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“Are you here by mistake? Meet the 1st Israeli woman to lead a men’s chess team


Competing in the World Team Chess Championship in Jerusalem this week, Ilana David from Beersheba is the first-ever Israeli woman to lead an all-male team. And she is, understandably, exasperated by the label.

“I am also the only woman in this open chess tournament – ​​as always,” she exclaimed to The Times of Israel, speaking at the opening of the championship where 12 teams, including Israel, competed for the title. world title this week- long competition.

David holds the title of Women’s International Master, won the Israeli Women’s Chess Championship in 1980 and was twice part of the Israel Olympic Chess Team, among other accolades.

“For me, being a good chess player is so normal, but for the world, I am a kind of exotic bird. When I first came to Israel and participated in tournaments of chess, people looked at me as if to say, “What are you doing here? Are you here by mistake?”

The problem persists worldwide today.

“Even in female-only chess games, there are often few female captains,” David said, explaining that although captains don’t play, they have the function of organizing and leading the team, signing match protocols and advising players on the offer or acceptance of draws or abandonment of games.

Chess players play a match as part of the World Team Chess Championship on November 20, 2022 in Jerusalem. (Courtesy of FIDE/Mark Livshitz)

“There is a general feeling that men are more suited,” she adds. “Some people still believe that women aren’t strong enough to lead a team.”

“It’s not due to biology”

Women are sorely underrepresented in professional chess as a whole. While the majority of chess tournaments are open to everyone, they are almost always male dominated.

Of approximately 1,700 grandmasters, only 37 are women, and there are currently no women among the top 100 players in the world according to FIDE, the International Chess Federation.

“It’s not about biology,” Judit Polgar, widely regarded as the greatest female chess player in history, told The Guardian. “It is just as possible for a woman to be the best as any man. But there are so many difficulties and social barriers for women in general in society. That’s what’s blocking. »

In 2021, Nona Gaprindashvili, a pioneering chess champion and the first woman in the world to be named a chess grandmaster in 1978, sued Netflix for defamation after her hit miniseries “The Queen’s Gambit” falsely claimed that she had “never faced men”.

In fact, Gaprindashvili from Tbilisi, Georgia has played and won against many men’s champions in his career.

In her legal statement, she described Netflix’s error as “patently false, in addition to being grossly sexist and derogatory.”

Some male chess giants, such as world champions Bobby Fischer of the United States and Garry Kasparov of Russia, were known to disparage female chess, the latter once saying that female chess players should stick to having children. Kasparov was forced to swallow his words after Judit Polgar beat him in a match in 2002; she described her victory as “one of the most remarkable moments of my career”.

Polgar’s career included being ranked No. 8 in the world and qualifying for the Candidates Tournament, in which the winner out of eight players faces the world champion in a duel for the title.

In September 2022, an Israeli chess grandmaster and commentator was sacked from the International Chess Federation after he said a female player wanted to be “like the men”.

“Completely Grand”

David started learning to play chess at the age of 4 in Baku, Azerbaijan, then part of the Soviet Union, where for the most part chess was highly respected and encouraged for men and women. women.

She was taught by her father and grew up playing alongside Garry Kasparov.

“We grew up together playing chess at the Olympic Palace in Baku,” David recalls. “We then traveled together for chess tournaments, he with his mother, me with mine.”

“Competing in chess at a high level was not just considered ‘professional’ but rather ‘super-professional’,” she adds, recalling how, as a 14-year-old prodigy, she received an allowance equivalent to the salary of a young engineer, accompanied by private coaching, free trips and numerous gifts.

“It was completely grand.”

Israeli chess team captain Ilana David standing next to two players during the World Team Chess Championship in Jerusalem, November 20, 2022. (FIDE/Mark Livshitz)

Today, such conditions are almost unheard of, especially for female players, she said, adding that there is a big difference in the prize money awarded to women-only chess championships compared to men, which which also discourages female players from pursuing the profession. .

Although the percentage of women in chess remains very low, David notes that in recent years “there is more support for chess in Israel, thanks to the work of the Israel Chess Federation”, citing a program that enables young children to study chess at school. school.

“Even if a child doesn’t become a chess champion, it will give him so much skill. It will serve them for the rest of their lives,” she says. “It’s a great contribution for the future.”

The Jerusalem World Chess Championship runs until November 26. The Israeli team did not reach the round of 16, finishing fifth out of six teams in their group.

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Groundbreaking international protections approved for sharks as Florida anglers push for higher catch limits


MIAMI-DADE COUNTY, Florida. – World leaders recently agreed to extend protections to more than two-thirds of the world’s shark population, whose numbers are rapidly declining due to the insatiable demand for shark fins.

Closer to home, Florida anglers are complaining that there are too many sharks, and NOAA is now re-evaluating its limits on the number of sharks that can be legally caught and killed.

Local 10 was on the water off Palm Beach as a team of CRF marine scientists carefully brought in an 8ft adult female bull shark. The 300-pound shark was placed in an unconscious tonic stillness as biologists gathered important data on her that could prove vital for the conservation of her species and all sharks.

“We really need to know how many sharks are here because in general shark populations are down,” said CRF marine biologist Mike Heithaus. “And while we’re doing better than most places here in the United States, we can still do better.”

An acoustic transmitter has been inserted into the shark so that they can now follow its every move.

“So all we’re trying to do is understand what areas these animals are actually using and how that type of area use changes over time,” said CRF marine biologist Yannis Papastamatiou. “So how does it change day and night? How does it change with the seasons? »

The urgent research comes at a time when extinction due to overfishing threatens 37% of all sharks and 70% of species specifically traded for their fins.

On average, the world kills 100 million sharks a year.

CRF shark researcher Diego Cardenosa zoomed in with Local 10 News from Hong Kong, where he continues his groundbreaking work developing protocols and tools to help law enforcement around the world crack down on illegal trade of shark fins.

“The status of shark populations around the world is definitely something to be concerned about,” Cardenosa said. “We have visual identification guides, we have DNA import toolkits that can be used to very easily identify species in fins.”

Cardenosa’s work is even more crucial now that CITES, the Convention on International Trade in Endangered Species of Wild Fauna and Flora, voted last week to increase protection for 54 species of requiem sharks and sharks. hammers targeted for their fins.

“So it’s like an open door for more regulations and more protections for these specific species around the world,” he said.

Locally in South Florida, the fight for conservation continues due to pressure from commercial and recreational fishermen who claim Florida’s Atlantic coast has become far too sharky.

NOAA is currently reassessing the number of sharks that commercial fishermen are allowed to harvest and is considering raising the retention limit from 45 large coastal sharks per vessel per trip to 55 sharks, excluding gray sharks, listed as vulnerable. .

According to Lauren Gaches of NOAA Fisheries Public Affairs, “NOAA Fisheries is currently developing the final rule to address quotas and retention limits and anticipates that the final rule will be posted to the Federal Register in the coming weeks.”

Recreational anglers also want the Florida Fish and Wildlife Conservation Commission to increase its bag limit, which is currently one shark per person per day.

“We’re starting to get to the point where there’s an imbalance,” said shark fishing tournament organizer Robert Fly Navarro.

They claim that the protections on the sharks caused a boom, which now prevents them from landing their catches because the sharks are stealing them.

“You lose 50% of what we hooked sharks,” Navarro said.

Scientists, however, push back.

“I wouldn’t call it a shark boom,” Papastamatiou said. “Remember, these were populations that were historically overexploited. So what you’re seeing is the recovery, potentially, of populations.

Scientists agree that there has recently been an increase in human interaction with sharks, but also indicate that there are more people and more boats in the water.

Since the pandemic, Florida now has a record of more than one million registered boats.

“Just because the sharks are taking more fish off the hooks doesn’t mean there are more sharks here,” Heithaus said.

It means that they have become intelligent.

“They’re catching a fish that’s already struggling, they don’t have to do the hunting part,” said FIU PhD student Candace Fields. “And they can just take a bite and pretty much get a free meal.”

The research team hopes this work will lead them to find ways to make sharks and fishermen co-exist. After all, a healthy ocean needs a healthy shark population.

“We have a large number of sharks,” Papastamatiou said. “Few places can say that and it’s a sign of a good healthy ecosystem. So it’s something to be proud of, it doesn’t mean the job is done, but it’s a good sign.

There is still a small problem with these CITES protections for sharks that world leaders have just approved.

Thursday is the CITES plenary session and Japan and Canada have been lobbying other countries to change those protections. A final vote will take place.


Federal Register: Atlantic Highly Migratory Species; Atlantic Shark Commercial Fishing Year 2023

Commercial Atlantic shark fishery in 2023: quotas, retention limits and opening date

Copyright 2022 by WPLG Local10.com – All rights reserved.

Israeli life sciences healthy with $5.2 billion in exports


With massive layoffs hitting Israeli high-tech hard in recent months, it was heartening to get an upbeat report on the health of its life sciences sector at the MIXiii Health-Tech.IL conference in Jerusalem. November 10.

Conference organizer Israel Advanced Technology Industries (IATI) shared the findings of its 2021 report with approximately 1,000 conference attendees from 30 countries. (“MIXiii” stands for the blend of health and technology, combined with Israel, international and innovation.)

Highlights were presented by the report’s lead author, Omer Gavish, a partner at PwC Israel and head of its Pharmaceuticals & Life Sciences division.

Omer Gavish presenting the IITA Life Sciences Industry Report 2021 at MIXiii in Jerusalem on November 10, 2022. Photo courtesy of PwC

Gavish said there are about 1,800 active life sciences companies in Israel, 80% of which were founded in the past decade.

“That’s a huge number, and it’s about the same in 2022,” he said. “The majority, more than 60%, are in the early stages.”

About $3.8 billion in investments flowed into private Israeli life sciences companies in 2021, with $1.5 billion of that invested in the last quarter alone. Digital health companies received $1.5 billion of the total, a 300% increase from 2020.

Foreign investment is on the rise

Gavish noted that $1 billion came from local investors, while foreign investors doubled their investments from 2020. This trend of foreign investment continued in the first nine months of 2022.

Among listed Israeli life sciences companies, 2021 marked the first year in which they surpassed $1 billion raised on the various US exchanges.

“US stock markets were, and remain, an important source of funding for life science companies in Israel,” Gavish said.

“Over the past decade, 21 Israeli life sciences companies have raised more than $6 billion on US stock markets, primarily on NASDAQ. More than 50% of this amount has been collected in the last four years”, although the trend has slowed down in 2022.

Nine life science companies raised $209 million on the Tel Aviv Stock Exchange (TASE) in 2021, a record for the past decade.

Record year for life sciences

The approximately $5 billion invested in private and public Israeli life sciences companies represents a 44% increase from 2020.

“It was another banner year for the industry,” Gavish said. “This is the first year that total investment has crossed the $5 billion mark, more than double what we had in 2019, which in itself was a great year.”

Israeli life sciences healthy with $5.2 billion in exports
Chart of capital raised by Israeli life sciences companies since 2012. Photo by Abigail Leichman

Average deal size also set a record high of $13.7 million per deal. TASE-listed life sciences companies closed an average deal of around $23 million, the highest in the past decade.

“As we predicted last year, the increase in investment – ​​which started with the period of the Covid-19 pandemic and continued through most of 2021 – was mainly in the sub-sectors digital health and medical devices,” he said.

Gavish said about $1.7 billion was invested in life science companies in the first nine months of 2022.

“This amount is higher than most years of the past decade despite a decrease from the corresponding period in 2021.”

However, he added, “At the end of 2021, we experienced a decline in capital markets. This trend continues in 2022 and has affected not only the number of public investments, but also the total investments in life sciences companies.

Booming exports

Exports of Israeli life science products are booming, Gavish reported. These products are mainly medical devices and pharmaceuticals.

Total pharmaceutical exports in 2021 amounted to $2.1 billion, an increase of 23% compared to 2020. Total medical device exports reached $3.1 billion in 2021, approximately 20% of more than in 2020.

According to the figures for the first half of 2022, it seems that the rise will continue.

Pharmaceutical exports during this first half totaled $1.5 billion, an increase of 50% compared to the corresponding period in 2021; and medical device exports totaled $1.6 billion, up from $1.5 billion in the corresponding six months of 2021.

Keep an eye on digital health

While the majority of Israeli life science companies over the past decade have been in medical devices, Gavish noted that “over the past two or three years, we see a steady decline in the number of these companies, or at least from them.”

Digital health is the fastest growing sector.

“This is the third year that we have seen an increase in the number of digital health companies, especially due to Covid-19. And you see this trend continuing this year for established companies and seed companies,” said said Gavish.

The digital health boom is also affecting the geographic distribution of Israeli life sciences companies.

Appliance and pharmaceutical companies tend to be located in Jerusalem, Rehovot, Ness Tziona and Haifa, close to hospitals, universities and research institutes such as the Weizmann Institute and the Technion.

But digital health companies choose the general high-tech hub of Tel Aviv.

Gavish explained that digital health companies are less connected to research institutes and hospitals; these are tech companies looking to compete outside of the traditional life science sphere.

Increased focus on wellness

In addition to digital health, the IATI report identifies four niche sectors with high growth potential in the coming years: wellness, food technology, climate technology and artificial intelligence (AI).

These sectors stood out for their innovation, rapid growth and attractiveness to investors.

“I think what’s interesting from a qualitative, not necessarily quantitative, perspective is that wellness and food technology are increasing,” Gavish said.

“Both are related to quality of life, to a more preventative approach and not just not finding solutions to care for patients after they get sick.”

What is the forecast?

“Even though we see the market is not doing well in 2022, even though the funding is not doing as well, there is substance in this industry and the future is looking good,” Gavish said.

Data for the first half of 2022 for the Israeli life sciences sector, he added, “is much better than the first half of 2021, even if the markets are not [doing] as well.”

Israeli life sciences healthy with $5.2 billion in exports
Karin Mayer Rubinstein, CEO and President of IITA, and Omer Gavish, Partner at PwC. Photo courtesy of Omer Gavish

IITA CEO and President Karin Mayer Rubinstein summed up: “In recent years, the life science and health technology industries have emerged as major growth engines for the Israeli economy. Our latest research highlights the need for additional support and investment so Israeli businesses can continue to create meaningful social impact.

Viruses carrying genes reach the brain in st


Gene therapies can treat and even cure some genetic diseases, but it is difficult to deliver the treatments to the parts of the body where they are needed. Researchers have engineered viruses called adeno-associated viruses (AAVs) to deliver cargo — like a functional copy of a gene — to specific cells and organs, but they don’t always arrive at their intended destination.

Researchers from the Broad Institute of MIT and Harvard have now developed a family of AAVs capable of reaching a particularly difficult target tissue: the brain. The team shows, in a study published in Mediumthat their AAVs are more than three times better at delivering their cargo into primate brains than the current primary AAV delivery vehicle, AAV9.

The new AAVs can cross the blood-brain barrier, which prevents many drugs from entering the brain. They also accumulate much less in the liver than AAV9, potentially reducing the risk of hepatic side effects that have been seen in other AAV9-based gene therapies. This family of AAVs, called the PAL family, could be a safer and more efficient way to deliver gene therapies to the brain.

The AAVs were designed in the lab of Pardis Sabeti, who is a fellow at the Broad Institute, a professor at Harvard University and the Harvard TH Chan School of Public Health, and a researcher at the Howard Hughes Medical Institute.

“We generated a massive pool of randomly generated AAV capsids and from there we narrowed down those capable of entering the brains of mice and macaques, delivering genetic cargo and transcribing it into mRNA. said the study’s lead author, Allie Stanton, a Harvard Medical School graduate student in the Sabeti lab.

A protective cover

Gene therapies consist of DNA, RNA, or other molecules that are transported around the body by delivery vehicles or vectors. AAVs are promising vectors because, as viruses, they are efficient in delivering their content into cells. Scientists replace natural AAV payloads with therapeutic DNA, gene-editing machinery, or other genetic information that they want to introduce into cells to treat disease.

“AAVs are a very good vector for gene therapy because you can put whatever you want inside its shell, which will protect it and get it into a wide variety of cell types,” Stanton said.

However, the majority of an injected dose of AAV typically ends up in the liver, meaning that high doses of AAV are required to obtain even a fraction in a different target tissue, such as the brain. In some cases, these high doses have resulted in liver damage and even death in clinical trials.

Engineering vectors to effectively target specific cells or organs could help reduce these unwanted side effects. Gene therapy researchers are working to make AAVs safer and more effective by altering the amino acid composition of the virus’s envelope, or capsid. Because there are billions of possible synthetic capsids of AAV, scientists can modify thousands to millions of viruses at once to look for those that serve a specific purpose – like crossing the blood-brain barrier.

Building Better Vectors

To develop a delivery system that could one day be used for hard-to-treat neurological diseases, Stanton and his colleagues focused on locating AAVs that cross the blood-brain barrier. They turned to a method developed in the Sabeti lab called DELIVER, in which scientists generate millions of capsids and search for AAVs that successfully deliver their payload to certain target cells. Using DELIVER, the team developed the PAL family of AAVs that cross the blood-brain barrier more efficiently than AAV9 – the only viral vector approved by the FDA for use in the nervous system.

They found that PAL AAVs were three times more effective at producing therapeutic mRNA in the macaque brain than AAV9.

The team also discovered that the modified viruses had a unique attraction to the brain. PAL-treated macaques had a quarter of the viral material in their livers like AAV9-treated primates, suggesting that the novel capsids may help limit the liver toxicity of other gene therapies.

The authors say that PAL AAVs could potentially work in humans given the similarity of macaques to humans, but added that AAVs did not work well in mice, making it difficult to test these vectors in mouse models of disease. In the future, the team hopes their work will provide a starting point for even more efficient viral vectors.

“We are encouraged by the early results of PAL-family AAVS, and can see several promising avenues of research using directed evolution and engineering to further increase their efficiency,” Sabeti said.


Support for this research was provided in part by an anonymous philanthropic donation, the Howard Hughes Medical Institute, the National Institutes of Health, a Shark Tank award from the Broad Institute’s Chemical Biology and Therapeutic Sciences program, and the American Society of Gene & Cell therapy.

Cited article
Stanton AC, et al. Systemic administration of novel modified AAV capsids facilitates enhanced transgene expression in the macaque CNS. Med. Online November 22, 2022. DOI: 10.1016/j.medj.2022.11.002.

About the Broad Institute of MIT and Harvard
The Broad Institute at MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe the molecular components of life and their connections; discover the molecular bases of the main human diseases; develop new and effective diagnostic and therapeutic approaches; and openly disseminate findings, tools, methods and data to the wider scientific community.

Founded by MIT, Harvard, Harvard-Affiliated Hospitals, and visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from every biomedical research community at MIT and around the world. Harvard and beyond, with collaborations spanning over a hundred private and public institutions in over 40 countries around the world.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Scientists unlock nature’s secret to super-selective binding


Diagram illustrating different types of binding interactions. Credit: Bastings/PBL EPFL

EPFL researchers have found that it is not just molecular density, but also pattern and structural stiffness, that control super-selective binding interactions between nanomaterials and protein surfaces. This breakthrough could help optimize existing approaches to virus prevention and cancer detection.

Much of biology boils down to the biophysical process of bonding: making a strong connection between one or more groups of atoms, called ligands, and their corresponding receptor molecule on a surface. A binding event is the first fundamental process that allows a virus to infect a host, or chemotherapy to fight cancer. But binding interactions – at least our understanding of them – have a “golden loop problem”: too few ligands on a molecule prevent it from binding stably to the right target, while too many can lead to unwanted side effects.

“When binding is triggered by a threshold of target receptor density, we call this binding ‘super-selective’, which is essential to prevent random interactions that could deregulate “, explains Maartje Bastings, head of the Programmable Biomaterials Laboratory (PBL) at the School of Engineering. “Since nature does not usually complicate things, we wanted to know the minimum number of binding interactions that would still allow super-selective binding. to arrive. We also wanted to know if the model the molecules are arranged in fact a difference in selectivity. It turns out that it is.”

Bastings and four from his Ph.D. students recently published a study in the Journal of the American Chemical Society which identifies the optimal number of ligands for super-selective binding: six. But they also found, to their delight, that the arrangement of these – in a line, circle or triangle, for example – also had a significant impact on the effectiveness of the link. They dubbed the phenomenon “multivalent pattern recognition” or MPR.

Scientists unlock nature's secret to super-selective binding

Geometric models of hexavalent vs random ligands (far right). Credit: Bastings/PBL EPFL

“MPR opens up a whole new set of hypotheses about how molecular communication in biological and immunological processes might work. For example, the SARS-CoV-2 virus has a spike protein template that it uses to bind to cell surfaces, and those templates could be really critical when it comes to selectivity.”

From coronaviruses to cancer

Because it is is so precise and so well understood that DNA is the perfect model molecule for PBL research. For this study, the team designed a rigid disk made entirely of DNA, where the position and number of all ligand molecules could be precisely controlled. After designing a series of ligand-receptor architectures to explore how density, geometry and nano-spacing influenced binding super-selectivity, the team realized that stiffness was a key factor. “The more flexible it is, the less precise it is,” says Bastings.

“Our goal was to carve out a place in as minimal a way as possible, so that every ligand molecule participates in the binding interaction. What we have now is a very nice toolbox to further exploit super-selective binding interactions in .”

Scientists unlock nature's secret to super-selective binding

Original microscopy data on different models of ligands on DNA materials. Credit: Bastings/PBL EPFL

The applications for such a “toolbox” are far-reaching, but Bastings sees three immediately valid uses. “Like it or not,” she says, “the SARS-CoV-2 virus is currently a first thought in virological applications. With the information from our study, one could imagine developing a super-selective particle with ligand motifs designed to bind to the virus to prevent infection, or to block a cell site so that the virus cannot infect it.”

Diagnostics and therapeutics such as chemotherapy could also benefit from super-selectivity, which could enable more reliable binding with cancer cells, for which certain receptor molecules are known to have higher density. In this case, would remain undetected, greatly reducing side effects.

Finally, such selectivity engineering could offer key insights into complex interactions within the immune system. “Because we can now precisely play with patterns of what’s happening at binding sites, we can, in a sense, potentially ‘communicate’ with the immune system,” says Bastings.

More information:
Hale Bila et al, Recognition of multivalent shapes by controlling nano-spacing in super-selective low-valence materials, Journal of the American Chemical Society (2022). DOI: 10.1021/jacs.2c08529

Quote: Scientists Unveil Nature’s Secret to Super-Selective Binding (2022, November 22) Retrieved November 22, 2022, from https://phys.org/news/2022-11-scientists-nature-secret-super-selective .html

This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

A man refuses to pay for his daughter-in-law’s tuition in medicine


A man is defended for his decision not to want to pay his stepdaughter’s tuition.

He posted the events leading up to the choice on the ‘AITA’ (Am I The A-hole) subreddit, a forum where users try to figure out whether or not they got it wrong in an argument that bothered them.

In his Reddit post, the man explained that he and his wife had been married for a decade and had a daughter from a previous relationship, Sarah.

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His daughter-in-law is currently working to go to medical school.

During her freshman year of college, Sarah worked toward a degree in biology, taking additional courses she will also need for medical school.

“She has had [a] dream of being a doctor and helping people since his mother and I met. The problem is that she’s not a very good student,” he wrote.

The man pointed out that Sarah had previously “failed her Biology 1 class” and was forced to retake the course to receive a higher grade.

“She really struggled in her graduate level biology class and finished with a C. She also got a C in her chemistry class. She got a B in calculus 1 and 2,” he said. he continued, adding that in the current semester, he’s learned she’s “going to do B’s and C’s in her science and math classes.”

Even though Sarah didn’t get impressive marks in her science and math classes, she only got high marks in all the other subjects.

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Due to his low grades in these courses, the man refuses to pay his medical school fees.

After learning how low Sarah’s grades were in those science and math classes, he decided to do some research.

“I’ve found that med school demands a lot, but at the top of the list is a high GPA and top grades in science and math,” he remarked, noting that his Current GPA is 3.2.

He continued, “With Sarah’s grades, she’s not getting into any medical school. I even looked into nursing school to see if I could convince her to go down this path and all the ones I have. examined require higher grades than she has.”

The man decided to discuss everything with his wife, but she maintained that medical schools “look at other things than grades”, which is the best thing for Sarah.

“She has a strong volunteer resume and she cares about people,” he added.

However, he refuted that none of this will matter if Sarah’s grades aren’t good enough, however, her mother was adamant that she will most likely excel in the school interview part. potential.

When Sarah came home for the Thanksgiving holiday, her stepfather sat her down and told her that she might want to “find out about another middle finger because she might not be cut out. to be a doctor”.

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“She ran up to her mum and we all argued. I admit I lost my temper and yelled that I wasn’t wasting any more money on something she would fail at.”

He told Sarah and his wife that he wouldn’t pay for her next semester of classes until she changed her major to something she can pass.

“I feel bad, really, but I’m not rich and I don’t have money to waste if she doesn’t get a chance to get into medical school,” he concluded. .

The majority of people who commented on the man’s Reddit post agreed that he was NTA (Not The A-hole).

“Medical schools are very competitive and each of them [has] a minimum GPA requirement. If her GPA is below that, they will automatically reject her without the possibility of an interview,” one user wrote.

Another user chimed in with a possible solution, writing, “A good compromise might be that you let her pay for school and if she excels you pay off her loans.”

“I’m all for supporting dreams, but based on her grades alone, it’s extremely unlikely that she’ll get into medical school, even if she gets perfect test scores,” added one. third user.

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Nia Tipton is a writer living in Brooklyn. She covers pop culture, social justice issues and current affairs. Follow her on Instagram and Twitter.

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nature could help reduce overpopulation


Xavier Pastor has spent his life fighting to protect the environmentt. Coming from a family with a maritime and fishing tradition, the Mallorcan is a biologist, oceanographer and ecologist and was one of the founders of Greenpeace Spain and president, as well as vice-president, of the organization Oceana for the defense of the seas. He was one of the pioneers of the environmental struggle in Spain.

After graduating in biology from the University of Barcelona, ​​he worked as a scientist at the Spanish Institute of Oceanography, participating in numerous fisheries research campaigns.

In 1984, he was one of the founders of Greenpeace Spain and contributed to the creation of the organization’s branches in Italy, Greece, Turkey, Tunisia and Malta, as well as leading various Greenpeace campaigns. in the United States before joining Oceana.

Today he is retired but continues his work on a voluntary basis serving as a bridge between environmental organizations in the Balearic Islands, such as Miralles, which he praises for their work in sharing their discoveries with the general public and not only the scientific world, and the general public. and private institutions. This with the aim of bringing everyone together in the fight against climate change, its main focus being the Balearics and the marine environment of the islands.

This week, in the context of the COP27 summit in Egypt, he told the Bulletin that the fight against climate change has reached its tipping point.

“I fear we are too late, there is still so much work to be done to help the poorest countries meet the targets set, while some of the world’s biggest polluters are slow to fully commit to the cause. . .
“We are going to have to learn to live with climate change and manage it. It can be slowed down and the impact reduced, but there is no turning back now,” he said.

“As we saw last week, climate change makes the Mediterranean one of the fastest warming seas in the world – with temperatures rising about 20% faster than the global ocean average. Marine plastic pollution has increased tenfold since 1980 and it is estimated that more than 10,000 tons of waste are dumped in the Mediterranean every year”.

Scientists already warned in 2015 that from the point of view of ecological and marine monitoring, the case of the Mediterranean was of particular interest in terms of plastic pollution. This semi-enclosed basin, with restricted outlets, is one of the most polluted regions in the world and the situation has only worsened.

“The problem is that up to 80% of the plastic in the waters of the Balearics and the Western Mediterranean comes from North Africa – Algeria in particular and to a lesser extent Tunisia and Morocco.
“Much of the waste is either dumped into the sea or dumped into the sea by rivers and then gets caught in the currents that bring the plastic to the Balearic Islands.

“This needs to be resolved. Politicians cannot sit idly by and ignore the problem because it is foreign to the Balearic Islands. We need to talk and work with these countries and look for ways to help solve their waste treatment systems to reduce plastic pollution in the sea.

“I took part in a big campaign about thirty years ago in Gibraltar, where most of the waste was dumped directly into the sea, causing serious damage to the marine ecosystem. We have succeeded in solving this problem, and a similar approach must be adopted for the damage caused by the countries of North Africa which have neither the money nor the know-how to find a solution. Perhaps they are not fully aware of the threat they pose to the Mediterranean, whether ecological or social.

“That said, under pressure from environmental groups, the Balearic government has achieved some success. The expansion of marine reserves is extremely positive and the way they are managed is very good. Take Cabrera, for example, it is the largest and best-managed natural marine reserve in the western Mediterranean and we have seen fish stocks grow rapidly over the last ten years; the same goes for El Toro and the Malgrats. So, with better management, countries and regions like the Balearic Islands, which have the funding, the technology, the expertise and the will to protect the environment, can make a difference. But unfortunately the poorest and least developed countries are missing out and that is where we need to engage,” he said.

But macro and micro plastic pollution is just one of the problems facing the marine environment of the Balearics and the Mediterranean.
As the world heats up, marine heatwaves are expected to become more frequent, according to the United Nations Intergovernmental Panel on Climate Change.

Climate change has already contributed to a 54% increase in the annual number of ocean heat days between 1925 and 2016.a team of international scientists found in 2018.
Scientists say the Mediterranean could experience at least one severe, long-lasting heat wave every year by 2100, according to a 2019 study in the journal Climate Dynamics.

“The sea and the land are getting warmer and warmer, just look at what we have experienced this summer in the Balearic Islands, plus we desperately need rain. Rising sea temperatures and an increase in CO2 in the sea ​​are a danger to marine life, moreover we have a rise in sea level which is already leading to the erosion of our beaches, while on land the temperatures are gradually becoming unbearable.

“I guess there’s a flip side to every crisis. In the next ten years, perhaps less, the Balearic Islands will become uncomfortably hot for tourists from northern Europe. We are already seeing an explosion of tourism in countries like Scotland, Iceland and Scandinavia and this could lead to a reduction in the number of tourists to the Balearic Islands, which I have been calling for for almost 30 years. The islands can no longer cope with the human footprint left by mass tourism. They have been suffering for decades, so nature can help create a more balanced tourism industry in the Balearic Islands and help bring the numbers down,” he said. “It’s a natural contradiction in a way.”

“A perfect example is the fact that the sewage treatment plants on the islands, especially in Mallorca, cannot cope with the amount of waste. The factories were built about 30 years ago and at the time were working extremely well. Now they can’t, that’s why every time it rains, the beaches are polluted when the sewers overflow. Luckily they are being replaced and modernized thanks to EU investment, but it took time,” he said.

“But at the same time nature can help create a more balanced tourist industry in the Balearic Islands, it will lead to an increase in the number of visitors to Northern European countries. This will have a negative impact on their environment and ecosystems. It is a vicious and unstoppable cycle.

“I suppose for the younger generations the impact might not be so extreme. For people of my generation, for example, we remember it, we know how it was in Mallorca and the Balearics there. is 30 or 40. We have witnessed what we have lost, how things have changed and the impact of climate change on the region.

The younger generations have not seen the radical change and the impact of climate change and mass tourism on the region so, understandably, they do not grasp the urgency to act radically.

“As far as the Balearic Islands are concerned, I push for the greater use of renewable energy, solar and even wave power. I am trying to persuade all institutions, whether it is the airport, hospitals, schools, large companies, to switch to solar, renewable energy and to produce their own electricity. If we are facing a drought, turning to desalination plants is not the solution because they are powered by very expensive means and emit large amounts of CO2, so it defeats the whole purpose . Any action we take now must be aimed at exploiting climate change. »

MCDB and SMTD students collaborate for Scientist Spotlight Day performance


Located in the Natural History Museum, students from the Department of Molecular, Cellular and Developmental Biology (MCDB) and the School of Music, Theater and Dance (SMTD) collaborated to present the work of performative art “ Movement Under the Microscope”. The event was part of the Science Communications Fellows program and included a science spotlight day with the aim of raising public awareness of ongoing research. The Scientist Spotlight offers Michigan researchers a chance to share their work with museum visitors and increase accessibility for K-12 students.

The Museum’s Scientist Spotlight Day featured researchers and students from a variety of scientific backgrounds in hopes of increasing engagement and awareness in the academic research community. This event is an ongoing initiative of the museum and requires its science communication fellows to help organize hands-on activities and games for visitors of all ages and interests. Research topics ranged from measuring the relationships between mental health and climate change, as well as the psychology behind COVID-19.

Rackham’s student Claudia Mak explained how photosynthetic cyanobacteria can rid the atmosphere of excess carbon dioxide. Mak also added that the pandemic has revealed a personal need for science communication.

“I’m really interested in science communication in general, speaking to the public and really helping to bridge that gap between the public’s understanding and knowledge of science and how science is actually conducted because I feel like , especially what we’ve seen with the pandemic, there’s a lot of fear around what science actually is,” Mak said. “I want to help people understand what (researchers) are actually doing.”

After the first half of the event, visitors gathered in the museum’s west atrium for the science theater production “Movement Under the Microscope.” This performance showcased the process of cell movement and cytoskeleton functions through human choreography. Morgan DeSantas, assistant professor at MCDB, and Tzveta Kassabova, associate professor of theater and drama at SMTD, combined their respective classes to create the performance.

DeSantas said she received a grant from the National Science Foundation for the event and that the event was important in promoting public awareness and sharing the value of accessible science communication with students.

“The goal was really to develop something that would do content for the museum, that would teach something about the cytoskeleton in a way that was accessible to a wide audience and also give STEM students the experience of conveying abstract ideas from more streamlined way and to give the movement that students experience in science themes,” DeSantas said.

Kassabova said there are similarities between the MCDB and theater, including the emphasis on movement, which made the collaboration possible.

“In a way, both classes work from movement in the different abilities, so it was fun to take ideas from biology and science and see how we can interpret them with movement,” said said Kasabova. “The scale is very different, but it was fun to observe what’s happening in the cell on a very different level and… make it visible to the human eye.”

Jade Marks, the museum’s science communications manager, served as the liaison between the museum and the classes throughout the planning of the show. Marks said involving SMTD students is integral to making science accessible.

“Science really is for everyone and should be for everyone,” Marks said. “It can be fun. It can be beautiful. It can be inspiring. And so I hope this performance is that of all of these students (SMTD), and they continue to seek out these kinds of collaborations that push them out of their comfort zone as their professional career progresses.

Kassabova said the performance helped STEM students gain a new appreciation for physical intelligence and movement. LSA senior Vaishnavi Krishnan, a member of the MCDB class involved in performance, said she had no art or performance background. However, she said she enjoyed the openness of the event and that it taught her new ways to visualize biological concepts, like polymerization.

“I think, especially in science classes, sometimes it’s very difficult to be able to visualize some of the processes going on, because it’s on such a small scale, and it can sometimes be so abstract,” Krishnan said. “I think this course has been a great way for me to see that you can actually represent these things and in a very simple way.”

During the event, the museum was also visited by various eighth-grade classes from local Michigan schools. Marks said middle and high school students are being asked to decide career paths and career choices at an increasingly early age and said she hopes students don’t see the arts and sciences at odds with each other, but rather as complementary fields of study.

“It doesn’t have to be science or the arts or the humanities versus technology or whatever way we try to analyze and divide our world,” Marks said. “It’s good to love science and to love art, and it’s good to work at the intersection of these disciplines. It is a meaningful and fulfilling place.

Daily News reporter Sirianna Blanck can be reached at sirianna@umich.edu.

HBKU’s Qatar Biomedical Research Institute Tackles Genome-Related Complexities in Triple-Negative Breast Cancer


Doha – The Qatar Biomedical Research Institute (QBRI), part of Hamad Bin Khalifa University (HBKU), recently published articles in two prestigious scientific journals identifying research findings on gene regulation in human cancers and a new method of classifying tumors that may lead to a tailored treatment for triple-negative breast cancer.

One of the most startling findings from recent genomics research is that only 2% of the human genome codes for functional proteins, an essential component of the work done by living cells. The function of the vast majority of the remaining genome – the so-called “dark matter” or “junk DNA” – remains to be elucidated. These data are surprising, given that approximately 75% of the genome may be active in a cell at any time.

“Emerging findings have revealed the transcription (or copying) of the vast majority of our DNA into RNA, without it being translated into functional proteins (called non-coding RNAs). However, having worked in the field of non-coding RNAs for more than 15 years, we know more than ever about their regulatory role in different cellular functions and their importance in tumor formation (tumorigenesis),” explained Dr. Nehad. Alajez, principal investigator at the Translational Center for Cancer and Immunity (TCIC) at QBRI.

In an article published in the prestigious Seminars in Cancer Biology by Elsevier, Dr. Alajez and his team highlight the crucial role of long non-coding RNAs (ncRNAs) in the regulation of the genome via their interactions with RNA-binding proteins (RBPs). The article covers various aspects of the interaction between lncRNAs and RBPs in the context of human cancers.

In breast cancer, a major problem accounting for the majority of cancer-related deaths in women, is the heterogeneous nature of the disease. While the classification of breast cancer into three types, HR-positive, HER2-positive and triple-negative (TNBC) breast cancer, has made it possible to propose a treatment adapted to patients of each subtype, tumor heterogeneity (variations in types of cancer cells within the same tumor) and differences in how patients respond to treatment remain a major clinical challenge.

Thinking differently is key to success, according to Dr. Alajez, who brings strong expertise in transcriptome analysis, non-coding RNAs and biomarker discovery to QBRI’s TCIC in their current focus on translational oncology and research. in precision medicine. In a second article, published in non-coding RNA, an open-access MDPI journal, the team used a novel approach to characterize the expression of tens of thousands of ncRNAs in TNBC, using artificial intelligence (AI) to unravel disease heterogeneity. The team was able to categorize TNBC into four different groups, with each group expressing a defined set of lncRNAs.

The authors revealed functional differences between the identified clusters and predicted the relapse-free survival of patients based on this new classification method. These results could potentially impact the stratification of patients into subgroups within the TNBC subtype, for personalized treatment in the future.

To develop this area, the team is currently conducting a large-scale experiment, using a gene editing tool (called CRISPR-Cas9 screening) that allows the manipulation of DNA in the cell to study their function. The results will offer insight into the function of hundreds of ncRNAs in TNBC, paving the way for the use of these candidates as potential prognostic and therapeutic targets. The results may provide the first-ever lncRNA dependency map of TNBC in the context of chemotherapy resistance. The research is carried out in collaboration with University College Dublin, with support from the Qatar National Research Fund.

For more information about QBRI’s Translational Cancer and Immunity Center, a national center of excellence and global center for biomedical and translational research related to diabetes, cancer and neurological disorders, please visit qbri.hbku.edu.qa .


About Hamad Bin Khalifa University

Innovate today, shape tomorrow. Hamad Bin Khalifa University (HBKU), a member of the Qatar Foundation for Education, Science and Community Development (QF), was founded in 2010 as a research-intensive university that acts as a catalyst of transformative change in Qatar and the region while having global impact. Located in Education City, HBKU is committed to strengthening and cultivating human capabilities through an enriching academic experience, an innovative ecosystem, and unique partnerships. HBKU offers multidisciplinary undergraduate and graduate programs in its colleges and offers research and scholarship opportunities in its institutes and centers. For more information about HBKU, visit www.hbku.edu.qa.

Artificial neural networks learn best when they spend time without learning at all


Summary: “Offline” periods during AI training mitigated “catastrophic forgetfulness” in artificial neural networks, mimicking the learning benefits that sleep provides to the human brain.

Source: UCSD

Depending on age, humans need 7 to 13 hours of sleep per 24 hours. During this time, a lot is happening: heart rate, breathing, and the ebb and flow of metabolism; hormone levels adjust; the body relaxes. Not so much in the brain.

“The brain is very busy when we sleep, repeating what we’ve learned during the day,” said Maxim Bazhenov, PhD, professor of medicine and sleep researcher at the University of California San Diego School of Medicine. . “Sleep helps reorganize memories and present them in the most effective way.”

In previous published work, Bazhenov and colleagues have reported how sleep builds rational memory, the ability to remember arbitrary or indirect associations between objects, people, or events, and protects against forgetting old memories. .

Artificial neural networks take advantage of the architecture of the human brain to improve many technologies and systems, from basic science and medicine to finance and social media. In some respects, they have achieved superhuman performance, such as computational speed, but they fail in one key aspect: when artificial neural networks learn sequentially, new information overwrites previous information, a phenomenon called catastrophic forgetting. .

“In contrast, the human brain is constantly learning and integrating new data into existing knowledge,” Bazhenov said, “and it generally learns best when new training is intertwined with periods of sleep for memory consolidation.”

Written in the November 18, 2022 issue of Computational Biology PLOS, Lead author Bazhenov and colleagues discuss how biological models can help mitigate the threat of catastrophic forgetting in artificial neural networks, enhancing their usefulness in a range of research interests.

The scientists used spike neural networks that artificially mimic natural neural systems: instead of information being communicated continuously, it is transmitted as discrete events (spikes) at certain times.

They found that when peak networks were trained on a new task, but with occasional offline periods that mimicked sleep, catastrophic forgetting was mitigated. Like the human brain, the study authors said, the networks’ “sleep” allowed them to replay old memories without explicitly using old training data.

Memories are represented in the human brain by patterns of synaptic weight – the strength or magnitude of a connection between two neurons.

“When we learn new information,” Bazhenov said, “neurons fire in a specific order, which increases the synapses between them. During sleep, the spike patterns learned during our waking state spontaneously repeat. This is called reactivation or proofreading.

Artificial neural networks take advantage of the architecture of the human brain to improve many technologies and systems, from basic science and medicine to finance and social media. Image is in public domain

“Synaptic plasticity, the ability to be modified or molded, is still in place during sleep and it may further enhance synaptic weight patterns that represent memory, helping to prevent forgetfulness or enable the transfer of knowledge from ‘old tasks to new ones.’

When Bazhenov and his colleagues applied this approach to artificial neural networks, they found that it helped the networks avoid catastrophic forgetting.

“This meant that these networks could learn continuously, like humans or animals. Understanding how the human brain processes information during sleep can help increase memory in human subjects. Increased sleep patterns can lead to better memory.

“In other projects, we are using computational models to develop optimal strategies for applying stimulation during sleep, such as auditory tones, which improve sleep rhythms and improve learning. This can be especially important when memory isn’t optimal, such as when memory declines with aging or in certain conditions like Alzheimer’s disease.

Co-authors include: Ryan Golden and Jean Erik Delanois, both at UC San Diego; and Pavel Sanda, Institute of Informatics, Czech Academy of Sciences.

About this AI and learning research news

Author: Scott Lafee
Source: UCSD
Contact: Scott La Fee – UCSD
Image: Image is in public domain

See also

It shows a little girl and a dog

Original research: Free access.
Sleep prevents catastrophic forgetting in peak neural networks by forming a joint representation of synaptic weight” by Maxim Bazhenov et al. Computational Biology PLOS


Sleep prevents catastrophic forgetting in peak neural networks by forming a joint representation of synaptic weight

Artificial neural networks overwrite previously learned tasks when trained sequentially, a phenomenon known as catastrophic forgetting. In contrast, the brain learns continuously and generally learns best when new training is interspersed with periods of sleep for memory consolidation.

Here, we used the spike network to investigate the mechanisms behind catastrophic forgetting and the role of sleep in preventing it.

The network could be trained to learn a complex foraging task, but exhibited catastrophic forgetfulness when trained sequentially on different tasks. In the synaptic weight space, training for new tasks shifted the synaptic weight configuration away from the variety representing the old task leading to forgetting.

Intertwining new training tasks with periods of offline reactivation, mimicking biological sleep, mitigating catastrophic forgetfulness by constraining the synaptic weight state of the network to the previously learned collector, while allowing the weight configuration to converge towards the intersection of the collectors representing the old and the new tasks.

The study reveals a possible strategy of synaptic weight dynamics that the brain applies during sleep to prevent forgetting and optimize learning.

Central Middle students chosen for honors choir


Mount Airy gets a new mayor, based on Tuesday’s election result which the two candidates involved say resulted from a high turnout.

Jon Cawley, who has served as North Ward town commissioner since 2008, lost to Mayor Ron Niland in a May 17 primary but was victorious in the rematch for Mount’s most elected post. Airy.

Unofficial Surry County Board of Elections results showed Cawley received 1,915 votes (5% of the total vote), against Niland, who received 1,511 (4%).

Big push for Cawley’s support recently, as well as two issues he says fueled the result – involving a controversial downtown masterplan and a sign request from a local racing legend – are credited for victory.

“I went there planning to win and I had a lot of support from a lot of people and a lot of people went out to vote,” Cawley said Wednesday.

“Treva Kirkman was my campaign manager and we talked about winning,” he said of the determined mindset involved.

“And I feel like we ran a clean campaign,” the mayor-elect added. “This campaign had a lot of abuse, but I didn’t participate in it.”

The owner reacts

Niland was kind in his comments Wednesday about the nonpartisan election verdict and the underlying factors.

“Well, I don’t know if I was surprised,” added the mayor, who was appointed to the post last year to replace David Rowe, who previously held it before stepping down in October 2020 over charges. health reasons.

Niland credited his opponent’s campaign team.

“They worked very, very hard and they worked hard on early voting and I didn’t,” Niland acknowledged of a storyline that included Cawley stepping out for the start of that process the morning he started October 20.

The results of the one-stop, mail-in early voting period that ended last Saturday were evident with the release of the first returns for the mayoral race on Tuesday evening.

Before ballots from one of the city’s five wards had been counted, preliminary figures incorporating early voting showed Cawley a 1,163-to-998 advantage that held and gradually increased over the as the evening progressed.

Cawley had a lead of 182 votes after the results from a single constituency were released, which reached the winning margin of 404 votes after all were tallied.

“And the participation helped,” said the challenger.

“I just want to congratulate the winners,” Niland said Wednesday, referring not only to the mayor’s contest, but also to the three Mount Airy Board of Commissioners races that will see the five-member group get a trio of new ones.

All those elected on Tuesday will be sworn in at the beginning of December.

“I’m disappointed, obviously,” Niland said of his loss. “But I’m optimistic about the future of our city.”

The mayor, also a former city manager here, says he plans to prepare an official statement on the situation to read at the next council meeting on November 17.

Downtown, Fleming Factors

Along with the campaign basics of working hard to get voters out, Cawley pointed to two issues that have emerged since the May primary that he says affected the outcome of the mayoral election.

One concerned the recent adoption by the city council of an updated master plan for downtown Mount Airy, which many citizens – and business people in the central business district – oppose, including by organizing a protest march on October 9.

Niland has been a strong supporter of the plan which critics fear will cause physical changes to streets and sidewalks that could damage the existing character of the downtown area.

Cawley voted against the plan on September 1, the same evening he was criticized by the majority of speakers in a public hearing, and said on Wednesday he thought it struck a chord with voters. “The rush to get this vote through for a reason that seems very hard to fathom.”

The other issue he says played a part involved a struggle from local body shop owner Frank Fleming, also known for his successful modified racing career. Fleming first hit a snag in his plan to use an existing panel at a site where he is developing a $2 million facility that will create jobs.

Fleming was banned from using the old sign due to exceeding city height regulations that apply to new businesses, despite its former use by a supermarket. Those rules were deemed petty and arbitrary by some observers and, as Cawley said on Wednesday, ran counter to common sense.

Cawley openly supported Fleming’s efforts to remedy the situation, which included appealing a zoning board’s decision to Surry County Superior Court.

City officials later approved an amendment allowing the local businessman to reuse the sign, with a host of his supporters in the audience, including a member of the NC General Assembly. Still, the damage seemed to have been done from a public perception standpoint.

“I think we need to do a better job of listening and taking more responsibility for educating the public,” Cawley suggested Wednesday of such situations.

“And I feel like we focused on the issues that were in front of us and people responded to our message,” the election winner said of his campaign team.

The mayor-elect cited public safety as the number one need he wants to tackle, particularly regarding staff departures from the city’s police and fire departments.

He had one last thought on Wednesday:

“Thank you to all these wonderful people who have supported me.”

Video: Did this male have a seizure when scratched?


Trail camera footage shows a male scratching before falling and having what appears to be a seizure. courtesy of Growing Deer TV

A video that was shared to Instagram earlier this month by Growing Deer TV shows trail camera footage of a male working a scratch in an undisclosed location. While raising his head to work an overhanging limb, the male suddenly hits the ground and has what appears to be a seizure. At least that’s the theory of Grant Woods, highly respected white tail biologist, habitat manager and host of Growing Deer TV.

Woods says a viewer named John Gibbs sent him the tracking camera footage and asked for his opinion. The video does not have a timestamp and Gibbs chose not to share the location where it was recorded.

“I had never seen anything like it, but after talking we think this male had a seizure,” Woods said, adding that he couldn’t think of any other reasonable explanation. “I’ve never heard of or seen anything like this, and none of my colleagues have mentioned a male acting like this.”

Going down the list of possible causes, Woods explains that seizures are not a symptom of chronic wasting disease (CWD) or epizootic hemorrhagic disease (EHD). He also doesn’t believe the seizure was caused by anything the deer ate, as it’s likely other deer in the area would have had a similar reaction and Gibbs saw no evidence of this.

Read more : Grant Woods has just sold the “proving grounds”. Here’s what he learned while building one of America’s most famous Whitetail properties

Gibbs has, however, recorded additional footage of the male since the seizure video was shared on November 1. The male returns to the scratch and acts completely normal in later videos. But when he and Woods looked closer, they noticed the deer was missing an eye. It is difficult to say for sure if the deer lost its eye before the video of the seizure was recorded, as this video only shows the right side of the deer. But if that has been indeed the case, Woods thinks he could offer a fuller explanation of the seizure.

“I assume – and it’s a total assumption – that he fought [with another buck] and somehow he got his eye gouged out,” Woods says. “And there was probably some neurological damage with that injury. We’re just putting things together here and I need to clarify that, but I think it’s a pretty logical conclusion.

Allegheny alumna returns for undergraduate seminars – The Campus


Allegheny, ’08 alumnus Emily Pfeufer, Ph.D. in Plant Pathology, returned to campus last Thursday, November 10, to share her experiences and wisdom about the world after her undergraduate studies.
Pfeufer originally returned to Allegheny in September for the blue and gold weekend when she was inducted into the Allegheny Athletic Hall of Fame for her success on the track and field team in the long jump and triple jump.
“She reached out and asked if we could have a coffee,” said biology professor Catharina Coenen. “And I said, ‘You’re a plant pathologist and I’m teaching two classes this semester that should meet you. I would like you to come and talk to these classes.
Plant pathology is the study of diseases that affect plants, which may be caused by pathogens or environmental conditions, according to Science Direct.
Pfeufer was unable to conduct his interviews in September due to the nature of his research, Coenen said.
“We had to work with certain clearances at the USDA to get him for class visits and to give a public seminar on his research,” Coenen said.
Pfeufer works with the Alien Diseases and Weeds Scientific Research Unit of the United States Department of Agriculture’s Agricultural Research Service, according to the published flyer detailing his seminar. Given her nature of federal employment, she could not comment privately on The Campus without authorizing the interview with her agency.
Pfeufer’s research examines potential threats to US food security that may arise in response to climate change — specifically plant diseases caused by “oomycetes.” According to the American Phytopathological Society, oomycetes are small, fungus-like parasitic aquatic molds.
“Plant pathologists tend to be completely under-recognized in their contribution to global food security,” Coenen said. “In my mind, they are major contributors to world peace because agricultural failures lead to hunger, which tends to lead to violence.”
Pfeufer’s evening research seminar detailed his recent findings on the oomycete genus Phytopythium and its relevant species. According to the flyer, his team found that higher temperatures and increased irrigation in response to climate change can increase phytopythium-induced diseases in citrus grown in the United States. His seminar summarized this ongoing research that spanned years.
In addition to giving a public seminar about his research, Pfeufer also attended several mentorship meetings with Coenen students to discuss bioscience options after completing his undergraduate studies.
“I was really excited about the opportunity to give students an idea of ​​what a career in plant pathology might look like,” Coenen said. “(But), I wanted (these events) to attract students who didn’t see themselves doing agriculture at all. I wanted them to be able to get something out of it even if their main interest was medicine or completely different areas of scientific research.
While the evening seminar focused on Pfeufer’s scientific research, class visits focused more on advising individual students, answering questions, and offering advice.
“(Pfeufer) focused a lot on (the explanation) that it’s important to do what you love and to try different things because even if you don’t like what you’re trying, it always helps you to find what you love,” Kaylee Sadowski said. , ’24.
Classroom presentations focused primarily on understanding graduate school application processes and the workforce, Sadowski said. Pfeufer offered advice on how best to present yourself in these situations.
“We talked about interviewing nerves, how scary they are,” Sadowski said. “And she told me to think that you were interrogating them too, and that they chose you.” So be yourself.
In addition to class discussions, Coenen also worked with Liam Jones, 23, co-chair of the newly reformed Allegheny Chapter of the Beta Beta Biology Honor Society – commonly referred to as “Tri-Beta” – to organize an informal luncheon. with Pfeufer.
“Liam was very excited to have a guest speaker visit as part of the Tri-Beta program,” Coenen said. “And so we arranged a pizza lunch as part of the tour.”
Tri-Beta, a national biology honor society, briefly disbanded its Allegheny chapter during the COVID-19 pandemic because officers were then unable to pass on leadership. The club was re-established last fall by Jones and co-president Hanah Simmons, ’23.
“I’ve been trying to get him to restart since last year as a junior in the first half,” Jones said. “(It) took a lot of work. Eventually we had people on board and everything fell into place, and we were able to start it this year.
Jones heard about the research seminar Pfeufer was about to give through Coenen. They decided to host the lunch with funding from the Darling Distinguished Speaker Fund, which was established to facilitate experiences with educational speakers for students.
Jones said one of his goals in hosting the lunch was to give students an opportunity to learn about areas of science that aren’t really present in Allegheny’s curriculum.
“I know there aren’t too many people interested in botany,” Jones said. “It’s kind of an area that we don’t have in Allegheny. One of my main goals when rebooting Tri-Beta was to try to do a lot of interests like zoology, microbiology, genetics, and when an opportunity to have someone from the field of botany s is presented, I jumped at the idea.
Emma Ruhl, 23, a student in Coenen’s microbiology class and lunch attendee, echoed the sentiment.
“I thought it was really interesting,” Ruhl said. “I think it’s a really interesting opportunity to get to know other careers in the organic department because sometimes I feel like we’re limited.”
The lunch setting also aimed to provide a more relaxed environment for students to have more conversation with Pfeufer.
“It was very relaxing,” Ruhl said. “It wasn’t like, ‘Oh my god, I’m so nervous. What should I say?’ But everyone seemed very cool. So that was nice.”
The students expressed mixed feelings about how the advice they received from Pfeufer affected their ideas about their future projects. Some, like Sadowski, came out of the talks feeling more confident about their career paths.
“I just thought (Pfeufer’s advice) was a nice little interview boost,” Sadowski said.
Others felt a little less clear about what their future career path might look like.
“It was helpful, but it also made me a little more confused, in a way,” Ruhl said. “It was just a lot of information to take in. I think it was beneficial to hear about it, especially from an elder, but it was also still uncertain for me because I’m still thinking. what I want to do after graduation.
Regardless, both students have always expressed an interest in attending more organized conferences like this in the future.
“Hopefully they can sponsor more,” Ruhl said. “I was very happy to hear that Tri-Beta had sponsored them as well.”
Tri-Beta meets every two weeks at Steffee B102. Students of all majors are invited to join in and share their love for science.
“We’re looking to grow our club because it’s a true honor society,” Jones said. “It’s not just a club. It’s a national honor society.

UT Southwestern Scientists Among Top 1% of Most Cited Researchers Worldwide: Newsroom


UT Southwestern scientists currently lead approximately 5,800 research projects with nearly $610 million in support from the National Institutes of Health, the State of Texas, foundations, individuals, and corporations.

DALLAS – November 17, 2022 – More than 20 scientists from UT Southwestern Medical Center are among the Most cited researchers in 2022 listed in the top 1% of researchers worldwide who have demonstrated significant and broad influence in their chosen field or areas of research. The list was announced today by the Clarivate Institute for Scientific Information.

Of the nearly 8 million researchers worldwide over the past decade, less than 1% have published multiple highly cited papers by their peers that rank in the top 1% citations for their field and year. The list includes UT Southwestern researchers in cardiology, psychiatry, diabetes, digestive diseases, cell biology, molecular biology, microbiology, biochemistry, immunology, and genetics. It includes leaders from Harold C. Simmons Cancer Center, Hamon Center for Regenerative Science and Medicine, Hamon Center for Research in Therapeutic Oncology, Peter O’Donnell Jr. Brain Institute, Touchstone Diabetes CenterHarry S. Moss Heart Center, Center for Depression Research and Clinical Care, UT Southwestern Children’s Medical Center Research InstituteCenter for Inflammation Research and UT Southwestern Peter O’Donnell Jr. School of Public Health.

“Research fuels the race for knowledge, and it is important that nations and institutions celebrate the individuals who drive the wheel of innovation,” said David Pendlebury, head of research analysis at the Institute. for Scientific Information by Clarivate. “The Highly Cited Researchers list identifies and celebrates outstanding individual researchers at UT Southwestern Medical Center who are having a significant impact on the research community, as evidenced by the citation rate of their work by their peers. These people are helping to transform human ingenuity into our world’s greatest breakthroughs – and it’s an honor to celebrate their accomplishments.

Considered a “who’s who” of influential researchers, the Highly Cited Researchers list is produced annually by the Institute for Scientific Information of Clarivate, a British analytics company. The recognition highlights scientists who demonstrate significant and broad influence reflected in their publication of several highly cited papers over the past decade. Highly cited papers rank in the top 1% in terms of citations for a field or fields and year of publication in the Web of Science. Among the global population of scientists and social scientists, the most cited researchers are 1 in 1,000.

The Highly Cited Researcher lists add to other recent recognitions for research at UT Southwestern.

For the third year in a row, UT Southwestern is ranked as the best health care institution in the world by Nature Index to publish high quality research in all fields and in the life sciences. The Nature Index compiles affiliate information from research articles published in 82 leading scientific journals, providing perspective on high-quality scientific discoveries around the world. UTSW also ranked second in the world this year among healthcare institutions in chemistry; top 10 in biochemistry and cell biology, earth and environmental sciences, and physical sciences; and among the top 25 in neuroscience.

UT Southwestern Medical Center ranked fourth in the nation and No. 1 in Texas for commercializing new biomedical technologies, seen as a critical step in putting its laboratory discoveries into clinical practice. UT Southwestern was the only Texas institution in the top 10 ranking, released by economic think tank Heartland Forward.

The institution’s faculty has received six Nobel Prizes and includes 24 members of the National Academy of Sciences, 18 members of the National Academy of Medicine, and 14 researchers from the Howard Hughes Medical Institute. UT Southwestern scientists currently lead approximately 5,800 research projects with nearly $610 million in support from the National Institutes of Health, the State of Texas, foundations, individuals, and corporations.

Additionally, UT Southwestern ranks among the top hospitals nationally in nine specialties according to US news and world reportincluding five specialties ranked among the top 25 in the country: heart, diabetes, respirology, urology and cancer.

About UT Southwestern Medical Center

UT Southwestern, one of the nation’s leading academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes and includes 24 members of the National Academy of Sciences, 18 members of the National Academy of Medicine, and 14 researchers from the Howard Hughes Medical Institute. Full-time faculty of more than 2,900 are responsible for groundbreaking medical advances and committed to rapidly translating scientific research into new clinical treatments. UT Southwestern physicians provide care in more than 80 specialties to more than 100,000 inpatients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits annually.

Precision Agriculture News 11/16 | AgWired



ZimmCast 701 – A view from above with Syngenta Crop Protection

In this week’s program, I will share interviews with Syngenta management at the company’s media summit.

In the program, I will share my conversation with Vern Hawkins, President, Syngenta Crop Protection, LLC, followed by Jeff Cecil, Head of North American Crop Protection Marketing. Vern will discuss a “Top View” and then Jeff will discuss “Syngenta CP Innovation and the Economics of Agronomy”.

I hope you like it and thank you for listening.



Practicing environmental awareness, sustainability | echo


It’s easy; people walk to a trash can, throw their rubbish in the bin and leave without thinking twice.

But how often do people think about where the garbage goes? How often do people take steps to sort waste and recycle it properly? The waste disposal method is so simple that people often don’t know how or where they throw their trash or recycling.

This is just one situation where a sustainability mindset would be beneficial.

Fortunately, there are several measures in place at Taylor University that encourage sustainability. These measures range from reducing food waste to conserving energy and water. Many of these measures are financially beneficial and simply good stewardship of many resources that people often take for granted.

“Taylor has a really good recycling program, although the students haven’t learned how to use it well,” said Phil Grabowski, assistant professor of the sustainability program.

Grabowski explained that when waste is properly sorted, the recycled waste is sold to a company, which generates revenue for the university. Trash in the bins has to go to a landfill, which Taylor has to pay for.

Not only is recycling more financially advantageous for the university, but it is also more sustainable for the environment. If something that should have been recycled goes in the trash, it will go to the landfill and stay there indefinitely.

“The message I want students to hear is just to recycle properly, pay attention to signs, put things in the correct bin and don’t throw your salad in the recycling bin because then the whole bag is contaminated and no one has time to sort through it all,” Grabowski said. “Things get contaminated and everything goes in the trash.

There are many other types of waste, such as water waste, food waste or energy waste.

Grabowski advises against unnecessarily long showers, as a lot of energy is used to bring water from its source to the tap. Not only will taking slightly shorter showers save water, it will also save the energy used to transport and heat the water.

“When students waste food — or someone wastes food — it goes to landfill, and usually it creates methane, which is a greenhouse gas,” Grabowski said. “Not only are there those kind of pollution aspects, but there’s also all the waste that went into growing this food, processing it and transporting it here.”

Fortunately, Taylor University has taken steps to prevent certain food waste, such as peelings and scraps, from being fed to an employee’s cows and pigs, and intact pans of frozen food then donated to the community.

When it comes to transport-related energy waste, driving short distances can be convenient, but walking is generally healthier for both body and mind. Walking also helps reduce the amount of gas emissions from cars. If faster transportation is needed, bicycles and skateboards are also great options.

In fact, Michael Guebert, co-chair of the Department of Biology, Environmental Science, Public Health, and Sustainability, offers bikes for rent and runs a garage next to the Ockenga Honors Lodge where students can repair their own bikes.

Some students might be inclined to ignore sustainability metrics or ask, “Why should I care? »

James Bates, environmental science major, provided an answer.

“The easy answer to ‘why should other people care’ is because you’re human and you live on the planet,” Bates said. “And if you’re a human and you live on the planet, whether you realize it or not, you’re very dependent on everything on the planet, and you’re even more directly dependent on the specific systems that you live in close proximity to. You depend on your region’s water cycle, your region’s carbon cycle, you depend on the crops that grow around you, (and) the trees and vegetation that grows around you.

Bates explained that his concern for the environment and creation stems from his knowledge and experience with this creation.

He likened this progression of knowledge to care to how one takes care of one’s own body; we learn to know our body, we learn to take care of it and we take care of it because we realize the importance of doing so.

“If we don’t invest in these (aspects of the environment) and make sure we don’t abuse these things, not only do we lose that part of our vocation which in Genesis we are called to take care of creation, but we also don’t reap the benefits of surviving, to put it bluntly,” Bates said.

Bates relayed the importance of fostering care and appreciation for the environment by putting yourself in a place to experience and learn about the environment.

He also expressed how easy it can be to overlook the importance of resources and the environment due to the accessibility of resources such as water, food and energy.

“I encourage students here to, at a minimum, at least think about the sources of the things they consume and use, be it water, electricity, food, […] many of them are finite sources,” Bates said. “So at a minimum, think about those things, and at a maximum, take action and change your way of life to use (resources) more conservatively.”

Students interested in learning more about environmental science can explore Taylor’s Stewards of Creation Club, which actively educates and works toward campus sustainability. For more information, contact Juniper Tucker at juniper_tucker@taylor.edu, Jared Hyatt at jared_hyatt@taylor.edu or Emily Hudson at emily_hudson1@taylor.edu. Additionally, there are volunteer sustainability assistants in the halls of residence who promote sustainable practices. Students from all majors and departments are welcome.

Researchers capture and tag giant lake sturgeon in New York


Researchers caught a huge lake sturgeon at Cayuga Lake in New York in October. The 154-pound, 6-foot-5 fish, caught by New York Department of Environmental Conservation (NYDEC) biologists conducting a population survey, was nearly twice as large as the largest sturgeon previously captured in Cayuga. It weighed only 5 pounds less than a sturgeon believed to be the largest ever encountered in New York. The fish, caught last year by researchers at Oneida Lake, weighed 159.4 pounds and was 26 years old.

The lake sturgeon is New York’s largest freshwater fish, but it is off-limits to recreational anglers. Nearly wiped out in the late 1800s by overfishing, dams and pollution, the endangered species is protected in the Empire State, where it is the subject of a restoration effort that began in 1992. Since then , New York has stocked 300,000 sturgeon in streams. where they once thrived, including Oneida, Cayuga, and some tributaries of Lake Ontario and the St. Lawrence River.

Many of these hatchery-raised fish carry Passive Integrated Transponder (PIT) tags that help scientists monitor sturgeon movements and growth. Researchers are also tagging any wild lake sturgeon they catch during their net surveys, as they did with the recently captured 6-foot-5 bird.

“Acoustic tags are scanned by receivers throughout the lake and are picked up as fish pass by, providing insight into where the fish are moving in the lake,” said biologist Emily Zollweg-Horan. senior aquatics at NYDEC. Syracuse Post Standard. She says the 66-square-mile Cayuga Lake has 42 tagged sturgeon out of an estimated population of 400, which is considered a major step towards recovery. NYDEC is expected to release a full progress report next year.

Read more : 8-year-old fisherman catches potential world record shovel sturgeon

An obstacle to the return of the species is its slow rate of maturation. Males reach sexual maturity between 8 and 19 years old and females between 14 and 23 years old. That said, the lake sturgeon is also one of the longest-lived freshwater fish, and females have been known to survive over 80 years.

New York fishing regulations prohibit intentionally targeting lake sturgeon, and any accidentally snagged by recreational anglers should be released immediately. Although listed as threatened or endangered in nearly every U.S. state where they are found, lake sturgeon are subject to limited recreational fishing in some states, including Minnesota, Wisconsin, and Michigan. . The IGFA world record all-tackle is a 168-pound lake sturgeon caught in Georgian Bay, Ontario in May 1982.

Lee Student will participate in the Pan American Kickboxing Championship in Brazil


MariLiis Bateman was recognized for her first place finish at the 2021 Pan American Championships

Lee University student MariLiis Bateman has been selected to compete for Team USA at the Pan American Kickboxing Championship in Brazil this month.

The championship is hosted by the World Associations of Kickboxing Organizations, the only kickboxing organization that has an International Olympic Committee recommendation and will potentially be included in the 2028 Olympics.

“This opportunity to represent Team USA and share the ring with the best fighters in the Pan Am region is an honor,” said Ms. Bateman. “I’m thrilled to demonstrate how hard I’ve worked over the past few months to become the best fighter I can be.”

Ms. Bateman has been with WAKO since 2018 and won first place in her first international competition, the 2021 Pan American/North Caribbean Championship. After attending several WAKO training camps this year, she was selected by Coach Team USA Rob Zbilski to compete at the international level again and gave herself a chance to defend her title.

The full-time student, in addition to being a skilled kickboxer, is the primary instructor and owner of Force Academy, a martial arts fitness facility in Cleveland. She works alongside her father, David Bateman, teaching martial arts classes to children and currently meets with 20 students twice a week.

Ms. Bateman’s father, who is also her trainer, inspired her love for kickboxing. She began training martial arts at the age of three and is now a 4th degree black belt, six-time AAU National Champion and 2020 Martial Arts Hall of Fame Female Instructor of the Year. the United States.

A bioscience junior with a major in pre-physical therapy, Ms. Bateman wants to use her degree in tandem with martial arts. “My dream is to have a sports and rehabilitation center for athletes to help train them and encourage them while they go through therapy,” Ms Bateman said. “I want to give athletes a way to learn about injury prevention, so they can have a better and longer athletic career. Especially in martial arts because it’s a contact sport with a lot of injuries, many coaches are not trained in these areas and therefore can harm athletes in the long run.

Not only does Ms. Bateman train rigorously off campus, she is also a hard worker inside the classroom.

“I am thrilled that MariLiis has this wonderful opportunity to compete in the Pan American Kickboxing Championship,” said Dr. Pamela Hobbs, assistant professor of health sciences at Lee. “I am not surprised by this honor because MariLiis is one of the hardest working and most successful young women I know. She sets goals and works hard to achieve those goals by doing her best whether it be in her schoolwork or in the sport of kickboxing, MariLiis is well deserving of this honor.

For more information on the 11th Pan American Kickboxing Championship, taking place November 16-20, visit www.wako.sport/events/12th-panamerican-championships/

For live viewing, visit www.youtube.com/c/WAKOKickboxing.

For more information on The Force Academy, please visit www.expertkarate.org.

MariLiis Bateman using the “flying knee” technique at WAKO headquarters during the 2021 annual training camp

MariLiis Bateman using the “flying knee” technique at WAKO headquarters during the 2021 annual training camp

Researchers uncover immunity genetics leading to worse COVID outcomes for men


Why do men perform worse than women because of COVID-19? A new study suggests it’s not something wrong with men, it’s something right with women. Specifically, the innate immune system of women.

A team of researchers from Princeton University, the Simons Foundation’s Flatiron Institute, the Icahn School of Medicine at Mount Sinai and the Naval Medical Research Center had begun studying a group of nearly 3,000 US Marine Corps personnel. before a COVID-19 outbreak during their training in 2020, and continued to follow them through infections and after. The results of their study appear in the current issue of the journal Cell Systems.

Using RNA sequencing and analysis of clinical measures, the research team found that although infected women had higher rates of symptoms, their average viral load was 2.6 times lower than that of infected women. men. They also identified molecular signatures that indicated a sex-specific genetic basis for the difference. “Sex-specific responses to COVID-19 are notoriously difficult to study, due to the many confounding variables, including comorbidities, differences in environment, physical fitness, etc.,” said Olga Troyanskaya, Professor of Computer Science and the Lewis-Sigler Institute for Integrative Genomics (LSI) and Director of Princeton Precision Health at Princeton University, Associate Director of Genomics at the Simons Foundation Flatiron Institute and one of two co-lead authors of the study.

“This study has created an unprecedented opportunity,” she said. “This group of Marines training and living together on base makes for a very large, well-controlled cohort. They’re all about the same age, live in almost identical conditions, eat similar foods. They’re about at the same fitness level. All had similar disease severity – asymptomatic or mild COVID. The other critical point was that this study included longitudinal PCR testing, blood collection and symptom reporting – leading to data before, during and after their COVID cases.

“Through a well-controlled longitudinal study of young Marine recruits, we were able to identify sex differences across many parameters, including symptoms, viral load, blood transcriptome, RNA splicing, and proteomic signatures,” said Stuart Sealfon, MD, the Sara B and Seth M. Glickenhaus professor of neurology at Icahn Mount Sinai and the study’s other co-lead author. “We found that women have higher expression of the antiviral interferon-stimulated gene (ISG) before infection, a wide range of genes that typically function to inhibit viral replication. Our results indicate that these ISG differences might influence sex differences in response to viral infection.

Identifying these ISG differences won’t immediately lead to a treatment plan, the researchers warn, but it does open a clear path for biomedical research.

“Identifying unique gender signatures will help inform the design of future medical countermeasures that can prevent and treat SARS-CoV-2 infections not only among military recruits, but also improve global public health” said Commander Andrew Letizia, Physician Assistant. director of the Naval Medical Research Center’s Infectious Diseases Branch and principal investigator and study author.

The authors note some limitations to their study, including that the cohort was mostly healthy young adults and did not include any cases of severe COVID-19, which limited their ability to draw firm conclusions about the appropriateness of these results for older or less healthy people. individuals or the development of more severe COVID-19.

Leverage Big Data

Troyanskaya is a computational biologist, using advanced analytical techniques to sift through huge datasets. This allowed the research team to sift through the many existing hypotheses about sex differences and find a causal explanation for the differences in results: the sex-specific molecular signatures that are present prior to infection.

“Women have a more active immune system, even before they get sick,” explained Natalie Sauerwald, one of the co-first authors, a researcher at the Flatiron Institute and a visiting research associate at Princeton University. The other co-first author, Zijun “Frank” Zhang, was also a postdoctoral researcher with Troyanskaya at Princeton and Flatiron before joining the research faculty of the Division of Artificial Intelligence in Medicine at Cedars-Sinai Medical Center.

“Our analysis indicates that women’s innate immunity is more activated before and during infection, helping to fight the virus more effectively,” Sauerwald said.

Immune warfare is grueling, which is also why women show more severe symptoms during COVID infections: higher fevers, more intense fatigue and more intense coughs.

“Remember that the symptoms are partly due to your immune system fighting the infection,” Troyanskaya said.

The result is that women feel sicker when fighting the disease, but they have lower viral loads and better outcomes than men with the same exposure.

It was already known that men had worse COVID outcomes, but what made this study unique was that the computer scientists had enough data — and, importantly, pre-infection blood tests — to create a model. causal linking sex-specific pre-infection innate immune states. response to infection and outcomes.

“There are many biological differences between males and females,” Sauerwald said. “Men have a higher incidence of cardiovascular disease and other comorbidities. There are hormonal differences and many other factors that could potentially explain this male-female difference in COVID. But with our data and modeling, we were able for the first time to show a significant link between differences in immune level before infection between the sexes and the outcomes we observed during infection.

For the COVID-19 Health Action Response for Marines (CHARM) study to investigate the basis of COVID sex differences, researchers collected and analyzed data from Marine recruits at the start of their training. A total of 2,641 men and 244 women who were initially seronegative for SARS-CoV-2 were followed for 12 weeks with regular screening for symptoms, PCR tests and blood sampling.

During those three months, which included two weeks of supervised quarantine and 10 weeks of marine training, a total of 1,033 men and 137 women tested positive for SARS-CoV-2. The study was conducted between May and September 2020, before the vaccines or treatments were released, and none of the participants were enrolled in any other clinical trials at the time.

Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection», by Natalie Sauerwald, Zijun Zhang, Irene Ramos, Venugopalan D. Nair, Alessandra Soares-Schanoski, Yongchao Ge, Weiguang Mao, Hala Alshammary, Ana S. Gonzalez-Reiche, Adriana van de Guchte, Carl W. Goforth, Rhonda A Lizewski, Stephen E. Lizewski, Mary Anne S. Amper, Mital Vasoya, Nitish Seenarine, Kristy Guevara, Nada Marjanovic, Clare M. Miller, German Nudelman, Megan A. Schilling, Rachel SG Sealfon, Michael S. Termini, Sindhu Vangeti, Dawn L. Weir, Elena Zaslavsky, Maria Chikina, Ying Nian Wu, Harm Van Bakel, Andrew G. Letizia, Stuart C. Sealfon, and Olga G. Troyanskaya, appears in the current issue of Cell Systems (DOI: 10.1016/j.cels.2022.10.005). This work was supported by the Defense Health Agency through the Naval Medical Research Center and the Defense Advanced Research Projects Agency as a member of Epigenetic characterization and observation (ECHO) program.

Elizabeth Dowling of Icahn Mount Sinai contributed to this article.

the future of space food

Bio-engineered yeast: the future of space food

Take a common form of yeast, a 3D printer, and some clever science, and what do you have? A versatile and nutritious food system for the demanding space travelers of tomorrow.

in a new Nature communication documentresearchers from Macquarie University and the ARC Center of Excellence in Synthetic Biology outlined a vision for a customizable food system that provides dishes with the taste, texture, and nutrients of their terrestrial counterparts.

The main ingredient used in the space food system is yeast Saccharomyces cerevisiae (S. cerevisiae), a food grade microorganism with thousands of years of use in baking, brewing and winemaking. Yeast cells are already nutritious, containing substantial protein, carbohydrates, small amounts of fat, and most of the essential amino acids humans need from food. With a little engineering, S.cerevisiae can be fortified to add nutrients, taste, color and texture.

“The best approach to sustaining extensive human space enterprises is to produce food on site,” said lead author Dr Briardo Llorente, from Macquarie University’s School of Natural Sciences.

Previous work has estimated that all the vitamins and macronutrients needed for a balanced human diet could feed 50-100 people per day from a 3000 L fermentation tank, making S.cerevisiae a candidate to develop into a microbial food production system.

More like star trek’s replicative food system, which synthesizes food on demand, this system would involve using the power of synthetic biology to give yeast the ability to produce the common nutrients and sensory attributes of food made on Earth such as flavors, colors, smells and textures. This will generate microbial-based foods with desirable sensory and nutritional profiles.

Scientists believe that 3D food printing technologies could be used to create personalized meals for astronauts using these modified yeast cells. This can come in the form of foods like sushi or lasagna, where each layer has a different color, taste and texture, or a compact protein-like bar that tastes and smells exactly like the desired food.

The innovative food system could also contribute to the circular economy, with manufactured food leaving little or no waste for space travelers while maximizing off-Earth food production capabilities.

“Essentially what we’re proposing is to develop technology and capabilities that will transform yeast from the basic microbe that we use to produce food into something much more potent that can actually be used as a complete food source,” Llorente said. “With further research, we can use synthetic biology to consolidate multiple sensory and nutritional attributes and develop innovative, sustainable and more environmentally friendly food production systems.”

While space is the obvious use case, given the limitations of producing food in harsh environments, Llorente and the team believe artificial yeast also has the potential to address sustainability right here on Earth.

“As we see modified food sources gain mainstream popularity, there is a growing market for the increased use of modified yeasts in addressing sustainability issues. These alternative foods may one day solve some of our most complex food security issues in a sustainable way while removing the pressure on natural ecosystems,” said Llorente.

Image caption: iStock.com/CesareFerrari

Meghan and Harry ‘return’ to UK in doubt over ‘sign of failure’ | royal | New


Last month it was reported that King Charles III had decided not to proceed with his plans to thin the monarchy and would instead keep the number of working royals at 11.

Her Majesty’s decision flies in the face of many critics and commentators who have speculated over the years that the monarch would streamline the list of royals holding official office.

For years there have been reports that King Charles wanted a smaller royal family which would make his operation a ‘lighter machine’ with ‘less gossip’.

Royal expert Gyles Brandreth even previously told Express.co.uk: ‘I think in future we’re going to go back to a much leaner version [monarchy].”

Like others, Mr Brandreth predicted that Charles, his wife and wife Queen Camilla, Princess Anne, Prince Edward, Sophie, Countess of Wessex, Prince and Princess of Wales would be featured prominently in this news version of the monarchy.

The ‘Magnificent Seven’ was the nickname given to the royal family team expected to take the lead during Charles’s reign.

However, with the number remaining at 11, there are four other senior royals who will continue to perform public service: Prince Richard, Duke of Gloucester; Birgitte, Duchess of Gloucester; Prince Edward, Duke of Kent and Princess Alexandra.

The Duke of Gloucester, Duke of Kent and Alexandra are all first cousins ​​of the late Queen Elizabeth II.

Richard is the second son of Prince Henry, Duke of Gloucester, while Edward and Alexandra are two of the children of Prince George, Duke of Kent, both younger brothers of King George VI.

Compared to other working royals, the Queen’s cousins ​​tend to go under the radar, with media coverage rarely focusing on their work and engagements.

However, some experts have noted the importance of this older generation of royals, highlighting their commitment to their service and to the monarchy.

Marlene Koenig, a historian who has spent more than 40 years researching European royalty, described Gloucesters as ‘the backbone of the royal family’, noting in particular the Duke’s unexpected introduction into the life of a member of the royal family.

Valley News – Forum, November 13: No Target Shooting at Windsor Site


Posted: 11/12/2022 10:00:15 PM

Modified: 12/11/2022 22:00:13

Target shooting prohibited at Windsor site

As a biologist who manages the Vermont Fish and Wildlife Department’s 826-acre Windsor Grasslands Wildlife Management Area (WMA), I am writing to remind the public that target shooting is prohibited on the property.

WMAs are stored and managed for many uses. Activities such as hunting, hiking, and wildlife viewing are all permitted in the Windsor Grasslands WMA and the other 100 WMAs in the department. Participants in these and other activities have enjoyed them side-by-side on the roads, trails and no-trail areas our WMAs provide.

However, target shooting requires additional infrastructure for safety and to minimize environmental impacts – infrastructure that is not present at Windsor Grasslands WMA.

This is why the ministry prohibits target shooting at Windsor Grasslands WMA. Since acquiring the property in 2018, we have installed signs to clarify the rules for public use of this property. Our game wardens investigated target shooting reports on the WMA and issued warnings and tickets to offenders. Unfortunately, illegal target shooting continues.

In October, department staff met with city officials, legislators and WMA users to discuss solutions. As a result of this meeting, I ask the public to take two steps to ensure the WMA is enjoyed safely and responsibly.

First, I ask local target shooters to choose the department’s Hammond Cove Range as a safe place to practice. Just a 15 minute drive from Windsor Grassland WMA, Hammond Cove has the infrastructure necessary for safe, responsible and enjoyable target shooting.

Second, I encourage all visitors to the Windsor Grasslands WMA to help stop illegal target shooting on the WMA by reporting offenders. Reports must include a license plate number and can be made by calling 802-828-1000 or emailing fwinformation@vermont.gov. Of course, hunting remains legal on the property and does not have to be reported.

Caring for our public lands for the enjoyment of all Vermonters and for the well-being of our state’s natural resources is everyone’s responsibility. Following the rules under which these lands are conserved ensures their continued access to the public and the benefit of Vermont’s biodiversity.

Chris Bernier

The author is a wildlife biologist with the Vermont Fish and Wildlife Department and oversees the Windsor Prairie Wildlife Management Area.

Invest in peace, not war

Join us if you think it’s wrong to use half of our federal taxes to fund wars and 800 military bases around the world while families in Vermont and New Hampshire live on the streets. Join us Tuesday mornings at the Ledyard Bridge with our “No War” message. You will find, as we do, that many of the hundreds of people who pass during the morning rush hour respond positively to the message “No War” and “Defuse Nuclear War”. In fact, given the strong pro-war message from the mainstream media, we think you’ll be pleasantly surprised.

But there must be more than one outcry against the war. After all, we the people are paying for this army while the White House (Republicans and Democrats) always leaves the door open for visits from the big arms manufacturers. A case in point, and a conflict of interest you might agree, is our current Secretary of Defense who recently served on the board of Raytheon Technologies. These politicians are supposed to be civil servants and not corporate employees. We the people will not sit idly by while our youth and our tax dollars are wasted in these wars overseas.

If you would like to express words of peace to your neighbours, bring a sign and join us – weather permitting – on Tuesdays anytime between 7.30am and 9.30am on the Norwich side of the Ledyard Bridge. For a list of sponsors and their contact details, please see the announcement in the Valley News Calendar.

Duncan Nichols


attend a local school
artistic performances

As the high school fall sports season draws to a close, families are looking forward to the holidays and anticipating the winter sports season. We start thinking about gifts and getting out the warmest clothes; trying to figure out what can be accomplished before sunset at 4:30.

Amid this flurry of late fall activity, I ask that you consider attending an arts performance at your local school, whether it be the fall play or an orchestral concert. and choir during the holidays. At a time when support and value for arts programs seem to be waning, community support for the work of these students is incredibly significant.

As with our sports teams, these students also practiced and rehearsed for months, working to achieve the desired level of perfection. All the while, perhaps unknowingly, they are learning skills that will serve them well beyond their middle and high school years. Our school communities are not just the budgets and building renovations we vote on every year. It is mainly the students inside and the families concerned. Consider supporting this slice of your community.

Our teachers and school staff work very hard every day to support these students in the classroom and, as a former teacher, I know that the school day does not end at the last bell. I also ask our teachers and staff… to please take an hour and a half after the last bell. Take a moment of your closely defended and deserved personal time and attend a performance by your students. That brief moment of support could mean the world to one of your student performers.

Hilary Roosevelt


Webinar: USGS Science Support for Binational Riparian Ecosystem Restoration Efforts in the #ColoradoRiver Delta (November 18, 2022) – USGS #COriver #aridification #CRWUA2022

Endpoint of the Colorado River, Mexico: Less than 80 years ago, the mighty Colorado River flowed unhindered from northern Colorado through the Grand Canyon, Arizona and Mexico before emptying into the Gulf of California . But as this NASA Earth Observatory satellite photo from September 2000 shows, irrigation and city water needs are now preventing the river from reaching its final destination. Rather, the Colorado River simply disappears into the desert sands. The Colorado River is visible in dark blue in the upper central portion of this image. The river ends just south of the multicolored patchwork of farmland in the northwest corner of the image, then unfurls at the foot of the Sierra de Juarez mountains. Only about 10% of all the water flowing through the Colorado River reaches Mexico, and most of it is used by the Mexican people for agriculture. photo credit: Nasa

Click the link to go to the USGS website and register:

Speakers): Patrick B. Shafroth, Distinguished Volunteer, Fort Collins Science Center; Pamela L. Nagler, physical scientist, Southwestern Center for Biological Sciences; Eduardo Gonzalez-Sargas, Research Scientist, Colorado State University

Date: November 18 at 2:00 p.m. Eastern Time

Summary: A treaty signed by the United States and Mexico in 1944 and various subsequent amendments (“minutes”) are the basis of binational agreements between the two countries, including water management of the Colorado River. One aspect of these agreements in the Colorado River Delta (in Mexico, downstream from the United States) involves the allocation and delivery of water from the Colorado River to support efforts to restore riverine ecosystems. In his A Sand County Almanac (1949), Aldo Leopold described the thriving ecosystems of the Colorado River delta. However, by the 1960s the combined effects of flow depletion and land conversion had greatly reduced the quantity and quality of these systems and the river rarely flowed to its terminus in the Gulf of California. While some of the USGS’s involvement in the delta began in 1998, significant efforts at several science centers began in 2014 and continue to the present in the context of Minutes 319 and 323. In the case of these two minutes, a portion of the Colorado River has been allocated to support efforts to restore native riparian forests, which provide critical habitat for migratory birds. Minute 319 largely focused on a single high or “pulsing” flow in 2014 and lower flows from 2015 to 2017. As part of minute 323, which began in 2018 (and is expected to end in 2026) , water deliveries are primarily used to irrigate managed restoration areas. USGS scientists have led and lead multiple efforts and support others related to these restoration activities. Under 319 minutes, USGS scientists conducted a series of studies related to “pulsating flow,” including surface and groundwater hydrology, riparian vegetation dynamics, large-scale changes in vegetation “greenness” and actual evapotranspiration (ETa), and sediment transport and transport. geomorphological change. The results of these efforts were published in a special issue of the journal, Ecological Engineering (2017) – USGS had five co-authors on eight of the issue’s 17 papers and served as co-editors. As part of 323 min, major research activities included the continued processing and analysis of remote sensing data to assess the large-scale dynamics of vegetation and ETa in the riparian corridor, and the development of several publications related to avian use of these delta habitats. Both of these outbreaks are largely conducted in the context of evaluating the effects of restoration efforts. Two key USGS activities over the past several years related to data provision have been to 1) provide actionable science to end users through the development of a searchable, remotely sensed database of the greenery of the vegetation and ETa, and 2) lead the development of a database system for data sharing and archiving within the Minute 323 Science and Monitoring community. This community includes a myriad of scientists and government, NGO and academic stakeholders on both sides of the border. Another important role of the USGS has been to provide technical assistance on a range of topics to our partners. During the remaining four years of Minute 323, planned activities include the continuation of ongoing efforts with regard to the evaluation of the results of restoration actions on variables such as vegetation, hydrological processes (for example, ETa), and avian ecology. New efforts include helping restoration practitioners improve understanding of the dynamics and influences of target restoration habitats and the importance of connectivity between habitat patches; help develop a system to provide early warning of water stress that can negatively affect vegetation in restoration sites; and expanding surface water and groundwater modeling efforts.

Mylab creates advanced genetic laboratory and cancer research center for MUHS


Maharashtra University of Health Sciences (MUHS) today launched a state-of-the-art Genetics Laboratory and Cancer Research Center designed by Mylab Discovery Solutions, Pune. The facility was inaugurated by Bhagat Singh Koshyari, Governor of Maharashtra.

The state-of-the-art laboratory will offer a wide portfolio of tests to analyze DNA, RNA, chromosomes and proteins by biochemical, cytogenetic and molecular methods to assess and diagnose congenital disorders, prenatal disorders, hematological and oncological disorders .

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India’s first privately built rocket is slated for November 15 launch

Skyroot Aerospace’s first mission, codenamed ‘Prarambh’, will carry the payloads of two Indian and one foreign customer and is expected to launch from the Indian Space Research Organization’s launch pad in Sriharikota.

“Mylab has transformed the diagnostic landscape with its innovative and market-leading solutions. The company is committed to applying its deep knowledge of science and technology to create solutions that help solve healthcare challenges,” Mylab said in a press release.

Mylab is an Indian biotechnology company focused on the development and commercialization of molecular, serological and immunological testing solutions and equipment for applications in clinical diagnostics, drug discovery, biomedical research, agrogenomics and animal and food safety.

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High blood pressure linked to 22% higher risk of severe Covid, new research finds

The link could have been confused with age and other factors known to influence both high blood pressure and Covid risk

Machine learning of binary “yes/no” systems can improve medical diagnostics, financial risk analysis, and more.


Similar to a mouse running through a maze, making ‘yes’ or ‘no’ decisions at every intersection, researchers have developed a way for machines to quickly learn all the twists and turns of a complex data system.

“Our method can help improve diagnosis of urinary disease, imaging of heart disease, and analysis of financial risk,” reported Abd-AlRahman Rasheed AlMomani of the Embry-Riddle Aeronautical University campus in Prescott, Arizona. .

The research has been accepted for the Nov. 11 edition of the peer-reviewed journal Patterns, an imprint of Cell Press, with Jie Sun and Erik Bollt of Clarkson University’s Center for Complex Systems Science. The goal of the work is to more efficiently parse binary (“Boolean”) data.

“We can see everything around us as a web of objects and variables interacting with each other,” said AlMomani, assistant professor of data science and mathematics at Embry-Riddle. “Understanding these interactions can improve our predictions and the management of a whole range of networks – from the regulatory networks of biology and genes, to aerial flight.”

Boolean or “yes/no” data is frequently used in the field of genetics, where gene states can be described as “on” (with high gene expression) or “off” (with little or no gene expression). gene), AlMomani explained. Learning Boolean functions and networks based on noisy observation data is essential for deciphering many different scientific and engineering problems – from pollinator plant dynamics and drug targeting to tuberculosis risk assessment of a person.

The challenge, AlMomani explained, is that the standard method of learning Boolean networks — called REVEAL (for Reverse Engineering Algorithm for Interference of Genetic Network Architectures) — mixes many different sources of information. The REVEAL approach thus increases computational complexity and cost, and researchers need to dampen the noise to analyze all the data. Moreover, the REVEAL method is not optimal for solving quantitative biology problems, which require discovering causal factors.

To eliminate incorrect answers more quickly, AlMomani and his colleagues used a method called Boolean Optimal Causal Entropy, which gradually reduces the number of correct solutions to a problem. The method essentially transforms a complex diagnostic process into a decision tree, where yes/no questions such as “Does the patient have a fever?” Nausea? Lower back pain?” can guide a clinician to the correct diagnosis.

AlMomani explained that many different scientific questions depend “on a Boolean variable which is basically zero or one. An event has occurred or it has not occurred. A patient will take a test and get a positive or negative result. We can then categorize that patient’s test results, medical history, and results as Boolean variables. »

To test their ideas, the researchers got their hands on a full set of 958 possible board configurations at the end of a game of Tic-Tac-Toe. The board and the different moves of the game were then expressed as mathematical problems in order to predict which player would win.

The researchers also tested their method using a dataset from cardiac spectroscopy images. Their system got the correct diagnosis 80% of the time.

The Patterns paper, “Data-Driving Learning of Boolean Networks and Functions by Optimal Causation Entropy Principle (BoCSE)”, was funded in part by the U.S. Army Research Office (Grant W911NF-16-1-0081) and the Simons Foundation (grant 318812).

DOI: 10.1016/j.patter.2022.100631

After the embargo has lifted, this document is available online at https://www.cell.com/patterns/fulltext/S2666-3899(22)00263-X.

About Embry-Riddle Aeronautical University

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Embry-Riddle educates more than 32,500 students at its residential campuses in Daytona Beach, Florida and Prescott, Arizona, at approximately 110 campuses worldwide and through online degree programs. U.S. News & World Report named Embry-Riddle Worldwide as the top national provider of online licensing programs.

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NSEDC pegs 2022 CBS at $100,000


By Peter Loewi
For the first time since January 2020, the public was able to attend the board meeting and annual meeting of the Norton Sound Economic Development Corporation, held November 2-4 in Nome. There was no audience present.
The board approved this year a community benefit sharing of $100,000 per community. This is in addition to the $2.94 million already approved for fuel subsidies and recovery from former Typhoon Merbok.
Wednesday was for committee meetings, the full board met on Thursday, and Friday was the annual meeting of members and the annual meeting of directors. On Friday, the newly elected board members were sworn in and received their committee assignments.
A number of personnel discussions within the Rules and Regulations Committee, as well as most members of the Finance Committee, took place in executive session.

Jim Menard, Alaska Department of Fish and Game Area Manager, joined the online meeting to provide an overview of the past season. For salmon, the off-vessel value was about the same as last year, he said, at $466,000. In 2021, it was $451,000, two amounts considerably lower than in the late 2010s, where it ranged from $1.2 million to a record high of $4 million in 2018. For 2021, did t he says, most of the payment was for the pink salmon fishery, but in 2022 the chum and silver salmon harvests were up, bringing in more. The number of friends was better than last year, but also not like the last teenagers; mate counts were low in the south but improved as they moved north.
The number of permits fished was down. The average over the last five years was 138 but there were only 108 this year.
Menard was asked by Nome board member JT Sherman about commercial pink salmon fishing openings. Menard explained that they could have been open much longer than they were, but buyer capacity was limited due to the crab focus and then a line issue with the chiller.
After salmon, the discussion turned to crab. Menard said that while he didn’t have the preliminary numbers, it looked like the indicative harvest level, GHL for short, would increase next year. The price of the crab was still unknown. “With the snow crab fishery closed, who knows what the price of Norton Sound red king crab will be,” he said.
Following Menard’s presentation, Tyler Rhodes, NSEDC Director of Operations, presented the report on fisheries research and development. He announced that Renae Ivanoff, a longtime program biologist, had become the director. Rhodes said they were finally able to complete their blue king crab investigation. By sampling at 42 stations, they found that 31 stations had at least one blue crab. They found 31 women, 52 sublegal men and 24 legal men.
Despite a late start due to weather and adapting to a new normal of high water impacts, all of their salmon count projects have gone well, Rhodes said. They had “just enough staff to operate,” he said. Some NSEDC projects have been hit by staffing issues, such as Clean Waters beach cleanups. They have hired a new biologist to work at Unalakleet and will be adding another. Both had been fisheries technicians, received NSEDC scholarships and returned to work, which Rhodes called a success for their scholarship program.

In the third quarter, the NSEDC awarded 108 scholarships totaling more than $332,000 and declined 43 applications. That leaves $558,000 on their $1.4 million budget for the year. The committee had increased scholarship amounts in the past for similar reasons and considered surveying students and providing more opportunities to explore careers.

Norton Sound Seafood Working Group
NSSP Director of Operations Justin Noffsker guided committee members through the season. In Nome, the focus was on crab and they paid $3.75 million to 25 fishermen for 309,000 pounds. The only hiccup, which was described once as a “headache” and then again as a “catastrophic failure,” was a hole in the coolant line.
In a follow-up email, Rhodes explained that the line had developed small holes that allowed water to enter the crab line’s overall refrigeration system. “This forced us to forgo the purchase of crab during a five-day window between June 26 and June 30. On June 30, we were able to get crab deliveries to a processing vessel that we had under contract while repairs were being made to the system at the Nome plant. . We were able to resume processing at the Nome plant on July 8. The new unit arrived later in the season, and we will be purchasing and installing additional refrigeration components before the start of next season,” Rhodes wrote.
At Unalakleet they worked on the roses, largely without interruption.
The Nome and Unalakleet dormitories, which sleep around 30 people in total, were at full capacity for the season, but staffing was a recurring theme. Nome NSSP factory manager Josh Osborne noted 18 community hires and 45 local hires, but ship manager Martin Lewis said they had struggled to find deckhands.
Rhodes, via email, explained that “We have been delighted to once again be able to offer our regional recruitment program to bring residents from the member community to Unalakleet and Nome for positions in our seafood factories. This program was suspended in 2020 due to COVID and reduced participation in 2021 due to reduced work opportunities associated with salmon and crab fishing failures that year. A resumption of activity in 2022 has once again enabled us to better exploit the program.
Noffsker ended his report by saying that the season had ended with the typhoon and their early preparations had paid off. The only issue was with Shaktoolik’s floating docks being swept away. Although they have been located, it is not clear if they are recoverable, and so far the only disaster funding that has been offered has been loans, an issue that other entities in the region also expressed.

Wednesday’s finance committee was the only committee meeting with public comment. Isaiah Towarak asked about long-term plans for future operations and the impact of the pandemic and rising interest rates. NSEDC President and CEO Ivanoff noted that there was an investment portfolio review on the agenda, but it was to be discussed at an executive meeting.
During the open sessions, two topics took up most of the discussion. The first was a capital budget request of $33,501 for the replacement of the chiller at the Nome plant. Rhodes said the failed part was already due for replacement, but supply chain issues had delayed installation. To prevent similar issues from happening again, this request was to purchase, ship and install parts of similar age.

The request has been approved to switch to full board.
The other subject of discussion was bulk fuel receivables and more particularly, the increase in the price of propane in the villages, which was discussed at length on Thursday during the meeting of the board of directors. Dan Harrelson of White Mountain, said he was told propane, which currently costs $285 for a 100-pound bottle, could reach $800 a bottle.

Quota and Acquisitions Manager Simon Kinneen said they were hoping for a quota increase for the coming year but still called it a good year despite the low quotas. “Prices remain high, which we are happy with,” he said. Despite the crab closures, he said, “we are very grateful to be well invested in golden king crab, which looks very promising for the future.”

Community Benefit Sharing
In August, the council approved a special CBS with the aim that communities use it to subsidize the cost of fuel oil. Rhodes asked the board to authorize the revision of the guidelines. When initially proposed, the funding would be distributed through a process similar to that of the NSEDC Energy Grant. Rhodes suggested distributing it based on the number of households in the community. The council accepted the amendment. The administration of the grant rests with each community, and at least five communities have already received the funding. Rhodes encouraged community members to contact their city administration to find out how the distribution would be implemented.
Director of Community Benefits Paul Ivanoff III said in addition to the $575 per household fuel subsidy and $100,000 per community for disaster recovery, now was the time to report the sharing amount 2022 community benefits. With a motion on the table to approve an additional $100,000 per community, two board members questioned the long-term viability of “such generosity.”
NSEDC President and CEO Janis Ivanoff said while these concerns are valid, “at this time we are comfortable as your staff with a community benefit share of $100,000 for 2022”. All board members voted to approve the amount.
Other new business on the agenda included grants for Head Start teachers from Kawerak to pursue a semester of higher education, community energy fund requests from Gambell and Teller, and major infrastructure fund requests from Stebbins and St. Michael.
The annual membership meeting lasted less than 15 minutes and was mostly devoted to member feedback, all of which was appreciation from staff and the board. CEO Janis Ivanoff noted that outgoing board members Truman Kava of Savoonga and Oscar Takak of Elim had served 25 years, all but six years since the founding of the NSEDC in 1992.
During the annual trustees meeting, new trustees Art Amaktoolik and Preston Rookok joined re-elected members JT Sherman of Nome, Milton Cheemuk of Saint Michael and Joe Garnie of Teller for an oath of office before discussing the nominations on committees and the election of company officers. Rookok will be a member of the Rules and Regulations Committee and the Scholarship Committee; Amaktoolik will be part of the Norton Sound Fisheries Development Committee and Seafood Working Group.
Unalakleet’s Frank Katchatag was re-elected chairman of the board and White Mountain’s Dan Harrelson won a close re-election as vice-chairman. Shaktoolik’s Harvey Sookiayak was retained as Sergeant-at-Arms. Dean Peterson of Golovin was reappointed to the Executive Committee. Joe Garnie was elected to fill Takak’s seat on the executive committee.

Busy opening of this year’s pheasant season, hunters report success – The Hamburg Reporter


The hunters are home, the dogs are resting, and Iowa’s pheasant season opening weekend is in the rearview mirror. Statewide reports ranged from excellent in the north to good in central and southwestern Iowa, with the consensus that the hunt will continue to improve once all the corn is harvested.

Reports said hunters moved in large numbers, filling parking lots and field access roads.

“That’s the best number of birds we’ve had since I’ve been in east-central Iowa. I still see hunters today,” said Curt Kemmerer, wildlife biologist for the Iowa Department of Natural Resources (DNR) Maquoketa Unit.

“Lots of hunters and lots of birds in central Iowa – a great opening,” said Capt. Matt Bruner, Iowa DNR Law Enforcement Office Supervisor for North Central. from Iowa.

“I counted 14 cars in a 475 acre area in northern Iowa. The guys I spoke to had seen birds but also commented on a lot more people than I have in the past” said TJ Herrick, wildlife biologist for Iowa DNR’s Clear Lake Unit.

“A lot of hunters on Saturday,” said Matt Dollison, wildlife biologist for Iowa DNR’s Nishnabotna Unit. “The number of birds was similar to last year. Hot weather and standing corn made the hunt a bit difficult.

Non-resident hunters were also plentiful, with hunters from Minnesota, Wisconsin, Illinois, Nebraska and Ohio accounting for up to a third of the cars in northern Iowa parking lots.

These field reports reflected what the August annual road survey had revealed.

“Our bird numbers are similar to last year, which should make some people pretty happy,” said Todd Bogenschutz, upland wildlife research biologist at Iowa DNR. “I think we are set for a good year of pheasant hunting, especially in the northwest, mid-west and mid-north regions. Central too. Quail also looks great in southwest and south-central Iowa.

Iowa pheasant season runs through January 10, 2023.

A new ionizable branched lipid dramatically increases the efficiency of mRNA delivery


Messenger RNAs (mRNAs) are biological molecules that transfer information encoded by genes from the nucleus to the cytoplasm for protein synthesis by ribosomes. mRNA sequences can be designed to code for specific proteins; the best-known example of this are mRNA vaccines for COVID-19. mRNA molecules are large and chemically unstable, so a vector must be used to deliver mRNA to cells. One of the most advanced technologies for mRNA delivery are lipid nanoparticles (LNPs), which are composed of ionizable lipids, cholesterol, helper lipids, and polyethylene glycol.

A team of researchers led by Assistant Professor Yusuke Sato and Professor Hideyoshi Harashima of Hokkaido University’s Faculty of Pharmaceutical Sciences and Kazuki Hashiba of Nitto Denko Corporation have developed a new branched ionizable lipid that, when ‘It is included in NLPs, greatly increases the efficiency of mRNA delivery. Their results were published in the journal Little Science.

Previous work has shown that ionizable lipids with branched tails increase the efficiency of mRNA delivery by LNPs. However, two major issues have prevented a systematic analysis of the branching effect of ionizable lipids. First, tail branching leads to a huge diversity of chemicals; second, the number of commercially available branched ionizable lipids is limited. To overcome these obstacles, the researchers generated a systematic lipid library of branched ionizable lipids and limited this library to a specific subset of branched lipids that could be described with just two parameters: total carbon number and symmetry. They then tested the 32 lipids in this library for their effect on the stability of LNPs containing mRNA (LNP-RNA).

The team found that RNA-LNPs that contained highly symmetric branched lipids exhibited greater microviscosity, and that higher microviscosity was positively correlated with increased stability of RNA-LNPs in storage. Highly symmetric branched lipids in RNA-LNPs are also positively correlated with protein expression in liver and spleen in mice. They determined that branch chain length affects organ selectivity.

The most stable storage and efficient delivery of mRNA was achieved by the branched lipid CL4F 8-6. The authors demonstrated that this particular lipid could be used in LNPs designed for gene editing, achieving a 77% deletion of the target gene in mice with a single dose of LNP.

This study revealed that branched lipids with a high level of symmetry contribute to optimal LNP properties for efficient intracellular delivery and stable formulations. Future work will focus on the development of expanded lipid libraries to understand the properties of other branched lipids and may lead to the design of novel lipids.


Journal reference:

Hashiba, K. et al. (2022) Branching of ionizable lipids can improve mRNA stability, fusogenicity, and functional delivery. Little Science. doi.org/10.1002/smsc.202200071.

2D and 3D MRIs Provide Reliable Measurements for ACL Surgery Planning : Newsroom


Jay P. Shah, MD

DALLAS – November 09, 2022 – Magnetic resonance imaging (MRI) can reliably establish measurements of anterior cruciate ligament (ACL) “fingerprints” that are critical to graft placement for reconstructive surgery, report researchers from UT Southwestern.

Jay P. Shah, MDassistant professor at Department of Orthopedic Surgery at UTSW, and his colleagues used two- and three-dimensional magnetic resonance imaging (MRI) to determine these measurements, an approach that had not been explored before. Their study was published in European radiology.

“This study proves that 2D and 3D MRI is reliable in determining the specifics of the ACL impression,” said Dr. Shah.

The ACL is a crucial stabilizing ligament of the knee, and a torn ACL is one of the most common ligament injuries with serious consequences in terms of morbidity, mobility and cost. Among athletes who sustain ACL tears, 37% are unable to return to pre-injury levels.

For younger patients, ACL tears are often repaired with reconstructive surgery. For successful reconstruction, tunnels must be created in the tibia and femur. The ACL impression is used to determine where these tunnels should be drilled for graft placement.

A magnetic resonance image (MRI) of the knee illustrates how the location of the anterior cruciate ligament (ACL) baseplate is determined, with measurements relative to nearby anatomical landmarks.

The anatomical placement of ACL grafts impacts postoperative stability and potentially the future risk of arthritis for patients. Improper placement of the tibial tunnels can lead to reduced rotational stability of the knee. Accurate measurements of ACL impressions will allow surgeons to reliably predict anatomy and plan surgery.

To determine where to make the tunnels, surgeons typically use arthroscopy, in which a camera connected to a tube is inserted through a small incision to view the joint. However, the locations of ACL indentations are not always clear under arthroscopy.

MRI has been used successfully to observe the structure of the ACL. Dr. Shah and a team of researchers reviewed 2D and 3D knee MRIs of 101 adult patients to measure the tibial-ACL and intermeniscal ligament-ACL margins. They then compared the measurements to those obtained under arthroscopy.

“We found that the mean differences between 2D and 3D measurements of the tibia-ACL and intermeniscal ligament-ACL are small, and 2D and 3D MRI can be reliably used to delineate foot plate anatomy. of the ACL,” said Dr Shah.

Establishing ACL impression measurements using MRI can help reduce surgery times, reduce recovery times and improve patient outcomes, Dr. Shah added. Future studies will evaluate the results of ACL reconstruction based on different impression measurements.

Other UTSW researchers involved in this study were Toan Nguyen, Shamrez Haider, David Tietze, Yin Xi, Uma Thakur and Avneesh Chhabra.

About UT Southwestern Medical Center

UT Southwestern, one of the nation’s leading academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty has received six Nobel Prizes and includes 24 members of the National Academy of Sciences, 18 members of the National Academy of Medicine, and 14 researchers from the Howard Hughes Medical Institute. Full-time faculty of more than 2,900 are responsible for groundbreaking medical advances and committed to rapidly translating scientific research into new clinical treatments. UT Southwestern physicians provide care in more than 80 specialties to more than 100,000 inpatients, more than 360,000 emergency room cases, and oversee nearly 4 million outpatient visits annually.

The inaugural Shanghai Masters Science Forum will be held


A photo shows lecturers attending the first Shanghai Masters Science Forum at Fudan University on November 15, 2022. [Photo provided to chinadaily.com.cn]

Focused on sharing scientific thoughts from leading experts around the world, the first Shanghai Master Forum on Science will be held at Fudan University on November 15.

Initiated by the Shanghai Committee of the Chinese People’s Political Consultative Conference and organized by the city’s science and technology administrators and Fudan University, this year’s forum will feature Nobel Laureate Professor Michael Levitt of Chemistry 2013, who will deliver the keynote address entitled AI for Science: Frontiers of Computational Biology.

Professor Levitt, who is also a member of the American National Academy of Sciences and a full professor of structural biology at Stanford University, is a pioneer in the development of a molecular dynamics simulation method for proteins and DNA. For many years he has been evaluating protein structure prediction and studying protein folding and packaging. He also established a scoring system for large-scale sequence structure comparison.

In 2018, Levitt joined Fudan University, where he founded the Multiscale Research Institute of Complex Systems (MRICS).

In his 60-minute keynote address at Xianghui Hall, Levitt will talk about the transformation of computational biology from a once marginalized topic to a mainstream topic.

An interdisciplinary field of computer science, biology, and big data, computational biology refers to the use of data analysis, mathematical modeling, and computer simulations to understand biological systems and relationships.

“Computational biology plays an important role, especially in the field of biomedicine, as it is necessary for the research of biological data design, comparison and analysis,” said Ma Yugang, Academician of the Chinese Academy. of Science and Deputy President of Fudan University to the Press. conference on Wednesday.

The forum also invited two co-speakers, Professor Ma Jianpeng and Qi Yuan, both from Fudan University, to share their thoughts and research findings on AI research, prospects and application. and its contribution to pharmaceutical development and innovation.

“The three speakers in the first forum will introduce the audience to the basic technology and knowledge of AI, as well as their thoughts on how to incite reform in fundamental topics and improve breakthrough in key scientific questions” , said Ma Yugang.

The organizers said that the forum, compared to the Global Laureates Forum and the Pujiang Innovation Forum held annually in the city, will focus more on collecting and sharing scientific thoughts, and thus become a platform to improve the construction of Shanghai to make it a science hub and technology innovation hub.

The organizer plans to hold six forums each year, with each event featuring a keynote speaker and up to two co-speakers.

When planes, wildlife collide, animals and humans are killed


SAN ANTONIO – From birds to skunks to turtles, many unlucky creatures get caught in the path of planes.

But it’s not just dangerous for animals. According to the Federal Aviation Administration, wildlife strikes around the world have killed more than 300 people and destroyed about 298 planes between 1988 and 2021.

The FAA published some of the significant strikes that occurred between January 1990 and March 2022, and three incidents at San Antonio International Airport were serious enough to be included.

In February 2001, for example, a black vulture shattered the right windshield as a plane approached the airport. Two passengers left with minor injuries. The pilot was unable to speak to the tower because the bird strike rendered the radios inoperative. The plane, however, landed without incident, despite being out of service for almost six months, and the cost of repairs and hospital bills came to $20,400.

In the United States, affected animals are recorded in the National Wildlife Strike Database – maintained by the FAA and the US Department of Agriculture – so that engine and aircraft manufacturers can design parts aircraft capable of withstanding impacts better. Airports also use the data to find and remove habitats that attract wildlife.

“The safety of the flying public is our No. 1 priority,” FAA National Wildlife Biologist John Weller said in a recent video on the Wildlife Strike Database.

On ExpressNews.com: San Antonio airport difficulties explained: short runways, lack of travelers, etc.

Ninety-seven percent of strikes in the database are from birds. Terrestrial mammals account for less than 2% of the impacts, while bats and reptiles fill in the rest. Mammal strikes are not as frequent, but they tend to be more damaging. Deer strikes are more common at general aviation airports than at commercial airports due to a lack of proper fencing.

Reporting strikes is voluntary, so the database, which dates back to 1990, represents only what airlines, airports, pilots and other sources choose to submit. There are over 250,000 recorded strikes in the database, with information associated with each occurrence, including aircraft type and animal species, time of day and location of the strike. impact.

Marcus Machemehl is responsible for keeping animals and wildlife away from airports in San Antonio. Here he loads an armadillo captured at San Antonio International Airport.

Robin Jerstad, San Antonio Express-News

Strike reports continue to rise, but according to this year’s Strike Database report, damaging strikes have fallen from 762 in 2000 to 657 in 2021.

On ExpressNews.com: As other Texans continue to pay less, San Antonio airfares return to pre-pandemic standards

And the FAA is looking to step up its efforts to reduce wildlife risk. Along with the USDA and Mississippi State University, the FAA recently began researching how airports and wildlife biologists could use drones to monitor and possibly disperse wildlife.

Although the database is mostly populated by various types of birds, many of which are recorded as unknown species, here are some of the less common animals sometimes caught in the path of an aircraft.

San Antonio

For San Antonio International Airport, an unknown bird on May 3, 1990 became the first entry in the database. It has logged over 1,580 entries since.

Keeping critters away from local airports is done a little differently in San Antonio. There is a wildlife biologist whose job it is to keep animals and wildlife away from airports in San Antonio. Marcus Machemehl is one of four wildlife biologists in the country employed at an airport, as most airports use contractors to remove animals.

Some rarities:

  • black-tailed hare
  • striped skunk
  • Bats — multiple species
  • Virginia Opossum
  • Coyote


For Austin-Bergstrom International Airport, the February 22, 1990 Falcons became the first entry in the database. He has recorded more than 2,540 since.

Some rarities:

  • striped skunk
  • Bats — several species,
  • Raccoon
  • domestic dog
  • Coyote


For Dallas Love Field, an unknown small bird in April 1990 became the first entry in the database. Southwest Airlines hit the animal. He has recorded more than 1,760 since.

Some rarities:

  • turtles
  • Rabbits
  • striped skunk
  • Bats — multiple species
  • Virginia Opossum
  • domestic cat
  • Foxes

For Dallas/Fort Worth International Airport, a brown-headed cowbird in May 1990 became the first entry in the database. He has recorded more than 7,370 since. In 2014, DFW won an FAA award for excellence in strike reporting.

Some rarities:

  • Bats — multiple species
  • Coyote
  • turtles
  • striped skunk
  • domestic dog
  • Raccoon
  • Foxes


For William P. Hobby Airport, an unknown small bird in May 1990 became the first entry. He has recorded more than 1,670 since.

Some rarities:

  • Bats — multiple species
  • Coyote
  • black-tailed hare
  • Virginia Opossum
  • domestic cat
  • domestic dog

For George Bush Intercontinental Airport, an unknown little bird in July 1990 became the first entry. It has recorded over 2,150 entries since.

Some rarities:

  • Bats – several species
  • Snakes
  • Virginia Opossum
  • Coyote
  • striped skunk
  • Nine-banded armadillo
  • Raccoon

Experts uncover the secret of people’s viral resistance. Here’s why it matters


In a groundbreaking discovery, researchers from Trinity College Dublin have found the secret that could help explain why some people are able to resist viral infections. Research that has been published in the prestigious journal Cell Reports Medicine can be used further to resolve why some people are infected with Covid-19 and some remain immune.

The study of the immune response to viral infections has been understood by screening the immune system of women who have been exposed to hepatitis C (HCV) by contaminated anti-D transfusions given over 40 years ago in Ireland.

The discovery may help to understand and advance the fundamental understanding of viral resistance to the potential development of treatments for the treatment of infected people.

Several thousand women in Ireland were infected with the hepatitis C virus between 1977 and 1979 as a result of contaminated anti-D, a drug given to rhesus negative pregnant women carrying rhesus positive fetuses made from plasma from blood donations. The drug stops the production of potentially harmful antibodies that could occur in subsequent pregnancies. Some of the anti-D used between 1977 and 1979 were contaminated with hepatitis C.

Three distinct populations emerged from this epidemic: people with chronic infection, those who were cured of infection by an antibody response, and those who appeared immune to infection but did not produce hepatitis C antibodies. .

Cliona O’Farrelly, professor of Comparative Immunology at Trinity School of Biochemistry and Immunology, is the senior author of the research paper. Cliona, who is based at the Trinity Biomedical Sciences Institute, said:

“We hypothesized that women who appeared resistant to HCV infection must have an enhanced innate immune response, which is the old part of the immune system that acts as the first line of defense.

“To test this, we needed to get in touch with women who were exposed to the virus more than forty years ago and ask them to help us by allowing us to study their immune systems to look for scientific clues that would explain their different responses.

“After a nationwide campaign, over 100 women came forward and we got unique and important insights. The fact that so many women – many of whom have been living with medical complications for a long time – have been willing to help shows how people want to engage in science and help pursue research that has the potential to have a real and positive impact on society, and we are deeply grateful to them.

In the end, the researchers recovered 90 previously infected women and nearly 40 members of the resistant group.

Then, in partnership with the Pasteur Institute in Paris, they requested blood samples from nearly 20 women in each group, which they stimulated with molecules resembling a viral infection and causing the activation of the innate immune system.

Jamie Sugrue, a PhD candidate in Trinity’s School of Biochemistry and Immunology, is the first author of the research paper. He said:

“By comparing the response of resistant women to those who were infected, we found that resistant donors had an improved response to type I interferon after stimulation. Type I interferons are a key family of antiviral immune mediators that play an important role in defending against viruses, including hepatitis C and SARS-CoV-2 or COVID-19.

“We believe that the increased production of type I interferon by our resistant donors, observed now nearly 40 years after initial exposure to hepatitis C, is what protected them from infection.

“These results are important because resistance to infection is a much overlooked outcome after viral outbreak, mainly because it is very difficult to identify resistant individuals – since they do not get sick after viral exposure, they wouldn’t necessarily know they were exposed. That’s why cohorts like this, while tragic in nature, are so valuable – they provide a unique opportunity to study the response to viral infections in a population by elsewhere in good health.

The lab is currently focusing its efforts on using these biological findings to dissect the genetics of viral resistance in HCV donors. Their research on HCV resistance has already sparked interest in other viral diseases, such as SARS-CoV-2 which causes COVID-19, globally.

(With ANI entries)

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This weirdly smart, crawling slime is redefining our understanding of intelligence: ScienceAlert


Imagine you are walking through a forest and rolling over a log with your foot. On its underside sprawls something wet and yellow – much like something you might have sneezed at…if that something was banana yellow and fanned out into elegant fractal branches.

What you would see is the plasmodium form of Polycephalic Physarum, the multi-headed slime mold. Like other slime molds found in nature, it performs an important ecological role, helping to break down organic matter to recycle it into the food web.

This weird little organism has no brain or nervous system; its mottled, bright yellow body is just a cell. This species of slime mold has thrived, more or less unchanged, for a billion years in its moist, decaying habitats.

And, over the past decade, it’s changed the way we think about cognition and problem solving.

“I think it’s the same kind of revolution that happened when people realized that plants could communicate with each other,” said biologist Audrey Dussutour of the National Center for Scientific Research.

“Even these tiny microbes can learn. It gives you a little humility.”

P. polycephalic in its natural habitat. (Kay Dee/iNaturalist, CC BY-NC)

P. polycephalic – adorably dubbed “The Blob” by Dussutour – isn’t exactly uncommon. It can be found in dark, moist, and cool environments like leaf litter on a forest floor. It’s also really special; although we call it a “mold”, it is not actually a fungus. It is also not an animal or a plant, but a member of the Protista kingdom – a sort of catch-all group for anything that cannot be clearly classified into the other three kingdoms.

It begins its life as several individual cells, each with a single nucleus. Then they merge to form the plasmodiumthe stage of vegetative life during which the organism feeds and develops.

In this form, fanning out in veins to forage for food and explore its surroundings, it is still a single cell, but containing millions or even billions of nuclei swimming in the cytoplasmic fluid confined within the bright yellow membrane.

brainless cognition

Like all organisms, P. polycephalic must be able to make decisions about its environment. He needs to search for food and avoid danger. It needs to find the ideal conditions for its reproductive cycle. And this is where our little yellow friend gets really interesting. P. polycephalic does not have a central nervous system. He doesn’t even have specialized fabrics.

Yet he can solve complex puzzles, like mazes, and memorize new substances. The kind of tasks we used to think only animals could do.

“We’re talking about brainless cognition, obviously, but also without any neurons. So the underlying mechanisms, the whole architectural framework of how it processes information is totally different from how your brain works,” said said biologist Chris Reid. from Macquarie University in Australia told ScienceAlert in 2021.

“By providing it with the same problem-solving challenges that we have traditionally given to animals with brains, we can begin to see how this fundamentally different system could achieve the same result. This is where it becomes clear that for many of them things – which we’ve always thought required a brain or some sort of higher information processing system – that aren’t always necessary.”

physeal veins(David Villa/ScienceImage/CBI/CNRS)

P. polycephalic is well known to science. Decades ago, it was, as physicist Hans-Günther Döbereiner of the University of Bremen in Germany explained, the “workhorse of cell biology”. It was easy to clone, store and study.

However, as our tools for genetic analysis have evolved, organisms such as mice or cell lines such as HeLa have taken over, and P. polycephalic fell by the wayside.

In 2000, biologist Toshiyuki Nakagaki from RIKEN in Japan brought the little beast out of retirement – ​​and not for cell biology. his paper, Posted in Naturewas titled “Maze Solving by an Amoeboid Organism” – and that’s exactly what P. polycephalic did.

Nakagaki and his team had placed a piece of plasmodium at one end of a maze, a food reward (oats, because P. polycephalic love oat bacteria) to another, and watched what happened.

The results were stunning. This strange little acellular organism managed to find the fastest way through every maze thrown at it.

“It sparked a wave of research into what other kinds of tougher scenarios we can test slime mold with,” Reid said.

“Virtually all of these were surprising in some way, and surprised researchers in how slime mold actually worked. It also revealed some limitations. revelation as to how this simple creature can accomplish tasks which have always been assigned and considered the domain of higher organisms.”

Filled with surprises

Nakagaki recreated the Tokyo Metro, with station nodes marked with oats; P. polycephalic recreated it almost exactly – except the slime version was more damage resistant, in which if one link was cut, the rest of the network could continue.

Another team of researchers found that the protist could effectively solve the traveling salesman problem, an exponentially complex mathematical task that programmers routinely use to test algorithms.


Earlier this year, a team of researchers discovered that P. polycephalic can “remember” where it has previously found food based on the structure of the veins in that area. This follows previous research by Dussutour and colleagues, which found that slime mold blobs can learn and remember substances they dislike, and communicate that information to other slime mold blobs. once merged.

“I’m always amazed at how, in a way, they are complex because they always surprise you in an experience, they would never do exactly what you choose to do,” Dussutour said.

In one case, his team was testing a growth medium used for mammalian cells and wanted to see if the slime would like it.

“This hated this. He started building this strange three-dimensional structure so he could take the lead and escape. And I’m like, ‘Oh my God, this organism’.”

A processing network

Although technically a single-celled organism, P. polycephalic is considered as a network, exhibiting a collective behavior. Each part of the slime mold works independently and shares information with its neighboring sections, without centralized processing.

“I guess the analogy would be neurons in a brain,” Reid said. “You have this brain which is made up of a lot of neurons – it’s the same with slime mold.”

This brain analogy is truly intriguing, and it wouldn’t be the first time P. polycephalic was compared to a neural network. The topology and structure of brain networks and slime mold patches are very similar, and both systems exhibit oscillations.

It’s not entirely clear how information is propagated and shared in slime mold, but we do know that P. polycephalicIts veins constrict to act as a peristaltic pump, pushing cytoplasmic fluid from section to section. And the oscillations of this fluid seem to coincide with encounters with external stimuli.

“These oscillations are thought to convey information, process information, by the way they interact and actually produce behavior at the same time,” Döbereiner told ScienceAlert.

“If you have a network of Physarum go to a certain food, it changes its oscillation pattern when it encounters sugar: it begins to oscillate faster. Due to these faster oscillations, the whole organism begins to change its pattern of oscillation and begins to flow in the direction where the food was found.”

He and his colleagues published an article in 2021 demonstrating that these oscillations are extraordinarily similar to the oscillations observed in a brain, only a hydrodynamic system rather than electrical signals.

“What is relevant is not so much what oscillates and how the information is transported”, he explains, “but that it oscillates and that a topology is relevant – is a neuron is connected to 100 neurons or just two; is a neuron connected just to its neighbors or is it connected to another neuron far away.”

physarium skullP. polycephalic growing on a life-size model of a human skull. (Andrew Adamatsky, artificial life2015)

Defining cognition

As exciting as her escapades may seem, any researcher working with her will tell you that P. polycephalic is not, in itself, a brain. It is not capable of higher level processing or abstract reasoning, as far as we can tell.

As intriguing as the notion may sound, it’s also not likely to evolve into something like a brain. The organism has had a billion years to do so and shows no signs of heading in that direction (although if any sci-fi writers like the idea, feel free to run with it).

In terms of overall biology, slime mold is extremely simple. And by that very fact, it changes the way we understand problem solving.

Just like other organisms, it needs food, it needs to navigate its environment, and it needs a safe place to grow and reproduce. These issues can be complex, yet P. polycephalic can solve them with its extremely limited cognitive architecture. It does this in its own simple way and with its own limitations, Reid said, “but that in itself is one of the beautiful things about the system.”

In a sense, this leaves us with an organism—a moist, slimy, moisture-loving blob—whose cognition is fundamentally different from ours. And, just like the Tokyo subway, it can teach us new ways to solve our own problems.

“It really teaches us about the nature of intelligence, challenges some views, and fundamentally expands the concept,” Reid said.

“It forces us to question those long-held anthropocentric beliefs that we are unique and capable of so much more than other creatures.”

A version of this article was first published in June 2021.

Melissa Rauch went from collecting unemployment to earning six-figure paychecks according to the Big Bang Theory


Melissa Rauch is best known for her portrayal of eccentric microbiologist Bernadette on the long-running and astronomically successful sitcom, The Big Bang Theory. Although most of the show’s iconic cast members led very different lives before the show, the pre-The Big Bang Theory life is arguably the most fascinating.

RELATED: What Has Melissa Rauch Been Up To Since ‘The Big Bang Theory’?

Rauch had acted long before The Big Bang Theory graced the small screen, earning fleeting roles in comedies like Kath and Kim and Best week ever. Although she received short-lived acclaim for these roles, the star had yet to land her breakout role.


After languishing in obscurity for several years, Rauch’s financial situation deteriorated to the point that she began living off unemployment checks. Here’s how in the midst of this destitute situation, Rauch landed the role of Bernadette, which gradually propelled her to stardom and millionaire status.

Melissa Rauch struggled to land roles in Hollywood

Melissa Rauch moved to Los Angeles in the mid-2000s after her one-woman show, Jenna Bush’s Miss Education, caught the attention of a Hollywood agent. The 42-year-old hoped the move would revitalize her acting career. However, it didn’t take long after his big move to realize that his dreams would not come true.

“We made a showcase of [‘Miss Education’ in L.A.],” she said In the wings in 2020, “and not many people showed up because not many people see theater in LA – so that was another lesson.”

Despite this setback, Rauch continued to pursue his dreams of stardom, landing short-lived roles on shows like true blood and Kath and Kim. Although the star often did well in auditions, she almost exclusively booked roles in comedy shows that never aired or were discontinued almost as soon as they premiered.

RELATED: Who Is ‘The Big Bang Theory’ Melissa Rauch’s Husband, Winston Beigel?

In fact, the first decade of Rauch’s career was marred by such devastating bad luck that she failed an audition to model for TGI Fridays.

“They said, ‘We just need a close-up of your hands serving the fajitas,’ or whatever,” Rauch recalled in an interview with In the wings, “and no kidding, I heard the director say, ‘Jesus Christ!’ They were so raw and beat up. I didn’t get the job.”

Melissa Rauch perceived unemployment before the Big Bang theory

It took years to write obscure shorts like The Condom Killer and compose songs like Partially stalked love between fleeting acting gigs before Melissa Rauch landed the iconic role of Bernadette.

By then, years of unsuccessfully trying to make a name for herself in Hollywood had drained the star’s finances so badly that she began living off unemployment checks.

RELATED: The Struggle Melissa Rauch Has Had Since The ‘Big Bang Theory’ Ended

I was a fan of the show when I got the audition,” Rauch revealed to The Hollywood Reporter. “That week I had gone to the unemployment office to get my unemployment check. I had to go to that seminar on how to get a job. It was horrible. It was a dark week! I got the audition in my email, and it said The Big Bang Theory, and it was a show that I was watching. I was excited and pissed off thinking there was no way.

Landing a role in The Big Bang Theory was a dream come true for Melissa Rauch

While most fans would agree that Melissa Rauch’s portrayal of Bernadette Rostenkowski-Wolowitz was nearly flawless, her audition was far from perfect. The Batman and Harley Quinn The star was so nervous that she momentarily picked up a Canadian accent midway through her performance.

“There were a ton of girls at the audition. When they brought me in for a second time for all the producers, they had narrowed it down to six of us,” she said. The Hollywood Reporter.

“In the audition, for some reason, I had to say the word ‘about’ and it came out ‘abouuuut’, and Chuck [Lorre] asked me if I was Canadian. My nerves made me sound Canadian!

So Rauch was understandably over the moon when the show’s casting team called her back with some positive news. “I got the call on my ride back to my shitty apartment, and I was so excited,” she said. “I stepped over the homeless man who was sleeping outside my building, opened the door and shouted to my husband that I had the role. It was for an episode at the time, and it was a dream come true.”

At the start of her The Big Bang Theory tenure, Rauch earned a hefty salary of $75,000 per episode. However, as the show neared its final chapter, Rauch earned over $500,000, making her one of the highest-earning actresses on television. In addition, Rauch earned a lot of money by acting in major productions like Ice Age: Collisionwhich gradually inflated his net worth to $20 million.

Sports biologist: Nabi’s appeal is unlikely to be upheld by a Swiss court | New


Last Tuesday, the Court of Arbitration for Sport (CAS) upheld the two-year ban imposed on Nabi, while ruling that the Estonian wrestler was an unfortunate victim and could not be called a cheater or a user of banned substances. At a press conference on Thursday, Nabi announced that he planned to appeal the decision to the Swiss Federal Court.

“It was an interesting nuance that was added to the verdict and which allows for different interpretations,” Port told ETV current affairs program “Ringvaade,” when discussing the CAS decision to point out that Nabi was a unfortunate victim in the case.

Following his ban by the Disciplinary Board of the Estonian Center for Integrity in Sport (ESTCIS), Nabi and his lawyers presented several possible scenarios to CAS to explain how the banned substance Letrozole was able to enter the wrestler’s body. One explanation was that Nabi may have ingested the substance by unknowingly eating contaminated turkey meat or liver. Another postulated that letrozole could have entered his body from the sweat or saliva of a training partner who had taken the substance himself. The wrestler’s contact with gym equipment or surfaces containing traces of letrozole has also been put forward as a possible explanation.

“Basically all the arguments they made were based on the premise that (the scenarios) are possible, but a lot of things in the world are possible,” Port said.

“Now, as to whether the evidence supports (these) possibilities, the court has found it to be insufficient. The court is not so much looking for the truth as it compares the evidence presented and decides which is more plausible,” he said. declared Port.

“In this case, it is said that if you are an athlete, you are solely responsible, which implies, among other things, that you may be placed in an unfair situation, however, you always have the right to demonstrate that you do not weren’t at fault,” Port explained.

“It’s one thing to have the intention – to want to do harm – but it’s another to not have paid enough attention to your food or anything else,” he said.

“To be honest, we don’t really know how this substance entered Heiki Nabi’s body. In its reasoning (for the verdict), the court added a sentence to say, that it did not know if (the substance being in Nabi’s body) was under his control or not,” Port said.

Port considers it highly unlikely that the decision will be overturned on appeal. “The Swiss Supreme Court does not address the nature or logic of the CAS judicial process, nor what Heiki Nabi argues about wanting to remove the requirement for an athlete to prove that he was not at fault “Port explained.

“It’s just about whether there were any mistakes made during the trial. If there were any mistakes in the process, then that process will be reversed. When you enter the private sports arena, you make a contract , which says you will compete under those specific rules. So far, that has been accepted as the norm around the world,” Port said.

Port concluded by saying he hopes Nabi will continue to compete in the future once his ban is served. “I hope Heiki Nabi picks himself up. I think he’s a very good and determined athlete. He’s had a lot of success so far, which is a testament to who he is. Regardless of whether their history whether bad or not, I respect people who can get out of tough situations,” he said.

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Maryland today | 19 seniors honored as Merrill Presidential Scholars


As an elementary education major, Jennifer Lopez ’06 singled out her first-grade teacher for being an influential mentor and even inspired her to spend hours pretending she was teaching her own class.

Lopez, who honored teacher Mary Lee at a 2005 ceremony for a new program called the Philip Merrill Presidential Scholars, later became a teacher herself.

Now she’s helping close the loop on a tradition of mentorship as the recipient of today’s 19th Annual Merrill Scholars Honor, where a UMD student will thank her for teaching him how to enjoy reading in her fifth grade class.

A total of 19 Philip Merrill Presidential Scholars will recognize K-12 teachers and UMD faculty who have guided, inspired, coached, tutored, and challenged them on their academic journeys. The program awards $1,500 scholarships, which are awarded in the K-12 teacher’s name to another student in that school district who will be attending UMD the following school year.

“The late Philip Merrill created this program to create a community of scholars, faculty members, and K-12 teachers who recognize the importance of teaching and mentoring the next generation” , said UMD President Darryll J. Pines. “We are grateful for a program that celebrates invaluable mentorship and for the many teachers who have a lasting impact on the lives of our students. »

The program also highlights the achievements of senior graduates, who are selected by university colleges and schools. The scholars’ internships and research work range from tackling climate change to tackling global disparities in mental health.

Scholar Joanna Hung, a student at Honors College Design Cultures and Creativity, helped launch a pilot college-readiness program for high school students with Down syndrome and redesigned the curriculum for Girls Talk Math, a camp UMD summer school for high school girls. Another researcher, Brian Tinker, is midshipman first class in UMD’s Naval ROTC program, studies lunar particles, and is an undergraduate lecturer at the A. James Clark School of Engineering.

“The accomplishments of these students are a testament to the power of teachers and mentors in an academic journey,” said William A. Cohen, Vice Provost and Dean of Undergraduate Studies. “The Merrill Presidential Scholars Program creates an important legacy of teacher excellence – from K-12 through middle school – that leads to outstanding student achievement.”

Lopez (née Dodge) was among the second cohort of UMD Merrill Scholars, who are selected by colleges and schools offering major undergraduate programs.

“I remember wondering if my first grade teacher would come for the ceremony, if she would say, ‘Jenny who? “, Lopez said. “But now I realize that she wouldn’t have missed it. It’s one of the greatest gifts for a teacher to say, ‘I remember your class and what you have counted.”

Nick Bailey ’23, a double major in operations management and business analysis as well as marketing, said the same about Lopez, who taught him at Westbrook Elementary in Bethesda.

“I remember reading the most books I’ve ever read in my life during those class times, and also how she pushed me out of my comfort zone,” Bailey said.

He was particularly touched by an assignment at the end of the fifth year: each student had to write a letter to their future self. Lopez saved the letters and sent them to his students when they graduated from middle school three years later.

“They were asking questions like, ‘Are we on the iPhone200 now?’ or ‘Did you do this travel team?’ But they were also writing about their goals for themselves,” Lopez said.

The letters also served as a reminder that their elementary teacher was always thinking of them, reminding them of what they could accomplish, Bailey said. “She cared about every student.”

The Philip Merrill Presidential Scholars for 2022-23 are:

Alexia Ayuk (Operations management and business analysis)
Teacher mentor: Renetta Herndon-Cintron, Our Lady of Good Counsel High School, Olney, Md.
Faculty Mentor: Pamela K. Armstrong, Department of Decision, Operations and Information Technology

Nick Bailey (Operations Management and Business Analytics, Marketing)
Mentor teacher: Jennifer Lopez, Westbrook Elementary School, Bethesda, Md.
Faculty Mentor: Mary B. Harms, Department of Marketing

Janna Chapman (Environmental Sciences and Technologies, Geographical Sciences)
Teacher mentor: Kristyn Madeja, Broadneck High School, Annapolis, Md.
Faculty mentor: Thanicha Ruangmas, first year of experience in innovation and research

Kyra Cromwell Roseau (Fire Protection Engineering)
Mentor Teacher: Rita Pascale, Bethesda-Chevy Chase High School, Bethesda, Md.
Faculty Mentor: Kenneth Isman, Department of Fire Protection Engineering

Aimee Dastin-van Rijn (Economy, Theatre)
Teacher mentor: Victoire D’Agostino, St. John’s International School, Waterloo, Belgium
Faculty Mentor: Stacy Kosko, Department of Government and Politics

Logan Dayter (geographical sciences)
Teacher mentor: Lauren Gardenbelle, South Carroll High School, Sykesville, Md.
Faculty Mentor: Sinead Farrell, Department of Geographic Sciences

Fred Angelo Garcia (Physics, Astronomy)
Mentor teacher: Yolanda King-Davis, Oxon Hill High School, Oxon Hill, Md.
Faculty Mentor: Massimo Ricotti, Department of Astronomy

Maanasa Gurram (Biological Sciences)
Mentor Teacher: Mary Jane Sasser, River Hill High School, Clarksville, Md.
Faculty Mentor: Najib El-Sayed, Department of Cell Biology and Molecular Genetics

Joanna Hung (Math)
Mentor teacher: Harrison Toy, Robert Frost Middle School, Rockville, Md.
Faculty Mentor: Dana Grosser-Clarkson, Center for Mathematics Education

Sterling Mullenix (Linguistic)
Mentor teacher: Jenny Mey, Bethesda-Chevy Chase High School, Bethesda, Md.
Faculty Mentor: Jeffrey Lidz, Department of Linguistics

Kuburat Oladiran (Psychology, Criminology and Criminal Justice)
Mentor teacher: Michelle Snape, Northwood High School, Silver Spring, Md.
Faculty Mentor: Heather Yarger, Department of Psychology

Deborah Omotoso (Family Science)
Mentor teacher: Dana Shieh, Bishop McNamara High School, Forestville, Md.
Faculty Mentor: Scott Roberts, Department of Psychology

Pravalika Palavarapu (Psychology, Sociology)
Mentor Teacher: Bryce Coon, Thomas S. Wootton High School, Rockville, Md.
Faculty Mentor: Nicole DeLoatch, Department of Sociology

Bradley Polkowitz (Operations Management and Business Analytics, Marketing)
Mentor Teacher: Cindy Bravaco, Colts Neck High School, Colts Neck, NJ
Faculty Mentor: Joseph Bailey, Department of Decision, Operations and Information Technology

Rachel Robin (Government and Politics, Communication)
Mentor teacher: Daniel McKenna, Poolesville High School, Poolesville, Md.
Faculty Mentor: Jaclyn Bruner, Department of Communication

Racheal Ssentongo (Aerospace Engineering)
Mentor teacher: Jack Stansbury, Poolesville High School, Poolesville, Md.
Faculty Mentor: Jarred Young, Department of Aerospace Engineering

Brian Tinker (Aerospace Engineering)
Mentor Teacher: Andrew Milcic, Severna Park High School, Severna Park, Md.
Faculty Mentor: Jarred Young, Department of Aerospace Engineering

Katelyn Wang (Kinesiology)
Mentor teacher: Danielle Borgia, Mount Hebron High School, Ellicott City, Md.
Faculty Mentor: Elizabeth Brown, Department of Kinesiology

Hanna Zakharenko (Journalism, Information Sciences)
Mentor Teacher: Warren Hynes, Westfield High School, Westfield, NJ
Faculty Mentor: Adam Marton, Philip Merrill College of Journalism

Stanford’s Academic Freedom Conference Is Hardly ‘Academicly Free’


The Graduate School of Business (GSB) will host its Academic Freedom Conference November 4-5. The conference, which sparked controversy over its speaker list and initial decision to close to the media, “aims to identify ways to restore academic freedom, open inquiry, and freedom of speech and expression on the campus and in the culture at large”, according to his website.

The conference drew criticism when Stephanie M. Lee, a reporter for The Chronicle of Higher Education, wrote on Twitter on October 19 that his request to attend the conference was refuse. The conference organizers later decided to direct the conference.

A open letter criticizing the conference, titled “A Closed Conference on Academic Freedom Is a Contradiction,” has garnered more than 50 signatures — most of them Stanford professors — as of November 2.

The letter raised fears that the conference was giving “shelter and immunity” to racism. He quotes speaker Amy Wax, who has already inflamed controversial for his racist remarks about blacks and Asians. Wax’s 2017 complaints that she had rarely seen black students at the University of Pennsylvania Law School, where she is a professor, graduating in the top half of their class, were later refuted by Penn Law School Dean Theodore Ruger.

“When [Wax’s] zeal to make a racist point takes precedence over his obligation to set the record straight or provide any evidence for his statements, we have a deep problem, one that no false calls for academic freedom can or should conceal” , the letter declared.

The rest of the speaker range also raised eyebrows.

Speakers include Niall Ferguson, a Hoover Senior Fellow who resigned of his leadership position in a campus free speech program after it was revealed he had urged a group of conservative students to conduct “opposition research” on a progressive student activist. Scott Atlas, Hoover Senior Fellow and former Trump adviser on the coronavirus who threatens suing more than 100 Stanford doctors and researchers who signed an open letter condemning his views on COVID-19, is also part of the lineup.

John H. Cochrane, senior Hoover scholar, speaker and member of the organizing committee, wrote in an email to The Daily that the organizing committee had invited a wide range of people, including those now critical of the conference – many of whom, according to Cochrane, ignored or declined the invitation. Other Stanford affiliates on the organizing committee did not respond to requests for comment.

Professor of French and Comparative Literature Joshua Landy said he was surprised to be invited to be part of a panel on biomedical sciences as a professor of literature. He declined and recommended that organizers attempt to recruit medical experts outside of Stanford if necessary.

“When it comes to matters of public interest, like medical matters, academic responsibility requires us to be careful what we say and to prioritize expert research,” Landy said.

The open letter also said the invitational nature of the conference is contrary to academic freedom. According to the letter, academic freedom is meant to encourage discussion, but conference organizers have created a “tightly sealed event.”

Cochrane wrote that the conference is invitation-only due to limited space and budget for food.

Reactions to the conference organizers’ decision to broadcast the conference live have been mixed.

Landy said he thought it was “great” that the conference was being broadcast live. “I just find it a bit sad that it excludes outside voices,” he said.

“I think it would have been even better if they had decided to open it up,” Landy said.

Cochrane, however, wrote that having hundreds of people does not make a “very good forum for open exchange”.

Comparative literature professor David Palumbo-Liu said the decision to livestream was “not good enough”. He added that the live broadcast would not give people the opportunity to challenge the speakers.

Some students have also criticized that the conference does not uphold the spirit of academic freedom.

Mallory Harris, Ph.D. in biology. student, said true academic freedom challenges power imbalances, but speakers include people in power who have used intimidation. Taimur Ahmad MA ’23, a master’s student in international politics, said events like this conference make it harder for people to find common ground.

Landy also said he feared the event was a “missed opportunity for bipartisanship,” citing Florida law. sign by Governor Ron DeSantis earlier this year, restricting discussion of race in schools and businesses. “Academic freedom is not a question of left or right,” he said.

When contacted for comment, GSB spokeswoman Amelia Hansen shared a statement from GSB Dean Jonathan Levin, stating that faculty and students have the freedom to support the creation of a “collision of ‘ideas’.

“However, not all talks, symposiums and lectures will represent the full range of viewpoints, and some may include controversial viewpoints precisely because of this freedom,” Levin wrote.

In response to criticism, Cochrane wrote that people who don’t like the way the Academic Freedom Conference is organized can organize their own conferences. “They don’t have to silence us to make their voices heard,” he wrote.

Engineering and oceans professor Stephen Monismith said he thought the University should sponsor an open conference on academic freedom, which he said he and a few others had proposed but “didn’t go very far”. Palumbo-Liu also mentioned past efforts to host an academic accountability event that did not receive support. The University did not respond to a question about past efforts to hold events.

“You can’t have a ‘collision of ideas’ if you’ve closed the conference [and] only admitted it to a passive audience,” Palumbo-Liu said. “So you basically do [an] almost a parody of academic freedom.

$710.5 million donated to support cancer and infectious disease research, skin-on-chip technology and a new approach to bone marrow transplantation


SEATTLE – November 2, 2022 – Below are summaries of recent Fred Hutchinson Cancer Center research results and other news.

If you are looking for sources for November Lung and Pancreatic Cancer Awareness Month, please see our lung cancer, həliʔil program and pancreatic cancer pages for a list of projects, experts and the latest news.

Research against cancer

Fred Hutchinson Cancer Center Receives $710.5 Million Gift to Accelerate Cancer and Infectious Disease Research
The Bezos family has committed $710.5 million over the next decade to accelerate Fred Hutch’s multifaceted approach to scientific discovery. The gift supports the organization’s efforts to dramatically accelerate the pace and scale of medical breakthroughs in cancer and infectious disease by harnessing the full potential of today’s science. The donation will support recruitment, research facilities, clinical research infrastructure and the expansion of immunotherapy research.
Media contact: Kat Wynn, kwynn@fredhutch.org

New approach could make bone marrow transplantation safer and stronger
Bone marrow transplants have transformed care for patients with blood cancers, but one of the downsides of treatment is graft-versus-host disease – a common side effect that occurs when transplanted cells see tissue receiver’s healthy as strangers and attack them. In a study published in Sciences Immunologya Fred Hutch team showed a new approach that prevented relapses in laboratory models of bone marrow transplantation to treat leukemia and multiple myeloma.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

The award will fund research into new therapies for metastatic prostate cancer
A three-year, $750,000 grant from the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation will allow Fred Hutch researchers to study therapies for metastatic prostate cancer. Dr. John Lee and the collaborators of Fred Hutch Drs. Peter Nelson and Roland Strong explore new treatments, in particular through the use of immunotherapy.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

Side effects of cancer chemotherapy and how to limit them
Researcher Fred Hutch Dr Gary Lymanlong-time thought leader in the American Society of Clinical Oncology (ASCO), as well as three colleagues, recently published an analysis in Nature Reviews Clinical Oncology offering a broad overview of common acute adverse events associated with chemotherapy and how to manage or prevent them.
Media contact: Claire Hudson, crhudson@fredhutch.org

Dr. Ruth Etzioni Receives $7.4 Million NCI Grant to Evaluate New Cancer Diagnostics
Researcher Fred Hutch Dr Ruth Etzioni received a seven-year Outstanding Investigator Award from the National Cancer Institute for continuing his work on new cancer diagnostics. The award, which comes with approximately $7.4 million in funding, will enable Etzioni and his team to create frameworks and tools to evaluate new cancer diagnostics such as new imaging modalities. nuclear and early detection tests for several cancers, commonly called liquid biopsies.
Media contact: Claire Hudson, crhudson@fredhutch.org

Infectious disease

Searching for herpes treatments with skin-on-chip technology
Researcher Fred Hutch Dr. Jia Zhu leads a group of researchers studying herpes simplex viruses, which are responsible for periodic outbreaks of cold sores in the mouth (HSV-1) or recurring ulcers in the genitals (HSV-2). With their new device, which she calls a “skin-on-chip” platform, Zhu and her team have built and tested a prototype tool that could help researchers accelerate the development of treatments for human herpes.
Media contact: Claire Hudson, crhudson@fredhutch.org

Health Equity

Spokane Regional Health District: Gaps in Cancer Care in Spokane
For their “Cancer Health Equity Now” podcast, members of Fred Hutch’s Office of Community Outreach and Engagement held a roundtable with staff from Sunnyside, Spokane and Seattle. They discussed the future of health equity work and reflected on the work of the past year.
Media contact: Kat Wynn, kwynn@fredhutch.org

Understanding tribal communities and cancer through storytelling, art
by Fred Hutch Public Art and Community Dialogue Program selected artist, storyteller and member of the Lower Elwha S’Klallam tribe Roger Fernandes to create a new mural. He believes that storytelling and art can contribute to this by tapping into the unconscious and the spiritual side of people and giving them strength and hope.
Media contact: Kat Wynn, kwynn@fredhutch.org

Awards and other news

Dr. Larry Corey receives the Alexander Fleming Prize
At a conference in Washington, D.C. on the science of infectious diseases, Dr. Larry Coreyvirologist and former president and director of Fred Hutch, received a lifetime achievement award. The rewardgiven by the Infectious Diseases Society of America, was established in 1964 in honor of the late Dr. Alexander Fleming.
Media contact: Claire Hudson, crhudson@fredhutch.org

Dr. Anat Zimmer Receives AAUW Fellowship
Computational biologist Dr. Anat Zimmer, postdoctoral researcher in Dr. Gavin Ha Fred Hutch’s lab, received a 2022-23 fellowship from the American Association of University Women. Zimmer, who moved with his family from Israel, joined Fred Hutch in the summer of 2021. His interests include systems biology and the application of computational tools to study, predict and prevent human disease.
Media contact: Kat Wynn, kwynn@fredhutch.org

Merkel cell carcinoma researcher Dr. Nick Salisbury named Brave Fellow
Postdoctoral researcher Dr. Nick Salisbury has just been named the third recipient to receive the brave camaraderie at Fred Hutch. Funded by Brooks Running on behalf of the Brave Like Gabe Foundationthe aim of the fellowship is to develop scientific leaders who will advocate for a diverse and inclusive biomedical research workforce focused on rare cancer research.The fellowship will fund Salisbury research into carcinoma at Merkel cells, a rare and aggressive form of skin cancer caused by Merkel cell polyomavirus.
Media contact: Kat Wynn, kwynn@fredhutch.org

Fred Hutch Hosts Inaugural Dr. E. Donnall Thomas Symposium
Leading researchers from around the world traveled to Seattle to discuss the future of transplantation, gene and cell therapies at Dr. E. Donnall Thomas’ inaugural symposium. Among the attendees celebrating his legacy was Dr. Rainer Storb, an early Fred Hutch scientist who worked with Thomas and still leads the transplant biology program; and graduate student David Granadier, whose poster on thymus regeneration received first prize from the conference organizers.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

Spotlight on Science
Spotlight on science is a monthly installment of articles written by Fred Hutch postdoctoral fellows that summarize new research papers by Hutch scientists. If you would like to know more or discuss these topics, contact: media@fredhutch.org

# # #

The Fred Hutchinson Cancer Center brings together comprehensive care and advanced research to provide the latest cancer treatment options and accelerate discoveries that prevent, treat and defeat cancer and infectious diseases worldwide.

Based in Seattle, Fred Hutch is an independent, nonprofit organization and the only National Cancer Institute-designated cancer center in Washington. We have earned a worldwide reputation for our track record of discoveries in cancer, infectious diseases and basic research, including significant advances in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and vaccines against COVID-19. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation therapy, proton therapy and related services and has network affiliations with hospitals in four states. Fred Hutch also serves as the cancer program at UW Medicine.

Please note that our organization was renamed Fred Hutchinson Cancer Center in April 2022, following the merger of longtime partners, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance.

East Saddle Forest Management Project Improves Elk Habitat


The Nez Perce-Clearwater National Forests and Clearwater Region of the Idaho Department of Fish and Game (IDFG) work together on management projects that improve wildlife habitat on national forest lands. One such project is East Saddle, where the Forest Service recently implemented a prescribed burn to improve habitat for elk and other wildlife.

The East Saddle Integrated Restoration Project, a collaborative project between the Forest Service and the IDFG, is located in the North Fork Ranger District of the Nez Perce-Clearwater National Forests, in areas of the Cayuse Creek drainage in south of the Old Kelly Creek work center, extending west. from the work center and north of Kelly Creek to the North Fork of the Clearwater. The primary objective of the project is to improve grazing for ungulate species, such as elk and deer, while improving summer and winter range and calving habitat for elk. Prescribed burning, timber harvesting and aspen restoration are all used in the project plan as means to achieve these goals.

On October 19, the Nez Perce-Clearwater National Forests conducted a prescribed burn as part of the East Saddle Project. Several units have been successfully burned, totaling approximately 1,000 acres.

“We’re really pleased with the results,” Nez Perce-Clearwater National Forests prescribed fire and fuels specialist TC Peterson said of the recent East Saddle prescribed burn. “On average, this burn consumed 80-90% of the targeted fuels in designated units, which is an excellent success rate.”

Supporting elk populations in this area of ​​the National Forest is a management priority for the Idaho Department of Fish and Game. The Lolo area The elk herd reached its peak of around 16,000 animals in the late 1980s, and the population has been in long-term decline ever since. Projects like East Saddle are collaboratively designed to enhance key summer, winter and transitional habitats that are needed for elk forage and calving habitat.

“The East Saddle prescribed burn is a great example of how fire can be used as a tool to improve forest conditions and wildlife habitat,” said Tara Ball, Regional Wildlife Biologist at IDFG. “Not only does prescribed burning stimulate new growth that improves forage for elk, but it also creates a mosaic of new and old vegetation, providing diverse habitat within the forest system that is important for many wildlife species. »

Although smoke is an inevitable by-product of prescribed burning projects, the smoke produced by a planned burn is far less than that which would be produced by a wildfire.

“Smoke from the October 19 fire at East Saddle rose about 2,000 feet above the ground and drifted east,” recalls Jim Wimer, fire information specialist at the National Forest. “During the afternoon, the winds were light, so the smoke mostly stayed over the Kelly Forks drainage.”

Smoke monitors deployed in the Missoula and Bitterroot valleys showed no impact on air quality during these prescribed fire operations. Later that night, smoke briefly drifted across the Continental Divide, but it dissipated quickly and air quality was unaffected.

The Idaho Department of Fish and Game and the Forest Service plan to continue partnering with projects like this.

“These kind of projects are what we expect to see more of, thanks to the Good Neighbor Authority agreement in place between the Forest Service and Idaho Fish and Game,” Ball said.

If you have questions about wildlife habitat improvement projects in the Nez Perce-Clearwater National Forests, please contact the Idaho Department of Fish and Game (208-799-5010) or the forest service (208-451-5585).

Corneal Langerhans cells in children with celiac disease

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  • Developing marine aquaculture to sustainably produce nutritious food


    Microalgae cultivation facility along the Kona Coast on the Big Island of Hawaii. Image courtesy of Cyanotech Corporation. Credit: Greene, CH, CM Scott-Buechler, ALP Hausner, ZI Johnson, X. Lei and ME Huntley. 2022. Transforming the Future of Marine Aquaculture: A Circular Economy Approach. Oceanography, p. 28, doi.org/10.5670/oceanog.2022.213, CC BY 4.0

    Land-based agriculture is the backbone of the global food production system. A new opinion piece published in the open access journal PLOS Biology advocates for increased investment in seaweed aquaculture systems as a way to meet nutritional needs while reducing the ecological footprint of food production. Written by Charles H. Greene at University of WashingtonFriday Harbor, Washington, and Celina M. Scott-Buechler of Stanford University, Palo Alto, California, the article was published on October 17.

    Adverse impacts on climate, land use, freshwater resources and biodiversity would result from increased agricultural and fisheries production to meet consumer demand. In their paper, the authors argue for shifting the focus from marine aquaculture down the food chain to algae. This could potentially meet the growing demand for nutritious foods in addition to reducing the ecological footprint of the current food system.

    Charles Green

    Charles Greene. Credit: Charles Greene, DC BY 4.0

    Microalgae could provide large amounts of nutritional protein and essential elements

    Amino acids are a set of organic compounds used to build proteins. There are about 500 naturally occurring known amino acids, though only 20 appear in the genetic code. Proteins consist of one or more chains of amino acids called polypeptides. The sequence of the amino acid chain causes the polypeptide to fold into a shape that is biologically active. The amino acid sequences of proteins are encoded in the genes. Nine proteinogenic amino acids are called "essential" for humans because they cannot be produced from other compounds by the human body and so must be taken in as food.
    " data-gt-translate-attributes="[{" attribute="">amino acids, in addition to other micronutrients, such as vitamins and antioxidants. Additionally, a marine aquaculture industry based on microalgae would not require arable land and freshwater, nor pollute freshwater and marine ecosystems with fertilizer runoff. The article does not address the potential for a new algae-based aquaculture industry to be culturally sensitive, how large-scale microalgae production would affect local dietary habits, or the taste of algae.

    According to the authors, “The financial headwinds facing a new marine microalgae-based aquaculture industry will be difficult as it must challenge incumbent industries for market share before its technologies are fully mature and can take full advantage of the scale. Financial investments and market incentives provided by states and federal governments can help reduce this green premium until the playing field is level. The future role of algae-based solutions in achieving global food security and environmental sustainability will depend on the actions governments take today.

    Greene adds, “Agriculture is the backbone of today’s global food production system; however, its potential to meet global nutritional needs by 2050 is limited. Marine microalgae can help fill the predicted nutrient gap while simultaneously improving overall environmental sustainability and ocean health.

    Interview with Associate Director of Research and Strategic Planning, Dr. Charles H. Greene

    What first inspired you to study microalgae and sustainability?

    About a dozen years ago, I came to the conclusion that too many Earth scientists were focusing only on the impacts of climate change and not looking for solutions to the problem. A colleague of mine, Dr. Mark Huntley, invited me to join his team studying the potential of marine microalgae in the production of biofuels. Over time, our thinking evolved and we realized that marine microalgae had enormous potential to address the global challenges of food and water security, climate change and many other aspects of environmental sustainability.

    What are the main conclusions that you gathered in your article?

    By adopting an integrated circular economy approach to growing marine microalgae, we can close the gap in human nutrition projected for 2050 and simultaneously reduce many of the negative impacts that our current food production system has on the climate and the environment. global environment.

    What surprised or interested you the most in your discoveries?

    We have always known that the high productivity of marine microalgae can help us reduce the carbon and land footprint of agriculture. However, what was an unexpected surprise was the amount of protein that could potentially be produced from such a small footprint of non-arable coastal land in the Global South. The implications of our results for sustainable development are profound.

    What are the next steps for research on this topic?

    As green venture capitalist John Doerr points out in his recent book*, it’s all about speed and scale. Our window of time to solve these global challenges is narrow, and the solutions are on a scale our policymakers find it hard to imagine, let alone invest. The future of algae-based solutions to achieve global food security and environmental sustainability will depend on the actions taken by the investment community and governments today.

    *Speed ​​and Scale: An Action Plan to Solve Our Climate Crisis Now

    Reference: “Algal solutions: Transforming marine aquaculture from the bottom up for a sustainable future” by Charles H. Greene and Celina M. Scott-Buechler, October 17, 2022, PLOS Biology.
    DOI: 10.1371/journal.pbio.3001824

    KUOW League of Murderous Creatures


    Move over, “murder hornets”. Many invasive species engage in biological killing, disrupting ecosystems and costing humans dearly.


    When it comes to invasive species, so-called “murder hornets” (officially: northern giant hornets) can be the buzzword. But many species are just as “deadly” as the Asian giant hornets that mysteriously appeared in the northwest corner of Washington State in 2019 and quickly made global headlines.

    “It’s a name the general public seems to love,” entomologist Sven Spichiger said at a 2020 news conference about Washington state’s efforts to eradicate the known insect from parts of Asia as the giant hornet or yak killer. “Looks like the media loves that too. I’m not a big fan of that,” he said.

    Northern giant hornets can indeed take down an entire hive of bees in minutes. Their bites can also be dangerous for larger animals.

    But nature involves a lot of “killing”: every creature that eats – or parasitizes, poisons or chokes – another is just as deadly. Species, like the northern giant hornet, that humans intentionally or accidentally transport away from their native range can quickly embark on expansive and costly kills.

    Biologists have long focused on the threat of invasive species, though pest campaigns rarely make headlines.

    Seeing the success of “murder hornets” in capturing the public imagination, we present six invasive species that pose a major threat to Washington State: KUOW’s League of Murder Creatures.


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    This mass murderer claimed millions of victims across the continent.

    The victims are bats and their killer is a fungus, known as Pd, short for unpronounceable but menacing Pseudogymnoascus destructans.

    The fungus that causes deadly ‘white nose syndrome’ in bats may soon face a new enemy, thanks to scientists in Washington state and beyond.

    Researchers have concocted a muddy concoction aimed at allowing an often deadly disease to survive, much like Covid-19 vaccines for humans.

    “We call it ‘yogurt for bats,'” said bat biologist Leah Rensel.

    READ: One way to fight a deadly pandemic: ‘yogurt for bats’

    Hornet Murder Mystery

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    Scientists in Washington and across the Pacific Ocean are working together to try to outsmart this deadly creature, the largest and most notorious species of its kind in the world.

    They hope they can use the species’ own chemical warning signals to lure it to its doom before it takes a foothold in Washington state.

    This murderous creature will be unveiled on November 7.

    Mystery Newtralizer

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    Some researchers call it the worst infectious disease known to science. He wiped out dozens of defenseless species from the face of the earth.

    Now a newly discovered relative of the disease has biologists worried about a new round of species deaths, with the Pacific Northwest particularly at risk.

    This murderous creature will be unveiled on November 14.

    4) Coming in November…

    English Ivy Mystery (2)

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    Meandering across the ground, this murderous creature extinguished life on millions of acres.

    Oregon banned the sale of this species ten years ago, but in Washington you can walk into the big box stores and buy it, no questions asked.

    A group in Edmonds, Washington, took the matter into their own hands. They discovered that fighting a common enemy can bring people together.

    This murderous creature will be unveiled on November 21.

    5) Coming in November…

    Miscellaneous Mystery 1

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    Though small, this murderous creature is voracious, adaptable, and prolific: a recipe for world domination.

    It exploded onto the Puget Sound scene in 2021 and has since made its way to Alaska.

    This murderous creature will be unveiled on November 21.

    Miscellaneous Mystery 2

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    Fluffy, cute and videogenic, this killer creature is adored on the internet and in real life.

    It’s also a mass murderer on an almost incomprehensible scale: killing an estimated two billion birds, 12 billion small mammals, and 650 million reptiles and amphibians a year in the United States.

    This murderous creature will be unveiled on November 21.

    Miami Dade College Partners with Nicklaus Children’s Hospital to Launch Scholarly Nurse Program


    Miami, October 28, 2022 – In an ongoing effort to address the nursing shortage, Miami Dade College (MDC) Benjamin León School of Nursing has partnered with Nicklaus Children’s Hospital offer students the Nursing Scholarship Program. MDC students working towards an associate degree in nursing can apply for the program and receive up to $10,000 to cover tuition, books, and fees. They also gain practical experience as health care aides and may eventually get a job. The deadline to apply for spring is November 16.

    Funded by Nicklaus Children’s Hospital, the Nursing Scholar program includes four semesters of didactic and clinical experiences as a student and student nurse trainee (SNIP). The SNIP is a day job opportunity for academic nurses to hire as health care aides to gain insight into the field of pediatric nursing at Nicklaus Children’s Hospital. Ten participants will be accepted each spring and fall semester.

    Students in their first semester can test the Certified Nursing Assistant (CNA) program and phlebotomy as part of the scholarship, which allows them to work for Nicklaus Children’s Hospital while completing the nursing program. As they progress through the program, they will also have the opportunity to test for EKG Technician certification.

    After completing the program, eligible graduates may be offered employment with Horizon Nursing Residency at Nicklaus Children’s Hospital to fulfill a two-year agreement with the organization. The selected scholarship nurse must complete the RN-to-BSN program if hired as a Horizon nurse.

    The MDC School of Nursing offers a comprehensive curriculum leading to an Associate of Science or Bachelor of Science degree, in addition to Licensed Practical Nurse and Certified Practical Nurse certifications. The MDC nursing program develops the personal and professional skills needed to provide exceptional patient care. Community health activities, clinical partnerships and the state-of-the-art Learning, Innovation and Simulation Center ensure that MDC graduates are prepared for real-world professional nursing practice in a variety of nursing environments. Health care. Upon completion of the associate degree program, graduates are eligible to sit for the National Council Licensure Examination for Registered Nurses.

    To apply for the Nursing Scholarship Program and for more information, visit https://www.nicklauschildrens.org/for-medical-professionals/for-students/nurse-scholars-program.

    About Nicklaus Children’s Hospital
    Founded in 1950 by Variety Clubs International, Nicklaus Children’s Hospital is South Florida’s only licensed specialty hospital exclusively for children, with approximately 800 attending physicians, including more than 500 pediatric subspecialists. The 309-bed hospital, known as Miami Children’s Hospital from 1983 to 2014, is renowned for its excellence in all aspects of pediatric medicine with numerous specialty programs consistently ranked among the best in the nation by US News and World Report since 2008. In the 2022-2023 ranking, the hospital tied with two other hospitals as Florida’s top children’s hospital. The hospital is also home to the largest pediatric teaching program in the Southeastern United States, and since 2003 has been designated a Magnet Institution of the American Nurses Credentialing Center (ANCC), the highest institutional honor in the nursing profession. For more information, please visit www.nicklauschildrens.org.

    About Miami Dade College
    Miami Dade College is the most diverse institution in the country. There are 167 nations and 63 languages ​​represented in its student body. The college’s eight campuses and outreach centers offer more than 300 distinct degree pathways, including associate’s and bachelor’s degrees, career certificates, and apprenticeships. Bachelor’s degree offerings include biological sciences, engineering, data analytics, information systems technology, education, public safety, supervision and management, nursing, assistant studies medical, cinema and others. MDC is the recipient of numerous national awards, including the Aspen Award. As Democracy’s College, MDC changes lives through accessible, high-quality teaching and learning experiences. It is home to the Miami Culinary Institute, Miami Animation & Gaming International Complex, Miami Fashion Institute, Eig-Watson School of Aviation, The Idea Center, Cybersecurity Center of the Americas, Cloud Computing Center, Center for Learning, innovation and simulation, the School for Advanced Studies and the New World School of the Arts, to name just a few of its most innovative programs. MDC has been named one of the nation’s “Great Colleges to Work For” since the program’s inception. The College embraces its responsibility to serve as an economic, cultural and civic leader for the advancement of our diverse global community. Its alumni and employees contribute more than $3 billion a year to the local economy, and MDC graduates hold leadership positions in every major industry. The MDC is renowned for its rich cultural programming. It is home to the Miami Book Fair, Miami Film Festival, Miami Freedom Tower National Historic Landmark, Tower Theater, Dyer Building, Koubek Center Mansion and Gardens, Live Arts Miami at MDC, the Lynn and Louis Wolfson II Florida Moving Image Archives, the Museum of Art and Design, a sculpture park, and a major art gallery and theater system on campus. MDC has admitted over 2.5 million students and has since its opening in 1960. Approximately 120,000 students are currently enrolled. For more information, visit www.mdc.edu.

    Matthews’ search for the truth throughout his career


    When he first heard about the African protozoa that cause sleeping sickness, Keith Matthews was hooked. “I heard a lecture as an undergraduate on trypanosomes,” he said, “and thought it sounded really fascinating.”

    He wrote to potential graduate school supervisors, eventually enrolling at the University of Glasgow to study how the parasite evades the host’s immune response.

    Keith Matthews

    After obtaining his doctorate, Matthews moved to Yale University on a NATO scholarship, then to the University of Manchester before transferring his laboratory to the University of Edinburgh, to study the trypanosome life cycle.

    “Innovative and groundbreaking research is a hallmark of Keith’s research group,” former mentor Christian Tschudi wrote in his letter supporting Matthews’ nomination for the American Society’s Alice and CC Wang Prize in Molecular Parasitology. for Biochemistry and Molecular Biology. Matthews will receive the award at Discover BMB 2023 in Seattle.

    Such work does not come out of nowhere. Matthews has established a lab environment where members feel free to innovate and help each other. “It depends on the people in the lab and their willingness to help each other,” he said. “Many breakthroughs have been the direct result of Ph.D. student work in the lab.

    He also makes mentoring a priority. “Nobody is doing their best,” he said. “You have to be constructive and help keep them excited.”

    And he’s still looking for answers about trypanosomes like he was as an undergrad. “There are searches where I still have no idea what the results are telling us,” he said.

    Although it can be frustrating, there is an upside: “We are lucky in parasitology; there are so many interesting questions out there. Ultimately, we seek the truth. It’s that simple.”

    How a trypanosome knows it’s time to change

    Transmitted by tsetse flies, trypanosomes infect mammals, including humans and cattle, causing trypanosomiasis or sleeping sickness. Keith Matthews studied how the life cycle of protozoa in mammals and flies is regulated and how the parasite controls its growth and infectivity.

    Trypanosomes replicate in the host’s bloodstream in what is called their ‘slender form’. But to successfully transfer to the tsetse fly, they must be in their “stumpy form”, in which they stop dividing. Matthews’ lab strives to explain how and why this change occurs.

    The team first used an RNAi screen to identify signaling in the trypanosome that tells it to switch to the stumpy form. Then they went up the path and looked for the external signal that triggers the waterfall.

    “In a way, we did it backwards,” Matthews said.

    They identified the parasite quorum-sensing mechanism, or the communication that there are enough of them in the host’s blood to be transmitted by the fly and that it’s time to prepare.

    The lab found that peptidases released by trypanosomes cleave host proteins, releasing small oligopeptides. When a high enough concentration of parasites are in the bloodstream, these oligopeptides are at a correspondingly high level and are transported by a molecule to the surface of the parasite, triggering the signaling cascade and transforming the slender forms into chunky ones, ready to live in the tsetse. fly.

    MTN Regional Technical Manager – Cameroon


    Location: Nigeria/Cameroon/Senegal Contract: 18-month CDD (renewable subject to funding)

    Salary: Local terms and conditions apply

    Purpose of the NTD Regional Technical Manager Role

    Currently, our drive to eliminate onchocerciasis is hampered by weak capacity to conduct entomological surveys as well as limitations of laboratories in endemic countries to provide diagnostic support on collected specimens. We are therefore actively seeking to employ a technical advisor to support national NTD programs in building NTD laboratory capacity, specifically focusing on onchocerciasis and, to a lesser extent, filariasis. lymphatic and other vector-borne NTDs. The incumbent will provide technical advice and assistance that will develop regional and global strategies, networks and collaborations to build laboratory NTD diagnostic capacity (survey methods, training, data collection and analysis) in the endemic countries.

    About the NTD Regional Technical Manager Job

    Key responsibilities will include, but not be limited to:

    • Lead the development of strategies, training modules and knowledge transfer initiatives to increase and strengthen onchocerciasis diagnostic capacity in endemic countries and programs.
    • Develop standardized training and refresher modules for the use of existing Ov16 and black fly PCR protocols, building on existing best practices and in-country laboratory expertise
    • Establishment of quality assurance protocols to cover common controls and test parameters, blind re-testing of randomly selected samples on ELISA and O-150 PCR within and between laboratories, calibration of the test in each laboratory by running a standardized calibration panel
    • Champion accreditations in all laboratories to meet national standards, eg SLIMTA, SLIPTA and GLP.
    • Ensure that collaborating laboratories complete the laboratory assessment tool and maintain a record of its use
    • Coordinate and align technical advice and activities in countries where Sightsavers is not the sole source of funding for onchocerciasis laboratory strengthening activities
    • Support the dissemination and application of best practices for onchocerciasis diagnostic capacity building, in line with global standards and emerging mHealth systems, in close collaboration with Sightsavers Director for Digital Health and Innovation
    • Support in the development of new funding proposals for onchocerciasis diagnostics implementation or research, ensuring that proposals are technically sound, deliverable and in line with WHO guidance and vision and to Sightsavers strategic priorities

    NTD Regional Technical Manager Knowledge, Skills and Experience


    • Proven work experience in a similar role at the regional level within international development
    • Laboratory experience working on Onchocerciasis diagnosis, especially Ov16 serological methods and O-150 molecular methods
    • Advanced degree or equivalent qualification in a relevant discipline such as biology, molecular biology, biotechnology or similar
    • Excellent written and spoken English
    • First-class communication and interpersonal skills
    • Excellent time management and organization
    • Experience designing and delivering training to laboratory staff
    • Availability to travel for field visits, attend meetings, workshops and conferences
    • Strong management and stakeholder engagement
    • Ability to work independently escalating risks and issues to the wider team and senior members


    • Understanding of research governance and ethical principles, particularly as they relate to research with vulnerable people
    • Knowledge of NTDs and health systems
    • Experience with GLP, SLIMTA or SLIPTA

    The Regional Technical Manager is a very varied and involved role and the above is not an exhaustive list of required job duties or skills. Please consult the job description for all the details.

    Interviews will likely take place virtually weekdays starting November 14, 2022. This will be a one-step interview process.

    How to register

    As an equal opportunity employer, we actively encourage applications from all sections of the community. Sightsavers is a confident leader in disability. Therefore, qualified individuals living with a disability are particularly encouraged to apply.

    To apply and for more details on the role, please go to our website and click on the Apply here icon.

    Sightsavers is an employer that tolerates no form of harassment and has zero tolerance for sexual exploitation and abuse. All potential applicants will be subject to rigorous background checks and vetting.

    Check positions, qualification, compensation and other details


    NABI Recruitment 2022: Check Positions, Qualification, Salary and Other Details

    NABI Recruitment 2022: National Institute of Agrifood Biotechnology (NABI) is an autonomous institute under the Department of Biotechnology, Government of India. Nabi is calling for applications from eligible candidates for the position of Associate Researcher-I, Senior Research Fellow and junior researcher on a temporary basis. The monthly salary is Rs. 47000.

    All interested candidates should present themselves for a walk-in interview at the National Institute of Agri-Food Biotechnology located at City of Knowledge, Sector-81, Mohali – 140306, Punjab November 2, 2022 at 9 a.m. accompanied by the duly completed application form available on the website www.nabi.res.in. . Incomplete application forms and applications that are not in the correct format may be summarily REJECTED.

    The deadline for submitting application forms is November 2, 2022.

    Check more details for NABI Recruitment 2022 below:

    Message name And no. vacancies for Nabi Recruitment 2022:

    1. Research Associate-1 (one position)

    Age: The age of the candidate must be 40 years old.

    Salary: Rs. 47,000 hrs + HRA.

    Duration: The RA scholarship is a purely temporary assignment and is only valid for a period of 2 years, and in exceptional cases depending on the progress of research, performance.

    2. Junior Researcher (one position)

    Age: 28 years old

    Salary: Rs. 3:00 p.m. + HRA.

    Duration: The appointment will initially be for a period of one year.

    3. Research Associate-l (one position)

    Age: 40 years old (relaxation is permissible in the case of SC/ST/OBC/PD candidates and women as per GOI instructions).

    Salary: Rs. 47,000 hrs + HRA.

    Duration: The RA scholarship is a purely temporary assignment and is only valid for a period of 2 years, and in exceptional cases depending on the progress of research, performance.

    4. Principal Investigator (one position)

    Age: 32 years of age (relaxation is permissible in the case of SC/ST/OBC/PD applicants and women as per GOI instructions).

    Salary: Rs. 15,000 hrs + HRA.

    Duration: One year.

    5. Junior researcher (own grant).

    Age: The age limit for candidates will be 28 years.

    Salary: Rs. 31000 + HRA.

    Duration: One year

    Qualification for NABI Recruitment 2022:

    Research Associate-l (one position)

    Ph.D. or equivalent degree or having 3 years of experience in research, teaching, and design and development after ME/M Tech with at least one research paper in Science Citation indexed (SCI) journal.

    Desirable: Proven experience in agricultural biotechnology, particularly in plant molecular biology and molecular marker and QTL mapping studies in cereal crops such as wheat; relevant research publications in peer-reviewed journals.

    Junior researcher (one position)

    Postgraduate degree in basic science or graduate/postgraduate degree in the professional course selected through a process outlined by one of the following-
    a) Scholars are selected through National Eligibility Tests – CSIR UGC NET including Lecturer (Assistant Professor) and GATE.
    b) The selection process through national-level reviews conducted by central government departments and their agencies and institutions.

    Desirable: Demonstrated experience in agricultural biotechnology and molecular biology, particularly in molecular marker and QTL mapping studies and experience in basic bioinformatics tools.

    Research Associate-l (one position)

    ME/M.Tech (Chemical Engineering) with 3 years of research/industry experience in converting lignocellulosic biomass to energy/chemicals with kinetic modeling Or

    PhD in Chemical Engineering/Chemical Technology from a recognized university/institute with at least one research paper in a Science Citation (SCI) indexed journal. The thesis must be in the field of converting lignocellulosic biomass into energy/chemicals with kinetic modeling.

    Principal Investigator (one position)

    Graduate Diploma in Basic Sciences or Graduate/Postgraduate Diploma in the professional course selected through a process outlined by any
    one of the following-

    Scholars are selected through National-CSIR UGC NET Eligibility Tests including Lecturer (Assistant Professor) and GATE.
    The selection process through national-level reviews conducted by central government departments and their agencies and institutions.


    Working knowledge of bacterial biosensing, particularly in aptamer generation, nanoparticle synthesis and bioassay development.

    Hands-on experience with TEM, SEM and fluorescence techniques will be appreciated.

    Relevant research publications in peer-reviewed journals.

    Junior researcher (own scholarship).

    Post-Graduate Diploma in Basic Science OR Post-Graduate/Graduate Diploma in Professional Scholars selected by any
    Eligibility test with own scholarship.

    Desirable: Enthusiastic about research and with proven research experience in the field of chemistry/nanoscience/biochemistry.

    Interview Details for NABI Recruitment 2022:

    All applicants are requested to appear for a walk-in interview with an application form, certificates of experience, publications, original diplomas and transcripts at National Institute of Agribusiness Biotechnology located at Knowledge city, Sector-81, Mohali – 140306, Punjab on November 2 at 9 a.m. Application forms are available on the website www.nabi.res.in.

    To read the official notification Click here

    Disclaimer: The recruitment information provided above is for informational purposes only. The recruitment information above is taken from the official website of the Organization. We do not provide any recruitment guarantees. Recruitment should be conducted in accordance with the official recruitment process of the company or organization that advertised the recruitment position. We do not charge any fees for providing this employment information. Neither the author nor Studycafe and its affiliates accept any responsibility for any loss or damage of any kind arising from any information contained in this article or for any actions taken in reliance thereon.

    Turtle vocalizations reframe the origins of auditory communication


    JTurtles may never take the top spot among the most prolific vocalizers in the animal kingdom, but it turns out they do indeed have something to say. In a new study published on October 25 in Nature Communication, researchers have found that turtles, along with other understudied animals, actually communicate using a diverse repertoire of vocal sounds. The study authors suggest their discovery may push the origins of acoustic communication back in time to the common ancestor of all lung vertebrates.

    Prior to the current study, many included species “were considered dumb,” says Gabriel Jorgewich-Cohen, a PhD student at the University of Zurich. American scientist. Listening carefully to recordings of 53 species, including turtles, lungfish, caecilians (a group of limbless amphibians) and the lizard-like endemic New Zealand tuatara, the team came to a different conclusion. : this vocalization is more widespread than previously thought, and that “the sounds emitted by turtles have the same evolutionary origin as our own vocal communication”, says Jorgewich-Cohen.

    The findings of the article fuel the debate around the ability of certain animals to communicate with each other. In 2020, two scientists published an article in Nature Communication in which they mapped the evolutionary phylogenies of approximately 1,800 voiced and unvoiced species and postulated that acoustic communication evolved independently in major Earth lineages (including frogs, birds, and mammals) in association with nocturnal lifestyles, new scientist reports. In this analysis, turtles were grouped into the non-vocal group.

    But evidence that seemingly unvoiced species actually use sound has been circulating outside scientific circles for decades, if not generations. Irene Ballagh, a UBC zoologist who was not involved in the work, says American scientist that his mother remembered hearing tuatara communicating with each other despite “quite definitive statements” to the contrary from the scientific community.

    Jorgewich-Cohen began probing hitherto understudied species by studying his own pet turtles. “I decided to record them, just to check”, he says new scientist. “I found several sounds there, then we continued [with more species]. And suddenly I had a good sampling and I could understand a bigger picture.

    From there, the team collected sounds from 50 additional turtle species, as well as lungfish, tuatara and caecilians. To better identify scenarios that could trigger sounds, Jorgewich-Cohen traveled to five countries to record each species for at least 24 hours, and did so in a variety of settings, including when the animals were alone or in same-sex or mixed groups, and even when underwater. Every species studied by the group produced at least one sound, and in many cases these recordings were the first time such sounds had been heard.

    While the study adds to scientists’ understanding of vocalizations in these groups, it also has implications for the evolution of auditory communications more broadly. When the researchers reanalyzed past phylogenies with their added data, they concluded that, rather than evolving multiple times, vocalization evolved once in a common ancestor. Specifically, Jorgewich-Cohen and colleagues traced vocalization back to lobe-finned fish. Eoactinistia foreyi, which is considered a possible last common ancestor of all vertebrate choanae (lungs). This would mean that voice communication evolved around 407 million years ago, at least 100 million years earlier than previously thought.

    University of Western Australia biologist Gerald Kuchling, who was not involved in the study, says new scientist that he was “not surprised that all seem to vocalize”, echoing the point of other experts that many choanates were omitted from previous studies. Talk to American ScientistTecumseh Fitch, an evolutionary biologist at the University of Vienna who reviewed the new study but was not involved in the work, calls it “an important contribution, both because the vocalizations of many species important are analyzed for the first time and because they lead to a convincing argument” that the behavior is well conserved over time.

    Jorgewich-Cohen recounts new scientist this vocalization may be even older, as lungless fish also produce sounds. “It could be that a lineage of these fish was the precursor to the type of sound we produce as [choanates],” he says. “So it could be that this sound production line is older than what I found.”

    Talk to American scientist, John Wiens, an evolutionary biologist at the University of Arizona and co-author of the 2020 study, says he doesn’t necessarily agree with the team’s findings. “One of the main purposes of their paper seemed to be to re-analyze our data and come to a different conclusion,” rather than to collect evidence to demonstrate that animals “actually use these sounds to communicate with each other.” That, he adds, “seems like a big omission.”

    Jorgewich-Cohen agrees that future studies will need to better establish the function of these sounds, American scientist reports, and speaking to the outlet, Ballagh says she hopes scientists will start to listen to and accept the knowledge of people living near these creatures. “I would really like to see more people follow up with more work linking sources of local and indigenous knowledge on potential vocalizations for species groups that are still listed as ‘no data’ in this article,” says Ballagh. . “I think the data might already be available in some form if we just start thinking more carefully about who we should be listening to.”

    Here are the 10 fastest growing jobs in education, according to a report


    STATEN ISLAND, NY — Pursuing a career in education continues to be very attractive, as there is always a need for more teachers. But job opportunities in education also extend far beyond standard primary school subjects.

    HeyTutor analyzed data from the Bureau of Labor Statistics’ employment projections to find the occupations with the largest projected increase in jobs from 2021 to 2031. The analysis ranks occupations by percentage increase in employment from 2021 to 2031, and according to BLS data, jobs in education are projected. grow by 7.2% during this period.

    Data journalism website Stacker used the analysis to compile the 10 fastest growing jobs in education.

    10. Teachers of Criminal Justice and Law Enforcement (Post-secondary)

    — Projected increase in employment from 2021 to 2031: 9.8% (+1,600 jobs)

    — Employment in 2021: 16,500 jobs

    To teach criminal justice or law enforcement at the post-secondary level, you’ll likely need a master’s degree, or even additional training like a doctorate. in criminology or law. Someone in this role could have the title of professor, adjunct professor or visiting instructor, according to Stacker.

    9. Biological Science Teachers (Post-secondary)

    — Projected increase in employment from 2021 to 2031: 12.4% (+7,500 jobs)

    — Employment in 2021: 60,200 jobs

    You will need at least a master’s degree, if not a doctorate. Topics covered in the field of biological sciences include anatomy, physiology, and biology. Most professionals in this job category work in colleges and universities, although some jobs also exist in hospitals, trade schools and scientific research facilities, according to Stacker.

    8. Technicians and museum curators

    — Projected increase in employment from 2021 to 2031: 12.7% (+1,600 jobs)

    — Employment in 2021: 12,700 jobs

    Museum technicians and conservators care for objects in a museum’s collection — whether they’re fossils, gems and plants or art, textiles and historical artifacts, Stacker says. . Technicians and curators restore and prepare collections for storage and documentation and prepare them for exhibition and organize exhibitions. Most jobs in this category require at least a bachelor’s degree and considerable museum experience, according to Stacker.

    7. Engineering teachers (post-secondary)

    — Projected increase in employment from 2021 to 2031: 13.3% (+6,100 jobs)

    — Employment in 2021: 45,800 jobs

    These teachers can educate students in subjects such as chemical, civil, electrical, industrial, mechanical, mineral, and petroleum engineering. Most of those jobs are in colleges and universities, with fewer jobs available in junior colleges and trade and technical schools, according to Stacker.

    6. Curators

    — Projected increase in employment from 2021 to 2031: 14.4% (+1,900 jobs)

    — Employment in 2021: 12,900 jobs

    If you want to play a more strategic role in museums, you can consider becoming a curator. They work with a museum’s collections – but instead of curating artifacts and objects, they may plan the acquisition of future objects, create themes and exhibits around them, or conduct special research projects , says Stacker. Curators may also work to educate the public about a museum’s collection and participate in visitor events.

    5. Tutors

    — Projected increase in employment from 2021 to 2031: 14.5% (+29,500 jobs)

    — Employment in 2021: 203,400 jobs

    According to Stacker, tutors work with students outside of primary education class time to support their understanding of learning or prepare them for standardized tests. They can cover a variety of topics, including math, reading, and SAT prep. Education requirements vary similarly – some tutoring jobs may require a bachelor’s degree, while others may seek current students.

    4. Preschool teachers (note: excludes special education)

    — Projected increase in employment from 2021 to 2031: 15.1% (+72,900 jobs)

    — Employment in 2021: 483,100 jobs

    According to Stacker, increased attention to early childhood education may have contributed to the projected growth in jobs for preschool teachers, a role that often requires only a high school diploma. They can be employed in day care centers or elementary schools and focus on the social, emotional, physical, and intellectual growth of 3- and 4-year-old children.

    3. Self-Enrichment Teachers

    — Projected increase in employment from 2021 to 2031: 17.6% (+61,300 jobs)

    — Employment in 2021: 347,100 jobs

    Self-enrichment educators can teach dance, art, music, martial arts, or driving – instructing their students in the subjects they want to learn for their personal enjoyment. These jobs vary widely by background and subject, meaning some may only require a bachelor’s degree, while others require a master’s or doctorate, Stacker said.

    2. Nurse instructors and teachers (post-secondary)

    — Projected increase in employment from 2021 to 2031: 21.5% (+18,700 jobs)

    — Employment in 2021: 87,000 jobs

    With a shortage of nurses on the horizon, there will be a need for more nurses – and therefore, nursing instructors and teachers to train them.

    This job usually requires at least a master’s degree, if not a doctorate, and teaching expertise. Colleges, universities, junior colleges, general medical and surgical hospitals, and technical and trade schools employ nursing instructors and teachers, according to Stacker.

    1. Teachers of health specialties (post-secondary)

    — Projected increase in employment from 2021 to 2031: 24.1% (+59,400 jobs)

    — Employment in 2021: 246,700 jobs

    According to Stacker, health specialty teachers can include instructors in dentistry, laboratory technology, medicine, pharmacy, public health, therapy, and even veterinary medicine. A master’s or doctoral degree is usually required.


    Cognizant collaborates with Qualcomm to launch the 5G Experience Center for Digital Transformation in industry verticals


    A new 5G experience center in Atlanta invites customers across industries to experience the true business value of 5G technology

    TEANECK, NJ, October 252022 /PRNewswire/ — Cognizant Expands Collaboration with Qualcomm Technologies, Inc., to Accelerate Enterprise Digital Transformation with New 5G Experience Center in Atlanta, Ga. This collaboration combines Cognizant’s deep experience in 5G, IoT, cloud and data analytics with smart edge devices, AI and 5G connectivity solutions from Qualcomm Technologies.

    Building on the improvements 4G brings to consumers’ mobile experience, 5G was designed for businesses, enabling and accelerating broad digital transformation journeys across all industries. Private 5G networks enable next-generation services, such as autonomous driving, robotic automation, synthetic biology, virtual reality, and smart manufacturing in ultra-reliable, low-latency, secure, and scalable ways.

    “Qualcomm Technologies is a pioneer in advancing 5G power to the intelligent edge, and we are proud to partner with them in this critical space,” said Vibha Rustagi, Global Head of IoT at Cognizant. “By aligning their expertise with Cognizant’s unique industry solutions in manufacturing, automotive, biopharma, retail and more, we will strive to help our customers simplify the complexities of technology, accelerate their digital transformations and stay focused on their business goals.

    Cognizant expands its 5G Experience Center footprint globally with the Atlanta location being the first of our planned 5G centers at North America. It builds on the success of Cognizant’s 5G center in Bengaluru, India. The center is designed to help customers imagine, test and deploy next-generation solutions by combining private 5G networks and Multi-Access Edge Computing (MEC) technologies to deliver unique benefits.

    The combination of 5G and MEC offers businesses the ability to create multiple virtual networks with the same physical hardware and support thousands of connected devices generating real-time data insights, with better network security. network and less congestion, leading to better business outcomes and more seamless end-user experiences.

    The center will open with several use cases ready for customers to explore, including:

    • Manufacturing: 5G connected cameras with video analytics leveraging MEC infrastructure can help customers dramatically speed up anomaly detection in manufacturing lines, enabling rapid intervention and problem resolution to maximize production yields and minimize downtime stop.
    • Supply chain management: Autonomous mobile robots, controlled, operated and integrated via 5G into warehouse management, fleet management and enterprise resource planning systems can enable more predictable and consistent sourcing of components in manufacturing, control more efficient inventory and a significantly reduced risk of workplace injury.

    “Qualcomm Technologies is at the forefront of accelerating digital transformation to solve complex business problems with differentiated end-to-end solutions,” said Savi CareSenior Vice President, Business Development and Partnerships at Qualcomm Technologies, Inc. “The business transformation journey begins with the 5G Experience Center, and we are excited to partner with Cognizant to provide enterprise customers with solutions based on our technology roadmap and our scale to meet their business objectives.”

    Over time, the 5G Experience Center for Digital Transformation will showcase additional solutions – pre-developed and custom-created with customers – aimed at solving specific business challenges and helping customers deliver experiences that meet changing expectations of their stakeholders.

    About Cognizant
    Competent (Nasdaq: CSP) modern business engineers. We help our customers modernize technology, reinvent process and transform experiences so they can stay ahead of our fast-paced world. Together, we make everyday life better. See how to www.cognizant.com or @cognizant.

    For more information contact:

    SOURCE Cognizant Technology Solutions

    UNL looks to University of Oregon for new head of College of Architecture


    The University of Nebraska-Lincoln announced a new head of its College of Architecture on Monday.

    Kevin Van Den Wymelenberg, currently assistant dean for research in the College of Design at the University of Oregon School of Architecture and Environment, will become dean of the college on Jan. 5, UNL said in a statement. Press release.

    He will replace Katherine Ankerson, who moved from the College of Architecture to the Chancellor’s Office earlier this year after being named Executive Vice-Chancellor.

    Ankerson called Van Den Wymelenberg “an accomplished educator and leader” with an entrepreneurial spirit and a commitment to innovation.

    “He brings the experience and expertise to lead the college into the future while building on its culture and traditions,” Ankerson said.

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    “Not only is Kevin an accomplished educator and leader, but he brings an understanding of how the hands-on learning that takes place in the studio can inform relevant research which, in turn, further informs transformative teaching in the classroom. class,” Ankerson added.

    Van Den Wymelenberg is used to running research laboratories, centers and institutes that integrate professors, administrators, researchers and students from different university departments.

    He founded the Institute for Health in the Built Environment and directs the Biology and the Built Environment Center and the Energy Studies in Buildings Laboratory at the University of Oregon.

    His research on indoor environmental quality has secured over $40 million in funding from multiple agencies, including the National Science Foundation, Environmental Protection Agency, US Department of Energy, and US Department of Agriculture since 2004.

    Prior to his stay in Eugene, Oregon, Van Den Wymelenberg was a professor at the University of Idaho in Boise.

    “I am incredibly impressed by the culture and community of this diverse and talented group of scholars, thinkers, planners and decision makers,” said Van Den Wymelenberg.

    Van Den Wymelenberg will receive a base salary of $230,000.

    A team from the University of Nebraska at Lincoln is developing a drought forecasting tool that will help the US Department of Defense in its efforts to monitor areas at risk of political instability.

    UNL students mobilize to protect the right to abortion and guarantee better conditions for graduate employees

    New post of deputy chancellor at UNL will lead online education efforts

    Contact the writer at 402-473-7120 or cdunker@journalstar.com.

    On Twitter @ChrisDunkerLJS

    New chair in biology aims to elevate program to new heights


    OXFORD, Mississippi — Sixue Chen, an accomplished biology researcher and incoming chair of the Department of Biology at the University of Mississippi, plans to use agricultural research and outreach to elevate the program nationwide.

    Chen, who specializes in the biology of plant stress response systems, came to UM from the University of Florida, where he conducted research on understanding more efficient plant mechanisms with the aim of improve domestic farming practices.

    Her research is driven by her childhood experience of growing up on a farm, but paradoxically having little to eat. Chen believes that studying topics such as the function of microscopic pores on the surface of plant leaves can reveal ways to improve agricultural practices and water conservation.

    Sixue Chen, new director of the Department of Biology, studies the mechanisms of more efficient plants with the aim of improving agricultural practices. Photo by Julia Dent

    This approach could help combat both world hunger and the looming freshwater crisis as the climate becomes more arid and less conducive to current farming methods.

    “One way to help end food insecurity is to make plants more resistant to stress,” he said. “After domesticating agricultural crops, farmers give these plants tons of water, which takes up 70% of our freshwater resources.

    “They don’t plan to make the plants more drought resistant because they assume there will always be plenty of water, but that’s not the case anymore. Countries all over the world are experiencing drought conditions, so my lab wants plants to use water more efficiently, like cacti.

    Another concern with modern farming practices is the effects of hazardous chemicals used in agriculture, Chen said. Some of these products increase the likelihood of cancer, as carcinogens, in humans who consume the products or otherwise encounter the pesticides or herbicides.

    This is a major concern as cancer is the second leading cause of death in the country, behind heart disease.

    Although he only recently joined the Ole Miss faculty, Chen already has a passion for helping the community and the state – with a primary focus on the future generation of scholars.

    “We are a flagship university, so how can we help our citizens get out of poverty? ” he said. “If we encourage early childhood education – get kids excited about learning science and getting an education – I think that’s a way out of poverty.

    “I was a really poor kid growing up; at that time, the only way out of poverty was through education.

    Chen hopes to propagate a community of diverse and science-loving scholars at the university.

    “Connections are important; social and academic events to bring people together offer more and more opportunities – not just for people, but potentially for the whole world,” he said.

    “The relationships you make in college can become job opportunities or other collaborative opportunities to advance your career or science, as we later know, all because a student was given the chance to talk to someone with similar interests at their university. ”

    Chen’s work promises to improve education and research across the College of Liberal Arts and the entire university, said Donald Dyer, associate dean for faculty and academic affairs and distinguished professor of modern languages. .

    “His disciplinary expertise will translate into valued leadership and his experience will serve the department well in terms of mentorship and future departmental success.” A successful researcher and scholar, he will oversee, among other things, one of the college’s largest faculties and one of the largest undergraduate majors.

    A Washington state woman fought off a black bear that tried to attack her by punching her in the nose, officials say


    Closeup of a young black bear in Ontario, CanadaGetty Images

    • A Washington state woman suffered non-life-threatening injuries after a bear attack, state officials say.

    • State biologist Rich Beausoleil told KING-TV the woman “blew” the bear “right in the nose.”

    • Police located and killed the bear near the site of the attack, according to the Department of Fish and Wildlife.

    A Washington state woman fought off a black bear that charged at her Saturday morning by punching her in the nose, according to a state wildlife biologist.

    According to the Washington Department of Fish and Wildlife statement, the bear attacked the woman when she left her dog outside at a residence near Enchantment Park and Blackbird Island in Leavenworth, Washington. The woman was transported to a hospital in Wenatchee, Washington with non-life-threatening injuries, the statement said.

    “She didn’t see it coming, so she couldn’t get fat, clap her hands, yell at the bear, wave her arms,” ​​said Washington state wildlife biologist Rich Beausoleil. at KING-TV. “These are the things we usually tell people to do, but if the bear knocks you down, then yes, your solution is to fight.”

    Beausoleil told the station that the woman “just turned around and blew ‘the bear’ right in the nose, which caused the bear to ‘start running.’

    Police found the bear near the scene of the attack with the help of a bear dog and killed it, the statement said. Two cubs were also transported to a local wildlife rehabilitation center. KING-TV reported that WDFW said the bear was euthanized because it was overweight, which caused it to forage for food in trash cans near people’s homes.

    The Department of Fish and Wildlife said in the statement that bears generally avoid people, but if a bear approaches, it recommends standing up, waving your hands above your head and talking. in a low voice.

    “Stand back avoiding direct eye contact. Do not run away from a bear,” the statement read.

    On Saturday, two college wrestlers were hospitalized after battling a grizzly bear that attacked them in Wyoming at Yellowstone National Park.

    The bear came crashing through a tree and one of the wrestlers only had time to shout “Bear! Bear!” before he is attacked.

    The Wyoming Game and Fish Department said it was investigating the incident in a statement.

    Read the original Insider article

    Emily Reeves: the systems biology revolution


    Photo source: Discovery Institute.

    In a new episode of Future IDs, biochemist and metabolic nutritionist Emily Reeves tells the story of the systems biology revolution, why it favors intelligent design and why it overturns Darwinian reductionism. This presentation was recorded at the 2022 Westminster Conference on Science and Faith in the Greater Philadelphia Area, which was jointly sponsored by the Discovery Institute’s Center for Science & Culture and Westminster Theological Seminary. Download the podcast or listen to it here.

    From Syria to Cambridge, Harvard Men’s Lightweight’s Abdullah Bannan shines on and off the water | Sports


    Beyond Harvard senior Abdullah Bannan’s light crew career, there is an impressive story: a story that demonstrates his resilience and strong desire to help others.

    Growing up in Aleppo, Syria, Bannan’s childhood was altered by his country’s civil war. Aleppo, Syria’s largest city, has been the center of a major military conflict between the government and numerous Sunni opposition rebel groups. The conflict began when Bannan was entering seventh grade, and he recalls hearing about “people protesting and children being kidnapped by the government.” Citizens were conscripted by President Bashar al-Assad’s regime to join the Syrian Armed Forces and its many allies, but many soon defected and joined the Free Syrian Army, a breakaway branch of the military that was formed in 2011 with the intention of overthrowing Assad.

    The world of fifth graders changed when fighting broke out in Aleppo on July 19, 2012. Bannan’s father, hoping to prevent the government from taking full power, was determined to stay in the city. But the shelling destroyed Bannan’s house, and he was forced to evacuate.

    “I think it’s ridiculous for me to talk about it in the past like it’s over,” Bannan wrote in an email. “I don’t know if it’s the age I experienced it, or the length of that experience, but it’s still a big part of who I am and it’s something that sticks in my mind at the moment. least 5 times a day.”

    Despite the hardships he and his family faced, Bannan found inspiration in a 2014 Class Day speech by Sarah Abushaar titled “The Harvard Spring.”

    “I didn’t know anything at the time, but I just knew that I wanted to do my best to change everything in my power to change,” Bannan wrote. “However, over the years it was obvious that anything I wanted to do would be limited in the political climate, so I wanted an education that would give me the chance to make a real change.”

    Bannan pursued studies in biology, which he first became interested in while attending Al-Basl High School for Exceptional Students, a government institution for gifted students, founded by the Syrian Ministry of Education in 1998 .

    “I first got into biology and chemistry when I participated in the National Biology Olympiad in high school and was able to experience concepts on a deeper level through courses at university. local,” he wrote. “[I] then I ended up competing and winning at the International Biology Olympiad, which really showed me how far passion can go, even in difficult circumstances.

    Following in Abushaar’s footsteps, Bannan continued his studies in chemical and physical biology at Harvard. However, the journey to Cambridge was difficult.

    “We couldn’t pay for the standardized tests ourselves from Syria because of the economic sanctions,” he said. “There were hardly any resources, and we all do our secondary studies in Arabic.”

    During her application process, Bannan heard about the Syrian Youth Empowerment Initiative through a friend of hers. Founded in 2015 by George Batah and Majed Abdulsamad, SYE is a program that pays standardized test fees, provides preparation resources and matches Syrian high school students with mentors who guide them through the college application process. . Today, Bannan serves as an active mentor for the organization.

    It wasn’t until he arrived at Harvard that Bannan pursued his lifelong interest in rowing, which he had never tried in Syria.

    “I grew up watching the Olympics with my family, and we always watched gymnastics, swimming and rowing,” Bannan wrote. “I’ve always been fascinated that sport is the right combination of strength and cardio.”

    Midway through his sophomore year, Bannan contacted rowing coaches at Harvard to ask if he could make the team. However, due to his relative inexperience in the sport, he had several intensive one-on-one sessions with the lightweight coaches to keep him up to date with the rest of the squad.

    “Abdullah’s story is unlike any other,” said teammate, second Brahm Erdmann. “He certainly took the road less traveled to become a rower at Harvard, which ironically makes him a typical member of our team: he seized an opportunity and ran away. That’s what Harvard’s varsity light crew represents.

    Despite his late start, Bannan has had many impressive accomplishments in his rowing career, one of which came in a race against Navy in the Haines Cup, which took place on the River Severn in Annapolis, USA. Maryland, April 23, 2021.

    In this race, Bannan “stroked” the boat, which meant he had to sit closest to the stern of the boat and set the pace and pace for the crew to follow. The stroker plays a vital role during the race, as this rate can determine whether a boat wins or loses a race.

    Bannan recalled that during the race he was nervous.

    “I was in a very mixed state when we stopped seeing the other two Navy boats[s],” he wrote. “But then one of my team mates shouted my name from the back which kind of brought me back to reality and reminded me of the other seven rowers behind me, all behind me , all doing their best to move the boat. ”

    The team ended up finishing second at 11.3 seconds, tied with the fifth-ranked Navy varsity team at 6:41.3.

    “It was the support of being around 30 other teammates cheering you on, as everyone pushed themselves to the absolute limits of their heart rate and lung capacity,” Bannan noted of the race.

    Another challenge Bannan overcame in his rowing career was his 2K test. Similar to the one-mile run test, the 2K rowing test assesses rowers’ endurance, performance and resilience. However, a week before his scheduled 2K, Bannan contracted Covid-19 so he was unable to train with the rest of the squad.

    “It really stressed me out as we had built up our fitness over the weeks leading up to the test and the coaches had made very specific plans for each of us to do well in this test,” he wrote. .

    However, determined to stay on track, he cycled through the basement of Dunster House with his mask on, managing to set a personal best.

    —Writer Derek Hu can be reached at derek.hu@thecrimson.com.

    A strange worm emerges from one of the longest rivers in South America | science and technology

    Biologist Carlos Lasso (with glasses) on a collecting expedition and the previously unknown worm he discovered in the Orinoco River.Alessio Romeo – La Venta

    A few years ago, biologist Carlos A. Lasso did a double take when he examined what turned out to be a strange-looking worm with a magnifying glass. He thought the object could have been “the root of a plant, plant stem or other unknown organism”.

    During the Covid-19 pandemic, he sent the sample to an expert. A few months later, specialist Mario Londoño, from the University of Antioquia in Medellín, confirms the discovery: it is a freshwater worm from the depths of the Orinoco, a 1,700 mile long river. which forms part of the border between Venezuela and Colombia.

    “Freshwater species are usually found near the coast. What’s remarkable is that I found these worms in deep, fast-moving water, more than 600 miles from the ocean,” says Lasso.

    Another thing that caught the biologist’s attention was that the worms “were attached to the molluscs.” According to Lasso’s hypothesis, this would imply a relationship between invertebrates.

    For more than 12 years, Lasso – a native of Madrid who has worked in Latin America for nearly four decades – has been carrying out surveys to study the biodiversity of aquatic fauna and hydrobiological resources at the mouth of the Orinoco. It is based in the Colombian municipality of Puerto Carreño, capital of the department of Vichada.

    “We take advantage of the dry season, from January to April – when the level of the river does not exceed 30 feet – to do the dives”, explains the researcher, affiliated with the Humboldt Institute in Bogotá.

    Lasso and Londoño believe that the specimen – unknown to the scientific community until now – belongs to the genus Manayunkiaof the Sabellidae family. It is “a vector of parasites in fish, such as salmon, which could be important for the aquaculture industry”, explains the biologist. He also thinks that in addition to its parasite-trapping abilities, the worm could constitute evidence “of the marine transgressions and regressions suffered by the Amazon and Orinoco regions”.

    A microscopic image of a freshwater worm recently discovered in the Orinoco.
    A microscopic image of a freshwater worm recently discovered in the Orinoco.Alessio Romeo – La Venta

    Some hotly debated scientific theories suggest that a wide, shallow sea covered large parts of South America – including the Amazon and the Orinoco basin – for millions of years. According to a 2017 study published in the journal Scientists progress, the Caribbean Sea bathed the freshwater territories of present-day Venezuela and Colombia twice during the Miocene, the first geological epoch. This thesis would explain the evolution and distribution of fauna in the region.

    “Like the Amazon, the Orinoco – which can reach over 300 feet in depth – has been subject to changes in its ecosystem, leading to the extinction of some species and the survival of others by adapting to the new conditions. This is already evident in jellyfish or freshwater stingrays, whose ancestors have been found in these rivers,” says Lasso.

    Biologist Carlos Lasso with a collaborator.
    Biologist Carlos Lasso with a collaborator.Alessio Romeo – La Venta

    With more than 1,650 fish recorded to date, one of the characteristics that characterizes the Orinoco ecosystem is its astonishing biodiversity. According to the Spanish biologist, “every time an exploration is carried out in this region, something new is discovered. Finding unknown organisms in tropical South American environments is relatively common.

    To find new wildlife, which often remains hidden in unexpected places, Lasso goes beyond standard collecting methods. “I do nighttime sampling at great depth with zooplankton trawls, with light traps and underwater dives,” he explains. Lasso has a habit of patiently inspecting the strangest habitats, often planting his magnifying glass inside trunks and roots.

    “At [Humboldt Institute], in collaboration with the University of Los Andes, we are conducting deep-sea studies of environmental DNA, known as metabarcoding,” he explains. This new technique – which studies free-living genetic material in ocean ecosystems and in many aquifer systems – is a non-invasive method to assess the composition and distribution of organisms in various habitats.

    Lasso and several specialists from the University of Antioquia have formed a working group to continue gathering knowledge about the new worm. “I am in charge of collecting ecological information…the other group focuses more on the genetic aspects [of the worm]“, explains the biologist.

    Chemistry professor Chad Mirkin receives a medal for his scientific work


    Northwest Chemistry Professor Chad Mirkin awarded the 2022 Faraday Medal from the Institution of Engineering and Technology, according to a press release Thursday.

    Mirkin, who has taught at the University since 1991, is the first New York University researcher to win the award – IET’s highest honor for outstanding scientific or industrial achievement. His work has focused on the development of biological and chemical diagnostic and therapeutic systems.

    “When people talk about leaders in world-class interdisciplinary research, Chad Mirkin tops the list,” NU Vice President for Research Milan Mrksich said in the statement. “This latest honor is a well-deserved recognition of his leadership at Northwestern and in the field of nanotechnology.”

    Mirkin has also invented high-speed, large-area printing technology, such as a 3D printing process that can produce hard, elastic, or ceramic parts at record quantities. He is also a pioneer in research on the discovery of materials based on artificial intelligence.

    Mirkin is the co-founder of the companies TERA-print and Azul 3D, both of which help transition advances in nanotechnology into life science, biomedical and advanced manufacturing industries.

    “People who have won in the past make up a list of those who have changed the world through science and engineering,” Mirkin said in the statement. “I’m obviously absolutely thrilled to be part of this crew.”

    Mirkin was honored at a ceremony in London on Thursday evening.

    E-mail: [email protected]

    Twitter: @charlottehrlich

    Related stories:

    Northwest chemistry teacher receives China friendship award

    Northwest researchers assemble gold and DNA into structures that manipulate light

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    ‘The London Patient’ Adam Castillejo speaks at the William Way Community Center to spread hope for future HIV treatment


    News — PHILADELPHIA—(October 20, 2022)—William Way Community Center, philadelphia cream STRUGGLE, TO BEATHIV Delaney Collaborative, Philadelphia Foundation, The Penn Center for AIDS To researchand The Wistar Institute are proud to announce that “The London Patient” Adam Castillejo will participate in a reception, followed by a round table and Questions and answers on Wednesday October 26 of 5:00 p.m. to 8:00 p.m. at the William Way Community Center.

    Castillejo is the second person known to be cured of HIV when his body became resistant to HIV infection after receiving a bone marrow transplant. In his case, the transplant was to treat Hodgkin’s lymphoma. Timothy Ray Brown, known as the “Berlin patient”, was the first person cured of HIV with a stem cell transplant, similar to Castillejo. Brown died in 2020 from a recurrence of cancer, and Castillejo revealed his identity that year so he could be an ‘ambassador of hope’ to inspire others living with it. HIV.

    Castillejo is an English-Venezuelan who has lived in London since 2000. In 2003 he was diagnosed with HIV. From then on, he chose a life of health – exercising, eating well and becoming a chef. In 2011, he was diagnosed with stage 4 lymphoma. After intense monitoring, many ups and downs in treatments, and intensive preparation, Castillejo received the stem cell transplant that cured him of HIV in London in 2016. After this treatment, his body became resistant to HIV the infection, and he subsequently stopped HIV medicines in 2017. Since 2020, he is international champion of HIV to research. His presentation in Philadelphia is the last leg of his international tour before returning home to London, UK.

    “More than 30 years ago, when the AIDS pandemic began, many of us thought we would not live to this day — to hear of someone being cured. But here we are. said William B. Carter, TO BEATHIV Chair of the Delaney Collaborative Community Advisory Board. “Sharing Mr. Castillejo’s story shows the importance for researchers to work with the community to develop a cure.”

    “Adam is a pillar of strength and inspiration and a testament to what HIV healing research can do. By sharing his story, he amplifies attention to this critical need in biomedicine and highlights the impact science can have,” said Luis J. Montaner, DVM., D.Phil.Herbert Kean, MD, family teacher, head of HIV Research Program at the Wistar Institute, and Co-Principal Investigator of the TO BEATHIV Collaborative Delaney. “Adam represents and champions what we are all working towards, a cure for HIV during our lifetime.

    To register for the event: https://redcap.med.upenn.edu/surveys/?s=FXW4TWKFRLJAKXLK

    Editor’s note: For more information or to cover the event, contact Darien Sutton at 215-870-2048 or [email protected].

    # # #

    The Wistar Institute, the first independent, not-for-profit biomedical research institute in the United States, brings together the talents of an international team of outstanding scientists through a highly enabled culture of biomedical collaboration and innovation, to solve some of the problems the world’s most challenging and important in cancer, immunology and infectious disease, and to produce groundbreaking advances in global health. In keeping with a pioneering heritage of leadership in nonprofit biomedical research and a track record of vital contributions in immunology and cell biology, Wistar scientists pursue innovative and courageous research pathways toward life science discovery and to accelerate the impact of the first scenic discoveries by shortening the path from the bench to the bedside. Wistar.org

    TO BEATHIV Delaney Collaboratory is part of an international consortium of more than 80 HIV researchers from academia, industry, government, and not-for-profit sectors working at a HIV cure. The Collaboratory is conducting three advanced trials to define effective ways to combine immunotherapy regimens towards a cure. TO BEATHIV.org

    philadelphia cream STRUGGLE is a federally licensed health center (FQHC) offer HIV treatment and primary care for people living with HIV/AIDS and those at high risk, as well as community education and awareness programs on HIV, hepatitis and other topics with an impact on public health. During the covid-19 pandemic, STRUGGLE provided no barriers, direct access covid testing more than 13,000 people in low-income neighborhoods across Philadelphia, and partnering with ten community organizations to bring covid vaccines to these communities.

    The Philadelphia Foundation, founded in 1918, strengthens the economic, social and civic vitality of Greater Philadelphia. It develops effective philanthropic investments, connects individuals and institutions across sectors and geography, and advances civic initiatives through partnerships and collaboration. A state-supported foundation, the Philadelphia Foundation administers more than 1,000 charitable funds created by its donors and awards more than 1,000 grants and scholarships each year. To find out more visit www.philafound.org.

    The William Way Community Center seeks to engage and support diversity LGBTQIA+ communities in the greater Philadelphia area through the arts & culture, empowerment and community connections. The Center wants it all LGBTQIA+ people feel safe, connected and empowered. We strive to be a community center whose staff, management and board of directors reflect the vibrant and diverse communities we serve. In these difficult times, the William Way LGBT The community center, and what it stands for, has evolved to meet the needs of the diverse people it serves.

    The Penn Center for AIDS Research (Penn CFAR) is one of 18 NIH-finance CFARs and understands HIV and AIDS researchers from the University of Pennsylvania, Children’s Hospital of Philadelphia (CHOP) and the Wistar Institute. The mission is to support and advance research in all areas of HIV/AIDS on the Penn/CHOP/Campus Wistar through campus, regional and national leadership; catalyze collaborative research through working groups, advocacy and strategic planning; education through seminars, courses and workshops; develop new HIV/AIDS researchers and research programs through pilot funding, mentorship and partnership programs; and research support through innovative shared resource hubs that offer unique services, materials, technical training and assistance, and collaborative support.

    Learn more about human fruit fly cancer


    Loss of Parafibromin/Hyrax results in loss of neural stem cell (NSC) polarity, leading to a shift from asymmetric to symmetric division. Upper panels: Dividing NSCs from control (left) and Hyrax knockdown (right) were labeled with cell-polarity protein aPKC (gray) and DNA (cyan). The asymmetric localization of aPKC is lost in the knockdown. Lower panels: Brain telophase NSCs were labeled with a phospho-Histone H3 mitotic marker (PH3 in magenta) and a GFP membrane marker (green) marking the cell outline. Blue lines and red lines indicate the diameter of two NSC daughter cells. Control NSC (left) divides asymmetrically to produce two daughter cells of distinct sizes, while Hyrax knockdown NSC (right) divides symmetrically to generate two daughter cells of similar sizes. Scale bars: 5 mm. 1 credit: Duke-NUS

    Scientists from Singapore and Spain have gained new insights into the activity of a tumor suppressor protein in fruit flies that could help understand certain human cancers. The study, published in PLOS Biologycould eventually lead researchers to new cancer treatments and prevention.

    Scientists at Duke-NUS Medical School collaborated with colleagues from the Institute for Biomedicine Research at the Institute of Science and Technology in Barcelona, ​​the Genome Institute in Singapore and NUS to study a human tumor suppressor protein called parafibromin. Parafibromin’s normal activities prevent tumors from growing, but deficiencies in these activities have been linked to several cancers, including hyperparathyroidism-jaw tumor syndrome and breast, gastric, colorectal, and lung cancers. Until now, the protein’s exact role in nervous system health and disease has remained unknown.

    Although fruit flies and humans may look very different, researchers often find that crucial molecular pathways, signaling and control systems are shared by many species, having originated early in the evolution of a wide variety of organisms.

    “As Hyrax – an evolutionary-related protein – is the analogue of parafibromin, we examined it in the development of brain cells in Drosophila fruit flies as a first step towards a better understanding,” said Dr. Deng Qiannan, first author of the study and researcher. with the Neurosciences and Behavioral Disorders (NBD) program at Duke-NUS.

    “We found that the Hyrax protein plays a critical role during Drosophila central nervous system development, and therefore we believe that parafibromin may also perform a similar function in humans,” said Dr. Cayetano Gonzalez, co – author of the study. and Head of the Cell Division Laboratory at the Barcelona Biomedicine Research Institute.

    The results revealed previously unknown functions of the protein in controlling cell polarity – the asymmetric organization of proteins – in stem cells that generate mature nerve cells. Loss of Hyrax function has been found to lead to the proliferation of neural stem cells in the Drosophila brain. This was linked to influences on cellular structures called centrosomes, which coordinate cell division, and the regulation of two other known tumor suppressor proteins, Polo and Aurora-A kinases.

    “Loss of cell polarity and centrosomal abnormalities are hallmarks of human cancers,” said Professor Wang Hongyan, corresponding senior author of the study and deputy director of the NBD program at Duke-NUS. “These surprising new findings may be very relevant to understanding the role of parafibromin in human cancers, perhaps especially in the brain.”

    Further research will be needed to determine if these findings in fruit flies can be applied to parafibromin in humans, and the research team has already begun new investigations with this aim.

    “Translating basic scientific research into discoveries of clinical significance is one of the primary goals of medical research. Professor Wang and his colleagues have taken a very exciting first step that could one day have an impact on cancer treatment and prevention,” said Professor Patrick Casey, Associate Dean Director for Research at Duke-NUS.

    Proteins resist nerve cell regression

    More information:
    Qiannan Deng et al, parafibromin governs cell polarity and centrosome assembly in Drosophila neural stem cells, PLOS Biology (2022). DOI: 10.1371/journal.pbio.3001834

    Provided by Duke-NUS Medical School

    Quote: Read more about human cancer in fruit flies (October 19, 2022) retrieved October 20, 2022 from https://phys.org/news/2022-10-human-cancer-fruit-flies.html

    This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

    Another wolf killed in Oregon, $11.5,000 reward offered


    DURKEE, Ore. (AP) — A collared wolf from the Lookout Mountain pack was fatally shot earlier this month in northeastern Oregon and police are asking for the public’s help in locating the person(s). responsible.

    On October 3, state Fish and Wildlife troopers received information from the agency that a collared wolf known as OR88 may have died in northeast Oregon. near Little Lookout Mountain, about 14 miles from Durkee, Oregon State Police said Wednesday.

    Soldiers and Fish and Wildlife personnel responded to the area and found the wolf’s body on Bureau of Land Management property. Soldiers believe the wolf was shot at the scene on October 2.

    The Oregon Wildlife Coalition and its conservation partners are offering to pay an $11,500 reward that leads to the soldiers being arrested and/or cited in this incident, police said.

    In Oregon last year, wildlife troopers found eight dead wolves in the same area. Animals have been poisoned, but the deaths remain unsolved and rewards have also been offered for tips leading to convictions.

    Six wolves found dead this year in northeastern Washington this year have been poisoned and a reward is also available, officials said last week.

    There were a minimum of 206 wolves and 33 packs in Washington state in 2021, according to an annual survey conducted by state and tribal biologists. Idaho had about 1,500 wolves, while Oregon had about 173 at the time.

    Asian elephants mostly roam outside protected areas – and that’s a problem


    Asian elephants spend most of their time outside protected areas because they prefer the food they find there, reports an international team of scientists. But this behavior puts animals and humans at risk, researchers say.

    The finding has important implications for the animals’ long-term survival as protected areas are the cornerstone of global conservation strategies to protect endangered species, the researchers say.

    If protected areas don’t contain the animals’ preferred habitats, they will roam, says Ahimsa Campos-Arceiz, who studies Asian elephants (Elephas maximus) at the Xishuangbanna Tropical Botanical Garden of the Chinese Academy of Sciences in Menglun, China. “It’s a good intention, but it doesn’t always work out that way.”

    Human-elephant conflict is the greatest threat to Asian elephants. In recent decades, animals from protected areas have increasingly wandered into villages. They often cause destruction, damage crops and infrastructure, and injure and even kill people.

    stray elephants

    To understand the effectiveness of protected areas for Asian elephant conservation, Campos-Arceiz and his colleagues set out to get an accurate picture of Asian elephant movements. They captured 102 individuals in Peninsular Malaysia and Borneo, recording 600,000 GPS positions over a decade. They found that most elephants spent most of their time in habitats outside protected areas, at forest edges and in regrowth areas. The conclusions are published in the Journal of Applied Ecology1 October 18.

    Researchers suspect that elephants venture outside because they like to eat grasses, bamboo, palms and fast-growing trees, which are common in disturbed forests and relatively rare under the canopy of old-growth forests.

    Philip Nyhus, a conservation biologist specializing in human-wildlife conflict at Colby College in Waterville, Maine, explains that Asian elephants live deep in dense forest and are therefore much more difficult to study than African elephants, which roam the open savannahs. “The sample size is impressive,” he says.

    The finding is not unexpected given past anecdotal observations of elephant behavior, Nyhus says. But now the data shows that this is a common strategy for the survival of these animals, and not just something seen in a subset of the population. The research provides strong evidence on how to set up appropriate protected areas that reduce the risk of wandering elephants, he says.

    “There will be conflicts”

    The findings don’t diminish the importance of protected areas, which provide long-term security for animals, says Campos-Arceiz, who carried out the fieldwork at Malaysia’s University of Nottingham in Selangor. “But they are clearly not enough.”

    The study suggests that “there will be conflict between humans and elephants,” says Guo Xianming, director of the Xishuangbanna National Nature Reserve Research Institute in Jinghong.

    Asian elephants roam villages for a combination of reasons: an increase in elephant populations, the forests of many reserves have become denser and unsuitable for the animals, and the increase in the loss and degradation of living outside.

    Last year, two herds of elephants made global headlines as they emerged from the Xishuangbanna National Nature Reserve and traveled hundreds of miles, wreaking havoc along the way. A herd spent five weeks at the botanical garden where Campos-Arceiz works. “It was intense,” he says.

    There is an urgent need to understand how people and elephants can better share the landscape, says Guo. And the first step is to better protect people’s lives and livelihoods. “It’s the only way to peaceful coexistence.”

    Reporting of the story was supported by the Howard G. Buffett Fund for Women Journalists of the International Women’s Media Foundation.

    News desk | ILLINOIS


    Philip Anderson, left, and Bingyang Zhang developed and tested the accuracy of a mathematical model capable of predicting the energetics of biological puncture systems.

    Photo by Fred Zwicky

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    CHAMPAIGN, Ill. — Researchers have created a model that can calculate the energy involved when one organism stabs another with its fangs, spines, spines, or other piercing parts. Because the model can be applied to a variety of organisms, it will help scientists study and compare many types of biological punch tools, the researchers said. It will also help engineers develop new systems to effectively pierce materials or resist drilling.

    The new findings are reported in the Journal of the Royal Society Interface.

    Zhang is holding a small cube of gelatin

    Zhang tested the model using a projectile piercing a gelatinous material that mimics animal tissue.

    Photo by Fred Zwicky

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    “The idea behind this was to provide a quantitative framework for comparing a variety of biological puncture systems with each other,” said Philip Anderson, professor of evolution, ecology and behavior at the University of ‘Illinois at Urbana-Champaign, who conducted the postdoctoral research. researcher Bingyang Zhang. “A first question of this research was how to measure these different systems to make them comparable.”

    “It’s a difficult problem to predict the properties of biological systems,” Zhang said.

    Animals and plants deploy a variety of strategies to stab their prey or defend themselves against other organisms, and even those that use similar strategies or tools modify those tools to suit their specific needs, the researchers said. Their targets also differ.

    “In vipers, for example, some bite mammals, which means they have to puncture the soft tissues enclosed in the skin, while others target reptiles, which have scales, which makes them stiffer and more rigid. harder to break through,” said Anderson, who studies mechanics and energetics. biological puncture systems.

    Parasitoid wasp stabs its ovipositor in the wood.

    Some parasitoid wasps, such as those of the genus Ichneumoncan use their ovipositors to stab wood.

    Photo by US Fish & Wildlife Service

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    Other organisms, like parasitoid wasps, can use their ovipositors to burrow through caterpillar skins, but can also penetrate fruit or even wood, he said.

    To develop a model that can be applied to a variety of systems, Zhang determined the key factors that must be included in any calculation of the energetics involved. These include changes in kinetic energy when the punch tool is used, but also take into account the material properties of the target tissue.

    A red-headed woodpecker uses its beak to pierce through wood.

    A red-headed woodpecker uses its beak to pierce through wood.

    Photo by Andy Reago and Chrissy McClarren, CC BY-SA 2.0

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    Edit embedded media in the Files tab and reinsert it if necessary.

    It involves calculations describing how the initial kinetic energy drives a puncture tool into a material, opening up new surfaces in the material as the fracture propagates. It also takes into consideration the frictional resistance and elasticity of the target tissue.

    The calculations were aimed at conical puncture tools, which are common in biological systems, the researchers said.

    Anderson is deploying the new model to aid in his studies of puncturing organisms like viper fangs, stingray spines, and parasitoid wasp ovipositors.

    “If we know the morphology or shape of damage created by a puncture tool, we can use this model to predict the amount of energy expended during a puncture scenario,” Zhang said. “Or we can predict different aspects of material property, for example, how it will fracture, which will be useful in engineering and biological applications.”

    The National Science Foundation supports this research.

    UC San Diego researchers named recipients of NIH New Innovator Awards


    Johannes Schöneberg/Photo by Catherine Eng

    The New Innovator Award will allow Schöneberg to understand how changes in the morphology and dynamics of the 4D mitochondrial network cause abnormalities in stem cell renewal. Breakthroughs in this area could contribute to the development of new therapies for cancer and bowel disorders. By opening this new window into mitochondrial biology, Schöneberg believes that new screening methods and treatment strategies can be developed that apply to the large number of diseases that are also linked to mitochondria, such as epilepsy, Parkinson’s and Alzheimer’s disease.

    “The science advanced by these researchers is poised to open new avenues of discovery in human health,” said Acting NIH Director Lawrence A. Tabak. “This unique cohort of scientists will transform what is known in the biological and behavioral world. We are privileged to support this innovative science.

    Established in 2007, the New Innovator Award, part of the NIH’s High-Risk, High-Reward Research Program, supports exceptionally innovative research conducted by scholars who are within 10 years of their final degree or residency. clinic and who have not yet received an NIH R01 or equivalent fellowship. In this program, researchers are encouraged to think beyond traditional boundaries and pursue innovative ideas in any area of ​​research relevant to the NIH mission to advance knowledge and improve health. Each year, the Pooled Fund invites applications, conducts rigorous peer review of proposals, selects grantees, and oversees programs that pursue major scientific opportunities and gaps in the broader research enterprise that are of significant importance to the NIH.

    Newly Identified Brain Molecule Orchestrates Immune System Responses to Alzheimer’s Disease and MS


    UVA Health researchers have discovered a molecule in the brain responsible for orchestrating immune system responses to Alzheimer’s disease and multiple sclerosis (MS), potentially allowing doctors to supercharge the body’s ability to fight these and other devastating neurological diseases.

    The molecule the researchers identified, called a kinase, is crucial for both clearing the plaque buildup associated with Alzheimer’s disease and preventing the buildup of debris that causes MS, the researchers found. It does this, the researchers showed, by directing the activity of brain cleaners called microglia. These immune cells were once largely ignored by scientists but have emerged in recent years as key players in brain health.

    Important new UVA findings may one day allow doctors to increase microglia activity to treat or protect patients against Alzheimer’s disease, MS and other neurodegenerative diseases, the researchers report.

    Unfortunately, doctors currently do not have effective treatments to target the root causes of most neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease or ALS. [amyotrophic lateral sclerosis, commonly called Lou Gehrig’s disease]. In our studies, we discovered a master controller of cell type and processes necessary to protect the brain from these disorders. Our work further shows that targeting this novel pathway provides a powerful strategy to eliminate toxic culprits that cause memory loss and impaired motor control in neurodegenerative diseases. »

    John Lukens, PhD, Sprincipal researcher, University of Virginia School of Medicine, Center for Brain Immunology and Glia (BIG), Carter Immunology Center, and UVA Brain Institute

    Toxic Brain Accumulation

    Many neurodegenerative diseases, including Alzheimer’s disease and multiple sclerosis, are thought to be caused by the brain’s inability to cleanse itself of toxic buildup. Recent advances in neuroscience research have shed light on the importance of microglia in clearing harmful debris from the brain, but the new UVA discovery offers practical insights into how this cleaning process occurs – and the disastrous consequences when it does not occur.

    Using a mouse model of Alzheimer’s disease, UVA researchers found that a lack of the molecule they had identified, spleen tyrosine kinase, triggered plaque buildup in the brain and caused mouse memory loss – like the symptoms seen in humans with Alzheimer’s disease. Additionally, neuroscientists were able to reduce plaque buildup by activating this molecule and microglia in the brain, suggesting a potential therapeutic approach for human patients, although this would require much more research and testing.

    “Our work has described a critical element of microglial function in Alzheimer’s disease and MS,” said researcher Hannah Ennerfelt, first author of a new scientific paper describing the findings. “Understanding the underlying biology of these cells during neurodegeneration may allow scientists and physicians to develop increasingly informed and effective therapeutic interventions.”

    The absence of the molecule in a mouse model of MS, meanwhile, led to the buildup of damaged myelin, a protective coating on nerve cells. When myelin is damaged, cells cannot transmit messages properly, causing MS symptoms such as mobility problems and muscle spasms. UVA researchers conclude in a new scientific paper that the molecule they identified, abbreviated as SYK, is “critically involved” in the crucial removal of myelin debris.

    “If stimulation of SYK activity in microglia can reduce the amount of myelin debris in MS lesions, developing new drugs to target SYK could halt the progression of MS and help reverse the damage,” said said Elizabeth L. Frost, PhD, critical researcher on the project. “This is a particularly promising option given that most drugs currently available for MS treatment attenuate adaptive immunity. These immunosuppressive drugs lead to susceptibility to infections and a higher risk of potentially such as progressive multifocal leukoencephalopathy. Additionally, some forms of MS do not have a strong involvement of the immune system, and therefore there are currently very limited treatment options for these patients.”

    “Targeting SYK in microglia,” she noted, “would circumvent multiple limitations of current MS treatments.”

    Based on their promising results, the researchers report that targeting the molecule to boost immune activity in the brain could offer a way to treat not just Alzheimer’s disease and MS, but also a ‘range’ of diseases. neurodegenerative.

    “These findings are particularly exciting because they point to a processing pathway where we could alter the behavior of these native brain cells, microglia, to behave in a more neuroprotective way,” said researcher Coco Holliday, a student. UVA undergraduate working in the Lukens lab. . “It could potentially be applied to a variety of different neurological diseases that all share the problem of a buildup of toxic waste in the brain. It was a very exciting project to be involved in.”

    Published results

    The researchers published their findings in the scientific journal Cell. The team consisted of Ennerfelt, Frost, Daniel A. Shapiro, Holliday, Kristine E. Zengeler, Gabrielle Voithofer, Ashley C. Bolte, Catherine R. Lammert, Joshua A. Kulas, Tyler K. Ulland, and Lukens. The researchers have reported no financial interest in the work.

    The research was funded by the National Institute of Aging of the National Institutes of Health, grantRF1AG071996-01; the National Institute of Neurological Disorders and Stroke, grant R01NS106383; the Alzheimer’s Association, grant ADSF-21-816651; the Cure Alzheimer Fund; The Owens Family Foundation; and several training scholarships.


    Journal reference:

    Ennerfelt, H., et al. (2022) SYK coordinates neuroprotective microglial responses in neurodegenerative diseases. Cell. doi.org/10.1016/j.cell.2022.09.030.

    Peter Hotez says new ‘Scrabble variations’ like BQ.1.1 could bring another winter wave of COVID to Texas


    On Sunday Dr. Peter Hotez posted a thread of tweets regarding our pandemic present and our possible future. Hotez, the dean of the National School of Tropical Medicine at Baylor College of Medicine and co-director of the Center for Vaccine Development at Texas Children’s Hospital, acknowledged that things feel pretty calm with COVID-19. He pointed out that in Texas, “we’re at about 6 new cases per 100,000, which is among the lowest we’ve been during the entire pandemic.”

    But Hotez’s work requires looking beyond the present. He expressed concern about the BQ.1.1 variant, which seems to be on the increase in Europe. As has been the case in past winters, problems in Europe often point to future problems here. His solution, however, remains much the same: Hotez continues to encourage everyone to maximize their boosters and get their children vaccinated.

    Q: How did it go with you?

    A very good one. Life is full and interesting. It’s crazy, but complete and interesting. But it’s nothing I didn’t sign up for. I find the thing that worries me, with all the stressors – COVID-19, the stock market, inflation, the potential for nuclear disaster in Eastern Europe – that must have a huge impact on the mental health of the American people. What I tell people is that if you’re feeling sad or depressed or upset or having panic attacks, that’s a normal reaction to living in extraordinary times. People need to hear this more.

    MORE HEALTH NEWS: St. Luke’s Health record system still offline 2 weeks after parent company ransomware attack

    Mental health issues are still stigmatized in this country. People should know, it’s not just you. Having mental health issues through it all means you’re a normal, good person. It is a normal physiological reaction to the state of the world.

    Q: You recently received good news regarding the approval of your halal vaccine, Indovac, in Indonesia. Where do things go from here?

    A: The original idea was that when it all started, we were getting pretty frantic calls from ministers of health and ministers of science around the world, because they realized the mRNA vaccine wasn’t getting to them. So the question was whether they could partner with us at Texas Children’s and Baylor College of Medicine to transfer the vaccine we were developing if they had the local capacity to develop vaccines.

    It was a combination of their interest and also knowing that they had abilities and knew what they were doing. The last thing you want is to work with someone who doesn’t pay close attention to quality control or quality assurance. Because it doesn’t take much to derail even a good vaccine because of misperception. I always say it doesn’t take much to vote a good vaccine off the island if there is a perception problem. It was therefore important that we did our due diligence not for financial purposes, but for quality purposes.

    We narrowed it down to four countries: India, Indonesia, Bangladesh and Botswana. Now in India, our Corbevax has entered 75 million guns. With Indovac, it’s 20 million doses, which is exciting because it’s vegan technology. It was important to have it certified halal.

    Q: It’s like when people wanted to measure this pandemic in weeks, you knew it was going to take years.

    A: Well, we played the long game for several reasons. The rapid evolution of variants. Despite what President Biden said in “60 Minutes,” it’s not over. It’s just a new Little Shop of Horrors. And it will continue.

    So remember this: COVID-19 is the third major coronavirus epidemic/pandemic of the 21st century. We had SARS in 2002 and MERS in 2012, then COVID-19. Mother nature tells us what she has in mind, generating new coronavirus pandemics every seven years or so. Based on that, we should expect COVID-25 or 26 and then COVID-32 or 33. We have to do better than trying to make a new vaccine every time. The big brass ring is to develop a universal coronavirus vaccine so we don’t have to worry so much. And I think it’s doable based on what we’re seeing so far.

    Q: That’s why you work with nations on building infrastructure.

    A: Yes, and recognizing vaccine ecosystems as currently defined is too narrow in scope. We focus on the multinational pharmaceutical companies, the Modernas, Pfizers and GSKs of the world, who have the best chops to make it happen. But it’s the best way to make sure vaccine equity is not achieved. It is not just a humanitarian concept. But because we know that the delta variant originated from an unvaccinated population in India last year. And omicron was born from an unvaccinated population in southern Africa. There is also an interest in doing so.

    MORE QUESTIONS AND ANSWERS: FDA Commissioner Says Anti-Science Rhetoric Puts US Last Among Wealthy Countries

    What we’re doing at Texas Children’s and Baylor is trying to find a way to better balance or expand the ecosystem to encompass low-income vaccine producers. This is what is missing in the geopolitical landscape at the moment. Not that multinational corporations are demons or villains. They distributed a lot of vaccines around the world. But we need a broader or decolonized ecosystem to ensure greater vaccine equity.

    Q: I’m afraid I look like a skipping record. But I feel like we should be more humble about the interconnectedness of the world.

    A: What’s really interesting is seeing these new variants of COVID emerge. It’s like watching a train roll down the tracks from miles away. Except in this case, the train started on the African continent and in Asia. First he travels to Western Europe, then to the UK. Once that happens, we know what happens next: Boston and New York. And we know it’s going to happen in Texas.

    We repeated a pattern. Now with these new omicron sub-variants – I call them the Scrabble variants, because they’re those high-value Scrabble letters like Q and X and V. We’re seeing cases increase again. At the moment we are in a good position, in Texas in particular. Cases are almost at their lowest. That’s great, but guess what? Scrabble variants with rising numbers worry me in the UK and France. What happens as we head into winter will be interesting. I think in January we could have another wave like we had last year winter and the winter before. That’s how we should plan it.

    Q: You also expressed concern about people skipping flu shots.

    A: Yes. The thing is, we’re still underperforming in our boosters. The new bivalent booster has only reached 11 million Americans so far. It’s something like 4 percent of the population that could get it. So people don’t run to get it. They walk. There’s a new Kaiser Family Foundation survey that found 30% of Americans “plan” to get it, whatever that means. And it’s still not very good.

    There is still a lot of work to do. With the flu shot, kids don’t get that or the COVID booster. We have a very vulnerable population. And I’m worried about these new escape variants of Scrabble. If you’re not boosted against BA.5, which is more like Scrabble variants than the original line, it’s like starting over. So it’s like smashing the football on the 20-yard line. I was on PBS NewsHour and called on the president to hold a press conference and really talk about the importance of these boosters. There is a bad moon rising.

    Q: What are the next steps for what you’re all working on?

    A: This will be done in two stages. Right now we are looking at a bivalent version of our Corbevax and potentially Indovac that targets the new omicron subvariants, including Scrabble variants. It’s a. From there, we are looking to see how we could develop a truly universal version of the vaccine. Our vaccine scientists are busier than ever. So it’s an exciting time, and the science is very interesting. Lab meetings are interesting and rewarding.

    MORE FROM ANDREW DANSBY: Rice professor Kiese Laymon gets MacArthur’s ‘genius grant’

    There is a famous book on molecular biology, written at the beginning of the molecular genetics revolution, when physicists were still thinking about how to do quantitative biology. It was by a guy named Hershey and it was called “We Can Sleep Later”. Even though sleep is very important and you are supposed to take care of yourself, this title sometimes comes to mind.

    Q: What is the lab like? Does it hum 24/7?

    A: It’s more cohesive, just people working in the trenches day after day, day after day. Often they are there on weekends and outside working hours. But they all hang in there. Even though everyone is exhausted and stressed and has this potential for burnout, they hang on. They are all heroes.

    Q: I see your Baylor School of Medicine logo, which is interesting. It reminds me of a lot of contemporary art I’ve seen in Honduras that took on Mayan themes.

    A: It was very deliberate. College tells me I can’t call it a logo. It is therefore an emblem. Apparently there is a registered trademark. The genesis of this one is rather interesting. With the National School of Tropical Medicine, the Baylor College of Medicine, I wanted it to be built on the model of the great schools of tropical medicine in London and Liverpool. The Liverpool School of Tropical Medicine and the London School of Hygiene and Tropical Medicine. They both had old world themes, Egyptian themes, in their logos. I thought we were in the new world now, so maybe the Mayan jaguar would be more appropriate. And although we work globally, including in Africa and the Middle East, I would say that our greatest activity is in Central America, Mexico, Mesoamerica and the tropical regions of South America.


    Azenta, Inc. (NASDAQ:AZTA) Short Interest Down 10.9% in September


    Azenta, Inc. (NASDAQ:AZTA – Get Rating) was the beneficiary of a sharp drop in short-term interest rates during September. As of September 30, there was short interest totaling 3,440,000 shares, down 10.9% from the September 15 total of 3,860,000 shares. Based on an average daily trading volume of 709,500 shares, the short interest ratio is currently 4.8 days. Currently, 4.7% of the company’s shares are sold short.

    Azenta Price Performance

    Shares of AZTA traded down $1.99 during Friday’s midday session, hitting $38.94. The stock had a trading volume of 918,492 shares, compared to an average volume of 903,290. Azenta has a fifty-two-week low of $37.61 and a fifty-two-week high of $124.79. The company has a market capitalization of $2.92 billion, a PE ratio of 1.35 and a beta of 1.56. The company’s 50-day simple moving average is $51.33 and its 200-day simple moving average is $65.68.

    Azenta (NASDAQ:AZTA – Get Rating) last reported results on Tuesday, August 9. The company reported EPS of $0.12 for the quarter, beating the consensus estimate of $0.08 by $0.04. Azenta had a net margin of 391.34% and a return on equity of 1.47%. The company posted revenue of $132.74 million in the quarter, compared to $132.70 million expected by analysts. In the same quarter last year, the company achieved EPS of $0.72. The company’s revenue increased 2.8% year over year. On average, analysts expect Azenta to post an EPS of 0.41 for the current year.

    Insider activity in Azenta

    In related news, COO Matthew Mcmanus purchased 8,625 shares of the company in a trade that took place on Friday, August 19. The shares were purchased at an average cost of $58.15 per share, with a total value of $501,543.75. As a result of the transaction, the chief operating officer now directly owns 29,467 shares of the company, valued at approximately $1,713,506.05. The purchase was disclosed in a legal filing with the SEC, which is available on the SEC’s website. In related news, COO Matthew Mcmanus purchased 8,625 shares of the company in a trade that took place on Friday, August 19. The shares were purchased at an average cost of $58.15 per share, with a total value of $501,543.75. As a result of the transaction, the chief operating officer now directly owns 29,467 shares of the company, valued at approximately $1,713,506.05. The purchase was disclosed in a legal filing with the SEC, which is available on the SEC’s website. Additionally, Chief Financial Officer Lindon G. Robertson acquired 4,350 shares in a trade on Friday, August 19. The shares were acquired at an average cost of $57.62 per share, for a total transaction of $250,647.00. Following completion of the transaction, the CFO now directly owns 100,571 shares of the company, valued at approximately $5,794,901.02. Disclosure of this purchase can be found here. Insiders own 1.62% of the shares of the company.

    Azenta Institutional Trading

    Several hedge funds and other institutional investors have recently changed their positions in the stock. Kayne Anderson Rudnick Investment Management LLC acquired a new stake in shares of Azenta in the second quarter valued at approximately $300,687,000. William Blair Investment Management LLC acquired a new stake in shares of Azenta in the second quarter valued at approximately $232,008,000. Artisan Partners Limited Partnership acquired a new equity stake in Azenta in the second quarter valued at approximately $221,422,000. Macquarie Group Ltd. acquired a new stake in shares of Azenta in the second quarter valued at approximately $160,068,000. Finally, State Street Corp acquired a new position in Azenta during the second quarter worth approximately $141,290,000. Institutional investors and hedge funds own 97.43% of the company’s shares.

    Analysts set new price targets

    Several research analysts have published reports on AZTA shares. Needham & Company LLC lowered its price target on Azenta shares from $94.00 to $74.00 and set a “buy” rating on the stock in a Wednesday, August 10 research report. Evercore ISI lowered its price target on Azenta shares to $68.00 in a Monday, August 15 research report. TheStreet upgraded Azenta’s shares from a “c-” rating to a “d+” rating in a Thursday, September 1 research note. Finally, B. Riley reduced his price target on Azenta shares from $94.00 to $82.00 in a Thursday, July 14 research note.

    About Azenta

    (Get an assessment)

    Azenta, Inc provides life science sample management and exploration solutions for the life science market in North America, Europe, China, Asia-Pacific and internationally. The Company operates through two reportable segments, Life Science Products and Life Science Services. The Life Science Products segment offers automated cold sample management systems for the storage of compound and biological samples; equipment for sample preparation and handling; consumables; and instruments that help customers manage samples throughout their research, discovery and development workflows.

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    This instant news alert was powered by MarketBeat’s narrative science technology and financial data to provide readers with the fastest and most accurate reports. This story was reviewed by MarketBeat’s editorial team prior to publication. Please send questions or comments about this story to contact@marketbeat.com.

    Before you consider Azenta, you’ll want to hear this.

    MarketBeat tracks daily the highest rated and most successful research analysts on Wall Street and the stocks they recommend to their clients. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the market ripples…and Azenta didn’t make the list.

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    Top performing students earn a spot on the WCM-Q Dean’s Honor List


    Doha – The Weill Cornell Medicine-Qatar (WCM-Q) Dean’s Honor List has recognized the academic performance of 53 high-achieving basic and pre-medical students at a ceremony.

    The list included students who achieved a cumulative grade point average of 3.75 or higher during the fall or spring semester of the 2021-22 academic year. An impressive 30 students scored a double win by earning a spot on the roster in both semesters.

    Speaking at the ceremony, Dr. Javaid Sheikh, Dean of WCM-Q said, “I would like to congratulate every student who has earned a well-deserved place on the Dean’s Honor List. It is not an easy accomplishment. It takes excellence and commitment to be named a high achiever, qualities that these students all demonstrated clearly, without a doubt. Congratulations once again.”

    Dr. Sean Holroyd, Associate Dean for Student Affairs at WCM-Q, said, “It’s wonderful to have so many students here today to celebrate their successful year with their colleagues and families. Having a place on the Dean’s Honor List represents a commitment and dedication to the study of medicine. These students have established a solid foundation on which they can deepen their knowledge as their medical studies progress. Cheer ! »

    One of the award-winning pre-med students of the Class of 2026, Aisha Al-Mulla, said, “To excel academically, I worked hard and overcame many challenges. I am therefore delighted to have this recognition. We medical students have a lot to do; the dean’s list marks the beginning of many achievements. Without the help of my family, I would not have had this opportunity, and I am truly grateful. I also want to express my gratitude to the WCM-Q instructors for their support and guidance over the years.

    WCM-Q alumnus Dr. Mohammed Al-Hijji, Class of 2011, now Consultant in Interventional and Structural Cardiology at Hamad Medical Corporation Cardiac Hospital, delivered the keynote address at the ceremony, saying, “ The best preparation for tomorrow is to do today’s work superbly well. I think this group of high achievers exemplifies that saying of Sir William Osler. Congratulations to you, your family, friends and mentors on this academic achievement. and this success. You are here tonight because of your perseverance and self-discipline to do great work. You are here tonight because you woke up each day at Weill Cornell to set an example as future leaders.
    Dean’s Honor List 202122

    Foundation Program

    Lolwa Al-Abdulghani, Abdulaziz Alansari, Yaqoub Al-Jaidah, Sara Al Kaabi, Maha Almarri, Sama Ayoub, Shahad Ibrahim, Jane Manyama.

    Pre-medical program

    Leena Aboidris, Amr Ahmed, Lina Ahmed, Younggyu Ahn, Ahmad Al-Ansari, Mohammed Al-Ansari, Nafla Al-Attiyah, Mohammed Al-Bishri, Maryam Al-Hamadi, Sumaya Hussein Ali, AlDana Al-Khalaf, Haya Al-Kuwari , Nawaf Al-Muhannadi, Aisha Al-Mulla, Fatima Almusleh, Amal AlNaemi, Yousef Al-Najjar, Noor Al-Sayegh, Manar Al-Shukri, Kareem Aly, Sushanthi Anandaraja, Maryam Arabi, Sarah Baig, Azwa Dilawar, Anam Ehtesham, Ahmed El-Naas, Kareem Fanous, Omar Hamad, Raghad Ibrahim, Nour Jaouni, Yazan Kaddorah, Aisha Kafoud, Ibtihal Kamal, Mohammed Keshaish, Surin Lee, Anns Mahboob, Hana Nishan, Aqib Abdul Rahman, Zoya Salahuddin, Aparajita Sarkar, Shaunak Sarker , Degiri Kalana Senevirathne, Leena Syed, Sanish Varghese, Mahmoud Yousef.


    About Weill Cornell Medicine – Qatar

    Weill Cornell Medicine – Qatar is a partnership between Cornell University and the Qatar Foundation. It offers a comprehensive six-year medical program leading to the Cornell University medical degree with instruction from Professors Cornell and Weill Cornell and physicians from Hamad Medical Corporation (HMC), Aspetar Orthopedic and Sports Hospital Medicine, Primary Health Care Corporation, Feto Maternal Center and Sidra Medicine, who hold positions at Weill Cornell. Through its biomedical research program, WCM-Q is building a sustainable research community in Qatar while advancing basic science and clinical research. Through its Faculty of Medicine, WCM-Q seeks to provide the best possible education for medical students, to improve current and future health care, and to provide high quality health care to the people of Qatar.

    For more information, please contact:
    Hanan Lakkis
    Associate Director, Media and Publications
    Weill Cornell Medicine – Qatar

    Robotic Intracellular Electrochemical Detection | Eurek alert!


    image: The intracellular detection robot automatically performs quantitative measurements on several cells.
    see After

    Credit: Weikang Hu, Southern University of Science and Technology

    A research team from Southern University of Science and Technology has developed an automated intracellular detection system, which provides a high-efficiency approach to revealing cellular intrinsic characteristics and heterogeneity for better investigation of disease progression or early diagnosis of the disease. The new research paper was published Sept. 2 in the journal Cyborg and bionic systems.

    The measurement of intracellular biochemical processes is important for quantitatively understanding the function of biological systems. Intracellular detection by nanopipette is an in situ, label-free and non-destructive measurement method. However, the small size of the cells and the tip of the nanopipette make it difficult to efficiently perform intracellular measurements by manual manipulation, which poses a barrier to obtaining statistically significant data. Therefore, the researchers designed a highly efficient and consistent intracellular detection system by integrating automation technology.

    First, the nanopipette-based sensor with a tip diameter of about 100 nm was designed, where a platinum ring on the tip of the nanopipette was used as a working electrode for the electrochemical detection of reactive species. oxygen (ROS). At the same time, the sensor was mounted on a high-precision micromanipulator with 5 nm motion resolution, and an inverted fluorescence microscope was used for visual feedback.

    Additionally, the team proposed a label-free cell detection algorithm, which can avoid the influence of fluorescent staining on cells and precisely locate penetration sites for highly efficient intracellular measurement. The algorithm automatically moves cells to a defocus plane to maximize the grayscale difference between adherent cells and the background, thereby simplifying cell detection and improving cell recognition rate.

    In addition, overshoot-free nanopipette tip positioning was developed to prevent tip damage caused by the tip colliding with the cell box during autofocus. Specifically, the normalized correlation coefficients when matching the templates at different z-axis positions were used as a focus metric to autofocus the nanopipette tip without tip overshoot or damage.

    Furthermore, proximity sensing based on ion current feedback was used to accurately determine the relative height between the nanopipette tip and the cell surface due to the widely varying thickness of adherent cells. When the tip of the nanopipette approaches the cell, the tip will be gradually blocked by the cell and the ion current through the opening of the tip will decrease. Therefore, the relative height between the tip and the cell can be measured accurately.

    Finally, cell penetration and electrochemical detection of ROS were assessed by human breast cancer cells and zebrafish embryo cells, and the variation in ROS signals indicates that the system is capable of a highly selective response to ROS and a quantitative measurement of intracellular ROS.

    This work provides a systematic approach for automated intracellular detection of adherent cells, laying a solid foundation for high-throughput detection, diagnosis and classification of different forms of biochemical reactions within single cells. In addition, the proposed system will also have important applications in lineage tracing for developmental biology and high-resolution manipulation of organelles in living single cells to study specific causes of diseases and development of new therapies.

    Authors of the article include Weikang Hu, Yanmei Ma, Zhen Zhan, Danish Hussain and Chengzhi Hu.

    This work is supported by the National Natural Science Foundation of China (61903177), the Shenzhen Science and Technology Program (Grant No. JCYJ20190809144013494) and the Science and Technology Program of Guangdong (Grant No. 2021A1515011813). This work is supported in part by the Science, Technology and Innovation Commission of Shenzhen Municipality under grant number. ZDSYS20200811143601004 and in part by Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou). The authors acknowledge assistance from SUSTech Core Research Facilities. We thank Prof. Dong Liu from the Department of Biology, Southern University of Science and Technology for providing zebrafish embryos.

    The article “Robotic Intracellular Electrochemical Sensing for Adherent Cells” was published in the journal Cyborg and bionic systems September 2, 2022, at DOI: https://doi.org/10.34133/2022/9763420


    Authors: Weikang Hu1, Yanmei Ma1, Zhen Zhan1, Danish Hussain1,2 and Chengzhi Hu1,3*

    Title of the original article: Robotic intracellular electrochemical sensing for adherent cells

    Log: Cyborg and bionic systems

    DOI: 10.34133/2022/9763420


    1 Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China

    2 Department of Mechatronics Engineering, National University of Science and Technology, Islamabad, Pakistan

    3 Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities, Southern University of Science and Technology, Shenzhen, China

    A brief introduction about the author Dr. Hu Chengzhi.

    Chengzhi Hu obtained his doctorate. graduated from the Department of Micro-Nano Systems and Engineering at Nagoya University in 2014. He was a postdoctoral associate at the Multi-Scale Robotics Lab at ETH Zurich between 2014 and 2018. Since 2018, he has been an associate professor at the Department of Mechanics and Power Engineering at Southern University of Science and Technology, China. It has engaged in the development of micro-/nano-robots, microfluidic chips, micro-/nano-tools and other bioMEMS devices for biological analysis and biomedical applications.

    Personal homepage: https://faculty.sustech.edu.cn/hucz/en/

    Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

    Announcements | The Spokesperson’s Review


    Announcements | The Spokesperson’s Review

    Categories: Jobs > medical_health

    Environmental Health Specialist

    Adams County Integrated Health Care Services has an opening for an Environmental Health Specialist. Duties include, but are not limited to; the application of environmental public health and safety principles and practices in a regulatory environment, providing professional oversight of various programs involving monitoring the application of mandatory health and health regulations, educating the public in areas and facilities such as: food safety, drinking water, waste water management, land use and development, school health and safety, solid waste, site risk assessment, chemical and physical risks, life, planning and emergency response in public health and epidemiology. The position requires a Bachelor of Science degree in any study related to environmental health: Earth Science, Food Science, Biology, Zoology or closely related field. Must be able to obtain registration in Washington State as a Sanitary Technician within two years of hire and have a valid driver’s license. Bilingual Spanish encouraged to apply. Salary is set on the EE4 county exempt pay scale with annual salary starting at $58,882.01 – $61,826.11 DOE. County benefits include medical, dental, paid sick leave, paid vacation, paid vacation, and retirement. Send your resume with 3 references to: Integrated Health Care Services 425 E Main Suite 700 Othello, WA 99344. 509-488-2031. Adams County is an equal opportunity employer. Open until full.

    New Study Reveals Age and Growth of Popular Recreational Fish | News, Sports, Jobs


    The Journal of Fish Biology has published the first robust study of the age and maturity of ulua aukea and omilu by Hawaiian scientists. These two trevallies are the most important inshore species targeted for recreational purposes in Hawaii, with many fishing clubs and tournaments devoted to them.

    Poseidon Fisheries Research (PFR) scientists studied ulua aukea, or giant trevally (Caranx ignobilis), and omilu, or bluefin trevally (Caranx melampygus), to determine their growth rate, longevity, and life span. maturity.

    The researchers collected more than 100 samples of each species from recreational anglers at fishing tournaments, as well as the Pacific Islands Fisheries Group and the Hawaii Division of Aquatic Resources.

    Scientists have found that, just like in humans, as these fish age, their size and weight can vary. The oldest ulua aukea weighed 50 pounds and was 31 years old, while the heaviest (80 pounds) was 24 years old. The oldest omilu was 24 years old and weighed almost 14 pounds. The scientists also found that the average size at maturity, a key measure of population, differed between males and females. The female ulua aukea matured at around 23 inches and 4.4 years old, while the males matured at around 18 inches and 2.8 years old.

    Omilu reached maturity at around 14.5 inches and 4.1 years for females and 13 inches and 2.9 years for males.

    “The data collected on age and maturity will be important for the future management of these highly prized and ecologically important predatory species in Hawaii,” said Cassie Pardee, study co-author and PFR fisheries biologist.

    Fishermen camp along the coast, ready to fight one of the toughest fighting fish and hoping to land a fish that can weigh over 100 pounds.

    “Ensuring that the best scientific data on ulua and omilu is available for stock assessments will enable fishers to continue to fish sustainably,” added John Wiley, PFR fisheries biologist and study co-author.

    Poseidon Fisheries Research is a Hawaii-based fisheries science research team conducting work in the Western Pacific region. Their goal is to fill data gaps to improve our understanding of local fisheries and the biology of associated species.

    Ultimately, they strive to provide the best scientific information available so managers can effectively regulate our aquatic resources and ensure sustainable fisheries for future generations.

    They work closely with fishing communities, using their local knowledge and expertise to help collect vital data while engaging them in ongoing research.

    They seek to bridge the gap between science and anglers, so they can both benefit from each other’s knowledge, work together to protect the waters and keep the harvesting of its organisms responsible.

    The famous Arecibo telescope will not be rebuilt – and astronomers are heartbroken


    The dish of the 305-meter-wide telescope at the Arecibo Observatory was destroyed at the end of 2020, after the support cables broke.Credit: Ricardo Arduengo/AFP via Getty

    After a world-famous radio telescope at the Arecibo Observatory in Puerto Rico collapsed two years ago, many scientists hoped the US National Science Foundation (NSF), which runs the facility, would eventually build a new one to replace it. Instead, the agency announced that it would establish a science, technology, engineering, and math (STEM) education center at the site. The revised plan could slow down or drastically alter the remaining research underway at Arecibo.

    “It’s heartbreaking,” says Héctor Arce, an astronomer at Yale University in New Haven, Connecticut, who is originally from Puerto Rico and has worked on Arecibo’s advocacy efforts. “To many, this seems like another unfair way to treat Puerto Rico’s colonial territory.”

    The NSF says it is following community recommendations by not planning to rebuild the large telescope and instead establishing the new education center. “We’re not shutting down Arecibo,” says Sean Jones, chief executive of mathematical and physical sciences at the NSF. “We believe this new approach and this new center will be catalytic in many areas.”

    The agency announced its plans in a call for proposals on Oct. 13. He’s asking for ideas to create and run an education center in Arecibo, at a cost of US$1-3 million per year over five years starting in 2023. That money may or may not include funds to run research facilities. in Arecibo still in use. , such as a 12-meter radio antenna and a lidar system that uses lasers to study the Earth’s atmosphere.

    The situation “could be worse,” says Abel Méndez, a planetary astronomer at the University of Puerto Rico in Arecibo, who uses the 12-meter antenna for research and teaching. But “it could be much, much better”.

    “It’s devastating to know that this is their ultimate decision,” says Desirée Cotto-Figueroa, an astronomer at the University of Puerto Rico at Humacao. “Especially despite all the efforts made by the staff and scientists of the Arecibo Observatory and by the scientific community in general to ensure that it continues to operate as the research center of excellence that it has always been with remaining observation facilities.”

    An education center

    A major question is how the Arecibo site will attract students and teachers if there is little active research to participate in. Helsinki in Finland. “How can we do this without world-class scientists, engineers and instruments?”

    The NSF says it asks for precisely those kinds of ideas. The new center could support ongoing work in astronomy and planetary sciences, or it could focus on other areas such as biological sciences, says James L. Moore III, chief education and resources officer. NSF Humans. “Here’s an opportunity to reimagine what the possibilities might be,” he says.

    The Arecibo Observatory has long been a powerhouse of STEM education in Puerto Rico due to its renowned telescope and its place in astronomical history. Students trained there have become professional astronomers and planetary scientists in many countries.

    The 305-meter-wide radio telescope that collapsed in 2020 has played a key role in many fields of science for more than half a century, including the search for extraterrestrial life, the discovery of the first extrasolar planets and gravitational waves , and the study of near-Earth asteroids and fast radio bursts.

    The NSF has operated the observatory since the 1970s, working with a series of contractors. It has been trying to reduce its investments in Arecibo since 2006, to transfer funding to new astronomical facilities. Supporters rallied and research continued, but the observatory faced new challenges in 2017, when Hurricane Maria damaged much of the facility, and in early 2020, when a series of earthquakes caused more damage.

    Then came the collapse of the 305-meter dish. One of its crucial support cables failed in August 2020, then another in November of that year, and the NSF decided it was too structurally faulty to repair. An engineering investigation revealed five factors that contributed to the collapse, including cable system design, delayed maintenance, and hurricane and earthquake damage.

    Nor is an observatory

    Research continued in the smaller facilities of the Arecibo Observatory. Currently funded projects using these facilities will be able to wind down, Jones says, and scientists can offer to continue their use as part of the new education center.

    The lidar facilities include a potassium laser that studies the temperature of layers of the Earth’s atmosphere and a new instrument planned to probe aerosols such as atmospheric dust. The 12-meter antenna serves as a node in a long-range astronomical network operated by European astronomers. Other research projects using it include Méndez’s studies of red dwarf stars and the habitability of planets around them.

    Many who work with Arecibo’s instruments are now scrambling to figure out how to slow down their research projects. Under the new plan, the site will no longer be called the Arecibo Observatory – becoming instead the Arecibo Center for STEM Education and Research.

    Simple, fast, and robust method makes whole mouse organs transparent for imaging


    The adage “Seeing is believing” was on the minds of Dr. Chih-Wei Logan Hsu and Dr. Joshua D. Wythe of Baylor College of Medicine as they and their colleagues developed an innovative technology called EZ Clear. This new method of tissue clearing has simplified and accelerated the process of making tissue optically transparent, allowing 3D imaging of whole intact tissues or even whole organs.

    Their new method, published in the journal eLife, was developed at Baylor’s Optical Imaging and Vital Microscopy Core (OiVM). Tissue clearing and whole-organ imaging have revolutionized biology, allowing the exploration of organs in three-dimensional space without compromising tissue architecture.

    “Previous methods were complicated, laborious and often required expensive equipment, as well as the use of hazardous organic solvents, which prevented widespread adoption of these methods,” said Hsu, co-director of OiVM and assistant professor of integrative physiology and education, innovation and technology at Baylor. “These challenges motivated us to develop a simpler clearing process that users could more easily complete, saving valuable time and resources to focus on the real issues they want to investigate in their systems.”

    “The beauty of this method is that you can analyze the sample from an aggregate or macro perspective without physically disrupting the natural organization of the tissue or organ,” said Wythe, associate professor of integrative physiology and neurosurgery at Baylor. He is also a member of the Dan L Duncan Comprehensive Cancer Center and the Cardiovascular Research Institute.

    “For example, researchers can now visualize neural connections between the eye and the brain. If done in sections, the process would disrupt natural tissue organization and is incredibly difficult to reconstruct in 3D, limiting our understanding of connections between neurons and other surrounding cells over larger volumes or areas.3D imaging circumvents these limitations, and the advent of EZ Clear makes 3D imaging accessible to most modern molecular biology labs “said Wythe.

    EZ Clear also preserves endogenous and synthetic labeling methods, such as fluorescence, without changing sample size. The study shows successful clearing and labeling of neurons and blood vessels in the brain, as well as vessels in the eyes, heart, kidneys, testicles and ovaries, and successful clearing of whole organs in the lungs, mouse liver and pancreas.

    “EZ Clear eliminates previous technical barriers, allowing researchers to inspect their organs of interest from a macro, whole-organ level, down to cellular resolution,” Wythe said. “It has eliminated previous practical, safety and economic challenges, while providing reproducible, high-quality visualization of the whole organ, which is an important prospect as it can provide new insights into the subject being studied.”

    EZ Clear is faster, cheaper and easier than previous clearing methods. “Researchers can now teach OiVM this tissue removal process that is easier to perform and reproducible. They can then implement it in their own labs and get results in 48 hours by following three simple steps, when other methods take weeks or even months. clean the fabric,” Hsu said. “Then they can bring the cleared organ to the OiVM for 3D imaging and analysis.”

    Other contributors to this work include Juan Cerda, Jason M. Kirk, Williamson D. Turner, Tara L. Rasmussen, Carlos P. Flores Suarez, and Mary E. Dickinson. The authors are all affiliated with Baylor College of Medicine.

    This project was supported by the Optical Imaging and Vital Microscopy Core and the Bioengineering Core at Baylor College of Medicine. Additional support was provided by grants from the National Institutes of Health (5T32GM088129-10, R01HL146745, R01HD099026, U42OD026645, R01HL159159, and 1S10OD016167), American Heart Association (22PRE916015), Cancer Prevention Research Institute of Texas (RP200402) , the Department of Defense (W81XWH18-1-0350) and the Canadian Institutes of Health Research (PJT-155922).

    Video: https://youtu.be/PqlJB3ROoas

    Source of the story:

    Materials provided by Baylor College of Medicine. Original written by Ana María Rodríguez, Ph.D.. Note: Content may be edited for style and length.

    Check the positions, salary range, qualification and how to apply here


    BARC Recruitment 2022 for 78 Positions: Check Positions, Salary Range, Qualification and How to Apply Here

    BARC Recruitment 2022: The app was invited for the “Research Associate” position at the Bhabha Atomic Research Center. BARC is recruiting these positions for the neutron and synchrotron beamline development project, energetic materials research and investigations of quantum spin phenomena. There are in total 78 posts in the departement. Research Associates will be set on one of 3 scholarships listed based on qualifications and experience. The level at which a fellow will be placed will be decided by the interview committee based on the quality of the PhD. thesis and Post-Ph.D. Research experience evidenced by the quality of publications and products, processes designed and developed and performance during the selection interview.

    Selection will be by interview only. Applications received will be pre-selected. Only shortlisted candidates will be interviewed. All selection information will be made available on the website, i.e. http://www.barc.gov.in. Applicants are advised to periodically visit the website for information and updates in this regard. The information displayed on the website will be considered as an intimation to the candidates.

    The deadline for submitting the application is – 28.10.2022

    Check Positions, Salary Scale, Qualification and other Details for BARC Recruitment 2022

    Job Name for BARC Recruitment 2022

    Research Associate

    Project Name for BARC Recruitment 2022

    1. Development of neutron and synchrotron beamlines, research on energetic materials and investigation of quantum spin phenomena

    2. R&D on various options for hydrogen power generation

    3. Cellular and Molecular Radiation Biology Research for Human Health

    4. Development of products, processes and technologies for sustainable agriculture, including the establishment of a Seed Village model

    5. Research on biological systems and their biotechnological applications in health and the environment.

    Total Vacancies for BARC Recruitment 2022


    Maximum Pay Scale for BARC Recruitment 2022


    Qualification for BARC Recruitment 2022

    PhD (Mechanical Engineering) or ME/M.Tech. (Mechanical Engineering) with two years of experience as of the date of application. Experience in mechanical design, fabrication, inspection and testing is preferred, but not required

    Ph.D. (PHYSICS) is preferred, but not required Ph.D. (Chemistry/Materials Science) would also be eligible. Research experience using synchrotron beam/X-ray/neutron scattering facilities is preferred but not required

    Strong experimental background in solid state chemistry/physics, knowledge of thin film growth and electrical transport measurements are highly desirable.

    Ph.D. (Physics) Applicants should have outstanding experience in the field of experimental condensed matter research and should have the aptitude for excellence in basic research. Expertise in Raman spectroscopy or Infrared/Brillouin spectroscopy is highly desirable. Experience working with high pressure devices and expertise in XRD analysis and computational methods is preferred.

    Ph.D. (Physics, Chemistry, Materials Science) Applicants should have outstanding research and development experience, relevant computer skills, organizational skills, verbal and written communication skills, and should be able to work effectively in a team and independently. Experience working with high pressure devices / single crystal X-ray diffraction / powder X-ray diffraction / EXAFS / spectroscopic studies / transport measurements / ab-initio calculations is preferred.

    Job Profile for BARC Recruitment 2022

    1. Development of neutron and synchrotron beamlines, research on energetic materials and investigation of quantum spin phenomena

    AR will need to develop single crystals of technologically important oxide materials and topological insulators using the optical floating zone technique. The RA will also study the physical properties of these crystals using internal neutron scattering and other related techniques with the aim of understanding how the magnetic properties relate to their chemical composition and atomic structure.

    2. R&D on various options for hydrogen power generation

    Development of an electrocatalyst, an assembly of membrane electrodes for the CuCl/HCl electrolysis step, kinetics and a sputtering reactor for the CuCl2 hydrolysis step of the Cu-thermochemical cycle Cl.

    Check full notification for full details

    To note – The Department does not award any such scholarships to fellows who have submitted a Ph.D. thesis and are awaiting evaluation of the thesis.

    To read the full notification – Click here

    Disclaimer: The recruitment information provided above is for informational purposes only. The recruitment information above is taken from the official website of the Organization. We do not provide any recruitment guarantees. Recruitment should be conducted in accordance with the official recruitment process of the company or organization that advertised the recruitment position. We do not charge any fees for providing this employment information. Neither the author nor Studycafe and its affiliates accept any responsibility for any loss or damage of any kind arising from any information contained in this article or for any actions taken in reliance thereon.

    Mary Marsha Green – Democratic Herald


    Mary Marsha Green was born in Springfield, Missouri on January 21, 1954.

    Marsha was the youngest daughter of Charles and Helen Morton. Survived by his brother Charles Morton. Marsha loved being in the water! She studied at South Southwest Missouri State University to become a biologist in which she used her love of water, children and nature. In 2014, Marsha co-authored the JOLT (Journey On Lake Texoma) program which has taught thousands of children about environmental science. Marsha not only co-wrote the program, but has spent her life putting the JOLT program into action. She walked hundreds of miles of trails with her students right behind her. Teach them to love and respect the world around them. Marsha shared her love of nature with all of her children and grandchildren. Taking them on fossil hunting, animal tracking and fishing are just a few of the ways she has shared her love of biology with her family and students. Marsha and her late husband William H. Green Sr. were avid bird watchers. Spending hundreds of hours studying the habits of birds in their natural environment while working hours building bird feeders. Marsha was also a member of the Daughters of the King where she spent countless hours praying for others. Marsha was a devout Episcopalian and was a member of the St. John’s congregation. St Johns was the only place she and her late husband frequented where they felt loved and accepted. Marsha had many talents. From art, cooking and sewing, to knee binding. She was an incredible mother, colleague, wife and friend. While Marsha loved her church and her students, she loved her family more. Proud mother of William H. Green Jr., April Lyon, Jeremiah Green, Emily Bloom, Luke Green, Maggie Krueger and James Green. Marsha leaves behind a new generation of greens to include ShaRaya, Nadia, Walker, Byron, Ezekiel, Aurora, Kate, Molly, Charley……and another on the way.

    Momma Green will be missed but her spirit will shine through us all. The memorial service will be October 15, 2022 at 10 a.m. @ St John the Apostle 720 FM 120 Pottsboro, TX 75076

    Reverend Dr. Marci Pounders, parish priest. Phone: (903) 786-4339

    2022 Homecoming Court crowned Monday night – The Daily Eastern News


    Nile Hile, a senior business management major, and Jaedah Franks, a junior biology major, became Eastern’s 2022 homecoming king and queen on Monday night.

    In the Grand Ballroom to begin Homecoming Week 2022, the 2022 Homecoming Court was crowned Monday evening with a King, Queen, Prince, Princess, Lord and Lady of the Faculty/Staff and a little prince and a princess.

    Hill, who represented Alpha Phi Alpha Fraternity, Inc., said he felt humbled to win Homecoming King and wanted to continue the tradition of a member of his fraternity to win Homecoming King.

    Last year’s reunion king Jeremiah Boyd-Johnson also represented Alpha Phi Alpha Fraternity, Inc.

    “I want to keep the tradition going, so I’m very honored to be picked and voted on by everyone,” Hill said. “So thank you to everyone who voted for me…It’s been a good experience, I’m so happy to be a part of it.”

    Hill thinks everyone has a voice on campus and it’s important to have one.

    “It’s important to know that everyone has a fair chance, everyone has a voice,” Hill said. “We have a presence here on campus, and it’s been going pretty well.”

    Homecoming Queen Jaedah Franks, a young bioscience student, and King Nile Hill, a senior management student, pose for a photo with sorority and fraternity siblings after the coronation ceremony of the reunion at the Union Grand Ballroom on Monday night. (Hannah Fergurson)

    Franks, who won Homecoming Princess at Homecoming Court 2021 and Miss Black EIU 2022, represented Black Student Union at this year’s Homecoming coronation.

    “It’s surreal,” Franks said. “After winning once you think the second time, ‘I may not win the second time,’ but I want to pray honestly and believe in myself and also have my sorority sisters, my brother of fraternity, who always encourage me.”

    Garrett Wilkin, a sophomore in kinesiology, and Anahi Osorio, a junior exercise science student, were crowned prince and homecoming princess in 2022.

    Wilkin, who represented Sigma Phi Epsilon, said winning Homecoming Prince was a great experience.

    “I’m happy,” Wilkin said. “I mean, [it’s] just [a] nice experience. I just love Hoco and all the events that are going on, I just love seeing people active on campus.

    Wilkin said his participation in many campus activities helped him get nominated in the first place.

    “I think how much I enjoy being out there and doing a lot of things,” Wilkin said. “I like to volunteer. I’m an assistant wrestling coach for Charleston. I do a lot of volunteer training. I do several clubs and I’m just active.

    Osorio also came forward. She has represented the campus recreation center and is a fitness instructor.

    “Something to take away is like I said, get out of your comfort zone and be yourself,” Osorio said. “Don’t let anything stand between you and your success and you try to step out of your comfort zone. So that’s one thing.

    Brittany Tierney, Assistant Director of Admissions, and Gary Bulla, Chair and Professor of the Department of Biological Sciences, were crowned Homecoming Faculty/Staff Lady and Lord, respectively.

    “It’s really exciting to see the students come out and get the excitement back to campus and for everyone to have a really great time kicking off Homecoming,” Tierney said. “And I want to thank Ashley and the whole reunion committee for all the work they’ve done to make this happen. They’re doing a great job.

    “It’s a great honor… And I don’t know who nominated me or anything,” Bulla said. “So it’s an honor to be nominated.”

    Four-year-old Lily Morris hugs her newly won Karina squishmallow showing the Lord Gary Bulla of Homecoming 2022 after being crowned as Homecoming’s Little Princess 2022 during the Homecoming Coronation ceremony at the Union Grand Ballroom on Monday evening. (Rob Le Cates)

    Tierney’s son Clayton and Lily Morris, the daughter of Geology and Geography Department office manager Amy Morris, were crowned homecoming prince and princess in 2022.

    They are both excited about the parade and Morris enjoyed having his crown.

    Cam’ron Hardy, Kyara Morales-Rodriguez and Drew Coffey contributed to this article.

    Katja Benz can be reached at 581-2812 or [email protected]

    WCM-Q students connect with directors of elite US residency programs


    Doha: Weill Cornell Medicine-Qatar (WCM-Q) students and faculty met with faculty from leading US healthcare institutions during the college’s annual Visiting Professor Program (VPP).

    The program was established in 2013 to help residency program directors become familiar with WCM-Q as an elite medical school that produces highly skilled physician-scientists who are extremely well prepared to enter training in residency locally at Hamad Medical Corporation or abroad at world-class universities. health facilities. The student-focused VPP takes place online over two days and gives students the opportunity to explore medical career options and benefit from the expertise of visiting faculty by asking questions about preparing for residency training and the application process.

    This year, 15 visiting professors from 12 major American medical institutions participated in the program: NewYork-Presbyterian Hospital/Weill Cornell Medical Center, University of Pittsburgh School of Medicine, Washington University School of Medicine, Johns Hopkins University School of Medicine, Stanford University School of Medicine, Columbia University Vagelos College of Physicians and Surgeons, Georgetown University School of Medicine, Emroy University School of Medicine/Grady Memorial Hospital, University of Mississippi Medical Center, the Medical College of Wisconsin/Froedtert Hospital, NewYork-Presbyterian Brooklyn Methodist Hospital, and the University of Maryland Capital Region Medical Center. The visiting professors specialized in emergency medicine, internal medicine, neurology, obstetrics/gynecology, psychiatry, physical medicine and rehabilitation, radiology, surgery and family medicine.

    The program began with a welcome message from Dr. Javaid Sheikh, Dean of WCM-Q, after which senior members of WCM-Q’s education leadership team presented the progressive, integrated and innovative medicine program six-year college and WCM-Q students. outstanding results, which include strong academic output and an exceptionally high rate of students obtaining residency training positions at leading U.S. institutions. The program also demonstrates WCM-Q’s status as a unique international medical school that has the same curriculum and assessment methods as Weill Cornell Medicine in New York. The event included keynote addresses from Dr. Peter Bulova of the University of Pittsburgh School of Medicine, Dr. Sara Krzyzaniak of Stanford University School of Medicine, Dr. Daniel Knoepflmacher of NewYork-Presbyterian Hospital/Weill Cornell Medical Center and Dr. Kathryn Dielentheis. from the Medical College of Wisconsin/Froedtert Hospital.

    WCM-Q’s Dr. Thurayya Arayssi, Associate Dean for Academic and Curriculum Affairs, said, “It is wonderful to be able to welcome such highly qualified faculty from some of the world’s leading academic health institutions to WCM-Q. The knowledge, expertise and wisdom they shared during the VPP will prove invaluable to our students as they plan their careers and dedicate themselves to delivering excellence in patient care.

    Dr. Amine Rakab, Assistant Dean for Clinical Learning at WCM-Q, said, “We are full of gratitude to the visiting professors who provide our students with such wonderful opportunities to explore a wide variety of career paths and to discern which residency training institutions will be best suited to their particular skills, interests and goals. At the same time, the VPP is of great assistance to our students in their efforts to produce residency applications of exceptional quality that meet the standards and expectations of residency program directors at academic health institutions in ‘elite.


    About Weill Cornell Medicine – Qatar

    Weill Cornell Medicine – Qatar is a partnership between Cornell University and the Qatar Foundation. It offers a comprehensive six-year medical program leading to the Cornell University medical degree with instruction from Professors Cornell and Weill Cornell and physicians from Hamad Medical Corporation (HMC), Aspetar Orthopedic and Sports Hospital Medicine, Primary Health Care Corporation, Feto Maternal Center and Sidra Medicine, who hold positions at Weill Cornell. Through its biomedical research program, WCM-Q is building a sustainable research community in Qatar while advancing basic science and clinical research. Through its Faculty of Medicine, WCM-Q seeks to provide the best possible education for medical students, to improve current and future health care, and to provide high quality health care to the people of Qatar.

    For more information, please contact:

    Hanan Lakkis
    Associate Director, Media and Publications
    Weill Cornell Medicine – Qatar

    Breaking Some Common Beliefs Surrounding White Tail Movement Due To Weather – Twin Cities


    One look at the title of this story, and many would assume I’m referring to the cold and snow that will hit Minnesota in late fall and early winter.

    As hunters, we know better. Snow and temperature drops are what drive many of us into the woods. It’s those comfortable and pesky weather conditions – sun and 70 degrees – that get a bad rap in the whitetail deer hunting world.

    If you listen to a podcast focused on deer hunting or consume whitetail deer hunting media, you’ve heard it. “A cold front is coming, and it’s going to make them money.” If the deer aren’t spotted, it’s those damn hot temperatures. Or maybe the wind is blowing too hard.

    It is such a common belief that bucks move more in cold conditions and stay tight until dark in warm weather that some hunters will simply stay out of the woods until a cold front hits.

    Science doesn’t support that much. Studies of GPS-equipped deer have found minimal evidence that weather influences deer movement. Regardless of the temperature, deer move the most at dusk and dawn because that is when they can see best.

    Mark Kenyon works for outdoor lifestyle company, MeatEater, and hosts the Wired to Hunt podcast focused on whitetail deer hunting. Kenyon wrote a story in 2020 titled “Does Temperature Affect Deer Movement? This piece focused on the divisive nature of this topic in terms of what science says and what hunters think they see in the woods.

    Those who study this will consistently say that if there is a link between increased male movement and temperature, it is minimal.

    “We saw changes when we had temperature changes,” Bronson Strickland of Mississippi State University said in Kenyon’s story about one of their studies. “When a front came along, we might see changes. But again, it wasn’t that dramatic. It was still subtle.”

    Maybe a little more movement during the day is all we hunters are looking for. It might be the difference between shooting a buck at last light and never seeing him. I’ve heard that argument, and it makes sense to me.


    For many years I lived by the mantra “must chase cold fronts”. This often led me to decide when and where to hunt, even during the rut. I was missing the potential for a lot of good hunts because of that.

    My experience hunting cold fronts is like any other weather I’ve hunted. There are good seats and bad seats. My mindset on their importance has completely changed, basically to not worry about the weather anymore.

    I love climbing a tree with temps in the mid 30’s. Seems fair to me, but I’ve had a lot of great encounters and some of my biggest dollar kills that have come in weather conditions while thinking popular is that it’s a waste of time to be in the woods.

    I think back to my first mature buck shot with a bow in my early twenties. It was an almost 80 degree day in mid-October. Hot during the “October lull”. What’s worse?

    Watched some deer move by the river on a sit down party, adjusted the next afternoon to that area and had a huge bodied Minnesota 9 pointer at 20 yards with an hour of daylight on the left.

    The 2020 opening weekend in Minnesota featured terrible conditions. Temperatures in the 80s and winds blowing from the south at over 30 mph.

    These winds allowed me to leisurely climb up a stream to set up over a low crossing and fire a 9 pointer that came out from a high point on the surrounding ridges.

    Like warm temperatures, wind is another popular weather condition that some people say hunting is pointless. That mindset would have kept me on the couch the night I fired my biggest shot yet on September 4 of this year in North Dakota.

    I saw this male with another 3.5 year old male during my first session of the season on the evening of September 3rd. Temperatures were in the 70s with light northeast winds. The wind shifted completely the next day to the southeast gusting to 25-30 mph.

    Again, the wind allowed me to quietly settle even closer to where I suspected these males were lying. With half an hour of light remaining, the 12 point was 2 meters away from me.

    The winds will almost always subside during the last hour of light. The deer will be up at this time and you will have had the opportunity to use the stronger winds of the day to get closer to where you suspect them to be.


    This male from North Dakota was shot on the morning of November 3, 2020 on a day when high temperatures got unusually warm to over 70 degrees. Regardless of weather conditions or the phase of the moon, things that fluctuate widely, white-tailed deer have evolved to time the rut in northern climates at very regular times each year to give fawns and does the greatest chance. of survival. (Eric Morken/Alexandria Echo Press)

    I don’t pay much attention to the weather conditions during the rut.

    My 2020 North Dakota dollar arrived on the morning of November 3 when high temperatures were in the 70s that day. Set up between two sleeping areas a few hundred yards apart, a 10-pointer arrived right on a deer’s tail around 8:30 a.m.

    Think of the rut this way – the timing is literally life or death sometimes for does and fawns in northern climates. White-tailed deer have a gestation period of around 200 days and they have evolved to achieve a perfectly timed reproductive peak that gives fawns the best chance of survival.

    It takes a lot of energy to raise fawns and it takes that extra nutrition that comes with spring greening. If fawns are born too early in northern climates, the risk of mortality is high due to weather conditions. Born too late, fawns run the risk of not being healthy enough to survive their first winter.

    It is important that most fawns fall during a similar period in the spring to overwhelm predators. Coyotes, wolves, bobcats, and bears can only eat a certain number of fawns in an area before the fawns are upright and can better escape.


    Eric Morken with a male from North Dakota that he shot with his bow on September 4, 2022
    Eric Morken with a male from North Dakota that he shot with his bow on September 4, 2022 during the opening weekend of the archery season. This male was shot on a day when winds were gusting over 25 mph from the southeast. High winds often die down by the last light of day, and these high winds during the day can be a great way to get closer to areas where hunters expect whitetail deer to lay down. (Eric Morken/Alexandria Echo Press)

    I recently had a conversation with Kip Adams of the National Deer Association. Adams is the NDA’s director of conservation with a master’s degree in wildlife biology from the University of New Hampshire.

    Rutting time, or the actual breeding that takes place, is very consistent each year in the northern two-thirds of the United States, Adams said.

    It’s not triggered by the weather or the phases of the moon, two things that fluctuate. It is determined by the photoperiod, ie the daily duration during which an organism receives light.

    “It’s extremely cut and dry,” Adams told me. “We can measure the fetuses of deer killed in late winter or spring, remount those deer, and we know exactly when those deer were bred. It’s not hearsay, “Hey, that’s when we think it’s the rut.” Biologists know exactly when this happens. In the northern United States, it depends a lot on the photoperiod. »

    Adams arrives as both a wildlife biologist and an avid deer hunter. He enjoys chasing cold fronts as much as anyone, but he doesn’t let the weather dictate when he’s in the tree.

    A popular peak breeding date in northern areas is November 15, with breeding occurring on a bell curve around this date. Adams said on Oct. 31 and through the first week of November, he’s in the woods to take advantage of that search stage where the bucks actively seek out the first receptive doe before that breeding peak.

    I get the plot from hunting on a freezing morning with 5-10 mph northwesterly winds on November 5th. This will excite me as much as anyone. But if you wait for these conditions to hit the woods, you’re missing out on a lot of potential big hunts this fall.

    The best startups in Tel Aviv Pipa News


    Tel Aviv’s startup scene underwent a transformation around 2019, shifting from a “holy grail exit” system to, as Startup Link CEO Eli David puts it, “creating companies that don’t want sell to Google immediately”.

    As has always been the case, the military remains the main source of founders – not only because almost everyone goes through it, but also because of its focus on problem solving and cybersecurity. , AI and robotics. Web3, gaming and productivity startups are on the rise as countries like India come online as customers. “We have a brain drain problem,” admits Michel Abadi, managing partner at Maverick Ventures Israel. “But we have a lot of patience.”


    “We map the immune system and all of its different parts, from cell types to cell states, to provide researchers with a complete map and a comprehensive understanding of the immune system,” says Luis Voloch. , who co-founded Immunai with Noam Solomon in 2018. The platform combines single-cell multiomics, machine learning, and functional genomics with high-quality patient data to identify and validate novel drug targets, reduce costs, and increase cure rates. successful drug development. A total of $295 million was raised in three rounds from Viola Ventures, Dexcel Pharma and Koch Disruptive Technologies. Immunai has 25 academic collaborations with institutions including Harvard, Stanford and Memorial Sloan Kettering and 30 partnerships with Fortune 100 pharmaceutical companies. The company, with offices around the world, achieved unicorn status in October 2021 – less three years after its founding – and acquired San Francisco-based computational biology startup Dropprint Genomics and Swiss bioinformatics company Nebion. Plans include developing the company’s own drug discovery pipeline from the compounds it has acquired. immunai.com

    Sara Safra, CEO and co-founder of Beewise, on the robotic hive.Photo: Jonathan Bloom

    be wise

    According to co-founder Sar Safra, “I have some of the clearest KPIs of any company I’ve started. “For every dollar we earn, we save two bees.” According to Safra, 75% of all fruits and vegetables are pollinated by bees, while 35% of bee colonies disappear each year. BeeWise, launched in 2018 by serial entrepreneur Safra and beekeeper Elijah Radziner, is on a mission to prevent colony collapse disorder. How? A robot that can shut down a hive if it detects pesticides, provides food when a colony is weak, and regulates temperature to keep bees alive. The company has raised $120m in four rounds involving local VCs Lool Ventures and Fortissimo Capital as well as US backers Corner Ventures and Insight Partners. It is opening new factories near larger bee populations and claims to reduce fallout from 35% to 8% where they are deployed. beewise.ag

    Execute: AI

    Run:AI has created a special virtualization layer for deep learning that can train AI models running on GPUs much faster than usual, using fewer resources. Since GPU accelerators are among the most expensive devices in a data center, efficiency is key. In 2018, Omri Geller and Ronen Dar launched Run:AI to control workloads from the cloud, pooling resources from large clusters of GPUs and between different AI workloads by automatically assigning computing power required for each task. share. “We’re doing the same thing for AI hardware that VMware and virtualization did for traditional computing,” Dar says. The company has raised $118 million in three funding rounds backed by Insight Partners, Tiger Global, TLV Partners and S-Capital VC. Since launching the product in 2020, the company’s revenue has grown ninefold, and future plans include managing inference workloads — AI trained like facial recognition software — from the cloud. run.ai


    Empathy combines technology and human support to help family members bereaved by military actions and emotional trauma following the death of a loved one. The app can help with funeral arrangements and validating a will, say founders Ron Gura and Jonathan Bergman, but the human support of care managers who offer emotional support is key. Founded in 2020, the company has raised $43 million in two rounds of funding from entities like Entire Capital and Aleph, as well as angel investors including Fiverr co-founder Micah Kaufman. Empathy reports that 92% of users said they felt better after using the app, and US Empathy users saved an average of $3,007. The company has now partnered with Goldman Sachs and New York Life to help employees. sympathy.com


    Most neurodegenerative diseases, such as Parkinson’s disease or Alzheimer’s disease, require highly subjective and insensitive symptom examination and diagnosis, which hampers rapid diagnosis, drug development, and accurate care. Neuralite, founded in 2021 by CEO Mica Brakestone and CTO Edmund Anonymous, is building the world’s largest symptom database, measuring over 1,000 volunteers to date. Neuralite recently secured its first commercial contract with a publicly traded pharmaceutical company to aid in therapeutic discovery for amyotrophic lateral sclerosis (ALS). The company raised $30.5 million in two rounds from Koch Disruptive Technologies, Samsung Next, Operator Partners and VSC Ventures. Three trials with patients with Parkinson’s disease and MS are planned for this fall, in collaboration with major hospitals. neurallight.ai


    LUSIX produces laboratory-grade diamonds for the gemstone market and industrial applications in its solar-powered laboratory. Company raises $135m – LVMH Luxury Ventures led the company’s recent $90m seed round, which aims to expand its production capacity in Israel with a second all-solar facility commissioned this summer . The company was founded in 2016 by physicist Yossi Yayon and entrepreneur Benny Landa as a spin-out from digital printing company Landa. “The journey of lab-grown diamonds has only just begun and is being increasingly embraced by consumers, especially Millennials and Gen Z,” Landa says. lusix.com

    best juice

    Better Juice uses enzymes from microorganisms to convert the sugar in fruit juices into indigestible fiber, which is said to reduce up to 80% of all sugars in the juice. Founded in 2018 by Eran Blachinsky of the Hebrew University of Jerusalem, it received $8 million in seed funding led by iAngels, as well as Food Tech Lab and The Kitchen Hub. Blachinsky says his process does not affect the smell or taste of the juice, although it does reduce sweetness. Manufacturers can design processes to select the amount of sugar they wish to eliminate. The recent round will fund other product lines, such as ice cream, soft drinks and jams. best-juice.com

    Yanib Maur, founder of Tavel.Photo: Jonathan Bloom


    “Farmers around the world are struggling to recruit fruit pickers, a situation that puts the entire industry at risk,” says Tavel founder Yaniv Maur. The company recently raised $32.1 million from agricultural equipment manufacturers, including Japan’s Kubota and China’s Forban, for its fleet of drones for picking, thinning and pruning in orchards. A single unit consists of a wheeled vehicle made up of four quadcopter drones that are electrically attached to the vehicle and equipped with meter-long mechanical claws and AI-powered eyes that can differentiate between fruits and their sizes . and measure maturity. The company plans a commercial rollout in southern Europe in late 2022. tevel-tech.com


    Since 1978, more than 8 million babies have been born through IVF – however, with around 3 million IVF cycles each year, the birth treatment ratio could be better, says embryologist Daniela Gilboa and fertilization specialist in vitro Daniel Seidman, founder of the AIVF. , The company combines AI-based computer vision with a database of previous studies to identify embryos most likely to be successfully fertilized without the need for invasive testing. Founded in 2018, the company has raised $35 million in multiple rounds from investors including Insight Partners and Adam Newman’s Family Office. After obtaining the European CE mark in 2021, the company is now planning to expand into the United States. aivf.co


    For a startup founded in 2018, Trigo picked a tough target to beat: Amazon, which opened 70 frictionless outlets. “We are the only company capable of converting existing stores into stand-alone stores,” says Michael Gabe, CEO and co-founder of Brother, Daniel. The company’s computer vision systems include camera hardware and encrypted “to-go” software that allows customers to pick up items and receive invoices before leaving the store. Trigo has secured $104 million in a series of rounds with backing from 83North, Vertex Ventures, Red Dot Capital Partners and Tesco, which opened its first till-less Trigo store in London in October 2021. Trigo is based in Germany, the United States. Netherlands. , and the UK in 2022. trigoretail.com


    Transgender interferes with both science and God’s design

    Transgender logo
    Hand holding a sheet of paper with transgender symbol and equal sign inside. |

    “Do not plant your vineyard with two kinds of seed; if you do so, the whole harvest will be defiled – both the crop you plant and the fruit of your vineyard” – Deuteronomy 22:9

    “God delivered them in the desires of their hearts to impurity to dishonor their bodies” – Romans 1:24

    “For their cause God gave them up to vile affections” Romans 1:26

    The Bible teaches that God created us male or female, and regardless of our own feelings or confusion, we must act according to the reality of God’s biological purpose. We know from Genesis 1 and 2 that the categories of masculine and feminine are part of God’s purpose for mankind. “Transgenderism” proposes to interfere with both science and God’s purpose, and is therefore the anthesis of His Word.

    While the Bible and biology know of no other categories of humans (or any other mammal) other than males and females, recent claims by gender activists include insisting that Americans must conform their language to a person’s subjective identity. Today, people who identify as transgender (or “gender non-conforming”) can use a veritable cornucopia of different terms to describe themselves.

    Getting colleges or the Olympics to allow “trans women” to compete in women’s sports is one thing; pretending it’s scientific (or even right) is something else. It should be noted that there are men and women in scripture who can express their masculinity and femininity in multiple ways, with scripture and science working with the binary categories of masculine or feminine.

    The “preferred genres” are only superficial. Sex-Based Physiology Lives On Forever

    There is no scientific argument that a person’s sex is determined at the time of conception and that fertilization of an egg can only occur with an “X” or “Y” sperm, which does not will determine that one of the two different sexes. After conception, the divergent developmental pathways of males versus females are immediate, substantial, and diverse down to the cellular DNA level. These branching paths persist throughout an individual’s life.

    Each nucleated cell in the human body has 46 sex-specific “XY” chromosomes (indicating male biological sex) or “XX” chromosomes (indicating female biological sex). These nucleated cells in turn have sex-specific functions that guide their development and biological function.

    Indeed, biological sex is more than just “skin deep”, it persists down to a microscopic, cellular level, and biological sex is indicated in the 100 trillion (or more) cells of the human body.

    Conclusion: the indelible imprint of biological sex—determined in utero and at design time — is not scientifically or clinically possibleto alter.

    Synthetic gender editing is extremely dangerous

    This physiological difference cannot be suppressed, no matter how much synthetic testosterone or estrogen one pumps into their bodies. “Puberty blockers” known scientifically as “gonadotropin-releasing hormones” (GnRH) in children ages 5 to 12, which HHS’s Office of Population Affairs (OPA) says are “safe” and “reversible” in its widely vaunted official report. , final guidance document. Recently, even the still Biden-backed and scientifically flexible FDA warned that it could cause life-threatening brain swelling, headaches, vomiting, a host of visual disturbances (including blindness) and/or Tumor-like masses in brain destroying HHS / OPA’s obvious dereliction of duty and science. You don’t have to be an FDA drug safety expert to know that using pharmacology to combat the biological programming of trillions of nucleated cells in the human body is going to have serious consequences.

    Biological men in women’s sport

    A recent review of two dozen transgender medical studies published in the British Journal of Sports Medicine explains the benefits of XY chromosomes at the cellular level. It shows that biological males have advantages in terms of muscle mass, lean body mass, muscle strength and two measures of endurance: hemoglobin and hematocrit, as well as indirect measures of transport efficiency. and oxygen supply. Although synthetic estrogens and/or anti-testosterone pharmaceuticals have been shown to slightly decrease these parameters – and even if normal levels of male testosterone are absent at the time of competition – the innate sexual advantage of latent effects of a lifetime of testosterone persists. Quoting the article’s conclusions: “Notwithstanding, the strength values, LBM [lean body mass] and muscle surface area of ​​trans women remain greater than those of [biological] women, even after 36 months of hormone therapy.

    Exposure to testosterone during puberty increases present and future physical performance and muscular endurance, and muscular endurance is influenced by oxygen consumption. Men have physiologically larger airways due to exposure to testosterone. According to the researchers of the journal BreathThe higher oxygen cost of respiration in women means that a greater fraction of total oxygen uptake and cardiac output is directed to the respiratory muscles, which influences physical performance.

    Even if one insists on using anti-gender pharmacology, the clear physiological sex differences between men and women will persist even after years of “gender transition” and are evident to even the most casual lay observer. Example: just look at a muscular man, image of broad-shouldered William “Lia” Thomas tight in an obviously ill-fitting women’s swimsuit shows that after a lifetime of endogenous testosterone production, he does not having a woman’s body, regardless of her current level of synthetically induced estrogen.

    The fairly obvious outward dimorphism between the male and female sexes are just a few of the many physiological and metabolic differences between the sexes – which are exactly which gender-specific sports were designed to correct.

    Men trying to enter women’s sport is a centuries-old pathology

    The male sex undoubtedly conveys a physiological advantage over the female sex. If you thought athletes like William Thomas were anything new trend, you would be wrong. Men trying to compete in women’s sports is nothing new, but historically they have been denied long before they got to the competitive stage.

    Media reports date back to at least the 1930s of men impersonating women in order to participate in women’s sports and gain ill-gotten fame. Because this problem has persisted over time, and in an attempt to prevent it, there have been regulations since the 1940s governing the participation of athletes outside the biological sexual binary.

    Surreal progressive colleges, universities and other professional organizations such as The Master’s Weightlifting want to ignore biology and chromosomal blood testing to illustrate their infinite DEI. This forever prevents American women from having a chance at victory. While a few short-lived professional organizations such as USA Cycling are finally starting to get the hang of it, it’s far from enough.

    The scientific answer will always have to be 1.) biological male sports and 2.) biological female sports. If the organizations insist on responding to the endless outrage of the “woke” crowds, the only acceptable alternative is to have a “third” category for transgender competitors.

    Admittedly, this will end up being problematic as well, because as of this writing, there are 112 (and counting) artificial genders (and counting).

    Dr. David Gortler is a pharmacologist, pharmacist, and health care and FDA policy watchdog researcher at the Center for Ethics and Public Policy in Washington, DC. He was a professor of pharmacology and biotechnology at Yale University School of Medicine, where he was also a faculty member at the Yale University Bioethics Center. He was then hired as an FDA physician who was appointed Senior Advisor to the FDA Commissioner for Drug Safety, FDA Science Policy, and FDA Regulatory Affairs. He is a columnist at Forbes, where he writes about drug safety, healthcare, and FDA policy.

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    Other SARS-CoV-2 proteins are important for d


    Researchers at the University of Maryland School of Medicine have identified how several SARS-CoV-2 genes affect disease severity, which could lead to new ways to develop future vaccines or develop new treatments. . Genes control the host’s immune system, contributing to the ferocity with which the body responds to a COVID-19 infection.

    Although people generally think that the spike protein that forms the structural “crown” is the driving factor behind each new variant of COVID-19, research results also show that mutations in these other “accessory” genes also play a role. a role in disease progression. . For this reason, the researchers believe that these accessory proteins warrant further study, as their mutations may become increasingly important as new variants emerge.

    Their findings were published on August 30, 2022 in PNAS.

    Omicron’s BA.4 variant, which circulated earlier this year, has been overtaken by the latest BA.5 variant of the virus currently circulating. Both of these variants appear to evade the immune system due to mutations in the spike protein. Because of these spike mutations, researchers say previous vaccines aren’t as effective at preventing the disease.

    “What’s interesting is that the BA.4 and BA.5 variants have the same genetic sequence for the spike protein,” said Matthew Frieman, PhD, Alicia and Yaya Foundation Professor of Viral Pathogen Research in the Department of Microbiology and Immunology at UMSOM. “That means it’s the other genes, the non-spike protein genes, that seem to affect how the virus copies itself and causes disease. So mutations in these other accessory genes are what allowed variants like BA.5 to outperform earlier versions of the virus.

    The SARS-CoV-2 virus has three types of genes – those involved in making more copies of the virus, those that make up the structure of the virus, and accessory genes that have other functions. For this new study, the researchers wanted to know the function of accessory genes. To do this, they recreated viruses that lacked each of the four accessory proteins, then infected mice with these new viruses or the original virus. Then they observed how each virus affected the mice.

    Dr. Frieman’s team of researchers found that the virus lacking the ORF3a/b gene caused milder infections than the original SARS-CoV-2 virus. Mice with this virus strain lost less weight and had less virus in their lungs than mice infected with the original virus. These results indicated that the ORF3a/b gene likely plays a role in making more copies of the virus through viral replication or in blocking the immune response to infection. Further experiments suggested that ORF3a/ba does extra work in the virus by appearing to activate the body’s innate immune system, the first line of defense launched by the immune system, signaling that a foreign invader must be defeated.

    In contrast, the researchers found that mice infected with a virus that lacked the ORF8 gene were sicker than mice with the original strain of SARS-CoV-2. These mice had increased lung inflammation compared to the original SARS-CoV-2 virus. The researchers said ORF8 appears to control the immune response in the lungs.

    “By inhibiting the immune response, ORF8 helps the virus replicate more in the lungs, which makes the infection worse. Once removed, it allowed the immune system to fight back stronger,” Dr. Frieman said.

    Next, the researchers looked at the significance of the spike protein for disease severity in each of the different SARS-CoV-2 variants. They took the original virus and replaced the spike gene with the spike gene of the alpha, beta, gamma, or delta variant. Then they infected cells and mice and watched how each of these viruses replicated and entered healthy cells. The virus uses the spike protein to hitch a ride on host ACE2 receptors found on the outside of cells lining the lungs in order to get inside and infect the cells.

    Dr. Frieman’s team found that the spike protein determines the severity of some of the variants, but not others. The gamma variant was weaker than other variants in its ability to replicate and infect. The researchers believe that mutations in genes outside of the “spike”, particularly in the ORF8 gene, appear to play a role in making this version weaker than the others. Although the gamma variant circulated in Brazil, it did not spread further around the world as it was overtaken by stronger variants.

    “While spike mutations are important for enhancing receptor binding and cell entry, researchers have also found that mutations in accessory proteins can alter the clinical presentation of the disease,” said Mark T. Gladwin, MD, Vice President of Medical Affairs at the University of Maryland, Baltimore and Professor Emeritus John Z. and Akiko K. Bowers and Dean, UMSOM. “We need to learn more about the role of accessory protein mutations in COVID-19 infection, especially as new variants and subvariants continue to emerge where these other proteins may play a more important role. .”

    The researchers plan to focus on dissecting more of ORF8 function in future studies.

    Other UMSOM authors include graduate student Marisa McGrath, postdoc Carly Dillen, PhD, research technician Lauren Baracco, and postdoc Louis Taylor, PhD; the other study co-authors were from the J. Craig Venter Institute.

    This work was supported by grants from the Bill and Melinda Gates Foundation, the National Institute of Allergy and Infectious Diseases (R01AI137365 and R03AI146632), and the J. Craig Venter Institute.

    About University of Maryland Medical School

    Now in its third century, the University of Maryland Medical School was incorporated in 1807 as the first public medical school in the United States. It continues today to be one of the world’s fastest growing leading biomedical research enterprises – with 46 academic departments, centers, institutes and programs, and a faculty of more than 3,000 physicians, scientists and allied health professionals, including members of the National Academy of Medicine and the National Academy of Sciences, and a two-time distinguished recipient of the Albert E. Lasker Award in Medical Research. With an operating budget of more than $1.3 billion, the School of Medicine works closely with the University of Maryland Medical Center and Medical System to provide intensive research, academic, and clinical care to nearly 2 million patients each year. The School of Medicine has nearly $600 million in extramural funding, with most of its academic departments ranking highly among all medical schools in the nation for research funding. As one of seven professional schools that make up the University of Maryland, Baltimore campus, the School of Medicine has a total population of nearly 9,000 faculty and staff, including 2,500 students, trainees, residents and fellows. The combined medical school and medical system (“University of Maryland Medicine”) has an annual budget of more than $6 billion and an economic impact of nearly $20 billion on the state and local community. The School of Medicine, which ranks first among 8th highest among public medical schools in research productivity (according to the Association of American Medical Colleges profile) is an innovator in translational medicine, with 606 active patents and 52 start-up companies. In the last US News and World Report ranking of best medical schools, released in 2021, UM School of Medicine is ranked #9 among the 92 public medical schools in the United States and in the richest 15% (#27) out of 192 public and private American medical schools. The School of Medicine works locally, nationally and globally, with research and treatment facilities in 36 countries around the world. Visit medschool.umaryland.edu

    Penn State Harrisburg workshop explores agriculture in the classroom


    Throughout the week, teachers from the Harrisburg area, and as far away as Rhode Island, participated in activities such as learning about automating hydroponic systems and growing and selecting plant tissue. .

    At the start of the week, teachers learned the basics of coding as Attaluri, assistant professor of mechanical engineering, and representatives from Intermediate Unit Tuscarora 11 helped them learn how to set up automated hydroponic systems – a technology that has been around for a while but facilitates a huge job market.

    “Next generation jobs will be very different,” Attaluri said. “These little new age skills are important.”

    Students need active learning, he said, and the workshop helps teachers narrow down complex projects so they can be implemented in classrooms.

    Eric Yoder, educational technology coordinator at Tuscarora Intermediate Unit 11, said the workshop was timely because new science standards being implemented in Pennsylvania emphasize hands-on learning and scientific practices.

    Jigar Patel, Innovation and Special Projects Coordinator at Intermediate Unit, noted that the workshop combines several disciplines – computer science, mathematics, engineering and biology.

    “It shows the interdisciplinary nature of what the real world looks like,” he said.