that blocks GLS1 was recently evaluated in a clinical trial for patients with ovarian cancer, and these patients developed resistance to standard chemotherapy. The current study provides evidence that this approach may possibly be detrimental due to the protective effect of GLS1.

Emil Lou, MD, Ph.D., FACP, associate professor at the Masonic Cancer Center School of Medicine and lead author of the study, said: “The expression of any drug target can vary from tumor to tumor. Overall, our finding that GLS1 is protective and associated with better patient outcomes provides reason to pause further thought about therapeutic targeting of GLS1, as knocking it out would block its protective effect and potentially harm patients.

The clinical trial for ovarian cancer patients targeting GLS1 in combination with another drug was terminated in the spring of 2022, and the results of the current study may serve as the basis for further investigation into the real role of this protein in ovarian cancer and why it may be associated at the molecular level with a better prognosis in patients.

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About the Masonic Cancer Center, University of Minnesota
The Masonic Cancer Center at the University of Minnesota is the only Comprehensive Cancer Center in the Twin Cities, designated “Outstanding” by the National Cancer Institute. As the Minnesota Cancer Center, we have served the entire state for over 30 years. Our researchers, educators and healthcare providers have worked to discover the causes, prevention, detection and treatment of cancer and cancer-related diseases. Learn more at cancer.umn.edu.

About University of Minnesota Medical School
The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and training the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We recognize that the U of M School of Medicine, both the Twin Cities Campus and the Duluth Campus, is located on the traditional, ancestral, and contemporary lands of the Dakota and Ojibwe, and dozens of other Indigenous peoples, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relationships with tribal nations. Learn more at med.umn.edu.

The price of perfection, how much do we pay for our beautiful gardens? | Coronado Island News

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At Coronado, we pride ourselves on our beautiful gardens. But at what cost ? Lately, many of us are noticing fewer bees in our gardens. I found dead bees on my driveway and this week I found a dead hummingbird.

Annoying and troublesome summer pests such as pepper thrips, spider mites, rose slugs, caterpillars and whiteflies are or soon will be in full force and many breed quickly in hot weather. Many homeowners or their landscapers will immediately seek out pesticides. Most insects in our gardens are not destructive pests. Some of them are harmless, and many are not only helpful to our plants, but essential to keeping our gardens healthy and thriving. Predatory and parasitoid insects such as lacewings, dragonflies, assassin bugs, tiny pirate bugs, damselfish bugs, lady beetles and hoverflies and their larvae feed on other insects and mites. This group of insects (along with spiders and birds) are our friends in our gardens and without them we would have greater pest problems. Pesticide sprays and systemic pesticides can endanger and kill harmless insects and beneficials. Organic pesticides such as Neem oil and Spinosad are toxic to bees present when sprayed. Spinosad has a label warning that it is toxic to bees exposed to treatment for 3 hours after application. This means that the spray should be done in the evening after the bees have finished working for the day.

Bees are disappearing at an alarming rate. The same goes for our other pollinators. All of us, young and old, love butterflies. These adorable adult bugs get their brand new bodies through magical caterpillar metamorphosis. Clearly something to behold when spraying to kill caterpillars. Hummingbirds are also important pollinators. They feed on nectar, but much of their diet consists of insects, including ants, aphids, fruit flies, and gnats. Hummingbirds delight us and no one would deliberately harm them, but we run that risk when we lose sight of the bigger picture and spray our gardens with toxic chemicals.

We can feel powerless in the face of many environmental issues like climate change. But we can make a difference for the environment by taking the simple step of refusing to use pesticides in our gardens. Learn about and implement the practice of Integrated Pest Management (IPM) https://www2.ipm.ucanr.edu/What-is-IPM/. The IPM approach uses non-chemical techniques for pest control. The “bad guys” are crushed with our fingers and blown off with jets of water from the hose. Damaged vegetation is pruned and removed from our gardens. The pests missed by these manual methods serve as an invitation for the “good guys” to come into our garden and feast. When absolutely necessary, IPM allows the use of the least toxic pesticides and only after specifically identifying and targeting the pest.

The health of our environment is not a game of chess where, once we are done playing, we can reset the board and play again tomorrow. We want beautiful gardens, but we must also want to be conscientious citizens of the earth who take great care to protect the environment. American biologist EO Wilson said: “If the insects disappeared, the environment would collapse into chaos.” We can all do our part by changing the way we think about and react to pest damage. This is an example where lowering our standards is a good thing. Nibbled plants are a sign of a sustainable garden. Perfection in our gardens is overrated, outdated and costly to Mother Nature and to us.

FLIGHT. 112, NO. 28 – 13 July 2022

Four researchers with MIT ties win Schmidt Science Fellowships | MIT News

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Four researchers with ties to MIT – Juncal Arbelaiz, Xiangkun (Elvis) Cao, Sandya Subramanian and Heather Zlotnick ’17 – have been honored with a competition Schmidt Science Fellowships.

Established in 2017, the fellowship program aims to bring together the world’s brightest minds “to solve society’s toughest challenges”.

The four MIT-affiliated researchers are among 29 Schmidt Science Fellows from around the world who will receive postdoctoral support for one or two years with an annual stipend of $100,000, as well as one-on-one mentorship and participation in the Global Meeting Series. from the program. Fellows will also have the opportunity to engage with thought leaders from science, business, politics, and society. According to price announcementFellows are expected to pursue research that deviates from the focus of their PhD, to help broaden and enhance their future as scientific leaders.

Juncal Arbelaiz is a PhD student in applied mathematics at MIT, completing her PhD this summer. His doctoral research at MIT is advised by Ali Jadbabaie, JR East Professor of Engineering and Head of the Department of Civil and Environmental Engineering; Anette Hosoi, Neil and Jane Pappalardo Professor of Mechanical Engineering and Associate Dean of the School of Engineering; and Bassam Bamieh, professor of mechanical engineering and associate director of the Center for Control, Dynamical Systems, and Computation at the University of California, Santa Barbara. Arbelaiz’s research focuses on designing optimal decentralized intelligence for spatially distributed dynamic systems.

“I can’t think of a better way to start my independent scientific career. I feel very excited and grateful for this opportunity,” says Arbelaiz. With her fellowship, she will use systems biology to explore how the nervous system encodes and processes sensory information to address future safety-critical artificial intelligence applications. “The Schmidt Science Fellowship will provide me with a unique opportunity to work at the intersection of biological intelligence and artificial intelligence for two years and will be a stepping stone towards my longer-term goal of becoming a bio-inspired artificial intelligence researcher. “, she says. .

Xiangkun (Elvis) Cao is currently a postdoctoral fellow in the lab of T. Alan Hatton, Ralph Landau Professor of Chemical Engineering and Impact Fellow at the MIT Climate and Sustainability Consortium. Cao received his Ph.D. in Mechanical Engineering from Cornell University in 2021, during which he focused on microscopic precision in the simultaneous delivery of light and fluids by optofluidics, with advances relevant to healthcare applications and of durability. As a Schmidt Science Fellow, he plans to be co-advised by Hatton on carbon capture, and Ted Sargent, professor of chemistry at Northwestern University, on carbon utilization. Cao is passionate about integrated carbon capture and utilization (CCU) from molecular to process level, machine learning to inspire smart CCU, and bridging technology, business and policy for CCU.

“The Schmidt Science Fellowship provides me with the perfect opportunity to work across disciplines to study integrated carbon capture and utilization from the molecular to the process level,” Cao says. “My vision is that by integrating carbon capture and use, we can simultaneously make scientific discoveries and unlock economic opportunities while mitigating global climate change. In this way, we can turn our carbon liability into an asset. .

Sandya Subramanian, a 2021 doctoral student from the Harvard-MIT Program in Health Sciences and Technologies (HST) in the field of medical engineering and medical physics, is currently a postdoctoral fellow at Stanford Data Science. She focuses on the topics of biomedical engineering, statistics, machine learning, neuroscience, and healthcare. His research focuses on the development of new technologies and methods to study the interactions between the brain, the autonomic nervous system and the gut. “I am extremely honored to receive the Schmidt Science Fellowship and to join the Schmidt community of leaders and scholars,” said Subramanian. “I’ve heard so much about fellowship and how it can open doors and give people the confidence to pursue challenging or unique journeys.”

According to Subramanian, the autonomic nervous system and its interactions with other body systems are poorly understood, but are thought to be involved in several disorders, such as functional gastrointestinal disorders, Parkinson’s disease, diabetes, migraines and eating disorders. The goal of his research is to improve our ability to monitor and quantify these physiological processes. “I’m really interested in understanding how we can use physiological monitoring technologies to inform clinical decision-making, particularly around the autonomic nervous system, and I look forward to continuing the work I recently started at Stanford in as a Schmidt Science Fellow,” she says. “A big thank you to all the mentors, colleagues, friends and leaders I have had the pleasure of meeting and working with HST and MIT; I couldn’t have done this without everything I learned there.

Hannah Zlotnick ’17 attended MIT for his undergraduate studies, majoring in biological engineering with a minor in mechanical engineering. At MIT, Zlotnick was a student-athlete on the women’s varsity football team, a UROP student in Alan Grodzinsky’s lab, and a member of Pi Beta Phi. For his doctorate, Zlotnick attended the University of Pennsylvania and worked in Robert Mauck’s lab in the departments of bioengineering and orthopedic surgery.

Zlotnick’s doctoral research has focused on harnessing remote forces, such as magnetism or gravity, to enhance engineered cartilage and osteochondral repair both in vitro and in large animal models. Zlotnick now plans to turn to the field of biofabrication to create tissue models of the knee joint to evaluate potential treatments for osteoarthritis. “I am honored to be part of the Schmidt Science Fellows community and excited to venture into the field of biofabrication,” said Zlotnick. “Hopefully this work uncovers new therapies for patients with inflammatory joint disease.”

Insects harbor more than a thousand microbe genes, which help them survive

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Hundreds of millions of years ago, microbes and plants could have given insects an evolutionary advantage by passing genes to them through horizontal gene transfer. In a study published in the journal Cell on July 18, researchers report that more than 1,400 genes belonging to 218 species of insects, including butterflies and moths, come from bacteria, viruses, fungi and plants. The study argues that these genes could have been essential to the evolution of insects by allowing them to develop beneficial traits in mating behavior, nutrition, growth and adaptation to environmental changes.

Horizontal gene transfer (HGT) is quite common between microbes. For example, bacteria use this mechanism to transmit antibiotic resistance genes between species, but more recently scientists have systematically studied the phenomenon between insects and microbes or plants.

“Previous studies have shown that HGT may have contributed to insect biodiversity, but no one knew how important a role it played in this process,” says lead author Xing-Xing Shen, an evolutionary biologist. at Zhejiang University in Hangzhou, China. “Since there are many high-quality insect genomes available for our analysis, I thought the time was right to systematically investigate the prevalence of HGT in insects.”

Shen’s team at Zhejiang University initiated this project in collaboration with Antonis Rokas, an evolutionary biologist at Vanderbilt University, by collecting 218 high-quality insect genome samples representing 11 of the 19 insect orders. species-rich insects. With the data, they were able to draw an evolutionary tree, identify displaced genes more commonly found in non-animal genomes, and examine factors that contribute to the fate of HGT in insects.

“There were HGT events everywhere we looked,” Shen says. “However, we don’t know if these gene transfers are beneficial for insects, or even the functions of most of these genes,” Shen says. He enlisted the help of another expert, Jianhua Huang, who studies insect gene functions at Zhejiang University.

“Shen walked into my office with a list of over 1,400 genes, and we had to decide where to start,” Huang says. The team decided to validate the function of the most prevalent foreign gene with no known functions in insects: LOC105383139.

“This gene was introduced horizontally into almost all moths and butterflies from a donor of the bacterial genus Listeria“, they report in the study, which means that this gene has persisted in the genome since the time of the common ancestor of moths and butterflies more than 300 million years ago.

They decided to remove this ancient gene from diamondback moth, a pest affecting broccoli and cabbage, and observe what kind of functions it has. “Amazingly, we saw that those butterflies lacking this gene cannot produce many viable eggs,” Huang said. “Then we found that the gene influences male courtship behavior.”

The group plans to do more research into the mechanisms underlying how this gene helps insects mate more efficiently and whether it can be exploited as a pest control tool.

Source of the story:

Material provided by Cell Press. Note: Content may be edited for style and length.

The name behind the popular Veronica bucket

Veronica Ayele Bekoe is the name behind the famous Veronica bucket. She is a retired biologist with over 40 years of experience in medical laboratory practice in Ghana.

The Veronica bucket is a household name in many domestic and public spaces in Ghana. Since its invention in 1993, it has served the important purpose of providing piped water for various sanitation purposes in Ghana and beyond.

Additionally, the Veronica Bucket has been instrumental in the fight against COVID-19 by promoting hand washing with soap under running water.

Veronica Ayele Bekoe comes from Jamestown in Accra, Ghana. Veronica received her basic education in Accra and later went to Aburi Girls High School for her secondary education. For her higher education, Veronica studied at Kwame Nkrumah University of Science and Technology (KNUST) from 1968 to 1972. She graduated with a Bachelor of Science in Biological Sciences/Biology. Veronica worked with the Ghana Health Service (GHS) Public Health and Reference Laboratory from 1972 to 2008.

Sharing how she came up with the Veronica Bucket, Veronica says she came across the idea because of a sanitation issue while working at the public reference lab. In 1993, a consultant named Joan Hetrick was sent by the Ghana Health Service to train laboratory workers in the country, and Veronica was chosen to accompany her.

During the visit, Veronica noted that some of the facilities did not have running water. The laboratory workers used bowls containing water to wash their hands. She worried about the health consequences of using standing water to wash her hands after each lab session.

According to Veronica, this situation motivated her to create something that could provide running water when needed. She fashioned a container from a piece of aluminum sheet and had a faucet attached to it. This marked the birth of the first Veronica Bucket that successfully served. Later, many copies were made using different materials and were distributed to the different health institutions in the country.

In an interview, Veronica revealed that the name “Veronica bucket” was proposed by Joan Hetrick, who was impressed with Veronica’s creativity and problem-solving abilities.

Veronica’s name is now recognized worldwide for the fame of the Veronica bucket. While working in the Ghana Health Service, Veronica was the lead person for the national AIDS and STI control programme. Ghana’s First Lady, Rebecca Akufo-Addo, has awarded Veronica Ayele Bekoe for her social innovation.

REFERENCE

Information from https://connecting-classrooms.britishcouncil.org/resources/home-learning/bringing-covid-19-under-control/veronica-bucket,

https://yen.com.gh/165651-veronica-bekoe-7-top-facts-genius-ghanaian-woman-designed-veronica-bucket-video.html, https://mobile.ghanaweb.com/person/ Veronica-Bekoe-3394 was used in this story

Removing Indigenous science from classrooms is ‘regressive’: Chief

Anishinabek Nation Open to Meeting with Ministry of Education Following Recent Decision to Remove Indigenous Science Framework from Ontario Curriculum

The Anishinabek Nation, along with Anishinabek educators, have expressed their concerns and expressed their willingness to meet with the Ministry of Education following the recent decision to remove the Indigenous science framework from the Ontario curriculum.

“The connection to the land is central to Anishinabek knowledge systems,” Grand Council of the Anishinabek Nation Chief Reg Niganobe said in a news release this week. “Our ancestors are the first engineers of this place. Long before Canada smoothed the land for railroads and roads, the Anishinabek traveled great distances using the original highways of this land – the waterways. They did this by using an environmentally friendly means of transport through coexistence in the ecosystem.

The Education Framework Agreement between Participating Self-Governing First Nations of the Anishinabek Education System, the Kinoomaadziwin Education Organization and the Government of Ontario, signed in 2017, outlines a new way forward for education. ‘education. This agreement specifies that the parties involved will support collaboration in the curriculum development and revision processes.

“The Anishinabek education system prioritizes Anishinabek culture, language, history and knowledge in education,” said KEB President Phyllis Anderson. “The education system has made great strides in strengthening relationships with ministry and school board partners. This decision creates barriers to the development and inclusion of a reciprocal curriculum based on reconciliation.

For more information, see the press release as follows:

The Anishinabek Nation and the Kinoomaadziwin Education Body (KEB) are disappointed to learn of the Ministry of Education’s decision to remove the Indigenous science framework from the Ontario curriculum. In collaboration with Anishinabek educators, the Anishinabek Nation is willing to host a meeting with the Ministry of Education to advocate for the inclusion of these expectations for all students in Ontario.

“The connection to the land is central to Anishinabek knowledge systems,” says Anishinabek Nation Grand Council Chief Reg Niganobe. “Our ancestors are the first engineers of this place. Long before Canada smoothed the land for railroads and roads, the Anishinabek traveled great distances using the original highways of this land – the waterways. They did this by using an environmentally friendly means of transport through coexistence in the ecosystem.

Ontario universities, colleges and schools have developed Indigenous research and resources in STEM (science, technology, engineering and math) – and this stage of ministry is not supported by the evolution of the field.

“Anishinabek education advocates have long fought for recognition of our learning systems,” said James Marsden, deputy chief of the Grand Regional Council of the Southeast Anishinabek Nation, education portfolio holder of the Anishinabek Nation. “Removing this framework from the Ontario curriculum is regressive and dishonors our partnership.

The Education Framework Agreement between Participating Self-Governing First Nations of the Anishinabek Education System, the Kinoomaadziwin Education Organization and the Government of Ontario, signed in 2017, outlines a new way forward for education. ‘education. This agreement specifies that the parties involved will support collaboration in the curriculum development and revision processes.

“The Anishinabek education system prioritizes Anishinabek culture, language, history and knowledge in education,” said KEB President Phyllis Anderson. “The education system has made great strides in strengthening relationships with ministry and school board partners. This decision creates barriers to the development and inclusion of a reciprocal curriculum based on reconciliation.

Article 15.1 of the United Nations Declaration on the Rights of Indigenous Peoples also states: Indigenous peoples have the right to dignity and to the diversity of their cultures, traditions, histories and aspirations which shall be duly reflected in education and public information.

Anishinabek science, technology, engineering and mathematics have existed on this land since time immemorial. It is imperative that Ontario and Indigenous partners work together in a spirit of reconciliation to create Indigenous STEM resources for a shared future.

“The fields of medicine and biology have been enriched through the use of the teachings and spirit of Indigenous traditional knowledge holders. From early interactions with settlers and the sharing of agricultural practices to biomedical research using compounds that have been used for millennia, Anishinabek scientific knowledge is integral to creating a shared knowledge base,” says M’ Chigeeng Ogimaakwe Linda Debassige. “Removing the Indigenous Science Framework from the Ontario curriculum is both irresponsible and disrespectful not only to our ancestors and the deep history of our First Nations peoples, but to all of Ontario by going to the Against the Truth and Reconciliation Commission’s Calls to Action. of Canada calling for the inclusion of Indigenous contributions in the school curriculum. We cannot erase the truth.

B3Galnt2 and B3Gl2 Antibody Market Overview, High Growth Opportunities, Segmentation, Trends by 2022-2030 – Travel Adventure Cinema

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    Township of Ephrata. will receive $150,000 to restore land along Cocalico Creek | Community News

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    When: Ephrata Township Supervisors Meeting, July 5th.

    What happened: Township Superintendent Steve Sawyer announced the township will receive an additional $150,000 from the Department of Conservation and Natural Resources to restore 16 acres along Cocalico Creek. This is in addition to the initial grant of $195,980, for an amended amount of $345,980. Supervisor Anthony Haws was absent.

    Background: The Cocalico Creek project will serve as the township’s pollution reduction project for its municipal segregated storm sewer system program, as required by the state Department of Environmental Protection. The project, designed to rehabilitate a 2,800 foot section of the creek stretching from Acorn Court to Autumn Blaze Way, is adjacent to the Autumn Hills neighborhood. The project is expected to start in late spring next year.

    The cost: At the April 19 meeting, the board voted unanimously to award a contract for the Cocalico Creek Restoration Project to Flyway Excavating Inc. for $798,720, almost double the estimated cost.

    Inflation influence: In September 2021, the township estimated the cost of the project at approximately $400,000. The cost doubled due to increased material costs attributed to inflation.

    Grants galore: In 2020, the Township of Ephrata also received a $145,300 grant from the Lancaster Clean Water Fund. Grants from the Lancaster Clean Water Fund and DCNR total $491,280.

    Remaining balance: The township will use its U.S. bailout funds to pay the remaining $307,440.

    Snake head report: Sawyer also opened a discussion on a June 26 report by Lancaster-based fisherman Michael Petrotsky on a June 25 snakehead derby that took place at Quarry Lake. Three anglers competed, however, none of them will qualify for the second round. In his report, there were 12 snakehead fish bites, but none were caught. He said he saw a snakehead over 30 inches in length within 8 feet of his kayak. He said the experiment confirmed his suspicions about the lake’s snakehead population.

    Quotable“I’m no biologist, but I would absolutely say there is a well-established lakeside population,” Petrotsky wrote in a June 26 email to the township.

    And after: Council will meet again at 7:00 am on July 19 at the Township of Ephrata Municipal Building at 265 Akron Road.

    Colorado Parks and Wildlife issues voluntary fishing closures on the Fraser River, Colorado River and Eagle River until further notice

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    The CPW may authorize the voluntary closure of fishing waters if it is determined that warming water temperatures could result in the mortality of fish if they experience stress during capture.


    Colorado Parks and Wildlife/Courtesy Photo

    Due to warm water temperatures, Colorado Parks and Wildlife is asking anglers to voluntarily avoid fishing on sections of the Fraser River, Colorado River, and Eagle River.

    Effective Friday, July 15, Parks and Wildlife is enforcing the following voluntary fishing closures from noon to 11:59 p.m. daily:

    • Fraser River from the County Road 8 bridge crossing at Fraser downstream to the confluence with the Colorado River near Granby
    • Colorado River from confluence with Fraser River near Granby downstream to confluence with Williams Fork River at Parshall
    • Colorado River from the Colorado Route 9 Bridge at Kremmling Downstream of the State Bridge
    • Eagle River from the Eagle County Fairgrounds in Eagle to the confluence with the Colorado River in Dotsero

    In addition to the partial day closures, a full day closure is in effect on the Colorado River from State Bridge downstream to Bair Ranch in Glenwood Canyon. These voluntary closures will remain in effect until further notice, with the possibility of a mandatory emergency closure to all fishing if conditions worsen or fisher compliance becomes an issue.



    “We know anglers care deeply about these cold water trout fisheries,” said Lori Martin, senior aquatic biologist for Parks and Wildlife Northwest Region. “We need their help to conserve these resources and that’s why we ask anglers to take the water and weather conditions into consideration when they go fishing. If the water seems too warm or the fish seem lethargic, it would be best to stop or find another fishing opportunity at higher elevations.

    Heat, dryness, and low water levels contribute to high water temperatures in Colorado rivers, depleting oxygen levels and leaving fish vulnerable. When the water temperature exceeds 70 degrees, fish often stop feeding and become more susceptible to disease. The hot temperature and low water levels can also lead to algae blooms in rivers and reservoirs, which leads to lower oxygen levels as the algae die and decompose.



    “Get out early to avoid the higher water temperatures commonly seen in the afternoon and evening,” Martin said. “Anglers are also encouraged to look for lakes and streams at higher elevations, where water temperatures are more appropriate and where fishing does not potentially add additional stress.”

    Martin also urged anglers to add a hand-held thermometer to their fishing kits so they can test the waters they intend to fish.

    “Fishermen can monitor the water temperature themselves and stop fishing when the water temperature starts approaching 70 degrees,” she said.

    Other suggestions include using a heavier tip and line to quickly reel in and release fish, always get your hands wet before handling a fish, and keeping the fish submerged while unhooking and releasing it. . Anglers are encouraged to avoid pulling fish out of the water even for a quick shot in these conditions. Mandatory and voluntary fishing closures and current conditions can be viewed on the Parks and Wildlife website. Anglers can also check with local parks and wildlife offices to find out about the water conditions at your destination before you travel.

    Dragon Docks delivers science for the benefit of humans – Space Station

    The SpaceX Dragon supply ship approaches the space station during an orbital sunrise over the Pacific Ocean. Credit: NASATV

    As the International Space Station traveled more than 267 miles above the South Atlantic Ocean, the SpaceX Dragon cargo spacecraft docked autonomously at the forward-facing port of the station’s Harmony module at 11 a.m. 21 EDT today, with NASA astronauts Bob Hines and Jessica Watkins monitoring operations from the station.

    The Dragon launched on SpaceX’s 25th contract commercial resupply mission for NASA at 8:44 p.m. Thursday, July 14, from Launch Complex 39A at the agency’s Kennedy Space Center in Florida. After Dragon has spent about a month attached to the space station, the spacecraft will return to Earth with cargo and research.

    Some of the science experiments Dragon delivers to the space station include:

    Map Earth Dust
    The Earth Surface Mineral Dust Source Investigation (EMIT) study, developed by NASA’s Jet Propulsion Laboratory in Southern California, uses NASA imaging spectroscopy technology to measure the mineral composition of dust in arid regions of the earth. Mineral dust blown through the air can travel significant distances and affect Earth’s climate, weather, vegetation and more. For example, dust containing dark minerals that absorb sunlight can warm an area, while light-colored mineral dust can cool it. Blown-in dust also affects air quality, surface conditions such as the rate of snowmelt, and the health of phytoplankton in the ocean. The survey collects images for a year to generate maps of mineral composition in regions of the Earth that produce dust. Such mapping could advance our understanding of the effects of mineral dust on human populations today and in the future.

    Faster aging of the immune system
    Aging is associated with changes in the immune response known as immunosenescence. Microgravity causes changes in human immune cells that resemble this condition, but occur faster than the actual aging process on Earth. The Immunosenescence Survey, sponsored by the US National Laboratory on the International Space Station, uses tissue chips to study how microgravity affects immune function during flight and whether immune cells recover after flight. Tissue chips are small devices that contain human cells in a 3D structure, allowing scientists to test how these cells respond to stresses, drugs and genetic changes.

    The ground in space
    On Earth, complex communities of microorganisms perform key functions in the soil, including cycling carbon and other nutrients and supporting plant growth. Dynamics of Microbiomes in Space, sponsored by NASA’s Biological and Physical Sciences Division, examines how microgravity affects metabolic interactions in soil microbe communities. This research focuses on microbial communities that break down chitin, a natural carbon polymer on Earth.

    Weather study for high school students

    BeaverCube is an educational mission that will teach aerospace science to high school students by having them design a CubeSat. BeaverCube will house a visible and two infrared imagers to measure cloud properties, ocean surface temperatures, and ocean color to study Earth’s climate and weather systems. It will also demonstrate an application for the use of shape memory alloy technology via an in-orbit calibration technique.

    Genes, not cells
    Cell-free technology is a platform for producing proteins without specialized equipment from live cells that need to be cultured. Genes in space-9, sponsored by the National Lab, demonstrates cell-free protein production in microgravity and evaluates two cell-free biosensors capable of detecting specific target molecules. This technology could provide a simple, portable, and inexpensive tool for medical diagnostics, on-demand production of drugs and vaccines, and environmental monitoring on future space missions.

    Better concrete
    Biopolymer research for in situ capabilities examines how microgravity affects the process of creating an alternative to concrete made from organic material and in-place materials, such as lunar or Martian dust, known as a biopolymer soil composite. Using available resources where construction is taking place increases the amount of shielding.

    These are just a few of the hundreds of investigations currently being carried out aboard the orbiting laboratory in the fields of biology and biotechnology, physical sciences, and earth and space sciences. Advances in these areas will help keep astronauts healthy during long-duration space travel and demonstrate technologies for future human and robotic exploration beyond low Earth orbit to the Moon and Mars through the program. NASA’s Artemis.


    Learn more about the station’s activities by following the space station blog, @space station and @ISS_Research on Twitter, as well as the ISS Facebook and Instagram accounts.

    Get weekly video highlights at: http://jscfeatures.jsc.nasa.gov/videoupdate/

    Get the latest news from NASA every week. Subscribe here: www.nasa.gov/subscribe

    Do you feel tired for no reason? Something is wrong with your liver

    If you feel tired, it can be a warning sign of non-alcoholic fatty liver disease (NAFLD), an umbrella term for a range of liver conditions affecting people who drink little or no alcohol. The main characteristic of NAFLD is that too much fat is stored in liver cells. Although it has become increasingly common around the world, little is known about the symptoms and causes of NAFLD.

    Some people with NAFLD may also develop nonalcoholic steatohepatitis (NASH), an aggressive form of fatty liver disease with inflammation of the liver. NASH can progress to advanced scarring (cirrhosis) and even liver failure. The effects of NAFLD are similar to the damage caused by excessive alcohol consumption.

    Swollen belly, enlarged blood vessels under the skin, larger than normal breasts in men, red palms, yellowish eyes and skin, due to a condition called jaundice, are some of the common symptoms of NASH or cirrhosis.

    If you’ve experienced any of these symptoms, seeing a doctor can help you diagnose and treat liver disease early.

    Specific foods that may be helpful for people with fatty liver disease are:

    Garlic

    According to a study published in Advanced Biomedical Research, garlic powder supplements have been shown to help reduce body weight and body fat in people with NAFLD.

    Foods High in Omega-3 Fatty Acids

    In a research article titled “Effects of Omega-3 Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis,” consuming omega-3 fatty acids may improve liver fat and high-lipoprotein cholesterol levels. density. Salmon, flax seeds, sardines and walnuts are rich in omega-3 fatty acids.

    Green tea

    The antioxidants found in green tea may help improve fatty liver symptoms.

    Broccoli

    Whole vegetables are known to be beneficial for people with fatty liver disease. Long-term consumption of broccoli can control fat accumulation in the liver

    soy protein

    Soy protein contains antioxidants called isoflavones which help reduce fat in the body and increase our sensitivity to insulin.

    Read all the latest news, breaking news, watch the best videos and live TV here.

    Scientists combine robotics with biology to build biohybrid microrobots

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    A team of scientists from the Department of Physical Intelligence at the Max Planck Institute for Intelligent Systems have combined robotics with biology by equipping E.coli bacteria with artificial components to build biohybrid microrobots. First, the team attached several nanoliposomes to each bacterium. On their outer circle, these spherical supports enclose a material (ICG, green particles) which melts when illuminated by near infrared light. Further towards the middle, inside the aqueous core, liposomes encapsulate water-soluble chemotherapeutic drug molecules (DOX).

    The second component that the researchers attached to the bacteria are magnetic nanoparticles. When exposed to a magnetic field, the iron oxide particles serve as a booster for this already highly mobile microorganism. This way it is easier to control the swimming of bacteria – an improved design towards in vivo application. Meanwhile, the rope binding the liposomes and magnetic particles to the bacteria is a very stable and hard-to-break complex of streptavidin and biotin, which was developed a few years ago (https://www.nature.com/articles/s41598-018-28102-9) and is useful when building biohybrid microrobots.

    E. coli bacteria are fast and versatile swimmers that can navigate through materials ranging from liquids to highly viscous tissues. But that’s not all, they also have very advanced detection capabilities. Bacteria are attracted to chemical gradients such as low oxygen levels or high acidity – both prevalent near tumor tissues. Treating cancer by injecting bacteria nearby is known as bacteria-mediated tumor therapy. The microorganisms flock to the place where the tumor is, grow there and thus activate the immune system of the patients. Bacteria-mediated tumor therapy has been a therapeutic approach for more than a century.

    Over the past few decades, scientists have been looking for ways to increase the superpowers of this microorganism even further. They equipped the bacteria with additional components to help them fight. However, adding artificial components is not an easy task. Complex chemical reactions are involved and the rate of density of charged particles on the bacteria is important to avoid dilution. The Stuttgart team have now set the bar quite high. They managed to equip 86 out of 100 bacteria with both liposomes and magnetic particles.

    The scientists showed how they managed to externally drive such a dense solution through different pathways. First, through a narrow L-shaped channel with two compartments at each end, with a tumor spheroid in each. Second, an even narrower configuration resembling tiny blood vessels. They added an extra permanent magnet to one side and showed how they precisely control drug-loaded microrobots to tumor spheroids. And third, going even further, the team navigated the microrobots through a viscous collagen gel (resembling tumor tissue) with three levels of stiffness and porosity, ranging from soft to medium to stiff. The stiffer the collagen, the tighter the network of protein chains, the harder it becomes for bacteria to find a way through the matrix. The team showed that once they add a magnetic field, the bacteria manage to navigate to the other end of the gel because the bacteria have a higher strength. Due to the constant alignment, the bacteria have found a way through the fibers.

    Once the microrobots are accumulated at the desired point (the tumor spheroid), a near infrared laser generates rays with temperatures up to 55 degrees Celsius, triggering a process of fusion of the liposome and a release of the enclosed drugs. A low pH level or an acidic environment also causes nanoliposomes to open – hence the automatic release of drugs near a tumor.

    “Imagine injecting such bacteria-based microrobots into the body of a cancer patient. With a magnet, we could precisely direct the particles to the tumor. Once enough microrobots surround the tumor, we point a laser on the tissue and thus trigger the release of the drug. Now not only is the immune system triggered to wake up, but the additional drugs also help destroy the tumor,” says Birgül Akolpoglu, a PhD student at the Department of Physical Intelligence at MPI-IS She is the first author of the publication entitled “Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery” co-directed by former postdoctoral researcher in the Department of Physical Intelligence, Dr. Yunus Alapan. It was published in Scientists progress July 15, 2022.

    This on-the-spot administration would be minimally invasive to the patient, painless, bear minimal toxicity, and the drugs would develop their effect where needed and not inside the whole body.”

    Dr. Yunus Alapan, former postdoctoral researcher in the Department of Physical Intelligence

    “Bacterial-based biohybrid microrobots with medical capabilities may one day fight cancer more effectively. This is a new therapeutic approach not too far removed from the way we treat cancer today,” says Professor Metin Sitti, who heads the Department of Physical Intelligence and is the latest author of the publication. “The therapeutic effects of medical microrobots in finding and destroying tumor cells could be substantial. Our work is an excellent example of basic research that aims to benefit our society.”

    Source:

    Journal reference:

    Akolpoglu, MB, et al. (2022) Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery. Scientific advances. doi.org/10.1126/sciadv.abo6163.

    Whitefish populations in trouble in the Great Lakes

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    LANSING — Three men pull a tired cart full of scientific equipment across the sand of Muskegon’s Pere Marquette Beach. Dressed in layers against the cold of late spring, their camouflage-print thigh-high boots give their gait a rocker character not typical of beachgoers.

    “It’s one of the most fun things we have to do in our job,” said Steve Pothoven, a fisheries biologist at the National Oceanic and Atmospheric Administration’s (NOAA) Great Lakes Environmental Research Laboratory in Muskegon. .

    Pothoven and fellow researchers Jeff Elliott and Aaron Dunnuck work on Lake Michigan beaches in May and June, studying how well young whitefish mature into adults.

    Lake Michigan and Lake Huron whitefish have a recruitment problem.

    Since the early 2000s, fewer young whitefish are reaching adulthood. Fewer adults mean fewer fish to catch for commercial fishermen.

    “We just don’t know much about these fish and what sustains them early in their lives,” Pothoven said.

    They are studying the problem at familiar and popular beaches – places like Pere Marquette and Grand Haven State Park.

    They get to work.

    Dunnuck hits the water. Walking straight into the lake, he drags 150 feet of weighted seine on the bottom, the water rising to his chest. Turning left, he walks parallel to the shore, the net uncoiling, forming a crescent as he returns to shore. He and Elliot pull in the net, scooping up any fish in its path.

    On land, they open the net to assess their catch.

    That day is little.

    A few small silvery fish – what most people would call “minnows” – lay in the net.

    They quickly identify and count all the fish, keeping the whitefish and discarding the rest.

    Dunnuck returns to the water with a small net on a pole with a small pot on the end to sweep up the water. He collects zooplankton – food for baby whitefish – to see what they have to eat.

    Back at the NOAA lab, Elliott examines zooplankton under a microscope, identifying the tiny animals based on differences in their otherworldly bodies. It will open the stomachs of young whitefish to compare what they eat with what lives in the water.

    Understanding the decline in lake whitefish recruitment is important as fisheries managers and regulators approach the deadline to update a 2000 Consent Order regulating recreational and commercial fishing in Lakes Huron and Michigan. .

    Prized for its mild flavor, finding whitefish on local restaurant menus is an important part of the “Up North” experience for summer tourists.

    Lake whitefish account for 95% of commercially caught fish sales in Michigan, with a dockside value of just over $4 million, Sea Grant, Michigan reported in 2020.

    For members of tribal communities, lake whitefish is much more than a source of income. Fish have been an integral part of their diet and culture for thousands of years.

    Understanding why young whitefish are struggling in much of the Great Lakes is a major goal of state and tribal fisheries research.

    Juvenile lake whitefish.

    “You have to remember that 99.9 percent of all fish eggs laid die,” said Mark Ebener, a fisheries biologist who worked 37 years for two Great Lakes intertribal organizations. He is the lead author of a 2021 study of declining lake whitefish recruitment published by the Great Lakes Fishery Commission.

    Most evidence of low lake whitefish recruitment points to one culprit: invasive mussels.

    The premise is that quagga mussels have fundamentally changed the way energy flows through the system, dramatically reducing zooplankton in coastal waters, Ebener said.

    Zooplankton are the primary food source for baby whitefish.

    The timing of the arrival of mussels and the decline in lake whitefish recruitment is likely more than a coincidence.

    “Yeah, definitely, we think that’s one of the main causes of the decline in whitefish recruitment – the lack of zooplankton,” Ebener said.

    With so many fish-loving people fighting so hard to defend themselves, a key question for negotiators is how much can be harvested each year if fewer reach adulthood.

    It now takes longer for lake whitefish to grow large enough to be fished commercially and old enough to reproduce in the next generation.

    “It used to only last two to three years and they were in the fishery, probably reproducing,” NOAA’s Pothoven said.

    Due to the mussel’s impact on the base of the food web, it now takes at least five years, and possibly up to seven or more, he said.

    “They don’t grow like they used to.”

    Pothoven and a team attempt to understand the early life of lake whitefish.

    The team is led by Kevin Donner, Great Lakes Fisheries Program Manager for the Odawa Indian Band of Little Traverse Bay in Harbor Springs.

    “For us, when we started this in 2013, the whitefish was already in decline, but we didn’t know how much,” Donner said.

    Jeff Elliott and Aaron Dunnuck collect juvenile whitefish in a seine net.

    Predicting the future is always risky.

    A major concern is that by the time they collect information on fish large enough to be caught commercially, six or seven years may have passed without anyone knowing that problems could arise when the fish were babies. No one was watching.

    “So if something bad happens, for example today, let’s say no whitefish are born for whatever reason, we’re going to continue our merry way for seven years before someone has enough data to say, ‘Oh my God, something is wrong. .’ Donner said.

    It could also go the other way.

    If the group’s work pays off, it could calm nerves and better predict how many are available for commercial harvest years in advance.

    Since 2013, the survey team has sampled beaches in the spring, primarily in the northern Lower Peninsula.

    Lake whitefish spawn in the fall, favoring protective rocky coastal areas. When the eggs hatch in the spring, whitefish larvae survive on a yolk sac, a pouch protruding from their belly filled with fat and other goodies, until they have grown large enough to hunt on their own.

    When this happens, they venture into open waters, many of them choosing the seemingly arid environment of popular sandy beaches.

    “Most people wouldn’t even know whitefish larvae existed right around their ankles just before they were comfortable swimming in the lake,” Donner said.

    There are places in the Great Lakes where baby whitefish are faring much better.

    Ebener said, “Lower Green Bay is always good, Saginaw Bay is good, Lake Huron North Channel is good, Lake Superior is always good. The problems are in the open waters of the main basin of Lake Michigan, Lake Huron and Lake Ontario.

    In areas where lake whitefish are doing best, mussels do not have the stranglehold they have on the open waters of Lakes Michigan and Huron.

    It has always been risky to be a baby whitefish. Improving their chances of survival, even just a little bit, can pay off big, Ebener said.

    If 99.995% of fish eggs don’t survive, even a tiny bump in surviving baby fish can be very important to the species, he said.

    “It’s a numbers game.”

    — Kurt Williams writes for Great Lakes Echo.

    Anglers suggest the most effective catfish baits

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    Catfish are perhaps one of Arkansas’ most misunderstood sport fish. They live in virtually every body of water in the state, grow to gigantic proportions, and are easy to catch with inexpensive equipment. Complement these characteristics with its fantastic flavor, and it’s a wonder anyone despises these hardy fish.

    The Arkansas Game and Fish Commission stocks thousands of catchable-sized river catfish each year through its hatchery system in small ponds and lakes that cannot cope with fishing pressure. Mother Nature produces millions more fish in Arkansas rivers and lakes every year. All it takes to catch them is a little patience and the right lure to entice them to bite. The secret ingredient to all good catfish lures is scent.

    Catfish can “smell” bait much better than many species of fish. Highly sensitive membranes inside the fish’s nostrils detect compounds in the water. The more these membranes have folds, the more the fish’s sense of smell is developed. Trout have about 18 of these folds, while largemouth bass may have as few as 10. Channel catfish have 140 of these specialized folds for smelling, allowing them to detect compounds as small as one part in 100 million.

    So what smells make the best bait for catfish? Here are some proven deals to keep you plugged in this summer.

    FISH SMELL

    The best smells of all will come from the foods the catfish are used to eating. Shad, small bream and parts of less desirable species such as carpsuckers and skipjack are the main producers for many catfish anglers.

    Justin Homan, chief biologist for the Arkansas Game and Fish Commission’s catfish team, said many veteran catfish anglers, especially those on the big rivers in eastern ‘Arkansas, prefer cut shad and skipjack. These oily fish give off an odor that large catfish seek.

    “When running jugs with my wife and granddaughter, we also tend to use cut baits, especially harder-skinned fish,” Homan said. “Pieces of carp or buffalo stay on the hook well and will bring in a lot of fish.”

    Homan says that flathead catfish like live bait fish much more than cut bait, so targeting these big fighters may require a little more effort to take care of your lures. Many anglers use goldfish purchased from bait dealers, and he has personally done well on Lake Conway running at night with live sunfish.

    “You have to catch the sunfish first and you can’t move it from another body of water, but they work great,” Homan said. “One tip is to check your bait around midnight. Chain cats can beat flatheads to your bait, and flatheads are most active after about midnight. Rebaiting then can really help attract bigger cats. “

    Any wild caught fish or crayfish cannot be transported to another body of water and used as bait unless used as dead bait. The risk of spreading disease or invasive species is too high when moving wild-caught live baitfish. If you want to use live bait fish but don’t have time to catch them in the body of water you will be fishing, goldfish, minnows and minnows can be purchased at bait shops come from baitfish farms certified to be free from diseases and other ailments that live fish can carry.

    CRIBS

    Catalpa worms, night owls and other flower bed crawlers also make great bait, and they can be pulled out of the ground and transported with no problem. Flipping over a few bricks from the flowerbed or scraping a few leaves and digging on the surface of the dirt should collect enough worms for a quick trip. Some anglers have taken worm collecting to the next level, using a special technique called “worm grunt” or “worm fiddle” to get bait quickly. Compost bins are also great places to find active red worms nicknamed “red wigglers”, which don’t grow as big as the night owls you find on the ground after a rain, but give plenty of action for entice capricious cats to bite.

    SPAM-TASTIC

    One of those overlooked grocery baits that works wonders is good old canned meat. As outdoor writer Don Wirth has always written in issues of Bassmaster Magazine’s humorous Harry ‘n’ Charlie columns, SPAM is not cured and ready to eat until it has collected half a inch of dust on top back of convenience store shelves. . Believe it or not, Arkansas’ current state record and once world blue catfish record of 116 pounds, 12 ounces was caught on this easy-to-store bait in 2001. That doesn’t make it’s hard to keep a box handy in the tackle box, and if the fish won’t bite, it’s not so bad with crackers and a little hot sauce. The same cannot be said for night owls.

    ANTI-VAMPIRE WEENIES

    Clint Coleman, assistant coordinator of the AGFC’s family and community fishing program, has seen his share of stinky lures, as he helps organize dozens of fishing tournaments each year. His favorite bait is hot dog chunks dipped in a mixture of Kool-Aid cherry and garlic powder. For some reason, this combination sets catfish on fire in fishing tournaments.

    “It’s easy to get to the store and easy to deal with the kids,” Coleman said. “Some kids might not want to play with the worms, livers, or stinky baits, but everyone will take a hot dog. The garlic will give off a lot of smell to fine tune the fish on your lure.”

    Coleman says not to worry about adding water to activate the Kool-Aid. The juice from the hot dogs is all it takes.

    CHICKEN LIVER

    Arkansas Wildlife Television host Trey Reid has had the opportunity to catch big catfish on the Mississippi River with real sticks, and he agrees that cut skipjack is the prime rib of the fishing world. cat, but for his excursions into smaller waters he always tends to the bait he was introduced to catfishing with – chicken livers.

    “You can pick it up at almost any grocery store on the way to the lake or store it in the fridge with slightly less complaints from family members than other wild concoctions,” Reid said. “Sometimes it’s good to keep it simple and remember that fishing doesn’t have to be a huge expense or take a ton of time to prepare.”

    KEEP IT CLEAN

    As weird as it sounds, you might not have to be stinky to get a good catfish bite. Jon Stein, district fisheries biologist for the AGFC in Rogers, says soap is one of the best baits used to sample channel catfish in nets.

    “The biologists were using a log of manufactured soy cheese as bait, but we also caught a lot of turtles,” Stein said. “Staff are now using Zote Soap to bait the nets. It attracts the river catfish without the turtles so we can focus on getting valuable information about the river catfish, including lengths, weights, population size (catch per net), age and can estimate how much of the population comes from stocked fish.

    Stein says that although he has never personally baited with soap, he has spoken to many on-water anglers who swear by him.

    “It has to be high in animal fat,” Stein said. “Some anglers say they melt it, pour it into ice cube trays, and put a hook on it so the soap hardens around the hook, and then they can keep things clean and organized on the water.”

    Zote is even scientifically proven to catch catfish, so to speak. A study conducted by Russell Barabe and Donald Jackson at Mississippi State University and presented to the American Fisheries Society in 2011 found that catfish catch rates between Zote soap and cut baits on trotlines were statistically insignificant. The study aimed to find alternatives to catfish baiting that would not catch certain species of endangered aquatic turtles. Soap caught no turtles while catching 193 blue catfish and 462 river catfish when fished from 11,000 trotline hooks in six coastal rivers overnight in Magnolia State .

    Do you have a favorite formula for catfish success? Send a comment to randy.zellers@agfc.ar.gov. If we can bear it, we might feature it in a future edition of the AGFC weekly fishing report.

    Randy Zellers is assistant chief of communications at the Arkansas Game and Fish Commission.

    Advocates show support for removal of Snake River dams

    They held a series of speeches, songs and dances as they called on Congress to act.

    WASHINGTON DC, DC — On Thursday, tribal members and Salmon Orca Project advocates met with federal officials, calling for the removal of the Snake River dams.

    They held a series of speeches, songs and dances as they called on Congress to act.

    “Action must be taken,” said Nez Perce Tribe President Samuel Penney. “We believe there is enough biological and scientific information available to make a decision that should be based on that and not be a purely political decision. The extinction crisis that we find ourselves in right now, there has to be have an urgent action – there is no time for further studies.”

    The Biden administration released two reports on Tuesday claiming that removing dams on the lower Snake River may be needed to restore salmon runs to historic levels. Replacing the energy created by the dams is possible, but it will cost between 11 and 19 billion dollars.

    A draft report by National Oceanic and Atmospheric Administration scientists found that changes are needed to restore salmon, ranging from removing one to four dams on the lower Snake River to reintroducing salmon in areas entirely blocked by dams. A second report investigated how power supplies could be replaced in the event of a dam failure.

    However, groups such as Northwest RiverPartners are pushing back, saying the data does not show that removing the dams would necessarily recover salmon. The group, which represents community-owned electric utilities and clean energy agencies, says the hydropower produced is essential to combating climate change.

    Major benefits of dams include making the Snake River navigable to Lewiston, Idaho, allowing barges to transport wheat and other crops to ocean ports. Removing the dams would require improvements in road and rail transportation to move crops.

    The dams also generate electricity, supply irrigation water to farmers, and provide recreational opportunities for residents.

    Last month, Senator Patty Murray and Governor Jay Inslee announced that replacing the benefits provided by the four giant hydroelectric dams on the lower Snake River in Washington state would cost between $10.3 and $27.2 billions of dollars.

    More than a dozen runs of salmon and rainbow trout are threatened with extinction in the Columbia and Snake rivers. Billions of dollars have been spent on the recovery of salmon and rainbow trout, but the fish continue to decline.

    LOOK: the best KING 5 stories on YouTube

    https://www.youtube.com/watch?v=videoseries

    Transfection Reagents and Equipment Market Exhibits Incredible Growth and Size, Future Innovations and Forecast

    Transfection Reagents and Equipment Market The research report is designed with a nice combination of industry insights, smart solutions, practical solutions, and latest technologies to provide better user experience. Under market segmentation, research and analysis is done on the basis of several market and industry segments such as application, vertical, deployment model, end user, and geography. To execute this market research, proficient and advanced tools and techniques have been used including SWOT analysis and Porter’s five forces analysis. Businesses can surely foresee reduced risk and failures with this market report.

    Data Bridge Market Research analyzes that the transfection reagents and equipment market will be worth USD 2.79 billion by 2029 and grow at a CAGR of 8.05% during the forecast period from 2022 to 2029. Transfection reagents and equipment will thrive with a growing awareness among patients about the benefits of advanced technologies. Transfection reagents and equipment are defined as electrostatic interactions used in transfection chemical reagents to connect to target nucleic acids and cell membranes. The oldest and cheapest method of delivering nucleic acids into cells is calcium phosphate.

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    Global Transfection Reagents and Equipment Market Scope and Market Size

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    • On the basis of product, the transfection reagents and equipment market is segmented into reagents, equipment
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    Transfection Reagents and Equipment Market Country level analysis

    The Transfection Reagents and Equipment market is analyzed and market size insights and trends are provided by country, product, method, application and end-user as listed above.

    The countries covered in the Transfection Reagents and Equipment market report are USA, Canada & Mexico North America, Germany, France, UK, Netherlands, Switzerland , Belgium, Russia, Italy, Spain, Turkey, the rest of Europe in Europe, China, Japan. , India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in Asia-Pacific (APAC), Saudi Arabia, United Arab Emirates, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

    North America dominates the transfection reagents and equipment market in terms of market share and market revenue and will continue to flourish its dominance during the forecast period. This is due to the increase in bio-based medical research, an increase in demand for protein treatments, and an increase in investment in the development of biologics in the country. Asia-Pacific, on the other hand, is expected to show the highest growth rate over the forecast period as population growth has been followed by lifestyle changes and adoption of new technologies.

    The country section of the Transfection Reagents and Equipment market report also provides individual market impacting factors and regulatory changes in the country market that impact current and future market trends. Data points such as consumption volumes, production sites and volumes, import and export analysis, price trend analysis, raw material cost, value chain analysis Downstream and Upstream are some of the major indicators used to forecast the market scenario for each country. In addition, the presence and availability of global brands and the challenges they face due to significant or rare competition from local and national brands, the impact of domestic tariffs and trade routes are considered while providing a forecast analysis of national data.

    Get details of report table of contents @ https://www.databridgemarketresearch.com/toc/?dbmr=global-transfection-reagents-and-equipment-market

    Some of the Major Key Players in the Industry:-

    Some of the major players operating in the transfection reagents and equipment market are Olympus Corporation, KLS Martin Group, B. Braun Melsungen AG, Medtronic, OmniGuide Holdings, Inc., Biolitec AG, Intuitive Surgical, Scanlan International, Getinge AB, Thermo Fisher Scientific Inc., Promega Corporation., QIAGEN, F. Hoffmann-La Roche Ltd, Bio-Rad Laboratories, Inc., MaxCyte, Inc., Lonza., Merck KGaA, Polyplus Transfection and Mirus Bio LLC. among others.

    Growth of health infrastructure Installed base and penetration of new technologies

    The Transfection Reagents and Equipment market also provides you detailed market analysis for each country, healthcare expenditure growth for capital goods, installed base of different product types for the Transfection Reagents and Equipment market , the impact of technology using lifeline curves and changes in healthcare regulation. scenarios and their impact on the Transfection Reagents and Equipment market. Data is available for the historical period from 2010 to 2020.

    Competitive Landscape and Transfection Reagents and Equipment Market Share Analysis

    Transfection Reagents and Equipment market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, research and development investment, new market initiatives, global presence, locations and production facilities, production capacities, company strengths and weaknesses, product launch, product breadth and breadth, application dominance. The data points above provided are only related to the companies focus on transfection reagents and equipment market.

    Browse In-Depth Research Report @ https://www.databridgemarketresearch.com/reports/global-transfection-reagents-and-equipment-market

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    About Data Bridge Market Research, Private Ltd

    Data Bridge Market Research Pvt Ltd is a multinational management consulting firm with offices in India and Canada. As an innovative and neoteric market analysis and consulting company with an unparalleled level of sustainability and advanced approaches. We are committed to uncovering the best consumer insights and fostering useful insights for your business to succeed in the marketplace.
    Data Bridge Market Research is the result of pure wisdom and practice that was conceived and incorporated in Pune in 2015. The company came into existence from the health department with far fewer employees having the intent to cover the entire market while providing best in class analysis. . Later, the company expanded its departments, as well as its reach by opening a new office in Gurugram in 2018, where a team of highly qualified personnel join hands for the growth of the company. “Even in the difficult times of COVID-19 where the virus has slowed down everything globally, the dedicated team at Data Bridge Market Research has been working around the clock to provide quality and support to our client base, which is also a testament to the excellence of our sleeve.”

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    A few suggestions as we enter hurricane season

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    Alex, Bonnie, Colin, Danielle, Earl, Fiona, Gaston, Hermine, Ian, Julia, Karl, Lisa, Martin, Nicole, Owen, Paula, Richard, Shary, Tobias, Virginia and Walter.

    These are the names to be given to hurricanes in the year of grace 2022.

    With a bit of luck, not a single one will leave a bad memory.

    No Camille, no André.

    Hurricanes have not always had predefined names.

    There was the 1873 hurricane that decimated Bluffton and the great Galveston hurricane that killed between eight and ten thousand Texans as it charged from the Gulf of Mexico on September 8, 1900.

    I remember 1942, the summer I rode a boat down Savannah’s 52nd Street after a most horrific hurricane knocked down many of the city’s ancient oak trees and caused the streets to flood at high tide, blocking the Savannah River sewers.

    The only warning we had of bad weather ahead was yellowing skies, no bird calls, and a local broadcaster who had heard another broadcaster in the hurricane’s path.

    If they could, the inhabitants of the outer islands evacuated to the mainland where we all collapsed, waited and endured.

    Notice there weren’t the energy efficient homes of today, nothing built of plywood and paper, casually reinforced with 2 by 4 lumber planks, sheet metal chimneys, and glass windows that were almost solid enough to resist a speed bullet.

    Homes of yesteryear were brick and mortar, single-glazed south-facing windows for evening breezes had wooden shutters, transoms and high ceilings encouraged air circulation.

    Solid construction.

    Some of the things we did then to deal with the oncoming storms apply today.

    “The more it changes, the more it is the same thing”, said Jean-Baptiste Alphonse Karr in 1849, stating the obvious.

    So can I offer a few suggestions as we enter the 2022 hurricane season.

    Pay attention to news broadcasts. TV weather forecasters love hurricanes. They’re all excited and follow that yellow spot and orange flare using words learned in Basic Weather Terms 101. They have no qualms bumping into each other “Jeopardy!” off the TV screen as they describe what happens on an island thousands of miles out in the Atlantic, showing palm trees shedding their leaves, rooftops blowing away and sailing into the afterlife, once calm aquamarine ocean waters whipped into foam. Downright scary.

    Know that they should be taken seriously when Jim Cantori shows up.

    For starters, even though gas prices are, well, expensive, consider Half Full your new Empty signal to fill up.

    If the hurricane exceeds category 2, even if you live in a solid house, consider leaving.

    If you live in a paper house. Leave.

    If you live where the road is higher than your driveway. Leave.

    If you live where the locals used to hunt with snake boots. Leave.

    Go early.

    Have an emergency plan before disaster strikes.

    If you have valuables, take them with you.

    The only photo of your great-aunt Susie who left you her collection of Confederate money? Bring the money.

    Deed of ownership, last will and testament, car registration, birth certificate, DD214, power of attorney, your checkbook, notarized certified hole-in-one verification. Good product. Put everything in the car. You may not need them, but you certainly won’t want to replace them. Battery? Bring them.

    Stop at the bank and get cash. Small bills.

    Don’t forget your medications and a way to refill your prescriptions.

    Understand that when you leave it may be a while before you are allowed to return, the electricity was probably off and whatever was left in the fridge spoiled and became the experimental laboratory of a biologist.

    Buy a paper map of South Carolina. If it doesn’t show where Estill is, don’t buy the map.

    Understand that there are dead spots in the countryside where there is no phone reception. Don’t panic. Continue west.

    If you stay behind, it’s a whole new ball game.

    Bring everything inside. Sandbag to divert water around the house. Climb the storm windows, fill the tub unless you plan to sit there rather than in the brick fireplace. Expect the electricity to go out. If you have a backup generator, good for you.

    Remember that if your generator runs on gasoline and not propane, you need to have fuel containers handy.

    Don’t have access to a gas stove? Get a portable butane stove, manual can opener and matches.

    And you’ll want to have battery-powered lamps, candles, a portable radio, a hatchet, a sense of humor, a super dose of patience, and faith in God.

    Go or stay.

    It’s the Lowcountry.

    Hurricanes or gentle breezes, you gotta love it.

    Annelore Harrell lives in Bluffton and can be reached at anneloreh@aol.com.

    How do Caribbean fire corals thrive while others disappear? | Science

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    Fire corals can be the bane of a diver’s existence. Accidental contact with one of them can cause excruciating pain. But they can also help save Caribbean reefs, which have been plagued by hurricanes, global warming, disease and an overabundance of algae. A long-term study found that fire corals (Millepora) are thriving there even as other corals are disappearing and could help preserve some of the 3D environment that helps make reefs such beautiful homes for fish and other organisms.

    Fire corals “are going to be very important habitat providers because they’re able to survive under those stresses,” says Colleen Bove, a marine ecologist at Boston University who wasn’t involved in the work.

    Thirty years ago, Peter Edmunds began conducting annual underwater life surveys off St. John, one of the US Virgin Islands. California State University marine biologist Northridge traced a 20-meter transect along an underwater reef. Each summer he photographed what grew there, including a 40-meter widened transect.

    By analyzing the abundance of each organism in these “photoquadrats”, Edmunds traced how algae and various corals have withstood hurricanes, warming sea temperatures and other environmental stresses. “What he did is really remarkable,” says Caroline Dubé, a marine biologist at Université Laval who studies the plasticity of Pacific fire coral. “There’s so much disturbance to coral reefs that it’s something that needs to be done more.”

    Fire corals look like typical hard corals but are actually close relatives of jellyfish; hence their nasty sting. They have the ability to grow either as leaves—spreading like a flat covering over rocks and other surfaces—or as “trees,” growing upwards with a stem and branches. More than 40 years ago, Jeremy Jackson, an ocean biologist at the American Museum of Natural History and the Smithsonian Tropical Research Institute, proposed that this plasticity would give fire corals an advantage as Caribbean reefs experience global warming. and hurricanes. Edmunds now concludes that Jackson was right.

    Overall, Edmunds’ long-term data indicates that many types of multicellular algae called macroalgae have invaded Caribbean reefs. But if hurricanes or other factors destroy macroalgae, fire corals move quickly and encrust surfaces, Edmunds reports today in the Proceedings of the Royal Society B. When the reef is crowded, the coral grows in its branching tree form, so it can continue to thrive in tight spaces and provide vertical structure for other organisms to nibble, live on, or otherwise use.

    Periodically, unusually warm water causes corals to lose their green algal partners and die, setting the stage for macroalgae to re-establish themselves. Hurricanes also blow on the branches of the tree. But fire coral is quickly coming back in one form or another, Edmunds found. Thus, this coral was able to maintain itself and even increase a little in abundance.

    “Their stony coral buddies don’t do a great job with leaf and tree production,” Edmunds says. “So in a world with frequent storms and fierce competition for bottom space, fire corals are poised to inherit shallow reefs.”

    Jackson is thrilled: “Edmunds’ remarkable persistence has allowed him to witness the ups and downs of fire coral dynamics.” Unfortunately, Edmunds’ data also shows that other corals are becoming increasingly rare. “Millepora could replace them as they decline due to marine heat waves and coral bleaching,” says Jackson.

    This may still be bad news for reefs in general. Nikolaos Schizas, a marine scientist at the University of Puerto Rico, Mayagüez, warns that fire corals may not save reefs because they don’t usually form reefs several meters high and wide. “We have to be realistic about the magnitude of that potential,” says Schizas.

    Edmunds’ data also reveals that fire corals have been repeatedly toppled by hurricanes and other disturbances, points out Terry Hughes, marine scientist at the Australian Research Council’s Center of Excellence for Reef Studies. corals. “But the study strongly suggests that they will fare better than the majority of corals.”

    Ninety-Three Sun Devil Student-Athletes Named to Spring Pac-12 Academic Honor Roll

    SAN FRANCISCO — Ninety-three Sun Devil student-athletes were recognized for classroom excellence on Tuesday, as the Pac-12 announced their Spring 2022 Academic Honor Roll.

    Any student-athlete on their respective team roster with a GPA of 3.3 or higher and who has served at least one year in residence at the facility, is eligible for the honor.

    The Spring 2022 Academic Honor Roll includes 1,097 student-athletes who competed in the
    Sports sponsored by the conference of baseball, beach volleyball, men’s and women’s golf,
    lacrosse, men’s and women’s rowing, softball, men’s and women’s tennis, and men’s and women’s outdoor track and field.

    As approved by conference athletic faculty representatives, any student-athlete participating in an NCAA-sponsored sport or emerging at a Pac-12 institution, regardless of league sponsorship, is also eligible for recognition. of the academic honor roll and includes 122 student-athletes from the spring sports like acrobatics and tumbling, men’s lacrosse, men’s volleyball and women’s water polo.

    Below is the list of Arizona State winners along with their major field of study.

    Baseball (7)
    Nate Baez (Finance)
    Christian Bodlovich (Interdisciplinary Studies)
    Kade Higgins (Liberal Studies)
    Luc La Flam (Finance)
    Danny Marshall (Accounting)
    Graham Osman (Finance)
    Brock Peery (Corporate Entrepreneurship)

    Beach volleyball (12)
    Taryn Ames (Marketing)
    Malina Baker (Social and Behavioral Sciences)
    Lila Bordis (Biological Sciences)
    Kate Fitzgerald (Biomedical Science)
    Cierra flood (Tips)
    Cambria Room (Corporate Entrepreneurship)
    Maria Kowal (Biomedical Science)
    Mady Salazar (Marketing)
    Lexi Sweeney (Company – Sports Company)
    Sarah Waters (Communication)
    Ivey Weber (Special education and primary education)
    Lauren Weintraub (Marketing – Professional Sales)

    Men’s Golf (6)
    Ryggs Johnston (Management)
    James Leow (Finance)
    jeewon park (Company – Sports Company)
    David Puig (Communication)
    Cameron Sisk (Company – Sports Company)
    Preston Summerhays (Communication)

    Women’s Golf (5)
    Alessandra Fanali (Company – Sports Company)
    Alexandra Forsterling (Interdisciplinary Studies)
    Amanda Linnier (Management)
    Breyana Matthews (Kinesiology)
    Ashley Menne (Company – Sports Company)

    Women’s Lacrosse (17)

    Katie Brodsky (Clinical Exercise Science)

    Kaylon Buckner (Applied Business Data Analysis)

    Rosie Davis (sports journalism)

    Bella Gaspar (Mechanical Engineering)

    Gigi Gaspar (Finance)

    Brynn Holohan (Criminology and criminal justice)

    Olivia Hood (Interdisciplinary Studies)

    Tess Keizer (Journalism and mass communication)

    Olivia Kroah (Nutrition – Human Nutrition)

    Grace Lilla (Business – Healthcare)

    Paige McGlothlin (Health services)

    Flynn Murphy (Company – Sports Company)

    Sydney Payne (Chemistry)

    Mina Scott (Bio Science – Neurobio Physiology & Behavior)

    Kaitlyn Skamas (Company – Sports Company)

    Lindsey Spies (Company – Sports Company)

    Anna Winkeler (Biochemistry)



    Men’s Outdoor Athletics (13)

    austin cox (Kinesiology)

    Joseph Dicke (MS in Computer Science)

    Wyatt Hanson (Electrical engineering)

    Hunter Kasprzyk (Finance)

    Ian Kebenei (Aerospace Engineering – Aeronautics)

    Dylan Kingston (Management)

    Luke Mason (MS in Computer Science)

    Connery McLaughlin (Chemical Engineer)

    Adam Meyer (Liberal Studies)

    Ian Schulz (Ungraduated graduate student)

    Jared Tracy (BS communication)

    TurnerWashington (Sports & Business Law)

    Jesper Wolski (Kinesiology)



    Women’s Outdoor Athletics (12)

    Gracie Carr (Kinesiology)

    Taryn Hankins (Feeding with milk)

    Sevanna Hanson (Kinesiology)

    Alona Johnson (Psychology – BS)

    Jenna Lee (Business Data Analytics)

    Beatrice Llano (Management of the organization)

    Kristen Masucci (Biological Sciences)
    Alizée Minard (Liberal Studies)

    Caitlin Rose (Feeding with milk)

    Haley Smith (Medical Microbiology)

    Jorinde van Klinken (Global Management – Global Trade)

    Christina Warren (Medical Microbiology)



    Softball (4)
    Yannira Acuña (liberal studies)

    Makenna Harper (Communication)

    Jazmine Hill (Psychology)

    Bella Loomis (Psychology – MA)



    Men’s Tennis (6)

    Spencer Brachman (Company – Sports Company)

    Moritz Hoffman (Business communication)

    Christian Lerby (Liberal Studies)

    Max McKennon (Company – Sports Company)

    George Stoupe (Company – Sports Company)

    Jonas Wilson (Economy)



    Women’s tennis (4)

    Marianna Argyrokastriti (Business communication)

    Natasha Hill (Company – Sports Company)

    Giulia Morlet (Company – Sports Company)

    Dominique Turkovic (Psychology – BS)



    Women’s water polo (7)

    Itzahiana Baca (Neuroscience / Minor: Psychology)

    Alison Cameron (Company – Sports Company)

    Emma Fraser (Justice Studies / Minor: Women’s and Gender Studies)

    Lara Kiss (Psychology – BS and Sociology – BS)
    Alba Olivé Martí (Art – Animation / Minor: Film and Media Production)

    Tarah Schaffer (Biological Sciences – BS / Minor: Psychology)

    Emilie Van Zonneveld (Criminology and Criminal Justice / Minor: Psychology)

    Participate now in our annual competition of the 10 best innovations!

    Owhat are you waiting for?

    Submissions to The scientistThe annual Top 10 Innovations competition is due to take place by July 18th, and that’s next Monday!

    Our annual competition showcases the most transformative advances in life science techniques and products. From game-changing sequencing technology to new variations of proven methods, the Top 10 innovations represent cutting-edge technologies poised to propel biomedical research forward. We want to hear from you: Whether you’re an individual tinkering on the bench or a company with a dedicated R&D team, tell us what you’ve brought to market in the last year that could benefit the science of life.

    Take two minutes to submit your product or technique for consideration in this year’s competition. The application consists of a short questionnaire, and the submission window will close on Monday, July 18, so register now!

    We started the Top 10 Innovations competition over a decade ago, and over the years we’ve celebrated some great products. Last year, our independent panel of expert judges selected the winning technologies which included a miniaturized microscopy platform, a microfluidic organ-on-chip, a single-cell spatial genomics instrument, and a CRISPR-based SNP detector. As we’ve seen over the past few years, our Top 10 Innovation winners don’t just cause a stir when they take the stage, they tend to have a lasting and profound effect on research and often on public health. .

    We look forward to seeing what products you bring to our attention this year. Just make sure the product you enter was released after August 1, 2021.

    To learn more about the history of our Top 10 Innovations competition, read more about previous winners.

    Worms as a model of personalized medicine

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    Use of four unrelated strains of the microscopic nematode C.elegans Hailing from different parts of the world, a group of worm biologists have developed a model system to study individual differences in metabolism. The use of C.elegans, a widely studied model organism, allowed the team to study the unique and complex interplay between genetics, diet, microbiota and other environmental factors that can affect fundamental metabolic processes in different individuals. This advance represents a potentially important step towards “personalized” or “precision” medicine, a relatively new discipline that tailors dietary advice and disease treatment to an individual’s genome sequence.

    The research, by Marian Walhout, PhD, the Maroun Semaan Chair in Biomedical Research and President and Professor of Systems Biology at UMass Chan Medical School and collaborators Erik Andersen, PhD, of Northwestern University and Frank Schroeder, PhD, of Cornell University, published in Natureidentifies a new metabolic condition related to the variation of hphd-1 gene from a strain of C.elegans found on the Big Island of Hawaii. The strain, known as DL238, exhibits abnormal accumulation and secretion of the metabolite 3-hydroxypropionate (3HP). Additionally, this strain was found to generate a set of novel metabolites that have 3HP conjugated to several amino acids. These new metabolites are not found in the laboratory strain used for decades to make fundamental biological discoveries. By conjugating 3HP to amino acids, DL238 removes 3HP, which is toxic at high concentrations.

    “This work is an important step toward developing metabolic network models that capture individual-specific differences in metabolism and more closely represent the diversity found across entire species,” Walhout said. “Using this system, we can begin to study interindividual metabolism and the unique interplay of metabolites, diets and environments at the individual level.”

    When the human genome was sequenced, clinical researchers envisioned an era where our personal genomic information could be used to tailor medical treatments to each individual’s needs, Walhout explained. Despite the completion of the Human Genome Project in 2003 and advances in genomics and deep sequencing technologies, personalized medicine remains more promising than reality.

    Part of the challenge in developing personalized medicine is that our DNA is only part of human health; an individual’s diet and environment both have a profound impact on metabolic processes. And because no two individuals have exactly the same diet, it is tedious to untangle the complex interplay of genetics, diet and environment and relate them to variations in metabolism. In addition to sequencing individual genomes, scientists would need to replicate metabolic measurements in people of the same age and gender, who ideally would also consume the exact same diet and experience identical environments.

    To meet this challenge, Walhout, a leader in gene metabolism and expression research, teamed up with Dr. Andersen, a quantitative genetics expert, and Dr. Schroeder, a chemist, to develop a system comparative study of interindividual variations in metabolism.

    The group designed a system where environmental conditions and diet were constant among “individuals” with variable genomes, just as our genomes vary from person to person. To do this, the four distinct strains of C.elegans with fully sequenced genomes – including the standard laboratory strain, two from Hawaii and another from Taiwan – were grown under identical conditions: each strain was grown at the same time in the same incubator and fed the same diet .

    “Each strain represents an individual,” said Olga Ponomarova, PhD, postdoctoral researcher at the Walhout lab and co-author of the study. “We collected around 100,000 animals from each strain and because they are all raised under the same conditions, given the same diet and have the same genome, it is possible to explore how the genetic differences between the four strains affect the metabolism. It’s like comparing four different people.”

    Basically, metabolism is the set of chemical reactions essential to the maintenance of life in organisms. The three main purposes of metabolism are: the conversion of food into energy for cellular processes; the conversion of food into building blocks for proteins, such as lipids, nucleic acids and some carbohydrates; and disposal of the waste generated by these two processes.

    A series of experiments including gas chromatography-mass spectrometry, high performance liquid chromatography-mass spectrometry and metabolic network analysis were performed and analyzed to identify possible differences and variations in metabolites among the four strains. As a result, over 20,000 probable metabolites, the small molecules that collectively effect metabolism, have been detected, most of which remain unknown.

    When the researchers compared the presence of metabolites between the four strains, they found over 200 metabolites that were highly specific to one of the strains. One metabolite, 3HP, was found in exceptionally high abundance in strain DL238 from Hawaii. Previous studies from the Walhout lab have shown that high levels of 3HP are found in nematodes whose diets are low in vitamin B12. These studies have shown that 3HP is formed during the breakdown of propionate via a B12-independent metabolic pathway, or shunt. 3-HP is then metabolized by the enzyme HPHD-1 and finally converted into acetyl-CoA.

    In the current study, researchers were able to trace the abundance of 3HP molecules in strain DL238 to a variation of the hphd-1 gene, which allows 3HP to build up. To compensate for the extra 3HP, the DL238 C.elegans developed a mechanism to “shunt” the excess molecule out of animal cells by associating 3HP with amino acids. This prevents the 3HP molecule from growing to toxic levels and may be an adaptation to changing nutrient conditions, according to Walhout, who called the system “a shunt within a shunt.”

    The study shows the power of evolution towards a pan-species metabolic network model for in-depth biological investigations. “We’re just beginning to scratch the surface,” Walhout said. “Our study only uses four strains, but the next step is to see what we find when we look at 100 different strains. Or what happens when we use the same strain but vary the diets.

    “We’ve put together a really robust model to measure metabolic variation between individuals,” Walhout said. “What made this possible, more than anything, was our unique, multidisciplinary collaboration. It was the expertise that each lab brought to this project that enabled this discovery.”

    The pandemic and retirements are fueling the shortage of substitute teachers in the state

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    In summary

    In years past, finding enough substitute teachers in California high schools was not a daily struggle. Now they are in high demand.

    Improving our democracy, together.

    $7,854 raised toward our goal of $50,000



    By Hope Gorecki, special for CalMatters

    Hope Gorecki is a former San Diego Unified School District English teacher who works as a substitute teacher at San Diego District and Grossmont High Schools.

    It’s 7 a.m. on a Wednesday morning after winter break at Monte Vista High School in Spring Valley, Calif., one of several high schools in the Grossmont Union School District.

    The principal’s secretary printed out color-coded spreadsheets of the day’s substitute schedule — orange for me, fuchsia for another substitute, green for MH, light blue for MS, and so on. We are still six substitute teachers short when the phone rings and another teacher calls for the day.

    We are now short of seven replacements, with a total of 15 absent teachers.

    Secretary changes what she calls her ‘daily puzzle’ for the third time, moving substitutes to cover necessary classes, asking those who can to stay late, asking regular teachers if they’re willing to quit during their periods of preparation to cover another teacher’s class.

    Later, I’ll be running – literally – across campus in a biology class to fill in for a specialist teacher. I will meet another substitute who does brisk walking, having given up his preparation period to replace a physical education class. To make matters worse, the librarian is absent, so the school will have to close the library, the place where too many students are corralized when there is no replacement to cover a class.

    Sadly, this is not an isolated event, but an all too common pandemic-induced event, not just at this high school, but in high schools across California. In years past, finding enough substitute teachers was not a daily struggle. Now, it seems every substitute teacher is in high demand.

    As one of three resident substitute teachers on site this year, I have been fortunate to be part of the school community, on the front lines of education during COVID-19 and then the pandemic. omicron. But it is not just teachers who call themselves ill that contribute to absenteeism; some lacked childcare due to new COVID restrictions.

    Before the pandemic, it was not uncommon for parents to send their children to school with sniffles, as long as they didn’t have a fever. But during the pandemic, a runny nose would send little ones straight home, keeping the working parent at home as well. I have often heard of the frustrations of teachers who were forced to lose another sick day due to what seemed like a perpetual cycle of sniffles.

    In my experience, most substitute teachers – perhaps 60% – are older adults, many of whom are retired teachers or other professionals. In just one week, I met a former physics teacher, a retired civil engineer, a published author, a retired physical education coach, and a former English teacher. Elders have learned the need for patience, which gives them the advantage of rarely being agitated by the emotional transitions of adolescents.

    Yet everyone has their tipping point. Between the health risk of working during the pandemic and the surprising new social and emotional adjustment that so many students have faced after a long school quarantine, many of our replacements have decided to quit. Some have moved to more affordable states, creating a wider surrogate shortage

    As for younger supply teachers, teaching is a good opportunity for those in the teacher certification program to gain both work experience and income. It’s also a good way to increase your visibility once you’ve completed the program and hope to be hired as a permanent teacher. According to Education Week, enrollment in the teacher certification program has plummeted, so we’ve lost a lot of that population to the subgroup.

    What can be done to replenish this vital but dwindling population of certified employees? Certainly, the well-deserved salary increase over the past year has been appreciated. But how about drastically reducing the California Commission on Teacher Credentialing’s 30-day supply teaching permit application fee — which is $102.50 — so as not to deter people initially? For those who renew their license every year, the fee should be waived altogether.

    We are in a new era that emphasizes treating others with kindness and equality. It is true that during the pandemic, substitute teachers have been more recognized. It’s amazing how encouraging a genuine “thank you for being here” can be. This is a step in the right direction, and I hope these courtesies continue. After a very stressful year, schools have realized how valuable substitute teachers are.

    For my part, I will continue this journey. Now if only my ride was cheaper.

    Little Squaw Creek underpinned by project in township | News, Sports, Jobs

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    Staff Photo / Bob Coupland Judith Mitchell, Senior Project Manager and Biologist at Davey Resource Group in Kent, left, and Liberty Trustee Arnie Clebone stand on the side of Little Squaw Creek in Churchill Park where work was carried out this summer and were also done in 2021 to improve the creek, which had safety issues due to erosion.

    FREEDOM – In response to erosion issues along Little Squaw Creek in Churchill Park that have created safety concerns, township officials have approved the second phase of the project for this summer. Work began in 2021.

    Little Squaw Creek runs through Liberty, coming from under State Road 193 near Giant Eagle in Churchill Park, then to Girard.

    Township administrator Arnie Clebone said the western section, which is downstream, was completed in 2021 and the eastern section, which is upstream, is underway this summer.

    “This project was carried out to preserve the integrity of the stream. Over the years, the park road began to erode the creek, undermining it and creating a safety issue,” he said. Officials were concerned that erosion on the creek side could cause the road to collapse.

    Rocks were placed in parts of the creek to improve flow and prevent erosion, Clebone said.

    Officials said the first phase would cost $250,000 and the second would cost nearly $300,000. Matching funds from the Ohio Public Works Commission’s Clean Ohio grant covered most of the project costs for both phases.

    Clebone said Liberty was to contribute 25% of the cost.

    He said township administrators were made aware of the erosion problem in the park last year by resident Jeff Smith, who worked for CT Consultants.

    Judith Mitchell, senior project manager and biologist at Davey Resource Group in Kent, said the company had carried out the environmental plans and monitoring work for the project.

    The project contractor was Gary Moderalli Excavating, who moved the rocks.

    Mitchell said the flow has changed over the years, “winding” through the park. This project, she says, will help stabilize it for a long time.

    She said creek erosion was a concern due to a power line base and nearby ball diamonds.

    “There were different sections of the creek that were eroding and causing a problem. Some sections were messy,” Mitchell, indicating that efforts have been made to protect not only the public using the park, but also the wildlife.

    “Erosion causes a lot of water quality degradation. This affects fish and frogs which find it difficult to live in the creek when mud from storm water enters it,” she says.

    Clebone said protecting water quality is also important.

    Mitchell said the main part of the construction is nearing completion and grass should be planted in the fall.

    Photos of the creek before the work was completed showed where the sides had eroded and where the ball pits were falling. Some sections were wider at 6-7 feet and deeper at 5 feet.

    Work has also been done on the small creeks that flow into Little Squaw Creek. Mitchell said a lot of water got stuck in a floodplain and quickly poured into the creek after heavy rains.

    Mitchell said the stream is like a bowl and a bowl can only hold so much. She said a normal thunderstorm fills the bowl, but a heavy thunderstorm causes it to overflow.

    Excess earth from the project has been placed in a separate area of ​​the park, creating a slope on a hill that will allow for sledding. The remaining stones were placed on the sides of the stream, creating a natural buffer. Benches have been placed on the sides of the stream as well as explanatory panels on the plant life.



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    Nuclear war would rewire the physical, biological and ecological states of the ocean – Eurasia Review

    Even the smallest nuclear war would devastate ocean systems, causing sharp declines in fish stocks, expanding ice caps in coastal communities and changes in ocean currents that would take decades or more to reverse, according to a Rutgers researcher and an international team of geoscientists. , led by Cheryl S. Harrison at Louisiana State University.

    “Our model is the first large-scale effort to quantify the effects of nuclear war on the oceans,” said Alan Robock, professor emeritus of climate science in the Rutgers Department of Environmental Sciences. and co-author of the study published in the journal American Geophysical Union Advances AGU.

    To model marine responses to nuclear conflict, Robock and his colleagues simulated a major US-Russian war and several smaller Indo-Pakistani wars. By examining the four countries’ nuclear arsenals and potential targets, the researchers calculated how much soot would be dispersed through the atmosphere by the resulting firestorms and block out the Sun.

    The researchers then used the Community Earth System Model (CESM), a climate simulation tool supported by the National Center for Atmospheric Research, to determine the short- and long-term effects of atmospheric soot on ocean functions.

    In the US-Russian War Scenario, shortwave solar radiation was reduced by 70% and the global average surface temperature decreased by 7 degrees Celsius (12 degrees Fahrenheit) in the first few months, with more extreme cooling in the northern hemisphere. In turn, the Arctic sea ice expanded by 10 million square kilometers (4 million square miles), covering more than 50% more area, including normally ice-free coastal regions that are important for fishing, aquaculture and shipping.

    In all scenarios – from the detonation of a hundred warheads to thousands – the ocean “does not return to the pre-war state when the smoke clears”, according to the study. “Instead, the ocean takes decades to return to normal, and parts of the ocean would likely remain in the new state for hundreds of years or more.”

    Along with expanding sea ice and developing what researchers call a “little nuclear ice age,” the cooling would alter ocean currents, upend ocean macronutrients, and deplete fish stocks by about 20 percent. during the first decade after the war.

    “A nuclear war would be a significant planetary tipping point,” Robock said. “With Russia at war with Ukraine and President Vladimir Putin threatening to use nuclear weapons, these findings are a strong warning that the world simply cannot go down this path.”


    Eye stimulation promises ‘remarkable’ treatment for depression and dementia

    According to new research, electrical stimulation of the surface of the eye can alleviate depression-like symptoms and improve cognitive function in animal models.

    Researchers discover noninvasive eye stimulation for depression and dementia.

    Scientists have found that electrical stimulation of the surface of the eye can alleviate depression-like symptoms and improve cognitive function in animal models. These important findings from a joint research team of LKS Faculty of Medicine, University of Hong Kong (HKUMed) and City University of Hong Kong (CityU) were recently published in brain stimulation and the Annals of the New York Academy of Sciences.

    Background

    Major depression is the most common serious psychiatric disorder in the world. Recently, the World Health Organization (WHO) reported that the COVID-19 pandemic has triggered a massive increase in the number of people suffering from depression and anxiety. About 25% of patients do not respond adequately to currently available treatments.

    In 2015, Dr. Lim Lee Wei, assistant professor at the School of Biomedical Sciences, HKUMed, and former researcher Lee Kuan Yew in Singapore, reported that deep brain stimulation of the prefrontal cortex in animal brains could alleviate depressive symptoms. and improve memory function. These therapeutic effects have been attributed to the growth of brain cells in the hippocampus, a region of the brain known to be involved in learning and memory functions. However, this technique, also known as deep brain stimulation, is invasive and requires surgery to implant electrodes inside the brain, which can lead to significant side effects such as infections and other complications. postoperative.

    Noninvasive eye stimulation for depression and dementia

    A joint research team from LKS Faculty of Medicine, University of Hong Kong (HKUMed) and City University of Hong Kong (CityU) has found that electrical stimulation of the surface of the eye can alleviate depression-like symptoms and improve cognitive function in animals. models. Members of the research team include (from left to right): Professor Chan Ying-shing, Dexter HC Man Family Professor of Medical Sciences, Professor of the School of Biomedical Sciences, Associate Dean (Development and Infrastructure), HKUMed and the Director of the Neuroscience Research Center, HKU; Dr. Leanne Chan Lai-hang, associate professor in the Department of Electrical Engineering, CityU; Yu Wing-shan, PhD student, School of Biomedical Sciences, HKUMed and Dr. Lim Lee Wei, Assistant Professor, School of Biomedical Sciences, HKUMed.

    Search Results and Meaning

    A team of researchers from Hong Kong has been looking for alternative ways to treat neuropsychiatric illnesses. They found that noninvasive stimulation of the corneal surface of the eye (known as transcorneal electrical stimulation, or TES) that activates brain pathways, resulted in remarkable antidepressant effects and reduced stress hormones in an animal model. of depression. Moreover, this technique also induces the expression of genes involved in the development and growth of brain cells in the hippocampus. This team of researchers is led by Dr. Lim Lee Wei; Dr. Leanne Chan Lai-hang, associate professor in the Department of Electrical Engineering, CityU; Professor Chan Ying-shing, Dexter HC Man Family Professor of Medical Sciences, Professor in the School of Biomedical Sciences, Associate Dean (Development and Infrastructure), HKUMed and Director of the Center for Neuroscience Research, HKU.

    In related experiments, doctoral student Yu Wing-shan and other research members from the School of Biomedical Sciences, HKUMed, investigated whether this approach could be used to treat Alzheimer’s disease, a common type of dementia with no definitive cure. They found that this noninvasive stimulation in mice significantly improved memory performance and reduced beta-amyloid deposits in the hippocampus, which is one of the hallmarks of Alzheimer’s disease.

    Dr. Leanne Chan Lai-hang, an expert in electrical stimulation of visual and non-visual brain targets, described the research: “Transcorneal electrical stimulation is a non-invasive method originally developed to treat eye disease, and it would be a major breakthrough. scientific breakthrough if it could be applied to treat neuropsychiatric diseases.

    “These research results pave the way for new therapeutic opportunities to develop a new treatment for patients suffering from treatment-resistant depression and dementia. Nevertheless, clinical trials need to be conducted to validate the efficacy and safety,” Professor Chan Ying-shing remarked.

    About the research team

    The research was led by Dr. Lim Lee Wei, Assistant Professor in the School of Biomedical Sciences, HKUMed and former Lee Kuan Yew Research Fellow in Singapore; Dr. Leanne Chan Lai-hang, associate professor in the Department of Electrical Engineering, CityU; Professor Chan Ying-shing, Dexter HC Man Family Professor of Medical Sciences, Professor in the School of Biomedical Sciences, Associate Dean (Development and Infrastructure), HKUMed and Director of Center for Neuroscience Research, HKU; and conducted at HKU’s Neuromodulation Lab in collaboration with CityU at the Neural Interface Research Lab. Yu Wing-shan was the lead researcher. She is the recipient of a prestigious Hong Kong PhD scholarship, awarded by the Hong Kong Research Grants Council.

    Thanks

    This scientific work was supported by the General Research Fund of the Hong Kong Research Grants Council (No. 17119420 and No. 11208218), the Fund for Basic Research (No. 201811159133 and No. 201910159163) and for Research Translational and Applied, No. 201910160010); and the CityU Strategic Research Fund (#7005632).

    References:

    “Antidepressant-Like Effects of Transcorneal Electrical Stimulation in Rat Models” by Wing Shan Yu, Anna Chung-Kwan Tse, Li Guan, Jennifer Lok Yu Chiu, Shawn Zheng Kai Tan, Sharafuddin Khairuddin, Stephen Kugbere Agadagba, Amy Cheuk Yin Lo, Man-Lung Fung, Ying-Shing Chan, Leanne Lai Hang Chan and Lee Wei Lim, May 27, 2022, brain stimulation.
    DOI: 10.1016/j.brs.2022.05.018

    “Transcorneal Electrical Stimulation Enhances Cognitive Function in Aged and 5XFAD Mouse Models” by Wing Shan Yu, Luca Aquili, Kah Hui Wong, Amy Cheuk Yin Lo, Leanne Lai Hang Chan, Ying-Shing Chan, and Lee Wei Lim, 25 June 2022, New York Academy of Sciences.
    DOI: 10.1111/nyas.14850

    WHRY Undergraduate Scholars Pursue Our Mission

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    Since 2015, Women’s Health Research at Yale has mentored 25 undergraduate students and counting. Along with our young faculty and graduate students, they learn crucial lessons about women’s health and sex and gender differences in health with them as they continue their education and begin their careers. Here is a sampling of what our alumni are up to now.

    Nafeesa Abuwala, ’19

    As a WHRY Fellow, Nafeesa worked with the Mental Health Outreach for MotherS (MOMS) partnership to help implement a culturally sensitive program for immigrant mothers and their children to overcome barriers to care.

    In 2020, she completed her Masters in Public Health through the five-year BA/BS-MPH program at the Yale School of Public Health. For the past two years, she has worked as a postgraduate fellow in the laboratory of Dr. Hugh Taylor, chair of the Department of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine. She has contributed primarily to research on reproductive endocrinology and fertility, focusing on the biology of the uterus.

    Before applying to medical school, Nafeesa will spend a year conducting public health research remotely with one of her mentors, exploring the benefits of peer counseling and breastfeeding in underprivileged communities. financial ressources.

    She credits WHRY and MOMS for helping shape her career goals to become an obstetrician-gynecologist with a strong connection to community and research to achieve social justice.

    “I benefited from being around other female scientists who felt the same way or had similar interests,” she said. “They felt confident in what they wanted to do in a way that gave me confidence in what I wanted to do. And that’s to advocate for patients and make sure they have agency when it is their own body.

    With WHRY, Nafeesa practiced her Spanish language skills while conducting and transcribing interviews and organizing data for qualitative research projects with MOMS. She said the experience cultivated skills that she will continue to use as she pursues her goal of becoming a public health-focused physician and helping improve access to healthcare for people. marginalized. Particularly women.

    “One thing that I really loved about our WHRY Fellowship roundtables was speaking critically about the gaps in our health science regarding women,” she said. “It was eye-opening at the time and a critical conversation that we all need to have.”

    Anjali Walia, ’21

    Anjali’s time at WHRY helped inform her decision to pursue a career in women’s health. She recently completed her freshman year at the University of California, San Francisco School of Medicine, where she is considering a specialty in obstetrics and gynecology and is conducting research to see if pregnant patients with severe preeclampsia should undergo a trial of labor.

    “I am very grateful to WHRY for focusing my interest in the area of ​​women’s health, especially as it extends far beyond reproductive health,” she said, noting that medical education does not always include evolving knowledge about how sex and gender influence so many people. aspects of biology and behavior. “I spoke to clinicians about possible research into sex and gender differences affecting conditions that don’t strictly involve female organs.”

    In addition, Anjali also sought outlets for the science communication skills she developed while writing for WHRY’s student blog. At UCSF, she joined a writing group and volunteered for a podcast dedicated to sharing the voices of healthcare providers through storytelling. She began coordinating an elective for students to serve as health coaches for inpatients at San Francisco General Hospital. And she explored opportunities with a group working to integrate sex education into the curriculum for medical school professional staff.

    Ke’ala Akau, ’22

    Last fall, Ke’ala began classes toward a master’s degree in public health through a five-year BA/BS-MPH program at the Yale School of Public Health. She focuses her studies on social and behavioral sciences as well as social justice and health equity.

    “As someone who wants to become a doctor, I think it’s important to understand the social determinants of health,” she said. “How does history influence the factors that create health disparities? »

    Last summer, she received a competitive scholarship for a scholarship with Downtown Soup Kitchen in New Haven, in collaboration with Executive Director Steve Werlin. Her work included writing and tracking grants, developing a social media strategy, and contributing to and writing the nonprofit’s newsletter.

    Ke’ala plans to take a year off before entering medical school, possibly working with a community organization while conducting research.

    “I’ve embraced what’s called community-based participatory research,” she said, noting how WHRY works with the policy lab. raise and its local collaborators. “It can be very helpful to involve community partners in every step of the process, from choosing study topics to analyzing and disseminating the results.”

    As a communications officer at WHRY, she explored the importance of inclusive language and policies to increase access to menstrual products. And while she’s not sure exactly where her career might take her, she imagines those skills will remain invaluable.

    “For physician leaders within health systems, communication is a big part of their role,” she said. “Whether it’s talking to a patient at the clinic, making an announcement, or advocating for a cause in the community. It is important that people have the information they need to make decisions about their health.

    Cecilia Crews, ’19

    Cecilia has just completed her first year as an MPH student at Columbia University’s Mailman School of Public Health in New York City. She is spending the summer in Ghana working on a research project evaluating a new emergency response system in the northern region of the country.

    “My public health interests have changed a lot over the years, certainly with the help of WHRY,” she said. “I’m interested in the systems that underpin these vertical programs, like HIV treatment or malnutrition. With my degree, I want to build stronger health systems in countries that are striving to expand beyond an aid relationship with the international community. Promote more sustainability in their health system.

    Her experience helping WHRY integrate sex and gender research findings into the medical school curriculum has continued to shape her thinking.

    “It needs to be integrated into every conversation,” she said. “Women’s health and the role that sex, gender, race and ethnicity play in health. To better prevent and treat diseases and conditions, we need to understand the social determinants of health. »

    This summer will mark Cecilia’s second service-related trip to Africa. Before the pandemic forced her to return home, she worked as a maternal and child health volunteer with the Peace Corps in Rwanda. Even though her plans take her far, her thoughts often return to her time with WHRY at home, working with WHRY Director Carolyn M. Mazure, PhD, and her mentor on the program project, Dr. Njeri Thande.

    “In the women’s health sections of public health classes, we might learn facts about women’s health status and not necessarily feel empowered or optimistic that the world can change,” he said. she declared. “But at WHRY, I learned to be more than an advocate. They helped me see what needed to change and take action.

    Nardos Kebede, ’20

    As a WHRY Fellow, Nardos Kebede worked in the behavioral neuroscience lab of Dr. Nii Addy, Associate Professor of Psychiatry, focusing on sex and gender differences in the neurobiological mechanisms of depression and addiction processes. After graduating, she spent the last two years in Dr. Addy’s lab advancing this work, including projects exploring gender differences in the effects of chronic stress exposure.

    “Before my fellowship with WHRY, I had some exposure to how research was conducted,” she said. “But the fellowship, that long lab time, and having mentors focused on women’s health has helped me articulate what’s missing and what kind of research I want to do.”

    In August, Nardos will begin a doctoral program in neuroscience at Emory University in Atlanta.

    “To move forward in my academic career, I really want to conduct studies where sex and gender are a primary focus of analysis and not just an afterthought,” she said. “I’m happy to be in this field and that others are moving in this direction.”

    Can an animal recognize its reflection? New studies overturn old ideas

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    In 2021, Bunny, a famous Sheepadoodle on TikTok, looked in a mirror and asked “who is that?” tapping his paws on the buttons on his augmentative and alternative communication (AAC) device. The much-watched video of her reflecting in a mirror sparked jokes that she was having an existential crisis. While it’s unclear whether Bunny was actually aware of her own identity in the mirror, the incident raises questions about animals’ self-awareness – and whether dogs can pass the “mirror test,” believed to be a defining test of animal intelligence that distinguishes certain creatures. ‘ the cognitive abilities of others.

    For strangers, the mirror test is used to determine if an animal has the ability for visual self-recognition, which is considered a marker of intelligence in animals. Scientific evidence has already suggested that dogs do not recognize themselves in the mirror, at least when it comes to previous mirror test experiments on dogs.

    The test, which was developed by psychologist Gordon Gallup in 1970, involves placing a visual marker on an animal’s body. Scientists then observe what happens when the animal is placed in front of the mirror, observing the animal’s reaction to both its reflection with and without the visual cue on its body. If an animal passes the mirror test, it will usually adjust its body position so that it can better see the marker on its body and pay more attention to that part of its body.

    RELATED: Bunny the ‘talking’ dog shares his dreams

    “The mirror test is designed to provide information about whether an animal can recognize itself in the mirror,” Leo Trottier, cognitive scientist and founder of How.TheyCanTalk Research and developer of the FluentPet system used by Bunny, told Salon by email. “Intrinsic to how this works is that the animal must be ‘naïve’ (must not have any preparation that could appropriately skew the result).”

    Trottier added that for this reason the visual marker is usually added to the animal when it is unconscious.

    “When the animal is shown in the mirror again, the animal passes the test if it touches itself where the mark is when it is able to see that it has been marked in the mirror,” explained Trotier.

    Currently, there are eight species of non-human animals that can naturally pass the mirror test: chimpanzees, bonobos, gorillas, orangutans, bottlenose dolphins, Asian elephants, wrasse and magpies. But is it possible that any animal can learn pass the mirror test, as Bunny seems (perhaps) about to do? Answering that requires delving into bigger questions about how these experiments are conducted.

    “‘You only need one talking pig,’ as the line goes – but does that also mean you only need one cat that recognizes itself in the mirror? ” said Trotier. “I’m not claiming that’s what’s happening here… but it’s really quite compelling.”

    “A big problem facing questions like these is that there are different and somewhat competing paradigms for how science is done,” Trottier said. “In the conventional paradigm, the interest is above all to find averages: people complete a crossword in X seconds when they drink water, and in Y seconds when they drink coffee.”


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    In this paradigm, Trottier said, exceptions are not synonymous with definitive answers. Part of the problem is that it is difficult to use inductive reasoning to characterize the behavior of everything animals of a given species when testing only one sample.

    “In the same vein, if we do the mirror test with 10 cats and find that none of them pass it, then we conclude that ‘cats cannot pass the mirror test,'” Trottier continued. . “There is, however, a whole other paradigm that is concerned with exceptions.”

    Trottier pointed to a YouTube video of a cat that seemed to recognize itself in the mirror.

    “‘You only need one talking pig,’ as the line goes – but does that also mean you only need one cat that recognizes itself in the mirror? ” said Trotier. “I’m not claiming that’s what’s happening here… but it’s really quite compelling.”

    “While the mirror test can tell us something about the capacity for self-awareness in animals that pass it, that does not mean that animals that fail the mirror test do not have self-awareness,” said said Plotnik.

    In 2018, questions swirled about which animals can pass the mirror test when a study published in PLOS Biology suggested that some fish had the ability to pass the mirror test. While the study was criticized and deemed “controversial” by some, the researchers ultimately concluded that the cleaner wrasse, a 10 centimeter long fish that lives in reefs and lives for up to 4 years, could pass the test. of the mirror.

    Joshua Plotnik, an assistant professor of psychology at Hunter College in New York, told Salon via email that when thinking about which animals can pass the mirror test, it’s crucial to consider the context of the animal. evolution.

    “The mirror test is an experimental task used to study an animal’s self-recognition ability, and has only been used experimentally to [around] 50 years,” Plotnik said. “Evolution works much slower, so when we study the evolution of cognition, we usually do it by comparing related species that diverged millions of years ago.”

    But more importantly, Plotnik questions whether the mirror test is the best indicator of self-recognition and self-awareness.

    “While the mirror test can tell us something about the capacity for self-awareness in animals that pass it, that does not mean that animals that fail the mirror test do not have self-awareness,” said said Plotnik. “Because the mirror test requires an animal to pay close attention to the reflection of its own body, it may not be a good test for animals that do not use vision as their primary sensory modality or that are not necessarily concerned with inspecting their body closely.”

    Plotnik added that different animals likely possess “different levels of self-awareness due to evolutionary processes.”

    “And all of these types of self-awareness are not measurable with a mirror,” Plotnik said. “The mirror test is simply a tool we use to study a type of self-recognition/self-awareness ability.”

    So does this mean that more animal species can pass the mirror test than we think?

    “I’m not sure there are many more species that will pass the mirror test, but I don’t think that really matters,” Plotnik said. “The mirror test is just one tool we use in animal cognition to understand the animal’s perspective or self-understanding.”

    Plotnik stressed that scientists need to develop more tools to study self-awareness in animals.

    Especially those tools that could allow us to better understand this ability in less visual species,” Plotnik said.

    Read more stories about animal cognition:

    NUS lecturer and marine scientist, 56, dies after battle with cancer – Mothership.SG

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    Ng Ngan Kee, a senior lecturer at the National University of Singapore (NUS) and avid crab researcher, died on July 5.

    Ng is well known among faculty, students and alumni of the NUS Department of Biological Sciences for teaching various biology modules.

    She had served in the department since 1988, after earning her BSc and Ph.D. from NUS.

    Ng was also a prominent figure in the local marine community for his studies of mangrove crabs.

    battle against cancer

    According to an official email from the Department of Biological Sciences, shared by fellow faculty member Matthew Lim in a Facebook post, Ng died after a battle with cancer.

    In a tribute posted by NUS lecturer and biologist N Sivasothi, he shared that she had handed over her teaching duties to others to focus more on her cancer treatment.

    Before that, she was a “selfless mentor and dedicated educator” who wanted the best for her students.

    Photo of Dr M’s guide to climate and environmental change: causes, effects, action / FB

    Sivasothi quoted Ng’s sister as saying:

    “She always talked about her work with a lot of passion and she fought her cancer the same way.”

    Ng’s characteristic altruism was a trait echoed by NUS Professor and former director of the Lee Kong Chian Natural History Museum (LKCNHM) Peter Ng.

    Ng was also a former student of Peter.

    Peter revealed to Mothership that Ng was diagnosed with stage 4 cancer in late 2021.

    Despite the tragic discovery, she initially insisted on continuing her teaching duties between her treatment sessions, which left Peter “livid”.

    He fondly describes her as a “mother hen”, someone filled with “boring optimism” and “extremely maternal instincts”, who would go out of her way to help her students solve their problems, whether academic or personal.

    “I think her co-workers always joke that her biggest problem, and for so many decades that I’ve told her, she has this inability to say no to people. And there’s a kindness in her heart and [an] optimism in spirit, which endears her to the people she works with.”

    Contributions to science

    Public tributes have also been posted by the LKCNHM, the St. John Island Marine Laboratory, a research facility run by NUS, as well as the Singapore Institute of Biology (SIBiol).

    Ng was a member of the latter and was a mentor to current and past members of the SIBiol Council as undergraduates. She also trained students for the annual International Biology Olympiad.

    Ng has “contributed tirelessly to both our society and the wider scientific community over the years,” SIBiol said in his post.

    Here is a video of Ng in the field (wearing black) posted by Lim, wading in the sea at Changi Beach to teach students how to catch fish for a biology module.

    “She was always very happy whenever she did this hands-on work (from my observations), going through the shellfish, fish and sea cucumbers that came in with the net,” Lim said.

    Her work on crabs and her contributions to the scientific community have brought her into contact with many other researchers around the world.

    Peter said:

    “In that sense, she found a very large, I guess, family of researcher friends around the world. And that’s why I think in a way her passing was globally tragic because it touched so many of people from so many countries. She was generous to the hilt.”

    Ng (center, in black), with other scholars in Taiwan.

    Talk to MothershipSivasothi also shared Ng’s accomplishments in detail.

    “Ngan Kee was a partner in crime in the Department of Biological Sciences. His concern for students and biodiversity translated into action – whether it was improving our modules, providing student support, take students out into the field, help clean up the mangroves, lead nature guides and offer school talks.

    She was a source of joy and support, always laughing even as we struggled through the pandemic. We missed her those few months but I’m glad she’s resting now, in the straits of Changi Beach, where she introduced hundreds of students to Singapore’s marine life.”

    Lim added that before his death, Ng had apparently requested a burial at sea, which involves releasing a person’s remains from a sea vessel into the ocean.

    Ng was cremated at Mandai Crematorium on July 7.

    Photo courtesy of N Sivasothi

    Photo from top of NUS website and Dr M’s guide to Climate and Environmental Change: Causes, Effects, Action / FB

    Universal influenza B vaccine induces broad and long-lasting protection, say biomedical scientists

    A new universal flu vaccine protects against influenza B viruses, providing broad defense against different strains and enhanced immune protection, according to a new study by researchers at Georgia State University’s Institute of Biomedical Sciences.

    The double-layered protein nanoparticle vaccine, which is constructed with a stabilized part of the influenza virus (the hemagglutinin (HA) stalk), induced broadly reactive immune responses and conferred robust and sustained immune cross-protection against the influenza B virus strains of the two lineages. The results are published in the journal Biomaterials.

    Influenza epidemics pose a major threat to public health, and influenza type B has coincided with several severe influenza epidemics. About a quarter of clinical infections are caused by influenza B viruses each year. Influenza B viruses are sometimes the dominant strains circulating during influenza seasons, such as the 2019-2020 U.S. influenza season, when the influenza B caused more than 50% of infections.

    Influenza B has two lineages that are genetically distinct and trigger different immune responses. Seasonal influenza vaccines are being developed with one or both influenza B virus lineages, but are limited by the ability of circulating strains to evade the immune system or vaccination. These vaccines are often ineffective because the variable part of the influenza virus (the HA head) evolves. Therefore, seasonal influenza vaccines must be reformulated and updated frequently. To overcome these limitations, a universal influenza vaccine containing conserved parts of the virus and providing substantial broad cross-protection against various viral strains is urgently needed.

    “In this study, we generated structure-stabilized HA stem antigens from influenza B and fabricated double-layered protein nanoparticles as universal influenza B vaccine candidates,” said Dr. Baozhong Wang, lead author of the study and professor emeritus at the Institute for Biomedical Sciences at Georgia State University. “We have found that layered protein nanoparticles incorporated into constant structure-stabilized antigens have potential as a universal influenza vaccine with enhanced potency and magnitude of immune protection.”

    The nanoparticle vaccine has been tested in cell culture and in mice. Cell culture studies revealed that protein nanoparticles were efficiently taken up to activate dendritic cells, which are essential for inducing protective immune responses against pathogens. The vaccine has been shown to be safe, biocompatible, biodegradable and highly immunogenic in animals.

    “Our next goal is to combine the influenza A nanoparticles from our previous study with the influenza B nanoparticles we have fabricated and tested here to create a multivalent universal influenza vaccine against influenza A and B,” said Wang.

    Study co-authors include Yufeng Song (first author), Wandi Zhu, Ye Wang, Lei Deng, Yao Ma, Chunhong Dong, Gilbert X. Gonzalez, Joo Kim, Lai Wei, Sang-Moo Kang, and Bao-Zhong Wang from the Center for Inflammation, Immunity & Infection at the Georgia State Institute of Biomedical Sciences. Deng is also affiliated with Hunan University in Changsha, China.

    The study is funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH).

    Source of the story:

    Materials provided by Georgia State University. Note: Content may be edited for style and length.

    For the first time, a Juneau bat tested positive for rabies

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    A veterinarian autopsies a silver-haired bat with rabies in Fairbanks. June 28, 2022. (Dr. Kimberlee Beckmen.)

    A bat in Juneau has tested positive for rabies. State biologists say it’s a first — and people aren’t at risk.

    The protocol for a suspicious bat is as follows: without touching it, you put it in a box and leave it overnight.

    “If this is a normal bat, we would expect it to fly away during this time,” said state wildlife biologist Roy Churchwell.

    He received a call from animal control about a suspicious bat outside an apartment building on Douglas Island in late June.

    “He was still there in the morning, which told us something was wrong,” he said.

    Churchwell went to get the bat, which had to be euthanized. He sent him to the state veterinarian, Dr. Kimberlee Beckmen in Fairbanks, who tested him for rabies.

    “This is the first time a bat on Douglas Island or in the Juneau area has tested positive, but that doesn’t mean we expect more cases,” Beckmen said in a statement. hurry. “This detection in a different location just underscores that the risk of bat rabies is still present in Southeast Alaska.”

    It’s only the sixth bat to test positive for rabies in Alaska in more than 45 years of testing, according to the state Department of Fish and Game. All six were found in Southeast Alaska, but this is the first in Juneau.

    “So far this is just an isolated case,” Churchwell said. “We’ve sent a couple more bats that haven’t tested positive to the Juneau area, so it’s not something we’re too worried about yet.”

    Karen Blejwas identified the bat as a silver-haired bat. She is a wildlife biologist with the ADFG’s Threatened, Endangered and Diversity program.

    “It’s actually only the fifth or sixth silver-haired bat specimen we’ve ever collected in Alaska. So that was unusual,” she said.

    They can be distinguished from the brown-haired bats typical of the region because they are larger and have rounded rather than pointed ears. They are usually recognizable by their silver hair.

    She said their numbers seem to be increasing in Southeast Alaska, but they’ve proven so difficult to catch that biologists have resorted to acoustic tracking them. Silver-haired bats have a distinct call, but you cannot hear it.

    “All echolocation calls are above the range of human hearing,” Blejwas said. “We have special ultrasonic microphones that we use to spy on bats.”

    Biologists take recordings of bat calls and lower the frequency so that it is within the range of human hearing. Blejwas is currently working with data from a citizen science monitoring project to try to determine regional bat populations.

    She and Churchwell agree that the most likely route of rabies exposure would be if an unvaccinated pet becomes entangled with a rabid bat and then transmits it to a human.

    “The key is to make sure your pets are all vaccinated,” he said.

    Churchwell says he only gets called in to check for three or four bats a year, and that’s usually because they’re hanging around the backstage of a home.

    [Sign up for Alaska Public Media’s daily newsletter to get our top stories delivered to your inbox.]

    A medium-chain triglyceride containing ketogenic diet exacerbates cardiomyopathy in a CRISPR/Cas9 gene-modified rat model with Duchenne muscular dystrophy

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  • Mah Noor, valedictorian of Yale-Bound from BMCC

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    Mah Noor, 2022 BMCC valedictorian, will major in cell biology at Yale University. Photo: Carl Glassman/Tribeca Trib

    This year, the class valedictorian for Borough of Manhattan Community College is Mah Nour. Yale University has accepted 19-year-old Noor for next fall and will offer a scholarship that will pay almost all of his $80,000 annual tuition. At Yale, she will specialize in cellular molecular biology and developmental biology. The first in her family to attend college, Noor plans to pursue a career as a pediatric surgeon. During his two years at BMCC, Noor maintained a perfect grade point average of 4.0 while participating in cell biology research under the mentorship of science professor Alexander Gosslau. She has also given remote English lessons to low-income Saudi children.

    Noor spent most of his early childhood in Sheepshead Bay, Brooklyn. But in 6th grade, she moved with her parents to their native Pakistan. Six years later, in 2020, the family moved back to New York and Noor enrolled in BMCC.

    In an interview with the Trib, Noor spoke about the lives of women in Pakistan and her desire to be an example for others.

    I think I only went out with friends once or twice in six years when I was living in Pakistan. The rest of the time I was with my family. When I came here I thought, Wow, that’s how it is, have the opportunity to explore. After years of being locked up in a house, this came as a nice surprise.

    Even though we are making progress in Pakistan, women are still struggling. We still have cases where 13 year olds are married to landlords, where a woman cannot leave the house without her husband’s permission and is not allowed to talk to men who are not a member of the family. Often girls are seen as burdens.

    When people get together, the men and women eat separately and after dinner the women go to their own room to talk. After I turned 16, I was allowed to join them for the first time. That’s when I found out what Pakistani women have to deal with. They were talking about their husbands, or their brother-in-law or their mother-in-law. How harshly and unfairly they were treated. How they are expected to cook, clean and be slaves in the house. A husband slapped his wife who forgot to pay a caterer for milk. She was laughing. She said, “I’ll never borrow again, he slapped me so hard.”

    I was so shocked. I will never forget that. The culture may have a way of manipulating its victims, making them believe that’s all they’re supposed to expect in life. It even passed to my generation. Boys my age, because they’re not the oppressed, they’re the oppressors. Their mothers pampered them and they were brought up to believe that the way their fathers treated their mothers was right and they continue. Even though we’re both educated and know it’s wrong, we normalize it.

    When I came here and had the opportunity to learn and be part of an equal society, I realized that everything I was taught was not only wrong, but it was a way of making victims of women.

    As one of our women said that night, “Things will be different for my daughter. She will study and she will learn. She will never have to cross what I have.

    I had the privilege of being educated, of understanding that what is being done there is wrong. I want to change this narrative. I want my education to not only be a step forward for me but for other women in my culture.

    Melbourne marine biologist saves rare paper nautilus from shallow water

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    A marine biologist has documented the rescue of a rare paper nautilus, “one of the strangest animals in the ocean”, as she helped the cephalopod find its way back into deeper waters.

    Australian marine biologist and diver Sheree Marris told Storyful that she saw the “crimson object” in ankle-deep water before she even had a chance to put on her mask.

    “On closer inspection, I immediately realized what it was,” she said, “a female paper nautilus that was clearly trapped and wading through the sandy shallows.”

    Paper nautiluses, also known as argonauts, are a type of octopus found in the open ocean. According to National Geographic, females make a parchment-like shell to transport incubating eggs and control where they swim.

    In the video, the argonaut can be seen rolling on the sand. “I could tell immediately that she was in trouble and stressed out,” Marris said. “When I got close, she inked, which is a defense mechanism.”

    Marris picked up the little cephalopod and swam it “far out into deeper water and away from the marina and any boats”.

    She documented the rescue in a four-part photo and video series, which she posted to her Instagram account between May 26 and July 2. Credit: Sheree Marris via Storyful

    Video Transcript

    [NO SPEECH]

    Refuge presents highlights of monthly biology activities | News, Sports, Jobs – SANIBEL-CAPTIVA

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    SAM WARREN Brown pelican chicks at the JN “Ding” Darling National Wildlife Refuge in Sanibel.

    jn “Ting” Darling National Wildlife Refuge Biological Science Technician Avery Renshaw recently reported on the Sanibel Refuge’s following biological activities for the month of June:

    – The biology team and shelter staff worked with Sarah Anderson, a master’s student in health, environment, and science journalism at Northwestern University’s Medill School of Journalism, on an article explaining how hydrology and pollution by nutrients affect the southwest Florida mangrove forests and the refuge. She came out on a mangrove restoration trip to Benedict Key, an island owned by a refuge. It has experienced intense erosion due to the loss of the root structure of the mangrove. To combat this, the island partners are working together to plant mangroves and re-establish an oyster reef to protect the growing mangroves. Anderson discussed other refuge hydrology projects aimed at restoring water flows in mangrove systems, such as culvert installations. Another issue highlighted is the impact of nutrient pollution on mangrove systems. This is a significant issue for the refuge due to the increased threat of water quality issues in the Lake Okeechobee system.

    – Regular surveys of beach shorebirds continue throughout the summer. There are 24 small tern nests on the refuge. They are a state-designated endangered species in Florida.

    – The biology team, with assistance from the Florida Department of Environmental Protection, conducted a survey of colonial waders and waterfowl nesting. It had 120 brown pelicans, 116 double-crested cormorants and seven reddish egrets – a state-designated endangered species – nests. All nests were either in the “in incubation”, “chicks” Where “unknown” phase. The sanctuary is likely in or approaching peak breeding season for many of the species it monitors during surveys.


    Amazon Air Delivery could be a source of income for black drone pilots in California

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    Photo via California Black Media

    *For Black drone pilots, e-commerce air parcel delivery could present them with new revenue or business opportunities. Last week, Amazon announced that its customers in Lockeford, a town of about 3,500 people in San Joaquin County, will become among the first to receive Prime Air drone deliveries.

    The technology company, the world’s largest e-tailer, chose Lockeford because of its historical ties to the aviation industry.

    “Lockeford residents will soon have access to one of the world’s leading delivery innovations,” said Assemblyman Heath Flora (R-Ripon), whose district includes the town. “It’s exciting that Amazon is listening to feedback from the San Joaquin County community to inform the future development of this technology.”

    Amazon’s drones fly up to 50 miles per hour and can carry packages weighing up to 5 pounds 400 feet in the air.

    MORE NEWS ON EURWEB: Congressman Al Green delivers a powerful speech as he honors the first anniversary of the June 19 observance | LOOK

    Drone - Shellie Baxter
    Photo via California Black Media

    Black people and the drone industry
    Technology and aviation industry watchers say drone pilots are currently in high demand and they expect their demand to continue to rise. The Association for Unmanned Vehicle Systems International (AUVSI) estimates that by 2025, at least 100,000 jobs will be created for drone pilots. Several companies are expected to spend more than $16 billion on drones over the next eight years, with advertising agencies, construction and security companies being among the foremost.

    According to the Economic Research Institute, the average salary for a drone pilot is $71,669 per year and $34 per hour in California. The average salary range for a drone pilot is between $50,891 and $88,659. Drone piloting entrepreneurship creates opportunities, experts say, to generate new revenue streams and create new businesses that support the industry.

    Jeffery Howell, a Navy officer currently stationed in San Diego, began his journey with drones when his wife gave him one for his birthday last year.

    “At first I was nervous,” Howell said. “I’ve never really flown a drone before, so I started watching YouTube videos in a row, learning the qualifications to fly drones legally and the weight classes. As I got deeper , there is a completely different world and community.

    Over time, Howell became more comfortable flying his drone and was interested in connecting with other pilots who looked

    Like him. Eventually, he stumbled upon the Facebook group, “Black Drone Pilots,” and connected with a community of over 300 pilots nationwide who not only shared his budding passion, but made a living from it.

    On the weekend of June 11, the black drone pilots held inaugural meetings in five different cities across the country. Howell attended the event in Newport Beach and had the opportunity to network and socialize with local pilots.

    “I was amazed to see the siblings getting together just to have a good time flying,” he said. “You could tell that those who weren’t as competent were getting advice from the more experienced riders. It was a beautiful thing to see.

    Inspired by his new network of professionals, Howell decided to start his own drone photography and video company “Air Speed ​​Aerial Productions”. To start his business, Howell needed to get his Park 107 certification from the Federal Aviation Administration (FAA). All drone pilots must take and pass this test to receive their commercial licenses. The test costs $175 to register and there are several guides online to help you study.

    Licensed drone pilots and entrepreneurs like Howell are welcome in an industry that still has room to grow in terms of diversity. There are 250,000 FAA-certified drone pilots. Ten percent are black and only 3% are black women.

    Ashlee Cooper is a certified drone pilot who founded Droneversity, a Delaware-based organization that teaches young teens the fundamentals, opportunities, and innovations of drone piloting and aviation, more broadly.

    “Aviation careers have always been a white male dominated field,” Cooper said. “Unless you were in the military or related to a pilot, it was unlikely you were going to exploit these positions within the aviation industry. Most of them don’t need a high school or university degree.

    Young people can take the Park 107 exam at age 16. Cooper’s company also offers courses to help them take and pass the exam.

    “Most of these young girls and boys are gamers. They naturally run away. The skill set is marketable. As with games, it requires hand-eye coordination and knowing how to function under pressure and solve problems quickly.

    Cooper, who is also a member of Black Drone Pilots, has transitioned from her background in molecular biology to piloting drones during the pandemic. His experience with secondary education has allowed his organization to reach out to teenagers and inspire them to pursue drone piloting as well.

    “I always feel like I’m late, however, I know my timing was divine, especially because of who I was able to help. Being a black woman in this industry has led to partnerships and a networking. There is a possibility as long as we provide fair access. By making it more accessible, you have more innovators. You can connect to the Black Drone Pilots Facebook page here to follow their updates, get a list of future events or learn how you can start your own drone piloting journey.

    Massive fish kills in Lake Michigan

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    If you’ve been to the lake recently, you may have noticed a large amount of dead fish washed up on the shore.

    The Michigan Department of Natural Resources says they know what’s going on here.

    Gaspereau die-offs have happened before. The DNR says we are seeing the first in over a decade.

    A fisheries biologist says there is good news for this to happen.

    If you were walking on the beach at Grand Haven State Park over the holiday weekend, you might have seen a lot of dead fish.

    “Their populations exploded in the 1950s and 1960s. There was basically not much for predators for them,” Jay Wesley, Michigan Department of Natural Resources Lake Michigan basin coordinator, told FOX. 17.

    The gaspereau is a fish several centimeters long and silver in color.

    DNR’s Jay Wesley says they are one of more than 180 invasive species in the Great Lakes.

    “So to think that we’re going to manage just for the natives is just impossible. So we just have to manage them as they come in and change our management strategy to stay on top,” Wesley added.

    This one comes from the Atlantic Ocean.

    “They come in shallower this time of year to spawn, and that puts them in areas where temperature changes are frequent. ‘they can’t find enough to eat there.’ Wesley said.

    He says fish die for both of these reasons and live in fresh water.

    “We probably have millions this year,” Wesley said. “No issues with, you know, pollution or anything, and like Michigan is probably the cleanest since the Clean Water Act came out.”

    And while your trip to the beach might not be so scenic right now, seeing all those dead fish can be good.

    The alewife is a prey fish, and Wesley says to better balance the ecosystem, MNR is considering stocking more salmon.

    “Chinook salmon feed exclusively on nearly 99% of their diet is gaspereau,” Wesley said.

    Follow FOX 17: Facebook – Twitter -Instagram-YouTube

    Scientists discover cancer trigger that could boost targeted drug therapies

    Researchers at the Department of Energy’s Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

    The team’s findings, published in Nature Communications Biology, open a new avenue for the development of selective drug therapies to fight a variety of cancers such as those that start in the breast and stomach.

    ORNL scientists set out to experimentally prove what they had first inferred from computational studies: that the plasminogen-apple nematode domain, or PAN, is linked to cell proliferation that drives tumor growth in and defense signaling during plant-microbe interactions in bioenergetic crops. The association was first made when researchers explored the genomes of crops like poplar and willow.

    In the latest study, the ORNL team identified four central amino acids called cysteine ​​residues in the HGF protein essential for the function of the PAN domain and studied their behavior in human cancer cell lines. They discovered that mutating one of these amino acids turned off the signaling pathway known as HGF-c-MET which is abnormally high in cancer cells, causing them to multiply and spread rapidly.

    Since cysteine ​​residues are known to have many functions, the scientists also randomly tested other cysteines in the protein and found that none of them had the same impact on stopping HGF-c-MET signaling. Mutating the four key cysteines had no effect on the overall structure of the protein and simply inhibited the cancer signaling pathway, the team noted in the study.

    Disrupting the right signal is one of the biggest challenges in developing new cancer therapies, said ORNL geneticist Wellington Muchero.

    “It’s very difficult to design molecules to interfere with an entire protein,” he said. “Knowing the specific amino acids to target in this protein is a big step forward. You don’t have to search for the entire protein; just search for those four specific residues.”

    Identifying these core residues is testament to the predictive power the team has built at ORNL, leveraging the lab’s expertise in plant biology and biochemistry, genetics, and computational biology, as well as its resources. supercomputing and CRISPR/CAS-9 gene editing tool.

    The discovery could lead to treatments for other diseases, including disrupting mosquitoes’ infection pathway to make them less able to carry the malaria parasite, and fighting the HLB virus that kills citrus fruits in Florida and California. by targeting the Asian citrus psyllid insect that spreads it. .

    In plants, ORNL scientists are using their knowledge of the PAN domain to improve resistance to pathogens and pests in biomass crops, such as poplar and willow, which can be broken down and converted into sustainable jet fuel. They are exploring the genetic processes that encourage beneficial interactions between plants and microbes to enhance the hardiness of these crops.

    The research demonstrates the close similarities in the DNA structure of plants, humans and other organisms, which make plants an important platform for discovery, Muchero said. “We can do things with plants that you can’t do with humans or animals in the research process,” he added.

    “I can work with equal effectiveness on plant and human cancers. The expertise is the same,” said Debjani Pal, a postdoctoral researcher at ORNL with a background in biochemistry and human cancer research. “We have established a globalized experimental platform here at ORNL that shows whatever system you use, plant or animal, if your hypothesis is correct, the science is reproducible in all of them, regardless of the cell line that you are using.”

    “At the bottom of it all, we have the same biological underpinnings,” Muchero said.

    Other team members from ORNL’s Biosciences Division include Kuntal De, Carly Shanks, Kai Feng, Timothy Yates, Jennifer Morrell-Falvey, Russell Davidson and Jerry Parks.

    The plant research was supported by the Biological and Environmental Research Program of the DOE Office of Science. Funding directed by the ORNL lab supported work with human cell lines. The researchers used resources from the Oak Ridge Leadership Computing Facility, a DOE Office of Science user facility, as well as the ORNL Science Computing and Data Environment.

    UT-Battelle operates the Oak Ridge National Laboratory for the DOE’s Office of Science, the largest support of basic physical science research in the United States. The DOE’s Office of Science works to address some of the most pressing challenges of our time. For more information, visit energy.gov/science.

    Infectious Vaccine Development Market Size, Scope and Forecast

    New Jersey, United States – The Infectious Vaccine Development Market The research report aims to provide a quick overview of the overall industry performance and important new trends. Important information, as well as conclusions, latest key drivers and constraints, are also described here. A wide range of quantitative and qualitative techniques are used by market analysts, including in-depth interviews, ethnography, customer surveys, and secondary data analysis. It becomes easy for major players to collect important data regarding key organizations along with information such as customer behavior, market size, competition and market needs. By referring to this Infectious Vaccine Development Market research report, it becomes easy for key players to take evidence-based decisions.

    This Infectious Vaccine Development Market research report adds the potential to impact its readers and users as the growth rate of the market is affected by innovative products, growing demand for the product, the richness in raw materials, increasing disposable incomes and changing consumption technologies. It also covers the effect of COVID-19 virus on market growth and development. Market participants can briefly study the report before investing in the market and expect higher returns. According to the report, the market scenario continues to fluctuate based on many factors.

    Get Sample Full PDF Copy of Report: (Including Full Table of Contents, List of Tables and Figures, Chart) @ https://www.verifiedmarketresearch.com/download-sample/?rid=37144

    Key Players Mentioned In The Infectious Vaccine Development Market Research Report:

    Berna Biotech, Emergent BioDefense Operations Lansing Inc., Organon Teknika Corp LLC, GlaxoSmithKline plc., Sanofi, Merck & Co Novartis AG, Barr Labs ID Biomedical Corp., MedImmune LLC.

    Several industries are interested in determining what the customers really want and the Infection Vaccine Development market report helps in this regard by carrying out detailed market research. Before bringing a new product to market, every business owner wants to know the demand for the product, and this market research report is the best guide for them. It further helps in meeting business requirements by covering all the latest advances in the market. The Infectious Vaccine Development Market report is the best way to keep a close eye on the activities of leading competitors as well as the strategies they are deploying for the expansion of their business. It further conducts in-depth analysis for the 2022-2028 assessment period to provide more business opportunities for business owners.

    Global Infectious Vaccine Development Market Segmentation:

    Infectious Vaccine Development Market, By Disease Type

    • Viral diseases
    • Bacterial diseases

    Infectious Vaccine Development Market, By Product Type

    • Recombinant vector vaccines
    • Live vaccines
    • Inactivated vaccines
    • DNA vaccines
    • Others

    Infectious Vaccine Development Market, By End User

    • Clinics
    • Hospitals (governmental and private)
    • Others.

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    Scope of Infectious Vaccine Development Market Report

    ATTRIBUTES DETAILS
    ESTIMATED YEAR 2022
    YEAR OF REFERENCE 2021
    FORECAST YEAR 2029
    HISTORICAL YEAR 2020
    UNITY Value (million USD/billion)
    SECTORS COVERED Types, applications, end users, and more.
    REPORT COVER Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends
    BY REGION North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
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    Answers to key questions in the report:

    1. Who are the top five players in the Infectious Vaccine Development market?

    2. How will the infection vaccine development market grow in the next five years?

    3. Which product and which application will occupy the lion’s share of the infection vaccine development market?

    4. What are the drivers and restraints of Infectious Vaccine Development Market?

    5. Which regional market will show the strongest growth?

    6. What will be the CAGR and size of the Infectious Vaccine Development market throughout the forecast period?

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    Comal ISD class crown reassigned after error discovered | Community Alert

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    Smithson Valley High School’s class of 2022 has a new valedictorian.

    In the days following the high school graduation ceremony held on May 28, it was found that a miscalculation by the school meant that the salutatorian was in fact supposed to be named valedictorian.

    In light of the recent change, Comal ISD announced that Smithson Valley High School graduate Ava Roat has been declared the school’s new valedictorian for the class of 2022.

    After informing Roat of the miscalculation, district administrators issued an apology to the former Salutatorian from her class of 706 students, according to a press release from CISD.






    Comal ISD Smithson Valley High School Class of 2022 valedictorian AvaRoat


    “Ava has distinguished herself as valedictorian of Smithson Valley High School,” said CISD Acting Superintendent Mandy Epley. “The rank calculation has been corrected to reflect that she is indeed the highest ranked graduate of Smithson Valley High School.”

    While Roat was able to serve as a salutatorian at the graduation ceremony, which allowed her to give a public speech, the misplaced secondary title left her without some of the scholarships given to top senior graduates, who promise to pay first-year tuition, according to the teenager’s mother, Julie Roat.

    “I was kind of told all my life that if I jumped through that hoop, or got that grade, or got perfect grades on standardized tests, I would get scholarships,” said Ava Roat. “Finding out that your work has come to fruition in a way that really has a financial impact and that I can no longer use this scholarship because I was forced to give it up (it’s disheartening).”

    The school district calculates official school rankings twice a year — once in January and again in June after the second semester ends, according to director of student counseling and support Curtis Herring.

    After calculating Roat’s class in her penultimate semester, she was ranked second in her class, and after the school’s unofficial final semester ranking calculation, which was done by hand, the Roat’s position remained the same.

    The error was discovered during the school’s final class ranking calculations, which follow the graduation ceremony, and it was discovered that Roat was in fact the school’s valedictorian for the class of 2022. ‘school.

    “It kind of felt like all my hard work meant nothing, because I had worked hard for that goal for the majority of my studies, and then, unfortunately, not being able to have that recognition on graduation day. graduation, it felt like it was the only day that mattered,” Roat said.

    Throughout her high school career, she maintained a 4.0 GPA each semester and was named the College Board National Merit Scholars and National Rural and Small Town Recognition Scholars.

    “I’ve always been academically motivated,” Roat said. “I look to my parents who modeled the value of hard work. I never want to settle for anything but the best I can give.

    Roat’s drive and determination extends to extracurricular activities – including student organizations such as Humans of SV, Key Club, National Honor Society, Spanish Club and Students United for Respect and Equality.

    Throughout her time in several of these clubs, she held important leadership positions, which gave her the opportunity to serve the campus and the community in several service projects.

    The recent graduate participated in an on-campus recycling program through Humans of SV, which required Roat to sort through trash to collect recycling around the school on a weekly basis for two years.

    Another service project was through the Key Club, where she helped organize a diaper drive for St. Jude Children’s Hospital, and students collected baby products for hospital patients. , and have multiplied their fundraising efforts over the years.

    “Being involved in student organizations on campus,” Roat said. “(It) gives you a sense of community. Being on such a large campus, these organizations provide you with the opportunity to gain a sense of purpose.

    Roat has earned over 60 hours of college credit through advanced internships and dual-credit courses while working part-time in the restaurant industry and volunteering in the community. She plans to attend Baylor University in the fall where she will major in biology and Spanish, and later earn a medical degree.

    Stock horse fields; student gets Goldwater scholarship

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    Here’s the latest news from Middle Tennessee State University.

    Stock horse fields

    Competing at the end of the semester at the American Stock Horse Association Collegiate and National Show in Sweetwater, Texas – and for the first time in Division 1 – MTSU’s stock horse team beat Texas Tech University to win the national title.

    In a 10-team field of teams from across the country, MTSU riders won the Division 2 National Reserve Champion title at the Hughes Ranch Traders National Intercollegiate Ranch and the Stock Horse National Championship in Amarillo, TX. MTSU also received a $1,000 marketing package for its ranch horse program.

    Eight MTSU students competed in the AHSA event held at the Nolan County Coliseum in Sweetwater, Texas, winning eight individual national awards and the coveted national title. Events included Cow Horse, Fun, Reining and Trail.

    A year ago, the Raiders finished fourth overall in Division 2 but won 10 combined championship and runners-up awards.

    The event sponsored by Hughes Ranch Trailers featured 115 runners from 14 colleges and universities in seven states. MTSU carried six runners to this event, each competing for individual prize money as well as National Champion and Reserve Champion honors.

    Notable individual global awards included:

    • Taylor Meek, a recent graduate and equestrian science major from Murfreesboro, winning eighth place overall in the non-professional limited all-around division.

    • JoBeth Scarlett, a junior animal science student from New Market, Tennessee, placed ninth overall in the non-professional limited all-around division.

    Other team members include Rachel Petree, Louann Braunwalder, Kara Brown, and Savannah Glinstra.

    Barry Goldwater Scholarship

    MTSU student Yaseen Ginnab from Nashville was awarded the Barry M. Goldwater Scholarship and is in Nova Scotia for three months on a Fulbright Canada program.

    Yaseen Ginnab of Nashville, a rising senior at MTSU, was awarded a prestigious Barry M. Goldwater Fellowship to further his research and this summer he is spending three months in Nova Scotia, helping with a Fulbright Canada project.

    This follows a National Science Foundation REU (Research Experience for Undergraduates) at Central Michigan University last summer and work in the joint lab of Bailey and biology professor Ryan Otter. last fall, assisting MTSU graduate students in two labs.

    The Fulbright-MITACS Globalink is for U.S. students interested in traveling to Canada to undertake advanced research projects in their area of ​​interest. Ginnab has applied and interviewed for seven internships. He was paired with his professor and biologist Gavin Kernaghan of Mount Saint Vincent University, documenting a fungus in the forest — plus a lab component, Ginnab said.

    The Goldwater Prize provides funding of up to $7,500 per year to cover tuition after other scholarships.

    After finally graduating from MTSU, Ginnab wants to pursue a master’s and doctoral degree.

    Contact reporter Nancy DeGennaro at degennaro@dnj.com. Keep up with restaurant news by joining Good Eats in the ‘Boro (and beyond) on Facebook and follow Murfreesboro Eats on TikTok.

    African scientists advance research on pathogenic bacteria – The Sun Nigeria

    By Sunday Ani

    Monday, June 27 marked the start of a concerted effort to combat an overlooked bacterial pathogen, Helicobacter pylori, simply called H. pylori, which is ravaging Africa. This is the day the Director of Research, Department of Molecular Biology and Biotechnology, Nigerian Institute of Medical Research (NIMR), Yaba, Lagos, Professor Stella Smith unveiled a team of African experts dedicated to the advancing H. Pylori research to form the LTD/GTE African Helicobacter and Microbiota Study Initiative. It was indeed a gathering of the best scientists in the world in the field of molecular biology.

    In his welcome address, Smith described H. Pylori as a type of bacteria that, when it enters the human digestive tract, can cause ulcers in the stomach lining or upper stomach. small intestine and ultimately lead to stomach cancer in humans. some individuals.

    “The pathogen has been implicated in an array of gastric disorders including peptic ulcer disease, gastritis, gastric mucosa associated with lymphoid tissue, lymphoma, and gastric adenocarcinoma,” she added.

    Smith’s efforts and concerns about the disease date back to his pre-doctoral degree days in Manchester, England, on a fellowship from the European Union. She said she was working on Campylobacter jejuni and C. coli in early 1994 when her supervisor told her students he had caught the virus. “While asking me if he was referring to an insect, he photocopied two pages on H. pylori, which I had never heard of until then, and gave me and, after reading, I thought it was for Caucasians. . But to my surprise, on returning home that evening, my landlady’s (Nigerian) sister told us that she had taken a test while she was pregnant and had been informed that she had H. pylori. There and there she asked me if I knew anything about H. pylori, and that’s when I realized it was a disease that affected all humans, not just Caucasians. she says.

    According to her, the incident sparked her interest in continuing her research on the subject after her doctorate, the cumulative efforts of which are assembling experts from several African countries to advance research on H. pylori, determine its precise prevalence , its diagnosis and management in Africa.

    She noted that 50% of the world’s population is thought to be infected with H. pylori, with people of different races and regions of the world having varying levels of severity and disease outcomes: “As early as 1994, the International Agency for Research on Cancer (IARC ), a division of the World Health Organization (WHO), has classified H. pylori as a Class 1 carcinogen. Given the status of this pathogen, researchers, policymakers, and governments in the Americas, Europe and Asia have paid particular attention to the diagnosis, treatment, management and eventual control of H. pylori,” she said.

    The lack of concerted efforts in Africa to control the disease as has been done in Europe, America and Asia, coupled with her desire to learn more about the disease led her to come into contact with experts from all over the world. Also during this research, she heard about the European Helicobacter and Microbiota Study Group (EHMSG), which has been in existence for over 30 years and this is what prompted her decision to bring together African experts as well. to form the African Helicobacter and Microbiota Study Group. (AHMSG), which is today registered as African Helicobacter and Microbiota Initiative LTD/GTE, with its registered office at NIMR, Lagos, Nigeria. The initiative, in addition to serving as an advisory body on research in the field of H. pylori, will also advance research on H. pylori, determine its prevalence, diagnosis, treatment and associated complications in Africa.

    She noted that H. pylori is more or less a neglected pathogen in Africa and called for more attention in this regard, although she said AHMSG was starting with the support of EHMSG, which has been around for a long time. over 30 years. and responsible for developing and updating the famous Maastricht/Florence Consensus

    Professor Delight Smith expressed her gratitude to Christian Schulz, Peter Malfertheirner and Richen Medical Science Group of Europe, whose unwavering support and partnership with AHMSG led to the groundbreaking event, which ushered in a research movement that would curb and would bring H. pylori to Africa at the bare minimum.

    The AHMSG, which has Professor Smith as President and Dr Mohamed Alboraie of Al Azhar University, Cairo, Egypt, as Secretary General, has 13 other members, whose areas of expertise range from gastroenterology to surgery, clinical microbiology, medical microbiology. , hepatology, microbiology and molecular epidemiology.

    The NIMR Chief Executive commended the group members for coming up with the idea, but noted that often Africa is not well represented on these issues, even when Africa has, perhaps, the voters. the most diverse.

    “So we won’t be able to get the proper benefits from these things, but it’s different because it’s Africa-centric. Therefore, it puts Africa in an advantageous position to be able to research and find solutions applicable to Africa and, of course, to the rest of the world,” he said.

    He also said: “I would like to congratulate the group for this as well as Professor Smith for putting together this number of his colleagues from different countries. It only shows that it is very well recognized in the field.

    In his goodwill message, the Vice Chancellor, Mountain Top University, Ibafo, Ogun State, awarded the school’s rating as having one of the best molecular biology laboratories in Nigeria to the institution’s partnership with the Professor Smith. “You are part of our success story, as your partnership and support of the research and academic training available in the biological sciences cannot be quantified. We hope our students will benefit from this initiative as we explore opportunities for partnership and collaboration. I pray that Africa and the world at large will benefit from this initiative,” he said.

    The Vice-Chancellor of the University of Lagos, represented by former Deputy Vice-Chancellor Professor O Familoni, said the African Best Minds initiative was a welcome development as many H. pylori patients experience many difficulties in dealing with the bacteria. . “While other bacteria are treated within seven days, this one takes about a month to be treated. I am confident that their studies and research in this area will give hope to patients who suffer from this disease. The fact that the African infection is treated in Africa is also a plus because it will ensure better treatment than elsewhere in Europe.Africans know their problem better than anyone,” he said.

    He pointed out that if Professor Smith could be part of the initiative, it means that the group was very competent. “You can rest assured that whatever the collaboration and expectations of the University of Lagos, we expect that very soon our school and the initiative will have a collaboration,” he added.

    The scientists present came from Europe (Germany, France and Spain), Asia (Japan) and Africa (Nigeria, Egypt, Cameroon, South Africa, Morocco, Tanzania and Senegal).

    Pet Talk: The Battle of Cattle, Bovine Respiratory Disease | Lifestyles

    One of the biggest problems cattle owners face is Bovine Respiratory Disease (BRD), a complex disease that can affect cattle of any age and breed.

    In North America, BRD is the leading cause of illness and death in cattle production systems, according to Dr. Matthew Scott, assistant professor of microbial ecology and infectious diseases at Texas A&M College of Veterinary Medicine & Biomedical Sciences’ Veterinary Education, Research, & Outreach Campus in Canyon, Texas.

    “Each year, the United States is estimated to lose approximately $1 billion due to treatment costs and production losses attributed to BRD,” Scott said. “Additionally, we can expect that nearly 20% of all cattle raised for beef production will require clinical treatment for BRD at some point in their lives.”

    BRD is considered a multifactorial disease complex because several factors play an important role in its development, including genetic susceptibility, immune system suppression, stress, cohabitation with sick cattle, sudden changes in weather/climate and exposure to bacteria, viruses, and/or parasitic pathogens.

    “We in the industry understand the risk factors that lead to increased levels of BRD, but we don’t fully understand how these factors convert to BRD in each animal,” Scott said. “Due to the transmissible nature of BRD, both small and large herds are at risk for development and outbreaks of BRD.”

    Another challenge associated with BRD is that as a prey species, cattle naturally try to hide signs of disease, making it difficult to detect disease before it causes severe symptoms.

    “One of the first signs of illness, especially BRD, is that cattle will tend to fall behind or isolate themselves from the rest of the group,” Scott said. “Other clinical signs may include fever over 104 F, runny nose and eyes, cough, tilted head/ear position, and signs of depression, such as decreased appetite, slow body movements and a reluctance to stand up.”

    When treating BRD, veterinarians focus on the health of both the individual animal and the herd as a whole.

    “Veterinarians working with cattle examine and treat diseases, including BRD, in individual cattle, but always with the herd in mind,” Scott said. “Due to the difficulty in diagnosing or predicting BRD before clinical signs, historical clinical information and disease rates within herds play an important role in making decisions about the treatment and management of BRD. “

    While there are many unknowns with BRD, there are also several known precautions cattle owners can take to reduce the risk of their animals becoming ill. The first of these precautions can begin as soon as new calves are born.

    “At birth, calves depend on colostrum (the first milk produced by a cow) to receive passive immunity against many different diseases,” Scott said. “Calves should receive an adequate amount of colostrum, typically 10% of their body weight, within the first few hours of life.”

    As calves grow, their immunity can be further boosted with vaccines, dewormers and proper nutrition.

    For cattle of all ages, reducing stress is one of the best ways to reduce the risk of BRD. This may include adequate ventilation, minimal pen movements, low-stress handling techniques, clean bedding, and free access to food and water.

    “Historically, BRD was often referred to as ‘shipping fever,’ because cattle transported from cow-calf operations to feeding operations were at increased risk of developing BRD,” Scott said.

    By striving to improve the health of livestock before moving and providing several days of rest upon arrival, owners can reduce the risk of developing BRD during the shipping process.

    Due to the challenges associated with BRD, many scientists and veterinarians, including Scott, are studying the disease in an effort to find better ways to detect, treat, and prevent the disease.

    “While no single approach or drug will solve all cases of BRD, advances in disease prediction models and diagnostics could allow us to anticipate the disease process, perhaps before livestock show signs. illness,” Scott said. “Veterinary involvement and research related to these advances could allow us to significantly reduce the negative impacts associated with BRD.”

    — Pet Talk is a service of the College of Veterinary Medicine & Biomedical Sciences, Texas A&M University. Stories can be found on the Pet Talk website. Suggestions for future topics can be directed to editor@cvm.tamu.edu.